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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2019-20-32-37</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-4376</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АКТУАЛЬНОЕ В ОТОРИНОЛАРИНГОЛОГИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ACTUAL IN OTORHINOLARYNGOLOGY</subject></subj-group></article-categories><title-group><article-title>Острые респираторные вирусные заболевания: современные подходы к диагностике и лечению</article-title><trans-title-group xml:lang="en"><trans-title>Acute respiratory viral diseases: modern approaches to the diagnosis and treatment</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8184-7312</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дербенева</surname><given-names>М. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Derbeneva</surname><given-names>M. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дербенева Мария Львовна, к.м.н., врач-оториноларинголог</p><p> </p></bio><bio xml:lang="en"><p>Mariya L. Derbeneva, Cand. of Sci.(Med.), Otorhynolaryngologist</p><p>8 Leninsky Prospect, Moscow, 119049</p></bio><email xlink:type="simple">mlderbeneva@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7988-4229</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гусева</surname><given-names>А. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Guseva</surname><given-names>A. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гусева Александра Леонидовна, к.м.н., доцент, кафедра оториноларингологии лечебного факультета</p><p>117997, Россия, Москва, ул. Островитянова, д. 1</p></bio><bio xml:lang="en"><p>Aleksandra L. Guseva, Cand. of Sci. (Med.), Associate Professor, Chair for Otorhinolaryngology of General Medicine Faculty</p><p>1 Ostrovityanova St., Moscow, 117997</p></bio><email xlink:type="simple">alexandra.guseva@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Городская клиническая больница №1 им. Н.И. Пирогова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pirogov City Clinical Hospital No1</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Российский национальный исследовательский медицинский университет имени Н.И. Пирогова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pirogov Russian National Research Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>14</day><month>11</month><year>2019</year></pub-date><volume>0</volume><issue>20</issue><fpage>32</fpage><lpage>37</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Дербенева М.Л., Гусева А.Л., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Дербенева М.Л., Гусева А.Л.</copyright-holder><copyright-holder xml:lang="en">Derbeneva M.L., Guseva A.L.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/4376">https://www.med-sovet.pro/jour/article/view/4376</self-uri><abstract><p>Острые респираторные вирусные инфекции (ОРВИ) являются одной из самых частых причин первичного обращения пациентов за медицинской помощью. Более 200 штаммов вирусов могут стать причиной развития ОРВИ, среди которых лидируют риновирусы. В статье обсуждаются эпидемиологические характеристики ОРВИ и вызываемый высокой заболеваемостью экономический ущерб обществу. Клиническая картина ОРВИ практически всегда сопровождается комбинацией таких симптомов, как выделения из носа, заложенность носа, боли в горле и кашель в сочетании с болями в мышцах, слабостью, быстрой утомляемостью, головной болью и снижением аппетита. Дифференциальная диагностика ОРВИ проводится с гриппом, аллергическим ринитом, стрептококковой ангиной, синуситом и отитом. Эффективной профилактикой является соблюдение гигиены рук. Обсуждаются возможности и эффективность сопутствующей вспомогательной терапии, в том числе с помощью деконгестантов, топических глюкокортикостероидов, растворов для орошения полости носа, нестероидных противовоспалительных препаратов, парацетамола и противокашлевых средств. Антибактериальная терапия не оказывает положительного действия на течение ОРВИ. Приведен клинический пример ведения пациентки с ОРВИ.