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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2015-13-118-123</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-347</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Обзоры</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Reviews</subject></subj-group></article-categories><title-group><article-title>Поражение почек у пациентов с неалкогольной жировой болезнью печени и хронической сердечной недостаточностью</article-title><trans-title-group xml:lang="en"><trans-title>Renal disease in patients with nonalcoholic fatty liver disease and chronic heart failure</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Драпкина</surname><given-names>О. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Drapkina</surname><given-names>O. M.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зятенкова</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zyatenkova</surname><given-names>E. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Государственный научно-исследовательский центр профилактической медицины, Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>National Research Center for Preventive Medicine, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Первый Московский государственный медицинский университет им. И.М. Сеченова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>First Moscow State Medical University named after I.M. Sechenov</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>30</day><month>12</month><year>2015</year></pub-date><volume>0</volume><issue>13</issue><fpage>118</fpage><lpage>123</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Драпкина О.М., Зятенкова Е.В., 2015</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="ru">Драпкина О.М., Зятенкова Е.В.</copyright-holder><copyright-holder xml:lang="en">Drapkina O.M., Zyatenkova E.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/347">https://www.med-sovet.pro/jour/article/view/347</self-uri><abstract><p>В настоящее время в рутинной клинической практике измерение СКФ при отсутствии факторов риска развития ХБП не распространено. Однако данные последних исследований показывают, что пациентам с НАЖБП необходимо оценивать СКФ даже при отсутствии классических факторов риска развития ХБП. Раннее выявление поражения почек у пациентов с ХСН и НАЖБП позволит подобрать правильные дозы лекарственных средств, избегая передозировки препаратов.</p></abstract><trans-abstract xml:lang="en"><p>Summary: in the present-day routine clinical practice, measurement of GFR in the absence of risk factors for the development of CKD is not common. However, recent research shows that evaluation of GFR in patients with NAFLD is imperative even in the absence of classical risk factors for CKD. Early detection of kidney damage in patients with CHF and NAFLD will enable to define the right dose of pharmacotherapy and avoid overdose.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ХСН</kwd><kwd>НАЖБП</kwd><kwd>фиброз печени</kwd><kwd>стеатоз печени СКФ</kwd><kwd>хроническая болезнь почек</kwd><kwd>N-терминальный пропептид коллагена III типа</kwd><kwd>Fatty Liver Index</kwd><kwd>NAFLD Fibrosis Score</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Российские национальные рекомендации. Хроническая болезнь почек: основные принципы скрининга, диагностики, профилактики и подходы к лечению. Клиническая нефрология. 2012. 4: 4-26.</mixed-citation><mixed-citation xml:lang="en">Российские национальные рекомендации. Хроническая болезнь почек: основные принципы скрининга, диагностики, профилактики и подходы к лечению. Клиническая нефрология. 2012. 4: 4-26.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Targher G, BertoLini L, RodeLLa S, Lippi G, Zoppini G, ChonchoL M. ReLationship between kidney function and Liver histoLogy in subjects with nonaLcohoLic steatohepatitis. Clin J Am Soc Nephrol, 2010. 5(12): 2166-2171.