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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2019-12-115-121</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-3142</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Эндокринология</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Endocrinology</subject></subj-group></article-categories><title-group><article-title>Ранняя комбинированная терапия сахарного диабета 2-го типа. Время новых решений</article-title><trans-title-group xml:lang="en"><trans-title>Early combination therapy for type 2 diabetes. Time for new decisions</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9960-524X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кондратьева</surname><given-names>Л. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kondratyeva</surname><given-names>L. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кондратьева Лариса Васильевна - кандидат медицинских наук, доцент.</p><p>125993, Москва, ул. Баррикадная, д. 2/1, стр. 1;тел.: +7(916) 544-55-90</p></bio><bio xml:lang="en"><p>Kondratyeva Larisa Vasilyevna - Cand. of Sci. (Med.), Associate Professor.</p><p>125993, Moscow, Barrikadnaya St., 2/1, b. 1; Tel.: +7(916) 544-55-90</p></bio><email xlink:type="simple">Kondratieva88@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное образовательное учреждение дополнительного профессионального образования «Российская медицинская академия непрерывного профессионального образования» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Budgetary Educational Institution of Additional Professional Education Russian Medical Academy of Continuing Professional Education of the Ministry of Health of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>30</day><month>08</month><year>2019</year></pub-date><volume>0</volume><issue>12</issue><fpage>115</fpage><lpage>121</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кондратьева Л.В., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Кондратьева Л.В.</copyright-holder><copyright-holder xml:lang="en">Kondratyeva L.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/3142">https://www.med-sovet.pro/jour/article/view/3142</self-uri><abstract><p>Заболеваемость сахарным диабетом неуклонно возрастает во всем мире. Большую часть заболевших составляют пациенты с сахарным диабетом 2-го типа, многие из которых уже при установлении диагноза имеют осложнения. Стратегия и определение тактики лечения пациентов с СД2 сегодня являются одними из приоритетных задач современной медицины.</p></abstract><trans-abstract xml:lang="en"><p>The morbidity of diabetes mellitus is steadily increasing worldwide. Most of the patients with type 2 diabetes, many of whom already have complications when diagnosed. Strategy and tactics of treatment of patients with DM2 today are one of the priorities of modern medicine.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>сахарный диабет 2-го типа</kwd><kwd>сахароснижающая терапия</kwd><kwd>ранняя комбинированная терапия</kwd><kwd>фиксированная комбинация метформина и ингибитора ДПП-4</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Type 2 diabetes mellitus</kwd><kwd>hypoglycemic therapy</kwd><kwd>early combination therapy</kwd><kwd>fixed-dose combination Metformin and DPP-4 inhibitor</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">IDF Diabetes Atlas, 8th edition. Brussels: International Diabetes Federation; 2017. Available from: https://www.idf.org/e-library/epidemiologyresearch/diabetesatlas/134-idf-diabetes-atlas8th-edition.html.</mixed-citation><mixed-citation xml:lang="en">IDF Diabetes Atlas, 8th edition. Brussels: International Diabetes Federation; 2017. Available from: https://www.idf.org/e-library/epidemiologyresearch/diabetesatlas/134-idf-diabetes-atlas8th-edition.html.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Carls G., Huynh J., Tuttle E. et al. Achivment of Glycated Hemoglobin Goals in the US Remains Unchanged Through 2014. Diabetes ther. 2017;8(4):863-873. doi:10.1007/s13300-017-0280-5.</mixed-citation><mixed-citation xml:lang="en">Carls G., Huynh J., Tuttle E. et al. Achivment of Glycated Hemoglobin Goals in the US Remains Unchanged Through 2014. Diabetes ther. 2017;8(4):863-873. doi:10.1007/s13300-017-0280-5.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Hu F.B., Stampfer MJ., Haffiier S.M., Solomon C.G., Willett W.C., Manson J.E. Elevated risk of cardiovascular disease prior to clinical diagnosis of type 2 diabetes. Diabetes Care. 2002 Jul;25(7):1129-1134.</mixed-citation><mixed-citation xml:lang="en">Hu F.B., Stampfer MJ., Haffiier S.M., Solomon C.G., Willett W.C., Manson J.E. Elevated risk of cardiovascular disease prior to clinical diagnosis of type 2 diabetes. Diabetes Care. 2002 Jul;25(7):1129-1134.