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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2019-19-30-36</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-5058</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ТАРГЕТНАЯ ТЕРАПИЯ ОПУХОЛЕЙ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Target therapy of tumors</subject></subj-group></article-categories><title-group><article-title>Вторая линия лечения гепатоцеллюлярного рака: от теории к практике</article-title><trans-title-group xml:lang="en"><trans-title>Second-line treatment of hepatocellular carcinoma: from theory to practical issues</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6244-4294</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бредер</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Breder</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., ведущий научный сотрудник онкологического отделения лекарственных методов лечения (химиотерапии) №17</p><p>115478, Россия, Москва, Каширское шоссе, д. 24</p></bio><bio xml:lang="en"><p>Dr. of Sci. (Med), Leading Researcher</p><p>23, Kashirskoye sh., Moscow, 115478, Russia </p></bio><email xlink:type="simple">vbreder@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4469-502X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лактионов</surname><given-names>К. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Laktionov</surname><given-names>K. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., заведующий онкологическим отделением лекарственных методов лечения (химиотерапевтическое) №17 </p><p>115478, Россия, Москва, Каширское шоссе, д. 24</p></bio><bio xml:lang="en"><p>Dr. of Sci. (Med), Professor, Head of the Department of Chemotherapy No.1 of the Thoraco-Abdominal Department</p><p>23, Kashirskoye sh., Moscow, 115478, Russia </p></bio><email xlink:type="simple">lkoskos@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Научно-исследовательский институт клинической онкологии имени академика РАН и РАМН Н.Н. Трапезникова, Национальный медицинский исследовательский центр онкологии имени Н.Н. Блохина</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Budgetary Institution «N.N. Blokhin Russian Cancer Research Center» of the Ministry of Health of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>04</day><month>12</month><year>2019</year></pub-date><volume>0</volume><issue>19</issue><fpage>30</fpage><lpage>36</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Бредер В.В., Лактионов К.К., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Бредер В.В., Лактионов К.К.</copyright-holder><copyright-holder xml:lang="en">Breder V.V., Laktionov K.K.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/5058">https://www.med-sovet.pro/jour/article/view/5058</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>гепатоцеллюлярный рак</kwd><kwd>сорафениб-рефрактерный</kwd><kwd>ленватиниб</kwd><kwd>регорафениб</kwd><kwd>анти-PD1</kwd><kwd>ниволумаб</kwd><kwd>пембролизумаб</kwd><kwd>кабозантиниб</kwd><kwd>рамуцирумаб</kwd></kwd-group><kwd-group xml:lang="en"><kwd>hepatocellular carcinoma</kwd><kwd>sorafenib-refractory</kwd><kwd>lenvatinib</kwd><kwd>regorafenib</kwd><kwd>nivolumab</kwd><kwd>pembrolizumab</kwd><kwd>cabozantinib</kwd><kwd>ramucirumab</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Публикация при поддержке АО «Байер»</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Bray F., Ferlay J., Soerjomataram I., Siegel R.L., Torre L.A., Jemal A. 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