medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2015-17-108-113medsovet-435Research ArticleЭндокринологияEndocrinologyДиабет и кость. Фокус на ингибиторы ДПП-4Diabetes and bone. Focus on DPP-4 inhibitorsБабенкоА. Ю.BabenkoA. Y.noemail@neicon.ruНикитинВ. С.NikitinV. S.noemail@neicon.ruКароноваТ. Л.KaronovaT. L.noemail@neicon.ruСеверо-Западный федеральный медицинский исследовательский центр им. В.А. АлмазоваРоссияFederal North-West Medical Research Centre Northw named after V.A. AlmazovRussian FederationИнститут эндокринологииРоссияFederal North-West Medical Research Centre Northw named after V.A. AlmazovRussian Federation201530122015017108113Copyright © Бабенко А.Ю., Никитин В.С., Каронова Т.Л., 20152015Бабенко А.Ю., Никитин В.С., Каронова Т.Л.Babenko A.Y., Nikitin V.S., Karonova T.L.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/435

Патология костного гомеостаза при сахарном диабете (СД) представляет собой значимую проблему, которая должна учитываться при выборе антидиабетической терапии. Многие антидиабетические препараты оказывают самостоятельное влияние на костный гомеостаз, и эти эффекты должны быть приняты во внимание при подборе лечения СД 2-го типа, особенно у пациентов с высоким риском остеопороза. Настоящий обзор посвящен обсуждению механизмов влияния как самого СД, так и различных групп сахароснижающих препаратов с акцентом на новые группы, вошедшие в российские алгоритмы за последнее десятилетие (агонисты рецепторов ГПП-1, ингибиторы ДПП-4, ингибиторы натрий-глюкозного ко-транспортера 2-го типа) на костный метаболизм и риск переломов. Он может быть полезен как исследователям, так и практикующим врачам, старающимся на современном уровне выбирать оптимальную терапию для своих пациентов.

Pathology of bone homeostasis in diabetes mellitus (DM) is a significant problem that must be considered when selecting anti-diabetic therapy. Many anti-diabetic drugs have a specific effect on bone homeostasis which should be taken into account when selecting treatment for type 2 diabetes, especially in patients at high risk of osteoporosis. This review discusses mechanisms of impact on bone metabolism and fracture risks of DM and various groups of antidiabetic drugs, focusing on new groups of drugs included in the Russian algorithms over the past decade (GLP-1 receptor agonists, DPP-4 inhibitors, sodium-glucose cotransporter 2 inhibitors). It can be useful to both researchers and clinicians who are striving to offer the therapy of choice to their patients today.

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The authors declare that there are no conflicts of interest present.