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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">medsovet-546</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ГАСТРОЭНТЕРОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>GASTROENTEROLOGY</subject></subj-group></article-categories><title-group><article-title>Желчнокаменная болезнь, холецистэктомия. Что дальше?</article-title><trans-title-group xml:lang="en"><trans-title>Cholelithiasis and cholecystectomy - what's next?</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Самсонов</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Samsonov</surname><given-names>A. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Плотникова</surname><given-names>Е. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Plotnikova</surname><given-names>E. Y.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рубан</surname><given-names>А. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Ruban</surname><given-names>A. P.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Багмет</surname><given-names>А. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Bagmet</surname><given-names>A. D.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ульянкина</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Ulyankina</surname><given-names>E. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>МГМСУ им. А.И. Евдокимова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>MSUMD named after AI Evdokimov</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГБОУ ВПО «КемГМА» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kemerovo State Medical Academy, Russia's Ministry of Health</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>МБУЗ «Городская поликлиника №4», Ростов-на-Дону</institution><country>Россия</country></aff><aff xml:lang="en"><institution>City Polyclinic №4, Rostov-on-Don</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ГОУ ВПО «РостГМУ» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Rostov State Medical University, Russia's Ministry of Health</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>30</day><month>12</month><year>2014</year></pub-date><volume>0</volume><issue>4</issue><fpage>50</fpage><lpage>54</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Самсонов А.А., Плотникова Е.Ю., Рубан А.П., Багмет А.Д., Ульянкина Е.В., 2014</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="ru">Самсонов А.А., Плотникова Е.Ю., Рубан А.П., Багмет А.Д., Ульянкина Е.В.</copyright-holder><copyright-holder xml:lang="en">Samsonov A.A., Plotnikova E.Y., Ruban A.P., Bagmet A.D., Ulyankina E.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/546">https://www.med-sovet.pro/jour/article/view/546</self-uri><abstract><p>Данная работа посвящена желчнокаменной болезни и холецистэктомии при бессимптомных желчных камнях. Описаны патогенетические механизмы развития постхолецистэктомического синдрома у пациентов после холецистэктомии без показаний, а также методы его диагностики. В разделе лечения постхолецистэктомического синдрома рассмотрены современные данные о применении препаратов с высоким уровнем доказательности и рекомендаций. Также в статье приводятся собственные исследования по улучшению моторно-эвакуаторных функций билиарного тракта и литогенности желчи после холецистэктомии у пациентов с желчнокаменной болезнью.</p></abstract><trans-abstract xml:lang="en"><p>The paper is devoted to gallstone disease and cholecystectomy associated with asymptomatic gallstones. The pathogenetic mechanisms of postcholecystectomy syndrome without clinical evidence in patients after cholecystectomy, as well as methods for diagnosis, are described. The section on the treatment of postcholecystectomy syndrome reviews recent data on the use of drugs with the highest level of evidence and recommendation. The article also tells about the results of own research devoted to the improvement of motor-evacuation function of the biliary tract and bile lithogenicity after cholecystectomy in patients with gallstone disease.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>желчнокаменная болезнь</kwd><kwd>холецистэкто-мия</kwd><kwd>постхолецистэктомический синдром</kwd><kwd>урсодезоксихо-левая кислота</kwd><kwd>литогенность желчи</kwd><kwd>cholelithiasis</kwd><kwd>cholecystectomy</kwd><kwd>postcholecystectomical syndrome</kwd><kwd>ursodeoxycholic acid</kwd><kwd>bile lithogenicity</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ильченко А.А Желчнокаменная болезнь. М.: Анахарсис, 2004.</mixed-citation><mixed-citation xml:lang="en">Ильченко А.А Желчнокаменная болезнь. М.: Анахарсис, 2004.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Пелещук А.П., Ногаллер А.М. Ревенок Е.Н. Функциональные заболевания пищеварительной системы. Киев, 1985.