</p></abstract><trans-abstract xml:lang="en"><p>Acute respiratory viral infections (ARVI) are one of the most common reasons patients seek ambulatory care. ARVIs can be caused by more than 200 strains of viruses, among which rhinoviruses remain a leading cause. The article discusses the epidemiological characteristics of ARVI and the economic damage caused by high incidence to the community. The clinical presentation of ARVI is nearly always accompanied by a combination of symptoms such as nasal discharge, nasal congestion, sore throat and cough combined with muscle pain, weakness, fatigue, headache and decreased appetite. Diagnosis of acute respiratory viral infections must be differentiated from influenza, allergic rhinitis, streptococcal tonsillitis, sinusitis and otitis media. Practicing hand hygiene is an effective way to prevent infections. The article discusses possibilities and effectiveness of concomitant adjuvant therapy, including the use of decongestants, topical glucocorticosteroids, nasal irrigation solutions, non-steroidal anti-inflammatory drugs, paracetamol and antitussive drugs. Antibacterial therapy does not have a positive effect on the course of ARVI. A clinical case describing the management of a patient with ARVI is provided.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>острые респираторные вирусные заболевания</kwd><kwd>кашель</kwd><kwd>вирусы</kwd><kwd>профилактика</kwd><kwd>противокашлевые средства</kwd></kwd-group><kwd-group xml:lang="en"><kwd>acute respiratory viral diseases</kwd><kwd>cough</kwd><kwd>viruses</kwd><kwd>prevention</kwd><kwd>antitussives</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Nichol K.L., D’Heilly S., Ehlinger E. Colds and influenza-like illnesses in university students: impact on health, academic and work performance, and health care use. Clin Infect Dis. 2005;40(9):1263-1270. doi: 10.1086/429237.</mixed-citation><mixed-citation xml:lang="en">Nichol K.L., D’Heilly S., Ehlinger E. Colds and influenza-like illnesses in university students: impact on health, academic and work performance, and health care use. Clin Infect Dis. 2005;40(9):1263-1270. doi: 10.1086/429237.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Sethi S. Infection as a comorbidity of COPD. Eur Respir J. 2010;35(6):1209-1215. doi: 10.1183/09031936.00081409.</mixed-citation><mixed-citation xml:lang="en">Sethi S. Infection as a comorbidity of COPD. Eur Respir J. 2010;35(6):1209-1215. doi: 10.1183/09031936.00081409.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Bizzintino J., Lee W.M., Laing I.A., Vang F., Pappas T., Zhang G., Martin A.C., Khoo S.K., Cox D.W., Geelhoed G.C., McMinn P.C., Goldblatt J., Gern J.E., Le Souëf P.N. Association between human rhinovirus C and severity of acute asthma in children. Eur Respir J. 2011;37(5):10371042. doi: 10.1183/09031936.00092410.</mixed-citation><mixed-citation xml:lang="en">Bizzintino J., Lee W.M., Laing I.A., Vang F., Pappas T., Zhang G., Martin A.C., Khoo S.K., Cox D.W., Geelhoed G.C., McMinn P.C., Goldblatt J., Gern J.E., Le Souëf P.N. Association between human rhinovirus C and severity of acute asthma in children. Eur Respir J. 2011;37(5):10371042. doi: 10.1183/09031936.00092410.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Royston L., Tapparel C. Rhinoviruses and Respiratory Enteroviruses: Not as Simple as ABC. Viruses. 2016;8(1). pii: E16. doi: 10.3390/ v8010016.</mixed-citation><mixed-citation xml:lang="en">Royston L., Tapparel C. Rhinoviruses and Respiratory Enteroviruses: Not as Simple as ABC. Viruses. 2016;8(1). pii: E16. doi: 10.3390/ v8010016.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Kardos P., Malek F.A. Common Cold – an Umbrella Term for Acute Infections of Nose, Throat, Larynx and Bronchi. Pneumologie. 2017;71(4):221-226. doi: 10.1055/s-0042-116112.</mixed-citation><mixed-citation xml:lang="en">Kardos P., Malek F.A. Common Cold – an Umbrella Term for Acute Infections of Nose, Throat, Larynx and Bronchi. Pneumologie. 2017;71(4):221-226. doi: 10.1055/s-0042-116112.