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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2016-2-26-31</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-35</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Беременность и роды</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Pregnancy and childbirth</subject></subj-group></article-categories><title-group><article-title>Профилактика пороков развития</article-title><trans-title-group xml:lang="en"><trans-title>Preventing malformations</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Воеводин</surname><given-names>С. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Voevodin</surname><given-names>S. M.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шеманаева</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Shemanaeva</surname><given-names>T. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Первый Московский государственный медицинский университет им. И.М. Сеченова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>the First Moscow State Medical University named after I.M. Sechenov</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>30</day><month>12</month><year>2016</year></pub-date><volume>0</volume><issue>2</issue><fpage>26</fpage><lpage>31</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Воеводин С.М., Шеманаева Т.В., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Воеводин С.М., Шеманаева Т.В.</copyright-holder><copyright-holder xml:lang="en">Voevodin S.M., Shemanaeva T.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/35">https://www.med-sovet.pro/jour/article/view/35</self-uri><abstract><p>Повреждение центральной нервной системы у плода является одной из важных тем в современной медицине, т. к. относится к тяжелым врожденным заболеваниям с неблагоприятным прогнозом, сопровождающимся гибелью плода и новорожденного или тяжелой инвалидизацией. Применение фолиевой кислоты или поливитаминов в периконцептуальный период относится к эффективным способам первичной профилактики пороков развития нервной трубки.</p></abstract><trans-abstract xml:lang="en"><p>Damage of the central nervous system of the fetus is one of crucial issues in the modern healthcare as it represents a severe congenital disease with a poor prognosis accompanied by fetal death or severe disability of the newborn. Administration of folic acid or multivitamins during the periconceptual period is an effective method for primary prevention of neural tube malformation.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>folic acid</kwd><kwd>DNA methylation</kwd><kwd>pregnancy</kwd><kwd>neural tube defects</kwd><kwd>fetal malformations</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Воеводин С.М., Шеманаева Т.В. 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