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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2015-XX-28-33</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-468</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ГИНЕКОЛОГИЧЕСКАЯ ЭНДОКРИНОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>GYNECOLOGICAL ENDOCRINOLOGY</subject></subj-group></article-categories><title-group><article-title>Современные тенденции медикаментозного лечения эндометриоза</article-title><trans-title-group xml:lang="en"><trans-title>Current trends in medicinal treatment of endometriosis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Орлова</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Orlova</surname><given-names>S. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Балан</surname><given-names>В. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Balan</surname><given-names>V. E.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Левкович</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Levkovich</surname><given-names>E. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Московский областной научно-исследовательский институт акушерства и гинекологии</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Moscow Regional Research Institute of Obstetrics and Gynecology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>30</day><month>12</month><year>2015</year></pub-date><volume>0</volume><issue>XX</issue><fpage>28</fpage><lpage>33</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Орлова С.А., Балан В.Е., Левкович Е.А., 2015</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="ru">Орлова С.А., Балан В.Е., Левкович Е.А.</copyright-holder><copyright-holder xml:lang="en">Orlova S.A., Balan V.E., Levkovich E.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/468">https://www.med-sovet.pro/jour/article/view/468</self-uri><abstract><p>Эндометриоз - одна из важнейших проблем современной гинекологии. Несмотря на значительные успехи современной медицины, до конца не ясен патогенез заболевания, нет единого мнения о критериях его диагностики, а в вопросах лечения до недавнего времени доминировали, обсуждались и совершенствовались преимущественно оперативные методики, энергии воздействия. Разнородность клинических проявлений, драматизм последствий для состояния репродуктивной системы, значительное снижение качества жизни характеризуют эндометриоз как чрезвычайно важную медико-социальную проблему, имеющую существенное демографическое значение.</p></abstract><trans-abstract xml:lang="en"><p>Endometriosis is one of the key challenges in modern gynecology. Despite significant advances in the present-day medicine, the pathogenesis of the disease is still not clearly defined, there is no consensus on diagnostic criteria; surgical techniques and energy-based methods of impact have been predominantly used, discussed and improved in the filed of treatment. Heterogeneity of clinical manifestations, disappointing consequences for the reproductive system, significant reduction in the quality of life make endometriosis a relevant medical and social problem with a huge demographic significance.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>эндометриоз</kwd><kwd>гормональная терапия</kwd><kwd>диеногест</kwd><kwd>endometriosis</kwd><kwd>hormonal therapy</kwd><kwd>dienogest</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Адамян Л.В. Эндометриозы: Руководство для врачей. Л.В. Адамян, В.И. Кулаков, Е.Н. Андреева. М.: Медицина, 2006.</mixed-citation><mixed-citation xml:lang="en">Адамян Л.В. Эндометриозы: Руководство для врачей. Л.В. Адамян, В.И. Кулаков, Е.Н. Андреева. М.: Медицина, 2006.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Руководство по амбулаторно-поликлиниче-ской помощи в акушерстве и гинекологии. Под ред. В.И. Кулакова, В.Н. Прилепской, В.Е. Рад-зинского. М.: ГЭОТАР-Медиа, 2007. С. 683-714.</mixed-citation><mixed-citation xml:lang="en">Руководство по амбулаторно-поликлиниче-ской помощи в акушерстве и гинекологии. Под ред. В.И. Кулакова, В.Н. Прилепской, В.Е. Рад-зинского. М.: ГЭОТАР-Медиа, 2007. С. 683-714.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Эндометриоз: Диагностика, лечение и реабилитация. Клинические рекомендации по ведению больных. Под ред. Л.В. Адамян. 2013. С. 9-37.</mixed-citation><mixed-citation xml:lang="en">Эндометриоз: Диагностика, лечение и реабилитация. Клинические рекомендации по ведению больных. Под ред. Л.В. Адамян. 2013. С. 9-37.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">В.