<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2015-1-7-11</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-482</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>БРОНХОПУЛЬМОНОЛОГИЯ И ЛОР</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>BRONCHIAL PULMONOLOGY AND ENT</subject></subj-group></article-categories><title-group><article-title>Место джозамицина в терапии острых респираторных инфекций бактериальной этиологии у детей</article-title><trans-title-group xml:lang="en"><trans-title>Josamicyn in the treatment of bacterial acute respiratory infections in children</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хохлова</surname><given-names>Т. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Khokhlova</surname><given-names>T. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Полякова</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Polyakova</surname><given-names>A. S.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бакрадзе</surname><given-names>М. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Bakradze</surname><given-names>M. B.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Научный центр здоровья детей РАМН</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Scientific Center of Children's Health RAMS, department of diagnostics and rehabilitation treatment</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>30</day><month>12</month><year>2015</year></pub-date><volume>0</volume><issue>1</issue><fpage>7</fpage><lpage>11</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Хохлова Т.А., Полякова А.С., Бакрадзе М.Б., 2015</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="ru">Хохлова Т.А., Полякова А.С., Бакрадзе М.Б.</copyright-holder><copyright-holder xml:lang="en">Khokhlova T.A., Polyakova A.S., Bakradze M.B.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/482">https://www.med-sovet.pro/jour/article/view/482</self-uri><abstract><p>В статье приведены современные сведения о природном антибиотике группы макролидов джозами-цине, результаты отечественных и зарубежных исследований по чувствительности и резистентности к нему различных видов возбудителей, а также данные и положительный опыт его применения в терапии острых респираторных инфекций у детей.</p></abstract><trans-abstract xml:lang="en"><p>The article provides latest information on the natural macrolide antibiotic josamycin, results of local and foreign trials of sensitivity and resistance of various kinds of pathogens to josamycin, evidence and success of using the antibiotic drug in the treatment of acute respiratory infections in children.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>антибактериальная терапия</kwd><kwd>дети</kwd><kwd>макролиды</kwd><kwd>респираторные инфекции</kwd><kwd>резистентность</kwd><kwd>джозамицин</kwd><kwd>antibiotic therapy</kwd><kwd>children</kwd><kwd>macrolides</kwd><kwd>respiratory infections</kwd><kwd>resistance</kwd><kwd>josamycin</kwd><kwd>antibiotic therapy</kwd><kwd>children</kwd><kwd>macrolides</kwd><kwd>respiratory infections</kwd><kwd>resistance</kwd><kwd>josamycin</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Infectious Diseases. Jonathan Cohen, Steven M. Opal Elsevier Ltd., 2010. Chapter 135. P. 13611365.</mixed-citation><mixed-citation xml:lang="en">Infectious Diseases. Jonathan Cohen, Steven M. Opal Elsevier Ltd., 2010. Chapter 135. P. 13611365.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Periti P, Mazzei Т, Mini E et al. Clinical pharmacokinetic properties of the macrolide antibiotics. Effects of age and various pathphysiological states (part I). Clin. Pharmacokinet., 1989, 16: 193-214.</mixed-citation><mixed-citation xml:lang="en">Periti P, Mazzei Т, Mini E et al. Clinical pharmacokinetic properties of the macrolide antibiotics. Effects of age and various pathphysiological states (part I). Clin. Pharmacokinet., 1989, 16: 193-214.