medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2019-15-50-61medsovet-5328Research ArticleБронхиальная астмаBronchial asthmaБиологическая терапия тяжелой астмы: новые цели и новые возможности леченияBiological treatment of severe asthma: new objectives and new treatment optionshttps://orcid.org/0000-0002-3162-2510НенашеваН. М.NenashevaN. M.

д.м.н., профессор, заведующая кафедрой аллергологии и иммунологии,

125993, Москва, ул. Баррикадная, д. 2/1, стр. 1

Dr. of Sci. (Med), Professor, Head of the Department of Allergology and Immunology, 

2/1, b. 1, Barrikadnaya St., Moscow, 125993

1444031@gmail.comРоссийская медицинская академия непрерывного профессионального образованияРоссияRussian Medical Academy of Continuing Professional EducationRussian Federation2019071220190155061Copyright © Ненашева Н.М., 20192019Ненашева Н.М.Nenasheva N.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/5328

Настоящая статья посвящена основным характеристикам тяжелой бронхиальной астмы (ТБА) и ее гетерогенности, в частности охарактеризована Т2-астма и представлена роль основных цитокинов, формирующих Т2-воспаление. Основной акцент сделан на роли ИЛ-4 и ИЛ-13 в патогенезе БА как ключевых цитокинов в запуске и поддержании Т2-воспаления, а также на новой биологической молекуле – моноклональном антителе – дупилумабе, направленном на α-субъединицу рецептора ИЛ-4 и блокирующем тем самым пути ИЛ-4 и ИЛ-13. Дупилумаб был недавно зарегистрирован в нашей стране для лечения среднетяжелой и ТБА, а также среднетяжелого и тяжелого атопического дерматита. В статье представлена клиническая эффективность и переносимость дупилумаба у пациентов со среднетяжелой и ТБА.

This article is devoted to the main characteristics of severe bronchial asthma (SBA) and its heterogeneity, in particular, T2 asthma is characterized and the role of the main cytokines forming T2-inflammation is presented. The main emphasis is made on the role of the IL-4 and IL-13 in the pathogenesis of AD as the key cytokines in the initiation and maintenance of T2-inflammation, as well as on a new biological molecule – monoclonal antibody – dupilumab, directed to the α-subunit of IL-4 receptor, thus blocking the pathways of IL-4 and IL-13. Dupilumab has recently been registered in our country for the treatment of moderate and severe BA, as well as moderate and severe atopic dermatitis. The article presents the clinical efficacy and tolerability of dupillumab in patients with moderate and severe BA.

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The authors declare that there are no conflicts of interest present.