medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2019-10-28-36medsovet-3050Research ArticleТАРГЕТНАЯ ТЕРАПИЯ ОПУХОЛЕЙTarget therapy of tumorsВторая линия терапии гастроинтестинальных стромальных опухолей: ожидает ли нас выбор?Second line of therapy for gastrointestinal stromal tumors: is there a choice?КоролеваА. М.KogoniaL. M.

врач-онколог многопрофильной клиники «Реавиз».

Dr. of Sci. (Med), Professor of Oncology and Thoracic Surgery Department of the Faculty of Advanced Training of Doctors of the State Budgetary Healthcare Institution of the Moscow Region «Vladimirsky Moscow Regional Research Clinical Institute».

alexthelynx-uni@yandex.ruКогонияЛ. М.KorolevaA. M.

д.м.н., профессор кафедры онкологии и торакальной хирургии факультета усовершенствования врачей Государственного бюджетного учреждения здравоохранения Московской области «Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского».

oncologist at the «Reaviz» Medical University.

lali51@yandex.ruМногопрофильная клиника «Реавиз».Россия«Reaviz» Medical University.Russian FederationГосударственное бюджетное учреждение здравоохранения Московской области «Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского».РоссияState Budgetary Healthcare Institution of the Moscow Region «Vladimirsky Moscow Regional Research Clinical Institute».Russian Federation2019220620190102836Copyright © Королева А.М., Когония Л.М., 20192019Королева А.М., Когония Л.М.Kogonia L.M., Koroleva A.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/3050

Гастроинтестинальные стромальные опухоли (ГИСО) являются редкими мезенхимальными новообразованиями. В настоящее время возможно проведение трех последовательных линий таргетной терапии диссеминированных ГИСО: первая линия – иматиниб, вторая линия – сунитиниб, третья линия – регорафениб. Статус мутации гена c-KIT является предиктором чувствительности ГИСО к иматинибу и сунитинибу. Часть больных прерывают лечение сунитинибом из-за выраженной токсичности. Регорафениб может быть использован во второй линии терапии ГИСО при непереносимости сунитиниба.

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The authors declare that there are no conflicts of interest present.