<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2019-19-120-124</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-5278</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКОЕ НАБЛЮДЕНИЕ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL OBSERVATION</subject></subj-group></article-categories><title-group><article-title>Клинический случай многолетнего применения алектиниба в лечении ALK-позитивного НМРЛ</article-title><trans-title-group xml:lang="en"><trans-title>Clinical case of prolonged use of alectinib in the treatment of ALK-positive NSCLC</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2981-7666</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Багрова</surname><given-names>С. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Bagrova</surname><given-names>S. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., научный сотрудник, онкологическое отделение лекарственных методов лечения (химиотерапевтическое) №1 </p><p>115478, Россия, Москва, Каширское шоссе, д. 23</p></bio><bio xml:lang="en"><p>Cand. of Sci. (Med.), Researcher, Oncology Drug Therapy (Chemotherapy) Department No. 1</p><p>23, Kashirskoe shosse, Moscow, 115478, Russia </p></bio><email xlink:type="simple">s.bagrova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6762-9511</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Коломейцева</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kolomeytseva</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., заведующая дневным стационаром</p><p>119121, Россия, Москва, ул. Погодинская, д. 6, стр. 1</p></bio><bio xml:lang="en"><p>Cand. of Sci. (Med.), Head of Day Patient Hospital, Outpatient Department</p><p>Bldg. 1, 6, Pogodinskaya St., Moscow, 119121, Russia </p></bio><email xlink:type="simple">almed2002@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Трусилова</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Trusilova</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., научный сотрудник, онкологическое отделение лекарственных методов лечения (химиотерапевтическое) №1</p><p>115478, Россия, Москва, Каширское шоссе, д. 23</p></bio><bio xml:lang="en"><p>Cand. of Sci. (Med.), Researcher, Oncology Drug Therapy (Chemotherapy) Department No. 1</p><p>23, Kashirskoe shosse, Moscow, 115478, Russia </p></bio><email xlink:type="simple">tev_86@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0703-2550</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Горбунова</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Gorbunova</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор, ведущий научный сотрудник, онкологическое отделение лекарственных методов лечения(химиотерапевтическое) №1</p><p>115478, Россия, Москва, Каширское шоссе, д. 23</p></bio><bio xml:lang="en"><p>Dr. of Sci. (Med.), Professor, Principal Researcher, Oncology Drug Therapy (Chemotherapy) Department No. 1</p><p>23, Kashirskoe shosse, Moscow, 115478, Russia </p></bio><email xlink:type="simple">veragorbounova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Национальный медицинский исследовательский центр онкологии имени Н.Н. Блохина</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Budgetary Institution «Blokhin National Medical Research Cancer Centre» of the Ministry of Health of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Поликлиническое отделение Московского научно-исследовательского онкологического института им. П.А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>P. A. Hertsen Moscow Oncology Research Institute – Branch of Federal State Budgetary Institution «Blokhin Russian Cancer Research Center» of the Ministry of Healthcare of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>06</day><month>12</month><year>2019</year></pub-date><volume>0</volume><issue>19</issue><fpage>120</fpage><lpage>124</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Багрова С.Г., Коломейцева А.А., Трусилова Е.В., Горбунова В.А., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Багрова С.Г., Коломейцева А.А., Трусилова Е.В., Горбунова В.А.</copyright-holder><copyright-holder xml:lang="en">Bagrova S.G., Kolomeytseva A.A., Trusilova E.V., Gorbunova V.