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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2016-2-60-63</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-41</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Инфекции в акушерстве и гинекологии</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Infections in obstetrics and gynecology</subject></subj-group></article-categories><title-group><article-title>Клиническая эффективность флуконазола в лечении вульвовагинального кандидоза</article-title><trans-title-group xml:lang="en"><trans-title>The clinical efficacy of fluconazole in the treatment of vulvovaginal candidiasis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Серов</surname><given-names>В. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Serov</surname><given-names>V. N.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Буралкина</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Buralkina</surname><given-names>N. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Борисенко</surname><given-names>М. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Borisenko</surname><given-names>M. Y.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мамедова</surname><given-names>Ф. Ш.</given-names></name><name name-style="western" xml:lang="en"><surname>Mamedova</surname><given-names>F. Sh.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Научный центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Scientific center for obstetrics, gynecology and perinatology named after acad. V.I. Kulakov</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>30</day><month>12</month><year>2016</year></pub-date><volume>0</volume><issue>2</issue><fpage>60</fpage><lpage>63</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Серов В.Н., Буралкина Н.А., Борисенко М.Ю., Мамедова Ф.Ш., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Серов В.Н., Буралкина Н.А., Борисенко М.Ю., Мамедова Ф.Ш.</copyright-holder><copyright-holder xml:lang="en">Serov V.N., Buralkina N.A., Borisenko M.Y., Mamedova F.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/41">https://www.med-sovet.pro/jour/article/view/41</self-uri><abstract><p>В статье отражены основные проблемы диагностики и лечения пациенток с вульвовагинальным кандидозом (ВВК). Отмечено, что Candida albicans вызывает кандидоз в 75-80% случаев. Клиническими формами ВВК являются: кандидоносительство, острый ВВК, хронический (рецидивирующий) вульвовагинальный кандидоз (ХРВВК). Описаны основные диагностические подходы к лечению и предотвращению рецидивов заболевания. Авторы представили данные об эффективности антифугального препарата Дифлюкан в борьбе с ВВК.</p></abstract><trans-abstract xml:lang="en"><p>The article tells about the key problems of diagnosis and treatment of patients with vulvovaginal candidiasis (VVC). Candida albicans causes 75--80% of candidiasis cases. Clinical forms of VVC include: Candida-carrying, acute VVC, chronic (recurrent) vulvovaginal candidiasis (CRVVC). The main diagnostic approaches to the treatment and prevention of recurrence of the disease are described. The authors presented data on the efficacy of the antifungal medication Diflucan in the fight against VVC.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>вульвовагинальный кандидоз</kwd><kwd>диагностика</kwd><kwd>лечение</kwd><kwd>Candida albicans</kwd><kwd>Дифлюкан</kwd><kwd>vulvovaginal candidiasis</kwd><kwd>diagnosis</kwd><kwd>treatment</kwd><kwd>Diflucan</kwd><kwd>Candida albicans</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Foxman B, Barlow R, D'Arcy H, Gillespie B, Sobel JD. Candida vaginitis: self- reported incidence and associated costs. Sex Transm Dis, 2000, 27: 230-235.</mixed-citation><mixed-citation xml:lang="en">Foxman B, Barlow R, D'Arcy H, Gillespie B, Sobel JD. Candida vaginitis: self- reported incidence and associated costs. Sex Transm Dis, 2000, 27: 230-235.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Ogouyemi-Hounto A, Adisso S, Djamal J, Sanni R, Amangbegnon R, Biokou-Bankole B, Kinde Gazard D,Massougbodji A. Place of vulvovaginal candidiasis in the lower genital tract infections and associated risk factors among women in Benin. J Mycol Med., 2014 Jun, 24(2): 100-5.</mixed-citation><mixed-citation xml:lang="en">Ogouyemi-Hounto A, Adisso S, Djamal J, Sanni R, Amangbegnon R, Biokou-Bankole B, Kinde Gazard D,Massougbodji A. Place of vulvovaginal candidiasis in the lower genital tract infections and associated risk factors among women in Benin. J Mycol Med., 2014 Jun, 24(2): 100-5.