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Reaven G.M. The role of insulin resistance and hyperinsulinemia in coronary heart disease. Metabolism. 1992;41(5), Suppl. 1:16-19.</mixed-citation><mixed-citation xml:lang="en">Reaven G.M. The role of insulin resistance and hyperinsulinemia in coronary heart disease. Metabolism. 1992;41(5), Suppl. 1:16-19.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Hsueh W.A., Law R.E. Cardiovascular risk continuum: implications of insulin resistance and diabetes. Am. J. Med. 1998;105(1A):4S-14.</mixed-citation><mixed-citation xml:lang="en">Hsueh W.A., Law R.E. Cardiovascular risk continuum: implications of insulin resistance and diabetes. Am. J. Med. 1998;105(1A):4S-14.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Morrish NJ., Wang S.L., Stevens L.K., Fuller J.H. et al. Mortality and causes of death in the WHO Multinational Study of Vascular Disease in Diabetes. Diabetologia. 2001;44(2):14-21.</mixed-citation><mixed-citation xml:lang="en">Morrish NJ., Wang S.L., Stevens L.K., Fuller J.H. et al. Mortality and causes of death in the WHO Multinational Study of Vascular Disease in Diabetes. Diabetologia. 2001;44(2):14-21.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Budoff MJ. Not all diabetics are created equal (in cardiovascular risk). Eur. Heart J. 2008;29(18):2193-2194.</mixed-citation><mixed-citation xml:lang="en">Budoff MJ. Not all diabetics are created equal (in cardiovascular risk). Eur. Heart J. 2008;29(18):2193-2194.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Haffner S.M., Lehto S., Ronnemaa T. Mortality from coronary artery disease in subject with type 2 diabetes and nondiabetic subjects with and without myocardial infarction. The New England Journal of Medicine. 1998;339:229-34. https://doi.org/10.1056/NEJM199807233390404.</mixed-citation><mixed-citation xml:lang="en">Haffner S.M., Lehto S., Ronnemaa T. Mortality from coronary artery disease in subject with type 2 diabetes and nondiabetic subjects with and without myocardial infarction. The New England Journal of Medicine. 1998;339:229-34. https://doi.org/10.1056/NEJM199807233390404.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Дедов И.И., Шестакова М.В., Александров А.А. и др. Алгоритмы специализированной медицинской помощи больным сахарным диабетом (5-й выпуск). Сахарный диабет. Приложение. 2011;3.</mixed-citation><mixed-citation xml:lang="en">Dedov I.I., Shestakova M.V., Aleksandrov A.A. et al. Algorithms for specialized medical care in diabetes mellitus (5th edition). Sakharnyi Diabet. Prilozhenie. 2011;3. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Дедов И.И., Шестакова, М.В., Майоров А. Алгоритмы специализированной медицинской помощи больным сахарным диабетом. 8-й выпуск. Сахарный диабет. 2017;8:1-112. doi: 1014341/DM20171S8.</mixed-citation><mixed-citation xml:lang="en">Dedov I.I., Shestakova M.V., Maiorov A. Algorithms for specialized medical care in diabetes mellitus. 8th edition. Sakharnyi Diabet. 2017;8:1-112. doi: 1014341/DM20171S8. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">International Diabetes Federation (IDF) Diabetes Atlas, 8th Edition. Brussels, Belgium: International Diabetes Federation, 2017.</mixed-citation><mixed-citation xml:lang="en">International Diabetes Federation (IDF) Diabetes Atlas, 8th Edition. Brussels, Belgium: International Diabetes Federation, 2017.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Дедов И.И., Шестакова М.В., Майоров А.Ю. Алгоритмы специализированной медицинской помощи больным сахарным диабетом. 2019;(9):20.</mixed-citation><mixed-citation xml:lang="en">Dedov I.I., Shestakova M.V., Maiorov A.Yu. Algorithms for specialized medical care in diabetes mellitus. 2019; 9th edition: 20. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Khunti K., Wolden M.L., Thorsted B.L. et al. Clinical inertia in people with type 2 diabetes: a retrospective cohort study of more than 80,000 people. Diabetes Care. 2013;36(11):3411-3417.</mixed-citation><mixed-citation xml:lang="en">Khunti K., Wolden M.L., Thorsted B.L. et al. Clinical inertia in people with type 2 diabetes: a retrospective cohort study of more than 80,000 people. Diabetes Care. 2013;36(11):3411-3417.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Inzucchi S.E., Bergenstral R.M., Buse J.B., et al. Management of hyperglycemia in type 2 diabetes, 2015: a patient-centered approach. Update to a position statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care. 2015;38:140-149. doi: 10.2337/dc14-2441.16.