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Страчунский Л.С., Козлов С.Н. Макролиды в современной клинической практике. Раздел II. Характеристика отдельных препаратов: 16-членные макролиды.</mixed-citation><mixed-citation xml:lang="en">Страчунский Л.С., Козлов С.Н. Макролиды в современной клинической практике. Раздел II. Характеристика отдельных препаратов: 16-членные макролиды.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Xiugong Gao, Radharaman Ray, Yan Xiao, Keiko Ishida, Prabhati Ray. Macrolide antibiotics improve chemotactic and phagocytic capacity as well as reduce inflammation in sulfur mustard-exposed monocytes. Pulmonary Pharmacology &amp; Therapeutics, 2010, 23: 97-106.</mixed-citation><mixed-citation xml:lang="en">Xiugong Gao, Radharaman Ray, Yan Xiao, Keiko Ishida, Prabhati Ray. Macrolide antibiotics improve chemotactic and phagocytic capacity as well as reduce inflammation in sulfur mustard-exposed monocytes. Pulmonary Pharmacology &amp; Therapeutics, 2010, 23: 97-106.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Morrison W Infantile hypertrophic pyloric stenosis in infants treated with azithromycin. Pediatric Infectious Disease Journal, 2007, 26 (2): 186-188.</mixed-citation><mixed-citation xml:lang="en">Morrison W Infantile hypertrophic pyloric stenosis in infants treated with azithromycin. Pediatric Infectious Disease Journal, 2007, 26 (2): 186-188.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Kucers' the use of antibiotics. A clinical review of antibacterial, antifungal, antiparasitic and antiviral drugs. M Lindsay Grayson, Suzanne M Crowe, James ~ McCarthy, John Mills, Johan W Mouton, S Ragnar Norrby, David L Paterson, Michael A Pfaller. 6th ed., 2010. P. 822.</mixed-citation><mixed-citation xml:lang="en">Kucers' the use of antibiotics. A clinical review of antibacterial, antifungal, antiparasitic and antiviral drugs. M Lindsay Grayson, Suzanne M Crowe, James ~ McCarthy, John Mills, Johan W Mouton, S Ragnar Norrby, David L Paterson, Michael A Pfaller. 6th ed., 2010. P. 822.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Ron Dagan, Keith P. Klugman, William Craig, Fernando Baquero. Evidence to support the rational that bacterial eradication in respiratory tract infection is an important aim of antimicrobial therapy. Journal of Antimicrobial Chemotherapy, 2001, 47: 129-140.</mixed-citation><mixed-citation xml:lang="en">Ron Dagan, Keith P. Klugman, William Craig, Fernando Baquero. Evidence to support the rational that bacterial eradication in respiratory tract infection is an important aim of antimicrobial therapy. Journal of Antimicrobial Chemotherapy, 2001, 47: 129-140.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">European centre for disease prevention and control. Antimicrobial resistance surveillance in Europe, 2012: 51-58.</mixed-citation><mixed-citation xml:lang="en">European centre for disease prevention and control. Antimicrobial resistance surveillance in Europe, 2012: 51-58.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Козлов Р.С., Сивая О.В., Кречикова О.И., Иванчик Н.В. Динамика резистентности Streptococcus pneumoniae к антибиотикам в России за период 1999-2009 гг. Клиническая микробиология и антимикробная химиотерапия, 2010, 12-24: 1-13.</mixed-citation><mixed-citation xml:lang="en">Козлов Р.С., Сивая О.В., Кречикова О.И., Иванчик Н.В. Динамика резистентности Streptococcus pneumoniae к антибиотикам в России за период 1999-2009 гг. Клиническая микробиология и антимикробная химиотерапия, 2010, 12-24: 1-13.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Сидоренко С.В., Грудинина С.А., Филимонова О.Ю., Столярова Л.Г., Савинова С.