medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2019-10-15-21medsovet-3048Research ArticleИММУНОТЕРАПИЯ В ОНКОЛОГИИImmunotherapy in oncologyИммунотерапия гепатоцеллюлярного рака: начало и перспективыImmunotherapy for hepatocellular cancer: beginning and future perspectivesКазанцеваМ. А.KazantsevaM. A.

к.м.н., младший научный сотрудник отделения химиотерапии № 1 торакоабдоминального отдела (клинических биотехнологий) Федерального государственного бюджетного учреждения «Национальный медицинский исследовательский центр онкологии имени Н.Н. Блохина» Министерства здравоохранения Российской Федерации.

Cand. of Sci. (Med.), Junior Researcher, Chemotherapy Department No. 1, Thoracoabdominal (Clinical Biotechnologies) Unit, Federal State Budgetary Institution «Blokhin Nation al Cancer Research Center» of the Ministry of Health of the Russian Federation.

Okruzhnovama@mail.ruБредерВ. В.BrederV. V.

д.м.н., ведущий научный сотрудник отделения химиотерапии № 1 торакоабдоминального отдела (клинических биотехнологий) Федерального государственного бюджетного учреждения «Национальный медицинский исследовательский центр онкологии имени Н.Н. Блохина» Министерства здравоохранения Российской Федерации.

Dr. of Sci. (Med.), Lead Researcher, Chemotherapy Department No. 1, Thoracoabdominal (Clinical Biotechnologies) Unit, Federal State Budgetary Institution «Blokhin Nation al Cancer Research Center» of the Ministry of Health of the Russian Federation.

vbreder@yandex.ruЛактионовК. К.LaktionovK. K.

д.м.н., заместитель директора по лечебной работе научно-исследовательского института клинической онкологии, заведующий отделением химиотерапии № 1 торакоабдоминального отдела (клинических биотехнологий) Федерального государственного бюджетного учреждения «Национальный медицинский исследовательский центр онкологии имени Н.Н. Блохина» Министер ства здравоохранения Российской Феде рации.

Dr. of Sci. (Med.), Deputy Clinical Director, Research Institute of Clinical Oncology, Chemotherapy Department No. 1, Thoracoabdominal (Clinical Biotechnologies) Unit, Federal State Budgetary Institution «Blokhin National Cancer Research Center» of the Ministry of Health of the Russian Federation.

lkoskos@mail.ruФедеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр онкологии имени Н.Н. Блохина» Министерства здравоохранения Российской Федерации.РоссияFederal State Budgetary Institution «Blokhin National Cancer Research Center» of the Ministry of Health of the Russian Federation.Russian Federation2019220620190101521Copyright © Казанцева М.А., Бредер В.В., Лактионов К.К., 20192019Казанцева М.А., Бредер В.В., Лактионов К.К.Kazantseva M.A., Breder V.V., Laktionov K.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/3048

Гепатоцеллюлярный рак (ГЦР) является значимой проблемой современной онкологии. До недавнего времени лекарственная терапия местно-распространенного и диссеминированного ГЦР была ограничена единственным препаратом – сорафенибом. Более глубокое понимание ключевых механизмов канцерогенеза и ускользания опухоли от иммунного ответа послужило основанием для изучения возможностей иммунотерапии в лечении злокачественных опухолей и ГЦР в частности. Первые клинические исследования показали, что иммунотерапия позволяет существенно улучшить непосредственные и отдаленные результаты лечения больных местно-распространенным и метастатическим ГЦР при управляемом профиле токсичности. В настоящее время в качестве второй линии лечения после прогрессирования заболевания на терапии сорафенибом зарегистрировано уже 2 ингибитора контрольных точек иммунного ответа – анти-PD-1-препараты ниволумаб и пембролизумаб. Одновременное появление нескольких новых лекарственных препаратов определяет необходимость проведения клинических исследований по выявлению оптимальных сочетаний препаратов и последовательности их использования в различных клинических ситуациях.

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The authors declare that there are no conflicts of interest present.