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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2016-3-10-17</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-53</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>САХАРНЫЙ ДИАБЕТ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>DIABETES MELLITUS</subject></subj-group></article-categories><title-group><article-title>SGLT2: новые подходы к комбинированной терапии сахарного диабета 2-го типа</article-title><trans-title-group xml:lang="en"><trans-title>SGLT2: new approaches to combination therapy of type 2 diabetes mellitus</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кононенко</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kononenko</surname><given-names>I. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Смирнова</surname><given-names>О. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Smirnova</surname><given-names>O. M.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Эндокринологический научный центр<country>Россия</country></aff><aff xml:lang="en">Endocrinological Scientific Centre<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>30</day><month>12</month><year>2016</year></pub-date><volume>0</volume><issue>3</issue><fpage>10</fpage><lpage>17</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кононенко И.В., Смирнова О.М., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Кононенко И.В., Смирнова О.М.</copyright-holder><copyright-holder xml:lang="en">Kononenko I.V., Smirnova O.M.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/53">https://www.med-sovet.pro/jour/article/view/53</self-uri><abstract><p>Несмотря на появление новых сахароснижающих препаратов, вопросы лечения СД 2-го типа по-прежнему остаются актуальными. С целью стандартизации и оптимизации оказания медицинской помощи больным СД разработаны международные и отечественные алгоритмы лечения СД 2-го типа [1, 2]. В современных алгоритмах основной акцент сделан на индивидуальный подход, безопасность и эффективность в лечении пациентов. Необходимо соблюдать баланс между достижением оптимального контроля гликемии и безопасностью терапии.</p></abstract><trans-abstract xml:lang="en"><p>Despite the emergence of new antidiabetic drugs, diabetes type 2 treatment remains a relevant issue. In order to standardize and optimize medical care to patients with diabetes, global and national algorithms for type 2 diabetes treatment were developed. [1, 2] The current algorithms focus on an individual approach, safety and effectiveness of treatment. A balance should be maintained between achieving optimal glycemic control and safety of therapy.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>сахарный диабет 2-го типа</kwd><kwd>комбинированная терапия</kwd><kwd>инсулинорезистентность</kwd><kwd>дисфункция бета-клеток</kwd><kwd>метформин</kwd><kwd>ингибитор SGLT2</kwd><kwd>дапаглифлозин</kwd><kwd>type 2 diabetes</kwd><kwd>combination therapy</kwd><kwd>insulin resistance</kwd><kwd>beta cell dysfunction</kwd><kwd>metformin</kwd><kwd>SGLT2 inhibitor</kwd><kwd>dap</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Inzucchi SE, BergenstaL RM, Buse JB, Diamant M et aL. Management of hyperglycemia in type 2 diabetes, 2015: A patient-centered approach: Update to a position statement of the American Diabetes Association and the European Association for the Study of Diabetes. 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