medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2016-2-102-104medsovet-50Research ArticleДИССЕРТАНТDISSERTANTАпоптоз в плаценте при преэклампсииPlacental apoptosis in pre-eclampsiaХовхаеваП. А.KhovhaevaP. A.noemail@neicon.ruКрасныйА. М.KrasniyA. M.noemail@neicon.ruТютюнникН. В.TyutyunnikN. V.noemail@neicon.ruСергунинаО. А.SerguninaO. A.noemail@neicon.ruГаничкинаМ. Б.GanichkinaM. B.noemail@neicon.ruАмираслановЭ. Ю.AmiraslanovE. Y.noemail@neicon.ruКанН. Е.KanN. E.noemail@neicon.ruТютюнникВ. Л.TyutyunnikV. L.noemail@neicon.ruНаучный центр акушерства, гинекологии и перинатологии им. акад. В.И. КулаковаРоссияScientific center for obstetrics, gynecology and perinatology named after acad. V.I. Russia’s Ministry of HealthRussian Federation20163012201602102104Copyright © Ховхаева П.А., Красный А.М., Тютюнник Н.В., Сергунина О.А., Ганичкина М.Б., Амирасланов Э.Ю., Кан Н.Е., Тютюнник В.Л., 20162016Ховхаева П.А., Красный А.М., Тютюнник Н.В., Сергунина О.А., Ганичкина М.Б., Амирасланов Э.Ю., Кан Н.Е., Тютюнник В.Л.Khovhaeva P.A., Krasniy A.M., Tyutyunnik N.V., Sergunina O.A., Ganichkina M.B., Amiraslanov E.Y., Kan N.E., Tyutyunnik V.L.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/50

Цель - определить наличие и степень выраженности апоптоза в плаценте при преэклампсии. В исследование была включена 31 пациентка. Все пациентки были разделены на 2 группы: I (основную группу) составили 11 беременных с преэклампсией, II (группу сравнения) - 20 здоровых пациенток. Проведена оценка апоптоза методом TUNEL в плаценте. Выявлено, что при преэклампсии уровень апоптоза в плаценте значительно выше уровня апоптоза у условно здоровых, а в отдельных случаях наблюдается разрушение стволовых ворсин за счет программируемой клеточной гибели стромы ворсин и синцитиотрофобласта. При преэклампсии окислительный стресс приводит к повышению уровня апоптоза в ворсинах плаценты. Апоптозу могут подвергаться не только клетки трофо-бласта, но и в некоторых случаях клетки стромы ворсин.

The objective was to determine the presence and severity of placental apoptosis in pre-eclampsia. The study included 31 patients. All patients were divided into 2 groups: group I (treatment) included 11 pregnant women with preeclampsia, group II (control) - 20 healthy patients. Gene expression was evaluated with qPCR assay, and placental apoptosis was assessed by the TUNEL method. It was found that the level of placental apoptosis in preeclampsia patients was significantly higher compared to that of apparently healthy females, and in some cases stem villi are destroyed due to programmed cell death in the villous stroma and syncytiotrophoblast. In preeclampsia, oxidative stress leads to increased levels of apoptosis in placental villi. Both trophoblast cells and, in certain cases, cells of the villous stroma are subject to apoptosis.

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The authors declare that there are no conflicts of interest present.