</mixed-citation><mixed-citation xml:lang="en">Targher G, BertoLini L, RodeLLa S, Lippi G, Zoppini G, ChonchoL M. ReLationship between kidney function and Liver histoLogy in subjects with nonaLcohoLic steatohepatitis. Clin J Am Soc Nephrol, 2010. 5(12): 2166-2171.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Hwang ST, Cho YK, Yun JW, et aL. Impact of nonaLcohoLic fatty Liver disease on microaLbuminu-ria in patients with prediabetes and diabetes. InternaL Medicine JournaL, 2010. 40(6): 437-442.</mixed-citation><mixed-citation xml:lang="en">Hwang ST, Cho YK, Yun JW, et aL. Impact of nonaLcohoLic fatty Liver disease on microaLbuminu-ria in patients with prediabetes and diabetes. InternaL Medicine JournaL, 2010. 40(6): 437-442.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">MikoLasevic I, Racki S, Bubic I, JeLic I, Stimac D, OrLic L. Chronic kidney disease and nonaLcohoLic Fatty Liver disease proven by transient eLas-tography. Kidney Blood Press Res, 2013. 37(4-5): 305-310.</mixed-citation><mixed-citation xml:lang="en">MikoLasevic I, Racki S, Bubic I, JeLic I, Stimac D, OrLic L. Chronic kidney disease and nonaLcohoLic Fatty Liver disease proven by transient eLas-tography. Kidney Blood Press Res, 2013. 37(4-5): 305-310.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">MikoLasevic I, Racki S, Bubic I, JeLic I, Stimac D, OrLic L. NonaLcohoLic fatty Liver disease (NAFLD) - a new factor that interpLays between infLammation, maLnutrition, and atheroscLerosis in eLderLy hemodiaLysis patients. Clin IntervAging, 2014 Aug 7. 9: 1295-303.</mixed-citation><mixed-citation xml:lang="en">MikoLasevic I, Racki S, Bubic I, JeLic I, Stimac D, OrLic L. NonaLcohoLic fatty Liver disease (NAFLD) - a new factor that interpLays between infLammation, maLnutrition, and atheroscLerosis in eLderLy hemodiaLysis patients. Clin IntervAging, 2014 Aug 7. 9: 1295-303.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Targher G, ChonchoL M, Zoppini G, Abaterusso C, Bonora E.Risk of chronic kidney disease in patients with non-aLcohoLic fatty Liver disease: is there a Link? J Hepatol, 2011. 54(5): 1020-9.</mixed-citation><mixed-citation xml:lang="en">Targher G, ChonchoL M, Zoppini G, Abaterusso C, Bonora E.Risk of chronic kidney disease in patients with non-aLcohoLic fatty Liver disease: is there a Link? J Hepatol, 2011. 54(5): 1020-9.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Joachim H Ix, Sharma K. Mechanisms Linking obesity, chronic kidney disease, and fatty Liver disease: the roLes of fetuin-A, adiponectin, and AMPK. JournaL of the American Society of NephroLogy. 2010. 21(3): 406-412.</mixed-citation><mixed-citation xml:lang="en">Joachim H Ix, Sharma K. Mechanisms Linking obesity, chronic kidney disease, and fatty Liver disease: the roLes of fetuin-A, adiponectin, and AMPK. JournaL of the American Society of NephroLogy. 2010. 21(3): 406-412.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Барышева О.Ю., Голубева А.М., Везикова Н.Н., Хейфец Л.М. Диагностика и лечение неалкогольной жировой болезни печени (обзор рекомендаций AASLD, ACG, AGA 2012).</mixed-citation><mixed-citation xml:lang="en">Барышева О.Ю., Голубева А.М., Везикова Н.Н., Хейфец Л.М. Диагностика и лечение неалкогольной жировой болезни печени (обзор рекомендаций AASLD, ACG, AGA 2012).</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">AnguLo P, Hui J, Marchesini G et aL. The NAFLD Fibrosis Score: A Noninvasive System That Identifies Liver Fibrosis in Patients with NAFLD. Hepatology, 2007. 4(45): 846-854.</mixed-citation><mixed-citation xml:lang="en">AnguLo P, Hui J, Marchesini G et aL. The NAFLD Fibrosis Score: A Noninvasive System That Identifies Liver Fibrosis in Patients with NAFLD. Hepatology, 2007. 4(45): 846-854.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">GastaLdeLLi A, Kozakova M, HojLund K, FLyvbjerg A, Favuzzi A, Mitrakou A, BaLkau B. Fatty Liver is associated with insuLin resistance, risk of coronary heart disease, and earLy atheroscLerosis in a Large European popuLation. HepatoLogy 2009: 49: 1537-1544.