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Palmenberg A.C., Spiro D., Kuzmickas R., Wang S., Djikeng A., Rathe J.A., Fraser-Liggett C.M., Liggett S.B. Sequencing and analyses of all known human rhinovirus genomes reveal structure and evolution. Science. 2009;324(5923):55-59. doi: 10.1126/science.1165557.</mixed-citation><mixed-citation xml:lang="en">Palmenberg A.C., Spiro D., Kuzmickas R., Wang S., Djikeng A., Rathe J.A., Fraser-Liggett C.M., Liggett S.B. Sequencing and analyses of all known human rhinovirus genomes reveal structure and evolution. Science. 2009;324(5923):55-59. doi: 10.1126/science.1165557.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Селькова Е.П., Гренкова Т.А., Гудова Н.В., Оганесян А.С. Итоги эпидсезона 2017/18 гг. по гриппу и острой респираторной вирусной инфекции. Особенности этиотропной терапии. РМЖ. Медицинское обозрение. 2018;(11):49-53. Режим доступа: https://www. rmj.ru/articles/infektsiya/Itogi_ epidsezona_201718_gg_pogrippu_iostroy_ respiratornoy_virusnoy_infekcii_Osobennosti_ etiotropnoy_terapii.</mixed-citation><mixed-citation xml:lang="en">Sel’kova E.P., Grenkova T.A., Gudova N.V., Oganesyan A.S. Results of 2017/18 epidemiological influenza and ARVI season. Features of etiotropic therapy. RMZH. Meditsinskoe obozrenie = RMJ. 2018;(11):49-53. (In Russ.) Available at: https://www.rmj.ru/articles/infektsiya/Itogi_epidsezona_201718_gg_pogrippu_ iostroy_respiratornoy_virusnoy_infekcii_ Osobennosti_etiotropnoy_terapii.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Allen L.V. Colds &amp; cough. Int J Pharm Compd. 2012;16(6):480-483. Available at: https://www. ncbi.nlm.nih.gov/pubmed/23259364.</mixed-citation><mixed-citation xml:lang="en">Allen L.V. Colds &amp; cough. Int J Pharm Compd. 2012;16(6):480-483. Available at: https://www. ncbi.nlm.nih.gov/pubmed/23259364.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Arroll B. Common cold. BMJ Clin Evid. 2011;2011. pii: 1510. Available at: https:// www.ncbi.nlm.nih.gov/pubmed/21406124.</mixed-citation><mixed-citation xml:lang="en">Arroll B. Common cold. BMJ Clin Evid. 2011;2011. pii: 1510. Available at: https:// www.ncbi.nlm.nih.gov/pubmed/21406124.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Thompson M., Vodicka T.A., Blair P.S., Buckley D.I., Heneghan C., Hay A.D.; TARGET Programme Team. Duration of symptoms of respiratory tract infections in children: systematic review. BMJ. 2013;347:f7027. doi: 10.1136/bmj.f7027.</mixed-citation><mixed-citation xml:lang="en">Thompson M., Vodicka T.A., Blair P.S., Buckley D.I., Heneghan C., Hay A.D.; TARGET Programme Team. Duration of symptoms of respiratory tract infections in children: systematic review. BMJ. 2013;347:f7027. doi: 10.1136/bmj.f7027.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Grief S.N. Upper respiratory infections. Prim Care. 2013;40(3):757-770. doi: 10.1016/j. pop.2013.06.004.</mixed-citation><mixed-citation xml:lang="en">Grief S.N. Upper respiratory infections. Prim Care. 2013;40(3):757-770. doi: 10.1016/j. pop.2013.06.004.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Rohilla A., Sharma V., Kumar S. Upper respiratory tract infections: an overview. Int J Curr Pharm Res. 2013;5:1–3. https://innovareacademics.in/ journal/ijcpr/Issues/Vol5Issue3/712.pdf.</mixed-citation><mixed-citation xml:lang="en">Rohilla A., Sharma V., Kumar S. Upper respiratory tract infections: an overview. Int J Curr Pharm Res. 2013;5:1–3. https://innovareacademics.in/ journal/ijcpr/Issues/Vol5Issue3/712.pdf.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Eccles R. Mechanisms of symptoms of common cold and flu. In: Eccles R., Weber O. (eds.). Common Cold. Basel: Birkhäuser; 2009:23–45. Available at: https://link.springer.com/chapter/10.1007/978-3-7643-9912-2_2.</mixed-citation><mixed-citation xml:lang="en">Eccles R. Mechanisms of symptoms of common cold and flu. In: Eccles R., Weber O. (eds.). Common Cold. Basel: Birkhäuser; 2009:23–45. Available at: https://link.springer.com/chapter/10.1007/978-3-7643-9912-2_2.