</mixed-citation><mixed-citation xml:lang="en">Inzucchi S.E., Bergenstral R.M., Buse J.B., et al. Management of hyperglycemia in type 2 diabetes, 2015: a patient-centered approach. Update to a position statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care. 2015;38:140-149. doi: 10.2337/dc14-2441.16.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Turner R.C. et al. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). JAMA. 1999;281(21):2005-12.</mixed-citation><mixed-citation xml:lang="en">Turner R.C. et al. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). JAMA. 1999;281(21):2005-12.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">UK Prospective Diabetes Study (UKPDS) Group. Lancet. 1998;352:837-853.</mixed-citation><mixed-citation xml:lang="en">UK Prospective Diabetes Study (UKPDS) Group. Lancet. 1998;352:837-853.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Liu Y, Hong T. Combination therapy of dipepti-dyl peptidase-4 inhibitors and metformin in type 2 diabetes: rationale and evidence. Diabetes Obes Metab, 2014;16(2):111-117. https://doi.org/10.1111/dom.12128. Epub 2013 Jun 3.</mixed-citation><mixed-citation xml:lang="en">Liu Y, Hong T. Combination therapy of dipepti-dyl peptidase-4 inhibitors and metformin in type 2 diabetes: rationale and evidence. Diabetes Obes Metab, 2014;16(2):111-117. https://doi.org/10.1111/dom.12128. Epub 2013 Jun 3.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Wu D., Li L., Liu C. Efficacy and safety of dipep-tidyl peptidase-4 inhibitors and metformin as initial combination therapy and as monotherapy in patients with type 2 diabetes mellitus: a meta-analysis. Diabetes Obes Metab. 2014;16(1):30-37. https//doi.org/10.1111/dom.12174. Epub 2013 Jul 16.</mixed-citation><mixed-citation xml:lang="en">Wu D., Li L., Liu C. Efficacy and safety of dipep-tidyl peptidase-4 inhibitors and metformin as initial combination therapy and as monotherapy in patients with type 2 diabetes mellitus: a meta-analysis. Diabetes Obes Metab. 2014;16(1):30-37. https://doi.org/10.1111/dom.12174. Epub 2013 Jul 16.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Bianchi C., Daniele G., Dardano A., Miccoli R., Del Prato S. Early Combination Therapy with Oral Glucose-Lowering Agents in Type 2. Diabetes. Drugs. 2017; 77(3):247-264.</mixed-citation><mixed-citation xml:lang="en">Bianchi C., Daniele G., Dardano A., Miccoli R., Del Prato S. Early Combination Therapy with Oral Glucose-Lowering Agents in Type 2. Diabetes. Drugs. 2017; 77(3):247-264.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Cho Y.M., Kieffer TJ. New aspects of an old drug: metformin as a glucagon-like peptide 1 (GLP-1) enhancer and sensitizer. Diabetologia. 2011;54(2):219-222.</mixed-citation><mixed-citation xml:lang="en">Cho Y.M., Kieffer TJ. New aspects of an old drug: metformin as a glucagon-like peptide 1 (GLP-1) enhancer and sensitizer. Diabetologia. 2011;54(2):219-222.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Davies MJ., DAlessio D.A., Fradkin J., Kerman W.N. et al. Management of Hyperglycemia in Type 2 Diabetes, 2018. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care. 2018 Dec;41(12):2669-2701. https://doi.org/10.2337/dci18-0033.</mixed-citation><mixed-citation xml:lang="en">Davies MJ., DAlessio D.A., Fradkin J., Kerman W.N. et al. Management of Hyperglycemia in Type 2 Diabetes, 2018. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care. 2018 Dec;41(12):2669-2701. https://doi.org/10.2337/dci18-0033.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Capuano A., Giugliano D., Sportiello L. et al. Dipeptidyl peptidase-4 inhibitors in type 2 diabetes therapy - focus on alogliptin. Drug Des. Devel. Ther. 2013;7:989-1001. http://dx.doi.org/10.2147/DDDT.S37647.</mixed-citation><mixed-citation xml:lang="en">Capuano A., Giugliano D., Sportiello L. et al. Dipeptidyl peptidase-4 inhibitors in type 2 diabetes therapy - focus on alogliptin. Drug Des. Devel. Ther. 2013;7:989-1001. http://dx.doi.org/10.2147/DDDT.S37647.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Nauck M.A, Ellis G.C, Fleck P.R, Wilson C.A, Mekki Q. Efficacy and safety of adding the dipeptidyl peptidase-4 inhibitor alogliptin to metformin therapy in patients with type 2 diabetes inadequately controlled with metformin monotherapy: a multicentre, randomised, double-blind, placebo-controlled study. Int J Clin Pract 2009;63:46-55.</mixed-citation><mixed-citation xml:lang="en">Nauck M.A, Ellis G.C, Fleck P.R, Wilson C.A, Mekki Q. Efficacy and safety of adding the dipeptidyl peptidase-4 inhibitor alogliptin to metformin therapy in patients with type 2 diabetes inadequately controlled with metformin monotherapy: a multicentre, randomised, double-blind, placebo-controlled study. Int J Clin Pract 2009;63:46-55.