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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2019-19-22-29</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-5047</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ИММУНОТЕРАПИЯ В ОНКОЛОГИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Immunotherapy in oncology</subject></subj-group></article-categories><title-group><article-title>Станет ли неоадъювантная иммунотерапия новой парадигмой лечения больных раком легкого</article-title><trans-title-group xml:lang="en"><trans-title>Will neo-adjuvant immunotherapy become a new paradigm in the treatment of lung cancer patients</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4469-502X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лактионов</surname><given-names>К. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Laktionov</surname><given-names>K. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор, заведующий отделением химиотерапии №1 торако-абдоминального отдела </p><p>115478, Россия, Москва, Каширское шоссе, д. 23</p><p>117997, Россия, Москва, ул. Островитянова, д. 1</p></bio><bio xml:lang="en"><p>Dr. of Sci. (Med), Professor, Head of the Department of Chemotherapy No.1 of the Thoraco-Abdominal Department</p><p>23, Kashirskoye sh., Moscow, 115478, Russia 1, Ostrovityanova Str., Moscow, 117997, Russia</p></bio><email xlink:type="simple">lkoskos@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6244-4294</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бредер</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Breder</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., ведущий научный сотрудник</p><p>115478, Россия, Москва, Каширское шоссе, д. 23</p></bio><bio xml:lang="en"><p>Dr. of Sci. (Med), Leading Researcher</p><p>23, Kashirskoye sh., Moscow, 115478, Russia </p></bio><email xlink:type="simple">vbreder@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0620-2696</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Юдин</surname><given-names>Д. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Yudin</surname><given-names>D. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., старший научный сотрудник</p><p>115478, Россия, Москва, Каширское шоссе, д. 23</p></bio><bio xml:lang="en"><p>Cand. of Sci. (Med), Senior Researcher</p><p>23, Kashirskoye sh., Moscow, 115478, Russia </p></bio><email xlink:type="simple">yudinden@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7817-8429</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Саранцева</surname><given-names>К. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sarantseva</surname><given-names>K. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., врач-онколог</p><p>115478, Россия, Москва, Каширское шоссе, д. 23</p></bio><bio xml:lang="en"><p>Cand. of Sci. (Med), Oncologist</p><p>23, Kashirskoye sh., Moscow, 115478, Russia </p></bio><email xlink:type="simple">sarantsevaka@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5749-9864</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лактионова</surname><given-names>Л. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Laktionova</surname><given-names>L. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор кафедры восстановительной медицины</p><p>115533, Россия, Москва, ул. Высокая, д. 19, корп. 2</p></bio><bio xml:lang="en"><p>Dr. of Sci. (Med), Professor of the Department of Restorative Medicine, </p><p> 30, Volokolamskoe shosse, Moscow, 123182, Russia</p><p> Deputy General Director for Medical Affairs</p><p>bldg. 2, 19, Vysokaya Str., Moscow, 115533, Russia </p></bio><email xlink:type="simple">laktionova@list.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8967-7987</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ардзинба</surname><given-names>М. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Ardzinba</surname><given-names>M. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., врач</p><p>115478, Россия, Москва, Каширское шоссе, д. 23</p></bio><bio xml:lang="en"><p>Cand. of Sci. (Med), Oncologist, Oncological Department of Medicinal Methods of Treatment No. 17 (chemotherapeutic)</p><p>23, Kashirskoye sh., Moscow, 115478, Russia </p></bio><email xlink:type="simple">merabii@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2154-3376</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Реутова</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Reutova</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., старший научный сотрудник</p><p>115478, Россия, Москва, Каширское шоссе, д. 23</p></bio><bio xml:lang="en"><p>Cand. of Sci. (Med), Senior Researcher</p><p>23, Kashirskoye sh., Moscow, 115478, Russia </p></bio><email xlink:type="simple">evreutova@rambler.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Егорова</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Egorova</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., доцент, профессор кафедры онкологии и лучевой терапии лечебного факультета</p><p>117997, Россия, Москва, ул. Островитянова, д. 1 </p></bio><bio xml:lang="en"><p>Cand. of Sci. (Med), Associate Professor, Professor of the Department of Oncology and Radiation Therapy of the Medical Faculty</p><p>1, Ostrovityanova Str., Moscow, 117997, Russia </p></bio><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Национальный медицинский исследовательский центр онкологии имени Н.Н. Блохина; &#13;
Российский национальный исследовательский медицинский университет имени Н.И. Пирогова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Budgetary Institution «N.N. Blokhin Russian Cancer Research Center» of the Ministry of Health of the Russian Federation,&#13;
Pirogov Russian National Research Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Национальный медицинский исследовательский центр онкологии имени Н.Н. Блохина</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Budgetary Institution «N.N. Blokhin Russian Cancer Research Center» of the Ministry of Health of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Медицинский центр в Коломенском</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal Medical and Biological Agency of Russia,&#13;
CJSC «Medical center in Kolomenskoye»</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>Российский национальный исследовательский медицинский университет имени Н.И. Пирогова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Budgetary Educational Institution of Higher Education «Pirogov Russian National Research Medical University» of the Ministry of Health of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>04</day><month>12</month><year>2019</year></pub-date><volume>0</volume><issue>19</issue><fpage>22</fpage><lpage>29</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Лактионов К.К., Бредер В.В., Юдин Д.И., Саранцева К.А., Лактионова Л.В., Ардзинба М.С., Реутова Е.В., Егорова А.В., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Лактионов К.К., Бредер В.В., Юдин Д.И., Саранцева К.А., Лактионова Л.В., Ардзинба М.С., Реутова Е.В., Егорова А.В.</copyright-holder><copyright-holder xml:lang="en">Laktionov K.K., Breder V.V., Yudin D.I., Sarantseva K.A., Laktionova L.V., Ardzinba M.S., Reutova E.V., Egorova A.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/5047">https://www.med-sovet.pro/jour/article/view/5047</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>неоадъювантная иммунотерапия</kwd><kwd>немелкоклеточный рак легкого</kwd><kwd>ингибиторы контрольных точек</kwd></kwd-group><kwd-group xml:lang="en"><kwd>neoadjuvant immunotherapy</kwd><kwd>non-small cell lung cancer</kwd><kwd>checkpoint inhibitors</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Eberhardt W.E., Mitchell A., Crowley J., Kondo H., Kim Y.T., Turrisi A. 3rd, Goldstraw P., RamiPorta R. 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