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Fine A.M., Nizet V., Mandl K.D. Large-scale validation of the Centor and McIsaac scores to predict group A streptococcal pharyngitis. Arch Intern Med. 2012;172(11):847-852. doi: 10.1001/archinternmed.2012.950.</mixed-citation><mixed-citation xml:lang="en">Fine A.M., Nizet V., Mandl K.D. Large-scale validation of the Centor and McIsaac scores to predict group A streptococcal pharyngitis. Arch Intern Med. 2012;172(11):847-852. doi: 10.1001/archinternmed.2012.950.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Rosenfeld R.M., Piccirillo J.F., Chandrasekhar S.S., Brook I., Ashok Kumar K., Kramper M., Orlandi R.R., Palmer J.N., Patel Z.M., Peters A., Walsh S.A., Corrigan M.D. Clinical practice guideline (update): adult sinusitis. Otolaryngol Head Neck Surg. 2015;152(2 Suppl):S1-S39. doi: 10.1177/0194599815572097.</mixed-citation><mixed-citation xml:lang="en">Rosenfeld R.M., Piccirillo J.F., Chandrasekhar S.S., Brook I., Ashok Kumar K., Kramper M., Orlandi R.R., Palmer J.N., Patel Z.M., Peters A., Walsh S.A., Corrigan M.D. Clinical practice guideline (update): adult sinusitis. Otolaryngol Head Neck Surg. 2015;152(2 Suppl):S1-S39. doi: 10.1177/0194599815572097.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Atkinson H., Wallis S., Coatesworth A.P. Acute otitis media. Postgrad Med. 2015;127(4):386390. doi: 10.1080/00325481.2015.1028872.</mixed-citation><mixed-citation xml:lang="en">Atkinson H., Wallis S., Coatesworth A.P. Acute otitis media. Postgrad Med. 2015;127(4):386390. doi: 10.1080/00325481.2015.1028872.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Aiello A.E, Murray G.F., Perez V., Coulborn R.M., Davis B.M., Uddin M., Shay D.K., Waterman S.H., Monto A.S. Mask use, hand hygiene, and seasonal influenza-like illness among young adults: a randomized intervention trial. J Infect Dis. 2010;201(4):491-498. doi: 10.1086/650396.</mixed-citation><mixed-citation xml:lang="en">Aiello A.E, Murray G.F., Perez V., Coulborn R.M., Davis B.M., Uddin M., Shay D.K., Waterman S.H., Monto A.S. Mask use, hand hygiene, and seasonal influenza-like illness among young adults: a randomized intervention trial. J Infect Dis. 2010;201(4):491-498. doi: 10.1086/650396.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Bolon M.K. Hand Hygiene: An Update. Infect Dis Clin North Am. 2016;30(3):591-607. doi: 10.1016/j.idc.2016.04.007.</mixed-citation><mixed-citation xml:lang="en">Bolon M.K. Hand Hygiene: An Update. Infect Dis Clin North Am. 2016;30(3):591-607. doi: 10.1016/j.idc.2016.04.007.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Kenealy T., Arroll B. Antibiotics for the common cold and acute purulent rhinitis. Cochrane Database Syst Rev. 2013;(6):CD000247. doi: 10.1002/14651858. CD000247.pub3.</mixed-citation><mixed-citation xml:lang="en">Kenealy T., Arroll B. Antibiotics for the common cold and acute purulent rhinitis. Cochrane Database Syst Rev. 2013;(6):CD000247. doi: 10.1002/14651858. CD000247.pub3.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Ivers N., Arroll B., Allan G.M. Delayed antibiotic prescriptions for URTIs. Can Fam Physician 2011;57:1287. Available at: https://www.ncbi. nlm.nih.gov/pubmed/12485551.</mixed-citation><mixed-citation xml:lang="en">Ivers N., Arroll B., Allan G.M. Delayed antibiotic prescriptions for URTIs. Can Fam Physician 2011;57:1287. Available at: https://www.ncbi. nlm.nih.gov/pubmed/12485551.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Fashner J., Ericson K., Werner S. Treatment of the common cold in children and adults. Am Fam Physician. 2012;86(2):153-159. Available at: https://www.ncbi.nlm.nih.gov/pubmed/22962927.</mixed-citation><mixed-citation xml:lang="en">Fashner J., Ericson K., Werner S. Treatment of the common cold in children and adults. Am Fam Physician. 2012;86(2):153-159. Available at: https://www.ncbi.nlm.nih.gov/pubmed/22962927.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Meltzer E.O., Caballero F., Fromer L.M., Krouse J.H., Scadding G. Treatment of congestion in upper respiratory diseases. Int J Gen Med. 2010;3:69–91. Available at: https://www.ncbi. nlm.nih.gov/pubmed/20463825.