А. Резистентность к макролидам и линкозамидам среди Streptococcus pneumoniae и Streptococcus pyogenes в Российской федерации. Клиническая фармакология и терапия, 2008, 17-2: 1-4.</mixed-citation><mixed-citation xml:lang="en">Сидоренко С.В., Грудинина С.А., Филимонова О.Ю., Столярова Л.Г., Савинова С.А. Резистентность к макролидам и линкозамидам среди Streptococcus pneumoniae и Streptococcus pyogenes в Российской федерации. Клиническая фармакология и терапия, 2008, 17-2: 1-4.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Сивая О.В. Устное сообщение, 2012.</mixed-citation><mixed-citation xml:lang="en">Сивая О.В. Устное сообщение, 2012.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Середа Е.В., Катосова Л.К. Место азитромицина в педиатрической практике. Совр. педиатр., 2010, 6(34): 1-3.</mixed-citation><mixed-citation xml:lang="en">Середа Е.В., Катосова Л.К. Место азитромицина в педиатрической практике. Совр. педиатр., 2010, 6(34): 1-3.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Nikolay Mayanskiy, Natalia Alyabieva, Olga Ponomarenko, Anna Lazareva, Lubovj Katosova, Alexander Ivanenko, Tatiana Kulichenko, Leila Namazova-Baranova, Alexander Baranov. Serotypes and antibiotic resistance of non-invasive Streptococcus pneumoniae circulating in pediatric hospitals in Moscow. Russian International Journal of Infectious Diseases, 2014, 20: 58-62.</mixed-citation><mixed-citation xml:lang="en">Nikolay Mayanskiy, Natalia Alyabieva, Olga Ponomarenko, Anna Lazareva, Lubovj Katosova, Alexander Ivanenko, Tatiana Kulichenko, Leila Namazova-Baranova, Alexander Baranov. Serotypes and antibiotic resistance of non-invasive Streptococcus pneumoniae circulating in pediatric hospitals in Moscow. Russian International Journal of Infectious Diseases, 2014, 20: 58-62.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Robert Sauermann, Rainer Gattringer, Wolfgang Graninger, Astrid Buxbaum and Apostolos Georgopoulos. Phenotypes of macrolide resistance of group A streptococci isolated from outpatients in Bavaria and susceptibility to 16 antibiotics. Journal of Antimicrobial Chemotherapy, 2003, 51: 53-57.</mixed-citation><mixed-citation xml:lang="en">Robert Sauermann, Rainer Gattringer, Wolfgang Graninger, Astrid Buxbaum and Apostolos Georgopoulos. Phenotypes of macrolide resistance of group A streptococci isolated from outpatients in Bavaria and susceptibility to 16 antibiotics. Journal of Antimicrobial Chemotherapy, 2003, 51: 53-57.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Таточенко В.К. Педиатру на каждый день -2012. 7-е изд., доп. М.: Боргес, 2012.</mixed-citation><mixed-citation xml:lang="en">Таточенко В.К. Педиатру на каждый день -2012. 7-е изд., доп. М.: Боргес, 2012.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">К Bae Hong, Eun Hwa Choi, Hoan jong Lee, Seong Yeon Lee, Eun Young Cho, Jae Hong Choi, Hyun Mi Kang, Jina Lee, Young Min Ahn, Yeon-Ho Kang and Joon-Ho Lee. Macrolide resistance of Mycoplasma pneumoniae, South Korea, 20002011. Emerging Infectious Diseases, 2013, Aug., 19(19): 1281-1283.</mixed-citation><mixed-citation xml:lang="en">К Bae Hong, Eun Hwa Choi, Hoan jong Lee, Seong Yeon Lee, Eun Young Cho, Jae Hong Choi, Hyun Mi Kang, Jina Lee, Young Min Ahn, Yeon-Ho Kang and Joon-Ho Lee. Macrolide resistance of Mycoplasma pneumoniae, South Korea, 20002011. Emerging Infectious Diseases, 2013, Aug., 19(19): 1281-1283.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Yang Liu, Xinyu Ye,l Hong Zhang, Xiaogang Xu, Wanhua Li, Demei Zhu, Minggui Wang. Characterization of macrolide resistance in Mycoplasma pneumoniae isolated from children in Shanghai, China. Diagnostic Microbiology and infectious disease, 2010, 67: 355-358.</mixed-citation><mixed-citation xml:lang="en">Yang Liu, Xinyu Ye,l Hong Zhang, Xiaogang Xu, Wanhua Li, Demei Zhu, Minggui Wang. Characterization of macrolide resistance in Mycoplasma pneumoniae isolated from children in Shanghai, China. Diagnostic Microbiology and infectious disease, 2010, 67: 355-358.