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Uvarova EV. Vulvovaginal candidiasis in girls (guidelines for a practitioner). Antibiot Khimioter., 2007, 52(4-5): 49-55. [Article in Russian]</mixed-citation><mixed-citation xml:lang="en">Uvarova EV. Vulvovaginal candidiasis in girls (guidelines for a practitioner). Antibiot Khimioter., 2007, 52(4-5): 49-55. [Article in Russian]</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Hoffmann JN, You HM, Hedberg EC, Jordan JA, McClintock MK. Prevalence of bacterial vagi-nosis and Candida among postmenopausal women in the United States. J Gerontol B Psychol Sci SocSci., 2014, Nov, 69 Suppl 2: S205-14.</mixed-citation><mixed-citation xml:lang="en">Hoffmann JN, You HM, Hedberg EC, Jordan JA, McClintock MK. Prevalence of bacterial vagi-nosis and Candida among postmenopausal women in the United States. J Gerontol B Psychol Sci SocSci., 2014, Nov, 69 Suppl 2: S205-14.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Hamad M, Kazandji N, Awadallah S, Allam H. Prevalence and epidemiological characteristics of vaginal candidiasis in the UAE. Mycoses., 2014 Mar, 57(3): 184-90.</mixed-citation><mixed-citation xml:lang="en">Hamad M, Kazandji N, Awadallah S, Allam H. Prevalence and epidemiological characteristics of vaginal candidiasis in the UAE. Mycoses., 2014 Mar, 57(3): 184-90.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Руководство по амбулаторно-поликлинической помощи в акушерстве и гинекологии под редакцией акад. В.И. Кулакова, проф. В.Н. Прилепской, В.Е. Радзинского. М.: «ГЭОТАР-Медиа», 2006. с. 1029.</mixed-citation><mixed-citation xml:lang="en">Руководство по амбулаторно-поликлинической помощи в акушерстве и гинекологии под редакцией акад. В.И. Кулакова, проф. В.Н. Прилепской, В.Е. Радзинского. М.: «ГЭОТАР-Медиа», 2006. с. 1029.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Nyirjesy P. Vulvovaginal candidiasis and bacterial vaginosis. Infect Dis Clin North Am., 2008, 22: 637-52.</mixed-citation><mixed-citation xml:lang="en">Nyirjesy P. Vulvovaginal candidiasis and bacterial vaginosis. Infect Dis Clin North Am., 2008, 22: 637-52.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Baykushev R, Ouzounova-Raykova V, Stoykova V, Mitov I. Reliable microbiological diagnosis of vulvovaginal candidiasis. Akush Ginekol (Sofiia), 2014, 53(4): 17-20.</mixed-citation><mixed-citation xml:lang="en">Baykushev R, Ouzounova-Raykova V, Stoykova V, Mitov I. Reliable microbiological diagnosis of vulvovaginal candidiasis. Akush Ginekol (Sofiia), 2014, 53(4): 17-20.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Bassyouni RH, Wegdan AA, Abdelmoneim A, Said W, AboElnaga F. Phospholipase and Aspartyl Proteinase Activities of Candida Species Causing Vulvovaginal Candidiasis in Patients with Type 2 Diabetes Mellitus. J Microbiol Biotechnol., 2015, Oct 28, 25(10): 1734-41.</mixed-citation><mixed-citation xml:lang="en">Bassyouni RH, Wegdan AA, Abdelmoneim A, Said W, AboElnaga F. Phospholipase and Aspartyl Proteinase Activities of Candida Species Causing Vulvovaginal Candidiasis in Patients with Type 2 Diabetes Mellitus. J Microbiol Biotechnol., 2015, Oct 28, 25(10): 1734-41.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Cassone A. Vulvovaginal Candida albicans infections: pathogenesis, immunity and vaccine prospects. BJOG, 2015, May, 122(6): 785-94.</mixed-citation><mixed-citation xml:lang="en">Cassone A. Vulvovaginal Candida albicans infections: pathogenesis, immunity and vaccine prospects. BJOG, 2015, May, 122(6): 785-94.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Beigi RH, Meyn LA, Moore DM, Krohn MA, Hillier SL. Vaginal yeast colonization in non-pregnant women: a longitudinal study. Obstet Gynecol., 2004, 104: 926-30.</mixed-citation><mixed-citation xml:lang="en">Beigi RH, Meyn LA, Moore DM, Krohn MA, Hillier SL. Vaginal yeast colonization in non-pregnant women: a longitudinal study. Obstet Gynecol., 2004, 104: 926-30.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Gongalves B, Ferreira C, Alves CT, Henriques M, Azeredo J, Silva S. Vulvovaginal candidiasis: Epidemiology, microbiology and risk factors. Crit Rev Microbiol., 2015, Dec, 21: 1-23.</mixed-citation><mixed-citation xml:lang="en">Gongalves B, Ferreira C, Alves CT, Henriques M, Azeredo J, Silva S. Vulvovaginal candidiasis: Epidemiology, microbiology and risk factors. Crit Rev Microbiol., 2015, Dec, 21: 1-23.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Aguin TJ, Sobel JD. Vulvovaginal candidiasis in pregnancy. Curr Infect Dis Rep., 2015 Jun, 17(6): 462.</mixed-citation><mixed-citation xml:lang="en">Aguin TJ, Sobel JD. Vulvovaginal candidiasis in pregnancy. Curr Infect Dis Rep., 2015 Jun, 17(6): 462.