</mixed-citation><mixed-citation xml:lang="en">Meltzer E.O., Caballero F., Fromer L.M., Krouse J.H., Scadding G. Treatment of congestion in upper respiratory diseases. Int J Gen Med. 2010;3:69–91. Available at: https://www.ncbi. nlm.nih.gov/pubmed/20463825.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Zalmanovici Trestioreanu A., Yaphe J. Intranasal steroids for acute sinusitis. Cochrane Database Syst Rev. 2013;(12):CD005149. doi: 10.1002/14651858.CD005149.pub4.</mixed-citation><mixed-citation xml:lang="en">Zalmanovici Trestioreanu A., Yaphe J. Intranasal steroids for acute sinusitis. Cochrane Database Syst Rev. 2013;(12):CD005149. doi: 10.1002/14651858. CD005149.pub4.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Eccles R., Winther B., Johnston S.L., Robinson P., Trampisch M., Koelsch S. Efficacy and safety of iota-carrageenan nasal spray versus placebo in early treatment of the common cold in adults: the ICICC trial. Respir Res. 2015;16:121. doi: 10.1186/s12931-015-0281-8.</mixed-citation><mixed-citation xml:lang="en">Eccles R., Winther B., Johnston S.L., Robinson P., Trampisch M., Koelsch S. Efficacy and safety of iota-carrageenan nasal spray versus placebo in early treatment of the common cold in adults: the ICICC trial. Respir Res. 2015;16:121. doi: 10.1186/s12931-015-0281-8.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Kim S.Y., Chang Y.J., Cho H.M., Hwang Y.W., Moon Y.S. Non-steroidal anti-inflammatory drugs for the common cold. Cochrane Database Syst Rev. 2009;(3):CD006362. doi: 10.1002/14651858.CD006362.pub2.</mixed-citation><mixed-citation xml:lang="en">Kim S.Y., Chang Y.J., Cho H.M., Hwang Y.W., Moon Y.S. Non-steroidal anti-inflammatory drugs for the common cold. Cochrane Database Syst Rev. 2009;(3):CD006362. doi: 10.1002/14651858.CD006362.pub2.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Irwin R.S., French C.L., Chang A.B., Altman K.W., CHEST Expert Cough Panel. Classification of Cough as a Symptom in Adults and Management Algorithms: CHEST Guideline and Expert Panel Report. Chest. 2018;153(1):196– 209. doi: 10.1016/j.chest.2017.10.016.</mixed-citation><mixed-citation xml:lang="en">Irwin R.S., French C.L., Chang A.B., Altman K.W., CHEST Expert Cough Panel. Classification of Cough as a Symptom in Adults and Management Algorithms: CHEST Guideline and Expert Panel Report. Chest. 2018;153(1):196–209. doi: 10.1016/j. chest.2017.10.016.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Захарова И.Н., Дмитриева Ю.А. Эффективность муколитических препаратов при кашле у детей. Consilium Medicum. Педиатрия. (Прил.) 2009;(03):72-77. Режим доступа: https://con-med.ru/magazines/ pediatry/pediatry-03-2009/</mixed-citation><mixed-citation xml:lang="en">Zaharova I.N., Dmitrieva Ju.A. Efficacy of mucolytics in children’s cough. Consilium Medicum. Pediatriya. (Pril.) = Pediatrics – suppl. Consilium Medicum. 2009;(03):72-77. (In Russ.) Available at: https://con-med.ru/magazines/pediatry/ pediatry-03-2009/</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Holzinger F., Chenot J.F. Systematic Review of Clinical Trials Assessing the Effectiveness of Ivy Leaf (Hedera Helix) for Acute Upper Respiratory Tract Infections. Evid Based Complement Alternat Med. 2011;2011:382789. doi: 10.1155/2011/382789.</mixed-citation><mixed-citation xml:lang="en">Holzinger F., Chenot J.F. Systematic Review of Clinical Trials Assessing the Effectiveness of Ivy Leaf (Hedera Helix) for Acute Upper Respiratory Tract Infections. Evid Based Complement Alternat Med. 2011;2011:382789. doi: 10.1155/2011/382789.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Прожерина Ю. Растительные средства для лечения кашля: эффективность, доказанная веками. Ремедиум. 2019;(1-2):27-30. doi: 10.21518/1561-5936-2019-1-2-27-30.</mixed-citation><mixed-citation xml:lang="en">Prozherina J. Herbal medicine for cough: centuries-old efficacy. Remedium. 2019;(1-2):2730. (In Russ.) doi: 10.21518/1561-5936-20191-2-27-30.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