</mixed-citation><mixed-citation xml:lang="en">GastaLdeLLi A, Kozakova M, HojLund K, FLyvbjerg A, Favuzzi A, Mitrakou A, BaLkau B. Fatty Liver is associated with insuLin resistance, risk of coronary heart disease, and earLy atheroscLerosis in a Large European popuLation. HepatoLogy 2009: 49: 1537-1544.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">BaLkau B, Lange C, VoL S, Fumeron F, Bonnet F. Nineyear incident diabetes is predicted by fatty Liver indices: the French D.E.S.I.R. study. BMC Gastroenterol, 2010. 10: 56 doi: 10.1186/1471-230x-10-56.</mixed-citation><mixed-citation xml:lang="en">BaLkau B, Lange C, VoL S, Fumeron F, Bonnet F. Nineyear incident diabetes is predicted by fatty Liver indices: the French D.E.S.I.R. study. BMC Gastroenterol, 2010. 10: 56 doi: 10.1186/1471-230x-10-56.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">CaLori G, Lattuada G, Ragogna F, Garancini MP, Crosignani P, ViLLa M, Bosi E, RuotoLo G, Piemonti L, Perseghin G. Fatty Liver index and mortaLity: the Cremona study in the 15th year of foLLow-up. Hepatology, 2011. 54: 145-152.</mixed-citation><mixed-citation xml:lang="en">CaLori G, Lattuada G, Ragogna F, Garancini MP, Crosignani P, ViLLa M, Bosi E, RuotoLo G, Piemonti L, Perseghin G. Fatty Liver index and mortaLity: the Cremona study in the 15th year of foLLow-up. Hepatology, 2011. 54: 145-152.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Arimoto T, Takeishi Y, Niizeki T, Nozaki N, Hirono O, Watanabe T, et aL. Cardiac sympathetic denervation and ongoing myocardiaL damage for prognosis in earLy stages of heart faiLure. J Card FaiL, 2007. 13: 34-41.</mixed-citation><mixed-citation xml:lang="en">Arimoto T, Takeishi Y, Niizeki T, Nozaki N, Hirono O, Watanabe T, et aL. Cardiac sympathetic denervation and ongoing myocardiaL damage for prognosis in earLy stages of heart faiLure. J Card FaiL, 2007. 13: 34-41.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Niizeki T, Takeishi Y, Arimoto T, Takabatake N, Nozaki N, Hirono O, et aL. Heart-type fatty acid-binding protein is more sensitive than troponin T to detect the ongoing myocardiaL damage in chronic heart faiLure patients. J Card FaiL, 2007. 13: 120-127.</mixed-citation><mixed-citation xml:lang="en">Niizeki T, Takeishi Y, Arimoto T, Takabatake N, Nozaki N, Hirono O, et aL. Heart-type fatty acid-binding protein is more sensitive than troponin T to detect the ongoing myocardiaL damage in chronic heart faiLure patients. J Card FaiL, 2007. 13: 120-127.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Драпкина О.М., Драпкина Ю.С. Фиброз сердца и печени: составляющие одного уравнения. Кардиология, 2014. 9: 4-8.</mixed-citation><mixed-citation xml:lang="en">Драпкина О.М., Драпкина Ю.С. Фиброз сердца и печени: составляющие одного уравнения. Кардиология, 2014. 9: 4-8.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Драпкина О.М., Ивашкин В.Т. Эпидемиологические особенности неалкогольной жировой болезни печени в России (результаты открытого многоцентрового исследования-наблюдения DIREG L 01903). Российский журнал гастроэнтерологии, гепа-тологии, колопроктологии, 2014. 4(4): 32-38.</mixed-citation><mixed-citation xml:lang="en">Драпкина О.М., Ивашкин В.Т. Эпидемиологические особенности неалкогольной жировой болезни печени в России (результаты открытого многоцентрового исследования-наблюдения DIREG L 01903). Российский журнал гастроэнтерологии, гепа-тологии, колопроктологии, 2014. 4(4): 32-38.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Drapkina ОМ, Ivashkin VT. Liver disease structure expLored in russian federation nationaL-wide direg-L-01903 study for non-aLcohoLic fatty Liver disease screening. Journal of Hepatology, 2011. March; VoL. 54, S332.</mixed-citation><mixed-citation xml:lang="en">Drapkina ОМ, Ivashkin VT. Liver disease structure expLored in russian federation nationaL-wide direg-L-01903 study for non-aLcohoLic fatty Liver disease screening. Journal of Hepatology, 2011. March; VoL. 54, S332.