Е. Радзинский, М.Б. Хамошина. Эндометриоз: лечить или не лечить, а если да, то чем? Фарматека, 2009, 9: 64-67.</mixed-citation><mixed-citation xml:lang="en">В.Е. Радзинский, М.Б. Хамошина. Эндометриоз: лечить или не лечить, а если да, то чем? Фарматека, 2009, 9: 64-67.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Fagervold B et al. Acta Obstet Gyn Scan, 2009, 8: 914-919. Fourquet J et al. Fertil Steril, 2010, 7: 2424-2428.</mixed-citation><mixed-citation xml:lang="en">Fagervold B et al. Acta Obstet Gyn Scan, 2009, 8: 914-919. Fourquet J et al. Fertil Steril, 2010, 7: 2424-2428.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Davis LJ et al. Cochrane Database Syst Rev, 2007, 3. CD001019. Vercellini P et al. Best Pract Res Clin Obstet Gynaecol, 2008, 22(2): 275-306.</mixed-citation><mixed-citation xml:lang="en">Davis LJ et al. Cochrane Database Syst Rev, 2007, 3. CD001019. Vercellini P et al. Best Pract Res Clin Obstet Gynaecol, 2008, 22(2): 275-306.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Kappou D et al. Minerva Ginecol, 2010, 62: 415432.</mixed-citation><mixed-citation xml:lang="en">Kappou D et al. Minerva Ginecol, 2010, 62: 415432.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Vercellini P et al. Hum Reprod Update, 2011, 17(2): 159-170.</mixed-citation><mixed-citation xml:lang="en">Vercellini P et al. Hum Reprod Update, 2011, 17(2): 159-170.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Chapron Ch et al. Human Reproduction, 2011, 26(8): 2028-2035.</mixed-citation><mixed-citation xml:lang="en">Chapron Ch et al. Human Reproduction, 2011, 26(8): 2028-2035.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Harada T et al. Fertil Steril, 2008, 90(5): 15831588.</mixed-citation><mixed-citation xml:lang="en">Harada T et al. Fertil Steril, 2008, 90(5): 15831588.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Barbieri RL. J Reprod Med, 1998, 43: 287-292.</mixed-citation><mixed-citation xml:lang="en">Barbieri RL. J Reprod Med, 1998, 43: 287-292.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">GnRH Klipping C et al. J Clin Pharmacol, 2012, 52: 1704-1713. Barbieri RL. Am J Obster Gynecol, 1992, 166: 740-745.</mixed-citation><mixed-citation xml:lang="en">GnRH Klipping C et al. J Clin Pharmacol, 2012, 52: 1704-1713. Barbieri RL. Am J Obster Gynecol, 1992, 166: 740-745.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Strowitzki T, Faustmann T, Gerlinger C, Seitz C. Dienogest in the treatment of endometriosis-associated pelvic pain a 12-week, randomized, double-blind, placebo-controlled study. Eur J Obstet Gynecol Reprod Biol, 2010.</mixed-citation><mixed-citation xml:lang="en">Strowitzki T, Faustmann T, Gerlinger C, Seitz C. Dienogest in the treatment of endometriosis-associated pelvic pain a 12-week, randomized, double-blind, placebo-controlled study. Eur J Obstet Gynecol Reprod Biol, 2010.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Schindler AE, Christensen B, Henkel A, Oettel M, Moore C. High-dose pilot study with the novel progestogen dienogest in patients with endometriosis. Gynecol. Endocrinol., 2006, 22: 9-17.</mixed-citation><mixed-citation xml:lang="en">Schindler AE, Christensen B, Henkel A, Oettel M, Moore C. High-dose pilot study with the novel progestogen dienogest in patients with endometriosis. Gynecol. Endocrinol., 2006, 22: 9-17.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Momoeda M, Taketani Y. Randomized double-blind, multicentre, parallel-group dose-response study of dienogest in patients with endometriosis. J. Pharmacol. Ther., 2007, 35: 769-783.</mixed-citation><mixed-citation xml:lang="en">Momoeda M, Taketani Y. Randomized double-blind, multicentre, parallel-group dose-response study of dienogest in patients with endometriosis. J. Pharmacol. Ther., 2007, 35: 769-783.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Harada Т, Momoeda М, Taketani Y, Aso T. Dienogest is as effective as intranasal buserelin acetate for the relief of pain symptoms associated with endometriosis-a randomized, double-blind, multicenter, controlled trial. Fertility and Sterility, 2009, 3(91): 675-681.</mixed-citation><mixed-citation xml:lang="en">Harada Т, Momoeda М, Taketani Y, Aso T. Dienogest is as effective as intranasal buserelin acetate for the relief of pain symptoms associated with endometriosis-a randomized, double-blind, multicenter, controlled trial. Fertility and Sterility, 2009, 3(91): 675-681.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