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/5278">https://www.med-sovet.pro/jour/article/view/5278</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>немелкоклеточный рак легкого</kwd><kwd>транслокация ALK</kwd><kwd>кризотиниб</kwd><kwd>алектиниб</kwd></kwd-group><kwd-group xml:lang="en"><kwd>non-small cell lung cancer</kwd><kwd>ALK translocation</kwd><kwd>alectinib</kwd><kwd>crizotinib</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Shaw A.T., Kim D.W., Nakagawa K., Seto T., Crinó L., Ahn M.J., De Pas T., Besse B., Solomon B.J., Blackhall F., et al. Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N Engl J Med. 2013;368(25):2385-2394. doi: 10.1056/NEJMoa1214886.</mixed-citation><mixed-citation xml:lang="en">Shaw A.T., Kim D.W., Nakagawa K., Seto T., Crinó L., Ahn M.J., De Pas T., Besse B., Solomon B.J., Blackhall F., et al. Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N Engl J Med. 2013;368(25):2385-2394. doi: 10.1056/NEJMoa1214886.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Tsao A.S., Scagliotti G.V., Bunn P.A. Jr, Carbone D.P., Warren G.W., Bai C., et al. Scientific Advances in Lung Cancer 2015. J Thorac Oncol. 2016;11(5):613-638. DOI: 10.1016/j.jtho.2016.03.012.</mixed-citation><mixed-citation xml:lang="en">Tsao A.S., Scagliotti G.V., Bunn P.A. Jr, Carbone D.P., Warren G.W., Bai C., et al. Scientific Advances in Lung Cancer 2015. J Thorac Oncol. 2016;11(5):613-638. DOI: 10.1016/j.jtho.2016.03.012.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Novello S., Mazieres J., Oh I.J., de Castro J., Migliorino M.R., Helland A., et al. Primary Results from the Phase III ALUR Study of Alectinib versus Chemotherapy in Previously Treated ALK+Non-Small-Cell Lung Cancer (NSCLC). Annals of Oncology 2017;28(suppl_5):v605-v649. doi: 10.1093/annonc/mdx440.058.</mixed-citation><mixed-citation xml:lang="en">Novello S., Mazieres J., Oh I.J., de Castro J., Migliorino M.R., Helland A., et al. Primary Results from the Phase III ALUR Study of Alectinib versus Chemotherapy in  Previously Treated ALK+Non-Small-Cell Lung Cancer (NSCLC). Annals of Oncology 2017;28(suppl_5):v605-v649. doi: 10.1093/annonc/mdx440.058.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Kerr K.M., López-Ríos F. Precision medicine in NSCLC and pathology: how does ALK fit in the pathway? Ann Oncol. 2016;27(Suppl 3):iii16-iii24. doi: 10.1093/annonc/mdw302.</mixed-citation><mixed-citation xml:lang="en">Kerr K.M., López-Ríos F. Precision medicine in NSCLC and pathology: how does ALK fit in the pathway? Ann Oncol. 2016;27(Suppl 3):iii16-iii24. doi: 10.1093/annonc/mdw302.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Solomon B.J., Mok T., Kim D.W., Wu Y.L., Nakagawa K., Mekhail T., Felip E., Cappuzzo F., Paolini J., Usari T., et al. First-line crizotinib versus chemotherapy in ALK-positive lung cancer. N Engl J Med. 2014;371(23):2167-2177. doi: 10.1056/NEJMoa1408440.</mixed-citation><mixed-citation xml:lang="en">Solomon B.J., Mok T., Kim D.W., Wu Y.L., Nakagawa K., Mekhail T., Felip E., Cappuzzo F., Paolini J., Usari T., et al. First-line crizotinib versus chemotherapy in ALK-positive lung cancer. N Engl J Med. 2014;371(23):2167-2177. doi: 10.1056/NEJMoa1408440.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Duruisseaux M., Besse B., Cadranel J., Pérol M., Mennecier B., Bigay-Game L., Descourt R., Dansin E., Audigier-Valette C., Moreau L., et al. Overall survival with crizotinib and next-generation ALK inhibitors in ALK-positive nonsmall-cell lung cancer (IFCT-1302 CLINALK): a French nationwide cohort retrospective study. Oncotarget. 2017;8(13):21903-21917. doi: 10.18632/oncotarget.15746.</mixed-citation><mixed-citation xml:lang="en">Duruisseaux M., Besse B., Cadranel J., Pérol M., Mennecier B., Bigay-Game L., Descourt R., Dansin E., Audigier-Valette C., Moreau L., et al. Overall survival with crizotinib and next-generation ALK inhibitors in ALK-positive nonsmall-cell lung cancer (IFCT-1302 CLINALK): a French nationwide cohort retrospective study. Oncotarget. 2017;8(13):21903-21917. doi: 10.18632/oncotarget.15746.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Peters S., Camidge D.R., Shaw A.T., Gadgeel S., Ahn J.S., Kim D.W. et al. Alectinib versus Crizotinib in Untreated ALK-Positive Non-SmallCell Lung Cancer. N Engl J Med. 2017;377(9):829-838. doi: 10.1056/NEJMoa1704795.</mixed-citation><mixed-citation xml:lang="en">Peters S., Camidge D.R., Shaw A.T., Gadgeel S., Ahn J.S., Kim D.W. et al. Alectinib versus Crizotinib in Untreated ALK-Positive Non-SmallCell Lung Cancer. N Engl J  Med. 2017;377(9):829-838. doi: 10.1056/NEJMoa1704795.