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Kimberly A. Workowski et al. Sexually Transmitted Diseases Treatment Guidelines. MMWR, 2010, 59(RR12): 1-110.</mixed-citation><mixed-citation xml:lang="en">Kimberly A. Workowski et al. Sexually Transmitted Diseases Treatment Guidelines. MMWR, 2010, 59(RR12): 1-110.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Sherrard J, Donders G, White D. European (IUSTI/WHO) Guideline on the Management of Vaginal Discharge. International Journal of STD &amp; AIDS, 2011, 22: 421-429.</mixed-citation><mixed-citation xml:lang="en">Sherrard J, Donders G, White D. European (IUSTI/WHO) Guideline on the Management of Vaginal Discharge. International Journal of STD &amp; AIDS, 2011, 22: 421-429.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Glockner A, Cornely OA. Candida glabrata-unique features and challenges in the clinical management of invasive infections. Mycoses., 2015, Aug, 58(8): 445-50.</mixed-citation><mixed-citation xml:lang="en">Glockner A, Cornely OA. Candida glabrata-unique features and challenges in the clinical management of invasive infections. Mycoses., 2015, Aug, 58(8): 445-50.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Li H, Zhang C, Chen Z, Shi W, Sun S. A promising approach of overcoming the intrinsic resistance of Candida krusei to fluconazole (FLC) - combining tacrolimus with FLC. FEMS Yeast Res., 2014, Aug, 14(5): 808-11.</mixed-citation><mixed-citation xml:lang="en">Li H, Zhang C, Chen Z, Shi W, Sun S. A promising approach of overcoming the intrinsic resistance of Candida krusei to fluconazole (FLC) - combining tacrolimus with FLC. FEMS Yeast Res., 2014, Aug, 14(5): 808-11.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Fan S, Liu X, Wu C, Xu L, Li J. Vaginal nystatin versus oral fluconazole for the treatment for recurrent vulvovaginal candidiasis. Mycopathologia, 2015, Feb, 179(1-2): 95-101.</mixed-citation><mixed-citation xml:lang="en">Fan S, Liu X, Wu C, Xu L, Li J. Vaginal nystatin versus oral fluconazole for the treatment for recurrent vulvovaginal candidiasis. Mycopathologia, 2015, Feb, 179(1-2): 95-101.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">White DJ, Habib AR, Vanthuyne A, Langford S, Symonds M. Combined topical flucytosine and amphotericin B for refractory vaginal Candida glabrata infections. Sex Transm Infect., 2001 Jun, 77(3): 212-3.</mixed-citation><mixed-citation xml:lang="en">White DJ, Habib AR, Vanthuyne A, Langford S, Symonds M. Combined topical flucytosine and amphotericin B for refractory vaginal Candida glabrata infections. Sex Transm Infect., 2001 Jun, 77(3): 212-3.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Szweda P, Gucwa K, Romanowska E, Dzierzanowska-Fangrat K, Naumiuk L, Brillowska-Dabrowska A, Wojciechowska-Koszko I, Milewski S. Mechanisms of azole resistance among clinical isolates of Candida glabrata in Poland. J Med Microbiol., 2015. Jun, 64(6): 610-9.</mixed-citation><mixed-citation xml:lang="en">Szweda P, Gucwa K, Romanowska E, Dzierzanowska-Fangrat K, Naumiuk L, Brillowska-Dabrowska A, Wojciechowska-Koszko I, Milewski S. Mechanisms of azole resistance among clinical isolates of Candida glabrata in Poland. J Med Microbiol., 2015. Jun, 64(6): 610-9.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Deorukhkar SC, Saini S. Echinocandin susceptibility profile of fluconazole resistant Candida species isolated from blood stream infections. Infect Disord Drug Targets, 2015, Dec 9.</mixed-citation><mixed-citation xml:lang="en">Deorukhkar SC, Saini S. Echinocandin susceptibility profile of fluconazole resistant Candida species isolated from blood stream infections. Infect Disord Drug Targets, 2015, Dec 9.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Shekari Ebrahim Abad H, Zaini F, Kordbacheh P, Mahmoudi M, Safara M, Mortezaee V. In Vitro Activity of Caspofungin Against Fluconazole-Resistant Candida Species Isolated From Clinical Samples in Iran. Jundishapur J Microbiol., 2015, Jun 27, 8(6).</mixed-citation><mixed-citation xml:lang="en">Shekari Ebrahim Abad H, Zaini F, Kordbacheh P, Mahmoudi M, Safara M, Mortezaee V. In Vitro Activity of Caspofungin Against Fluconazole-Resistant Candida Species Isolated From Clinical Samples in Iran. Jundishapur J Microbiol., 2015, Jun 27, 8(6).</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Guidelines for outpatient care in obstetrics and gynecology ed. by V.I. Kulakov, prof. V.N. Prilepskaya, V.E. Radzinsky "GEOTAR-Media", 2006. p. 1029.</mixed-citation><mixed-citation xml:lang="en">Guidelines for outpatient care in obstetrics and gynecology ed. by V.I. Kulakov, prof. V.N. Prilepskaya, V.E. Radzinsky "GEOTAR-Media", 2006. p. 1029.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
