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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2019-19-150-156</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-5338</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Онкогинекология</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Oncogynecology</subject></subj-group></article-categories><title-group><article-title>Возможности улучшения результатов лечения первичного рака яичников</article-title><trans-title-group xml:lang="en"><trans-title>Primary ovarian cancer: possibilities for improving treatment outcomes</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хохлова</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Khokhlova</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., заведующая отделением противоопухолевой лекарственной терапии</p><p>117997, Россия, Москва, ул. Академика Опарина, д. 4</p></bio><bio xml:lang="en"><p>Dr. of Sci. (Med.), Head of Department of Anticancer Drug Therapy</p><p>4 Akademika Oparina Street, Moscow, 117997, Russia  </p></bio><email xlink:type="simple">SVKhokhlova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии имени академика В.И. Кулакова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov of the Ministry of Health  of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>07</day><month>12</month><year>2019</year></pub-date><volume>0</volume><issue>19</issue><fpage>150</fpage><lpage>156</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Хохлова С.В., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Хохлова С.В.</copyright-holder><copyright-holder xml:lang="en">Khokhlova S.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/5338">https://www.med-sovet.pro/jour/article/view/5338</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>рак яичников</kwd><kwd>первая линия лечения</kwd><kwd>бевацизумаб</kwd><kwd>антиангиогенез</kwd></kwd-group><kwd-group xml:lang="en"><kwd>ovarian cancer</kwd><kwd>first-line therapy</kwd><kwd>bevacizumab</kwd><kwd>antiangiogenesis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Siegel R.L., Miller K.D., Jemal A. 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Open-label, multicentric phase II trial of pembrolizumab (Keytruda®) with chemotherapy versus chemotherapy alone (standard of care) as neo adjuvant treatment of ovarian cancer not amenable to front line debulking surgery. NEOPEMBROV. Ongoing, NCT number: NCT03275506, ClinicalTrials.gov.</mixed-citation><mixed-citation xml:lang="en">RandomizedA Arandomized. Open-label, multicentric phase II trial of  pembrolizumab (Keytruda®) with chemotherapy versus chemotherapy alone  (standard of care) as neo adjuvant treatment of ovarian cancer not amenable to front line debulking surgery. NEOPEMBROV. Ongoing, NCT number: NCT03275506, ClinicalTrials.gov.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">A phase III, multicenter, randomized, study of Atezolizumab versus placebo administered in combination with paclitaxel, carboplatin, and bevacizumab to patients with NewlyDiagnosed stage III or stage IV ovarian, fallopian tube, or primary peritoneal cancer. IMagyn050. Ongoing, NCT number: NCT03038100, ClinicalTrials.gov.</mixed-citation><mixed-citation xml:lang="en">A phase III, multicenter, randomized, study of Atezolizumab versus placebo administered in combination with paclitaxel, carboplatin, and bevacizumab to patients with NewlyDiagnosed stage III or stage IV ovarian, fallopian tube, or primary peritoneal cancer. IMagyn050. Ongoing, NCT number: NCT03038100, ClinicalTrials.gov.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">A Randomized Phase II Trial of Avastin (A) or Avastin and Erlotinib (AE) as First Line Consolidation Chemotherapy After Carboplatin, Paclitaxel, and Avastin (CTA) Induction Therapy for Newly Diagnosed Advanced Ovarian, Fallopian Tube, Primary Peritoneal Cancer &amp; Papillary Serous or Clear Cell Mullerian Tumors. Ongoing, NCT number: NCT00520013, ClinicalTrials.gov.</mixed-citation><mixed-citation xml:lang="en">A Randomized Phase II Trial of Avastin (A) or Avastin and Erlotinib (AE) as First Line Consolidation Chemotherapy After Carboplatin, Paclitaxel, and Avastin (CTA) Induction Therapy for Newly Diagnosed Advanced Ovarian, Fallopian Tube, Primary Peritoneal Cancer &amp; Papillary Serous or Clear Cell Mullerian Tumors. Ongoing, NCT number: NCT00520013, ClinicalTrials.gov.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">A randomized phase II trial of CarboplatinPaclitaxelBevacizumab vs CarboplatinPaclitaxel-Bevacizumab-Rucaparib vs Carboplatin-Paclitaxel-Rucaparib in patients with advanced (stage III B-C-IV) ovarian, primary peritoneal and fallopian tube cancer preceded by a phase I dose escalation study on Rucaparib-Bevacizumab combination. MITO 25. Ongoing, NCT number: NCT03462212, ClinicalTrials.gov.</mixed-citation><mixed-citation xml:lang="en">A randomized phase II trial of CarboplatinPaclitaxelBevacizumab vs  CarboplatinPaclitaxel-Bevacizumab-Rucaparib vs Carboplatin-Paclitaxel-Rucaparib in patients with advanced (stage III B-C-IV) ovarian, primary peritoneal and fallopian  tube cancer preceded by a phase I dose escalation study on Rucaparib-Bevacizumab combination. MITO 25. Ongoing, NCT number: NCT03462212, ClinicalTrials.gov.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