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Bosi E., Ellis G.C, Wilson C.A, Fleck P.R. Alogliptin as a third oral antidiabeticdrug in patients with type 2 diabetes and inadequate glycaemic control onmetformin and pioglita-zone: a 52-week, randomized, double-blind, activecontrolled, parallel-group study. Diabetes Obes Metab. 2011;13:1088-1096.</mixed-citation><mixed-citation xml:lang="en">Bosi E., Ellis G.C, Wilson C.A, Fleck P.R. Alogliptin as a third oral antidiabeticdrug in patients with type 2 diabetes and inadequate glycaemic control onmetformin and pioglita-zone: a 52-week, randomized, double-blind, activecontrolled, parallel-group study. Diabetes Obes Metab. 2011;13:1088-1096.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Rosenstock J., Rendell M.S., Gross J.L., Fleck P.R., Wilson C.A., Mekki Q. Alogliptin added to insulin therapy in patients with type 2 diabetes reduces HbA(1c) without causing weight gain or increased hypoglycaemia. Diabetes Obes Metab. 2009;11:1145-1152.</mixed-citation><mixed-citation xml:lang="en">Rosenstock J., Rendell M.S., Gross J.L., Fleck P.R., Wilson C.A., Mekki Q. Alogliptin added to insulin therapy in patients with type 2 diabetes reduces HbA(1c) without causing weight gain or increased hypoglycaemia. Diabetes Obes Metab. 2009;11:1145-1152.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Zannad F., Cannon C.P., Cushman W.C. et al. Heart failure and mortality outcomes in patients with type 2 diabetes taking alogliptin versus placebo in EXAMINE: a multicentre, randomised, double-blind trial. Lancet. 2015;385(9982):2067-2076.</mixed-citation><mixed-citation xml:lang="en">Zannad F., Cannon C.P., Cushman W.C. et al. Heart failure and mortality outcomes in patients with type 2 diabetes taking alogliptin versus placebo in EXAMINE: a multicentre, randomised, double-blind trial. Lancet. 2015;385(9982):2067-2076.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Российское общество эндокринологов. Применение препарата алоглиптин бензоат (Випидия®) при терапии пациентов с сахарным диабетом 2 типа в реальной клинической практике на территории РФ. Анонс результатов промежуточного анализа. Сахарный диабет. 2018;21(5).</mixed-citation><mixed-citation xml:lang="en">Russian Society of Endocrinologists. Administration of aloglip-tin benzoate (Vipidia®) for the treatment of patients with type 2 diabetes in real clinical practice in the Russian Federation. Announcements of interim analyses. Sakharnyi Diabet. 2018;21(5). (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Inzucchi S.E., Bergenstal R.M., Buse J.B. et al. Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care 2012;35:1364-1379.</mixed-citation><mixed-citation xml:lang="en">Inzucchi S.E., Bergenstal R.M., Buse J.B. et al. Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care 2012;35:1364-1379.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Kahn S.E., Haffner S.M., Heise M.A., et al. Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy. N Engl J Med. 2006;355:2427-2443.</mixed-citation><mixed-citation xml:lang="en">Kahn S.E., Haffner S.M., Heise M.A., et al. Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy. N Engl J Med. 2006;355:2427-2443.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Phung OJ., Scholle J.M., Talwar M., Coleman C.I. Effect of noninsulin antidiabetic drugs added to metformin therapy on glycemic control, weight gain, and hypoglycemia in type 2 diabetes. JAMA. 2010;303(14):1410-1418.</mixed-citation><mixed-citation xml:lang="en">Phung OJ., Scholle J.M., Talwar M., Coleman C.I. Effect of noninsulin antidiabetic drugs added to metformin therapy on glycemic control, weight gain, and hypoglycemia in type 2 diabetes. JAMA. 2010;303(14):1410-1418.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Del Prato S., Camisasca R., Wilson C., Fleck P Durability of the efficacy and safety of aloglip-tin compared with glipizide in type 2 diabetes mellitus: a 2-year study. Diabetes Obes Metab. 2014;16:1239-1246.</mixed-citation><mixed-citation xml:lang="en">Del Prato S., Camisasca R., Wilson C., Fleck P Durability of the efficacy and safety of aloglip-tin compared with glipizide in type 2 diabetes mellitus: a 2-year study. Diabetes Obes Metab. 2014;16:1239-1246.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Bianchi C. et al. Early Combination Therapy with Oral Glucose-Lowering Agents in Type 2 Diabetes. Drugs. 2017; 77:247-264. doi: 10.1007/s40265-017-0694-4.</mixed-citation><mixed-citation xml:lang="en">Bianchi C. et al. Early Combination Therapy with Oral Glucose-Lowering Agents in Type 2 Diabetes. Drugs. 2017; 77:247-264. doi: 10.1007/s40265-017-0694-4.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