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Michael Harris, Julia Clark, Nicky Coote, Penny Fletcher, Anthony Harnden, Michael McKean, Anne Thomson. Guidelines for the management of community acquired pneumonia in children: update 2011. Thorax., 2011, 66: 2.</mixed-citation><mixed-citation xml:lang="en">Michael Harris, Julia Clark, Nicky Coote, Penny Fletcher, Anthony Harnden, Michael McKean, Anne Thomson. Guidelines for the management of community acquired pneumonia in children: update 2011. Thorax., 2011, 66: 2.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">John S. Bradley,1,a Carrie L. Byington,2,a Samir S. Shah,3,a Brian Alverson,4 Edward R. Carter,5 Christopher Harrison. The Management of Community-Acquired Pneumonia in Infants and Children Older Than3 Months of Age: Clinical Practice Guidelines by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America, 2011.</mixed-citation><mixed-citation xml:lang="en">John S. Bradley,1,a Carrie L. Byington,2,a Samir S. Shah,3,a Brian Alverson,4 Edward R. Carter,5 Christopher Harrison. The Management of Community-Acquired Pneumonia in Infants and Children Older Than3 Months of Age: Clinical Practice Guidelines by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America, 2011.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Бакрадзе М.Д. Новые лечебно-диагностические и организационные технологии ведения детей с острыми лихорадочными заболеваниями. Дисс. д-ра мед. Наук. М., 2009.</mixed-citation><mixed-citation xml:lang="en">Бакрадзе М.Д. Новые лечебно-диагностические и организационные технологии ведения детей с острыми лихорадочными заболеваниями. Дисс. д-ра мед. Наук. М., 2009.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Treatment of acute group A beta!hemolytic streptococcal tonsillitis in children with a 5-day course of josamycin. Portier H, Bourrillon A, Lucht F et al. Arch Pediatr., 2001, 8(7): 700-6.</mixed-citation><mixed-citation xml:lang="en">Treatment of acute group A beta!hemolytic streptococcal tonsillitis in children with a 5-day course of josamycin. Portier H, Bourrillon A, Lucht F et al. Arch Pediatr., 2001, 8(7): 700-6.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Кречиков В.А., Катосова Л.К., Копытко Л.Н., Розанова С.М., Шилова В.П., Кречикова О.И., Иванчик Н.В., Козлов С.Н. Сравнение микробиологической эффективности 7- и 10-дневного курса джозамицина при остром стрептококковом тонзиллофарингите у детей: предварительные результаты Российского многоцентрового исследования. Клиническая микробиология и антимикробная химиотерапия, 2009, 11(2): 21.</mixed-citation><mixed-citation xml:lang="en">Кречиков В.А., Катосова Л.К., Копытко Л.Н., Розанова С.М., Шилова В.П., Кречикова О.И., Иванчик Н.В., Козлов С.Н. Сравнение микробиологической эффективности 7- и 10-дневного курса джозамицина при остром стрептококковом тонзиллофарингите у детей: предварительные результаты Российского многоцентрового исследования. Клиническая микробиология и антимикробная химиотерапия, 2009, 11(2): 21.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Таточенко В.К. Джозамицин в педиатрической практике. Педиатрия, 2011, 90(5): 125-128.</mixed-citation><mixed-citation xml:lang="en">Таточенко В.К. Джозамицин в педиатрической практике. Педиатрия, 2011, 90(5): 125-128.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Ушкалова Е. Значение лекарственных форм для рациональной антибиотикотерапии. Лекарственная форма Солютаб. Врач, 2007, 3: 1-4.</mixed-citation><mixed-citation xml:lang="en">Ушкалова Е. Значение лекарственных форм для рациональной антибиотикотерапии. Лекарственная форма Солютаб. Врач, 2007, 3: 1-4.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