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Shaw A.T., Gandhi L., Gadgeel S., Riely G. et al. Alectinib in ALK-positive, crizotinib-resistant, non-small-cell lung cancer: a single-group, multicentre, phase 2 trial. Lancet Oncol. 2016;17(2):234-242. doi: 10.1016/S1470-2045(15)00488-X.</mixed-citation><mixed-citation xml:lang="en">Shaw A.T., Gandhi L., Gadgeel S., Riely G. et al. Alectinib in ALK-positive, crizotinib-resistant, non-small-cell lung cancer: a single-group, multicentre, phase 2 trial. Lancet Oncol. 2016;17(2):234-242. doi: 10.1016/S1470-2045(15)00488-X.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Ou S.H., Ahn J.S., De Petris L., Govindan R., Yang J.C., Hughes B., Lena H., Moro-Sibilot D., Bearz A., Ramirez S.V., et al. Alectinib in crizotinib-refractory ALK- rearranged non-small-cell lung cancer: a phase II global study. J Clin Oncol. 2016;34(7):661-668. doi: 10.1200/JCO.2015.63.9443.</mixed-citation><mixed-citation xml:lang="en">Ou S.H., Ahn J.S., De Petris L., Govindan R., Yang J.C., Hughes B., Lena H., Moro-Sibilot D., Bearz A., Ramirez S.V., et al. Alectinib in crizotinib-refractory ALK- rearranged non-small-cell lung cancer: a phase II global study. J Clin Oncol. 2016;34(7):661-668. doi: 10.1200/JCO.2015.63.9443.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Gadgeel S.M., Ganghi L., Riely G.J., Chiappori A.A., West H.L., Azada M.C. et al. Safety and activity of alectenib against systemic disease and brain metastases in patients with crizotinib-resistant ALK-rearranged non-small-cell lung cancer: results from the dose-finding portion of a phase 1/2 study. Lancet Oncol. 2014;15(10):1119-1128. doi: 10.1016/S1470-2045(14)70362-6.</mixed-citation><mixed-citation xml:lang="en">Gadgeel S.M., Ganghi L., Riely G.J., Chiappori A.A., West H.L., Azada M.C. et al. Safety and activity of alectenib against systemic disease and brain metastases in patients with crizotinib-resistant ALK-rearranged non-small-cell lung cancer: results from the dose-finding portion of a phase 1/2 study. Lancet Oncol. 2014;15(10):1119-1128. doi: 10.1016/S1470-2045(14)70362-6.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Реутова Е.В., Лактионов К.К. Новые возможности в лечении больных ALK-позитивным немелкоклеточным раком легкого. Онкология. Журнал им. П.А. Герцена. 2019;8(3):226-230. doi: 10.17116/onkolog2019803115226.</mixed-citation><mixed-citation xml:lang="en">Reutova E.V., Laktionov K.K. New opportunities in the treatment of patients with ALK-positive non-small cell lung cancer. Onkologiya. Zhurnal imeni P.A. Gertsena = P.A. Herzen Journal of Oncology. 2019;8(3):226-230. doi: 10.17116/onkolog2019803115226.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Camidge D.R., Peters S., Mok T., Gadgeel S.M., Cheema P.K., Pavlakis N., Marinis F.D., Stroyakovskiy D.L., Cho B.C., Zhang L., et al. Updated efficacy and safety data from the global phase III ALEX study of alectinib (ALC) vs crizotinib (CZ) in untreated advanced ALK+NSCLC. ASCO 2018. Available at: https://ascopubs.org/doi/abs/10.1200/JCO.2018.36.15_suppl.9043.</mixed-citation><mixed-citation xml:lang="en">Camidge D.R., Peters S., Mok T., Gadgeel S.M., Cheema P.K., Pavlakis N., Marinis F.D., Stroyakovskiy D.L., Cho B.C., Zhang L., et al. Updated efficacy and safety data from the global phase III ALEX study of alectinib (ALC) vs crizotinib (CZ) in untreated advanced ALK+NSCLC. ASCO 2018. Available at:  https://ascopubs.org/doi/abs/10.1200/JCO.2018.36.15_suppl.9043.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Mok T.S.K., Shaw A.T., Camidge R.D., Gadgeel S.M., Rosell R., Dziadziuszko R., et al. Final PFS, updated OS and safety data from the randomised, phase III ALEX study of alectinib (ALC) versus crizotinib (CRZ) in untreated advanced ALK+ NSCLC. Annals of Oncology. 2019;30(Suppl_5):mdz260.006. doi: 10.1093/annonc/mdz260.006.</mixed-citation><mixed-citation xml:lang="en">Mok T.S.K., Shaw A.T., Camidge R.D., Gadgeel S.M., Rosell R., Dziadziuszko R., et al. Final PFS, updated OS and safety data from the randomised, phase III ALEX  study of alectinib (ALC) versus crizotinib (CRZ) in untreated advanced ALK+ NSCLC. Annals of Oncology. 2019;30(Suppl_5):mdz260.006. doi: 10.1093/annonc/mdz260.006.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