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Ivashkin V, Drapkina O, Ashikhmin Y. PrevaLence and risk factors for non-aLcohoLic fatty Liver disease in Russian Federation. Journal of Hepatology, 2010, 52: 138-139.</mixed-citation><mixed-citation xml:lang="en">Ivashkin V, Drapkina O, Ashikhmin Y. PrevaLence and risk factors for non-aLcohoLic fatty Liver disease in Russian Federation. Journal of Hepatology, 2010, 52: 138-139.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Shen Z, Munker S, Luo F, Ma H, Yu C, Li Y Effect of Non-ALcohoLic Fatty Liver Disease on Estimated GLomeruLar FiLtration Rate CouLd Be Dependent on Age. PLoS One, 2015. Jun 18. 10(6):e0130614. doi: 10.1371/journaL. pone.0130614. eCoLLection 2015.</mixed-citation><mixed-citation xml:lang="en">Shen Z, Munker S, Luo F, Ma H, Yu C, Li Y Effect of Non-ALcohoLic Fatty Liver Disease on Estimated GLomeruLar FiLtration Rate CouLd Be Dependent on Age. PLoS One, 2015. Jun 18. 10(6):e0130614. doi: 10.1371/journaL. pone.0130614. eCoLLection 2015.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Machado MV, GongaLves S, Carepa F, Coutinho J, Costa A, Cortez-Pinto H. Impaired renaL function in morbid obese patients with nonaLcohoLic fatty Liver disease. Liver Int, 2012. 32: 241248. doi: 10.1111/j.1478-3231.2011.02623.</mixed-citation><mixed-citation xml:lang="en">Machado MV, GongaLves S, Carepa F, Coutinho J, Costa A, Cortez-Pinto H. Impaired renaL function in morbid obese patients with nonaLcohoLic fatty Liver disease. Liver Int, 2012. 32: 241248. doi: 10.1111/j.1478-3231.2011.02623.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Драпкина О.М., Гегенава Б.Б. Фиброз миокарда у больных с сахарным диабетом. Рациональная фармакотерапия в кардиологии, 2013. 9(1): 58-61.</mixed-citation><mixed-citation xml:lang="en">Драпкина О.М., Гегенава Б.Б. Фиброз миокарда у больных с сахарным диабетом. Рациональная фармакотерапия в кардиологии, 2013. 9(1): 58-61.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Драпкина О. М., Дуболазова Ю. В. Применение биологических маркеров в диагностике диа-столической сердечной недостаточности. Сердечная недостаточность, 2011. 12(6): 364-372.</mixed-citation><mixed-citation xml:lang="en">Драпкина О. М., Дуболазова Ю. В. Применение биологических маркеров в диагностике диа-столической сердечной недостаточности. Сердечная недостаточность, 2011. 12(6): 364-372.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Drapkina O, Deeva T, Ivashkin V. Patients with metaboLic syndrome and NAFLD: Assessment of obesity and heart fibrosis degree. Journal of Hepatology, 2015, 62: 735.</mixed-citation><mixed-citation xml:lang="en">Drapkina O, Deeva T, Ivashkin V. Patients with metaboLic syndrome and NAFLD: Assessment of obesity and heart fibrosis degree. Journal of Hepatology, 2015, 62: 735.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Korneeva ON, Drapkina OM, Ivashkin VT. Predictive vaLue of epicardiaL fat as new marker of metaboLic syndrome and earLy vascuLar damage in patient with nafLd. Journal of Hepatology, 2013, 58: 543.</mixed-citation><mixed-citation xml:lang="en">Korneeva ON, Drapkina OM, Ivashkin VT. Predictive vaLue of epicardiaL fat as new marker of metaboLic syndrome and earLy vascuLar damage in patient with nafLd. Journal of Hepatology, 2013, 58: 543.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Drapkina ОМ, Ivashkin VT. IACE in treatment of arteriaL hypertention in patients with non aLcohoLic fatty Liver. Journal of Hepatology, 2011, 54: 332-333.</mixed-citation><mixed-citation xml:lang="en">Drapkina ОМ, Ivashkin VT. IACE in treatment of arteriaL hypertention in patients with non aLcohoLic fatty Liver. Journal of Hepatology, 2011, 54: 332-333.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Drapkina ОМ, Ivashkin VT. S-ademetionine (same) and simvastatin in patients with nonaLcohoLic fatty Liver disease and metaboLic syndrome. Journal of Hepatology, 2012, 56: 507.</mixed-citation><mixed-citation xml:lang="en">Drapkina ОМ, Ivashkin VT. S-ademetionine (same) and simvastatin in patients with nonaLcohoLic fatty Liver disease and metaboLic syndrome. Journal of Hepatology, 2012, 56: 507.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">AnguLo P. Use of ursodeoxychoLic acid in patients with Liver disease. Curr Gastroenterol Rep, 2002. 4: 37-44.</mixed-citation><mixed-citation xml:lang="en">AnguLo P. Use of ursodeoxychoLic acid in patients with Liver disease. Curr Gastroenterol Rep, 2002. 4: 37-44.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">von HaehLing S, SchefoLd JC, Jankowska EA et aL. UrsodeoxychoLic Acid in Patients With Chronic Heart FaiLure. A DoubLe-BLind, Randomized, PLacebo-ControLLed, Crossover TriaL. J Am Coll Cardiol, 2012. 59: 585-92.</mixed-citation><mixed-citation xml:lang="en">von HaehLing S, SchefoLd JC, Jankowska EA et aL. UrsodeoxychoLic Acid in Patients With Chronic Heart FaiLure. A DoubLe-BLind, Randomized, PLacebo-ControLLed, Crossover TriaL. J Am Coll Cardiol, 2012. 59: 585-92.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">BahrLe S, Szabo G, StiehL A et aL. Adjuvant treatment with ursodeoxychoLic acid may reduce the incidence of acute cardiac aLLograft ejection. J Heart Lung Transplant, 1998. 17: 592- 8.</mixed-citation><mixed-citation xml:lang="en">BahrLe S, Szabo G, StiehL A et aL. Adjuvant treatment with ursodeoxychoLic acid may reduce the incidence of acute cardiac aLLograft ejection. J Heart Lung Transplant, 1998. 17: 592- 8.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Paumgartner G, Beuers U. Mechanisms of action and therapeutic efficacy of ursodeoxy-choLic acid in choLestatic Liver disease. Clin Liver Dis, 2004. 8: 67-81.</mixed-citation><mixed-citation xml:lang="en">Paumgartner G, Beuers U. Mechanisms of action and therapeutic efficacy of ursodeoxy-choLic acid in choLestatic Liver disease. Clin Liver Dis, 2004. 8: 67-81.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Korneeva ON, Drapkina OM, Ivashkin VT. Simvastatin and ursodeoxychoLic acid in patients with nonaLcohoLic fatty Liver disease and metaboLic syndrome Journal of Hepatology, 2010, 52: 146.</mixed-citation><mixed-citation xml:lang="en">Korneeva ON, Drapkina OM, Ivashkin VT. Simvastatin and ursodeoxychoLic acid in patients with nonaLcohoLic fatty Liver disease and metaboLic syndrome Journal of Hepatology, 2010, 52: 146.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Suzuki A, Lymp J, Sauver JS, AnguLo P, Lindor K. VaLues and Limitations of serum aminotrans-ferases in cLinicaL triaLs of nonaLcohoLic steato-hepatitis. Liver Int, 2006. 26: 1209-1216.</mixed-citation><mixed-citation xml:lang="en">Suzuki A, Lymp J, Sauver JS, AnguLo P, Lindor K. VaLues and Limitations of serum aminotrans-ferases in cLinicaL triaLs of nonaLcohoLic steato-hepatitis. Liver Int, 2006. 26: 1209-1216.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Ratziu V, de Ledinghen V, Oberti F, Mathurin P WarteLLe-BLadou C, Renou C et aL. FRESGUN. A randomized controLLed triaL of high-dose ursodesoxychoLic acid for nonaLcohoLic steatohepatitis. J Hepatol, 2011. 54: 1011-1019.</mixed-citation><mixed-citation xml:lang="en">Ratziu V, de Ledinghen V, Oberti F, Mathurin P WarteLLe-BLadou C, Renou C et aL. FRESGUN. A randomized controLLed triaL of high-dose ursodesoxychoLic acid for nonaLcohoLic steatohepatitis. J Hepatol, 2011. 54: 1011-1019.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Banu D. OzeL Coskin at aL. Effects of ursodeoxychoLic acid therapy on carotid intima media thickness, apoLipoprotein A1, apoLipoprotein B, and apoLipoprotein B/A1 ratio in nonaLcohoLic steatohepatitis. Eur. J. Gastroenterol Hepatol 2015, 27: 142-149.</mixed-citation><mixed-citation xml:lang="en">Banu D. OzeL Coskin at aL. Effects of ursodeoxychoLic acid therapy on carotid intima media thickness, apoLipoprotein A1, apoLipoprotein B, and apoLipoprotein B/A1 ratio in nonaLcohoLic steatohepatitis. Eur. J. Gastroenterol Hepatol 2015, 27: 142-149.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