</mixed-citation><mixed-citation xml:lang="en">Пелещук А.П., Ногаллер А.М. Ревенок Е.Н. Функциональные заболевания пищеварительной системы. Киев, 1985.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Иванченкова РА. Хронические заболевания желчевыводящих путей. М.: Атмосфера, 2006.</mixed-citation><mixed-citation xml:lang="en">Иванченкова РА. Хронические заболевания желчевыводящих путей. М.: Атмосфера, 2006.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Mills JC, Stappenbeck TS, Bunnett NW. Gastrointestinal disease. In: McPhee SJ, Hammer GD, eds. Pathophysiology of Disease: An Introduction to Clinical Medicine. 6th ed. New York, NY: McGraw-Hill Medical; 2010.</mixed-citation><mixed-citation xml:lang="en">Mills JC, Stappenbeck TS, Bunnett NW. Gastrointestinal disease. In: McPhee SJ, Hammer GD, eds. Pathophysiology of Disease: An Introduction to Clinical Medicine. 6th ed. New York, NY: McGraw-Hill Medical; 2010.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Marschall HU, Einarsson C. Gallstone disease. J Intern Med., 2007, 261: 529-542.</mixed-citation><mixed-citation xml:lang="en">Marschall HU, Einarsson C. Gallstone disease. J Intern Med., 2007, 261: 529-542.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Cuevas A, Miquel JF, Reyes MS et al. Diet as a risk factor for cholesterol gallstone disease. J Am Coll Nutr, 2004, 23:187-196.</mixed-citation><mixed-citation xml:lang="en">Cuevas A, Miquel JF, Reyes MS et al. Diet as a risk factor for cholesterol gallstone disease. J Am Coll Nutr, 2004, 23:187-196.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Ветшев П.С. Желчнокаменная болезнь / П.С. Ветшев, О.С. Шкроб, Д.Г. Бельцевич. М.: ЗАО «Медицинская газета», 1998.</mixed-citation><mixed-citation xml:lang="en">Ветшев П.С. Желчнокаменная болезнь / П.С. Ветшев, О.С. Шкроб, Д.Г. Бельцевич. М.: ЗАО «Медицинская газета», 1998.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Abdominal symptoms: Do they predict gallstones? A systematic review Berger-M-Y, Van-der-Velden-J-J-I-M, Lijmer-J-G, De-Kort-H, Pains-A, Bohnen-A-M. Scandinavian Journal of Gastroenterology, 2000, 35/1: 70-76.</mixed-citation><mixed-citation xml:lang="en">Abdominal symptoms: Do they predict gallstones? A systematic review Berger-M-Y, Van-der-Velden-J-J-I-M, Lijmer-J-G, De-Kort-H, Pains-A, Bohnen-A-M. Scandinavian Journal of Gastroenterology, 2000, 35/1: 70-76.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Which abdominal symptoms are due to stones in the gallbladder Jorgensen T, Kay L, Hougaard Jensen К Gastroenterology, 1994, 106: A342.</mixed-citation><mixed-citation xml:lang="en">Which abdominal symptoms are due to stones in the gallbladder Jorgensen T, Kay L, Hougaard Jensen К Gastroenterology, 1994, 106: A342.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Symptomatic and silent gall stones in the community Heaton-K-W, Braddon-F-E-M, Mountford-R-A, Hughes-A-O, Emmett-P-M. Gut, 1991, 32/3: 316-320.</mixed-citation><mixed-citation xml:lang="en">Symptomatic and silent gall stones in the community Heaton-K-W, Braddon-F-E-M, Mountford-R-A, Hughes-A-O, Emmett-P-M. Gut, 1991, 32/3: 316-320.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Abdominal symptoms and gallstone disease: An epidemiological investigation, Jorgensen-T. Hepatology, 1989, 9/6: 856-860.</mixed-citation><mixed-citation xml:lang="en">Abdominal symptoms and gallstone disease: An epidemiological investigation, Jorgensen-T. Hepatology, 1989, 9/6: 856-860.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Vogt DP. Gallbladder disease: an update on diagnosis and treatment. Cleve Clin J Med,, 2002, 69:977-984.</mixed-citation><mixed-citation xml:lang="en">Vogt DP. Gallbladder disease: an update on diagnosis and treatment. Cleve Clin J Med,, 2002, 69:977-984.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Bar-Meir S. Gallstones: prevalence, diagnosis and treatment. Isr Med Assoc J, 2001, 3: 111-113.</mixed-citation><mixed-citation xml:lang="en">Bar-Meir S. Gallstones: prevalence, diagnosis and treatment. Isr Med Assoc J, 2001, 3: 111-113.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">University of Maryland Medical Center. Gallstones and gallbladder disease. www.umm.edu/patiented/articles/what_gall-stones_gallbladder_disease_000010_1.htm. Accessed November 27, 2012.</mixed-citation><mixed-citation xml:lang="en">University of Maryland Medical Center. Gallstones and gallbladder disease. www.umm.edu/patiented/articles/what_gall-stones_gallbladder_disease_000010_1.htm. Accessed November 27, 2012.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Максимов В.А. Дуоденальное исследование. / В.А. Максимов, А.Л. Чернышев, К.М. Тарасов М.: МГ, 1998.</mixed-citation><mixed-citation xml:lang="en">Максимов В.А. Дуоденальное исследование. / В.А. Максимов, А.Л. Чернышев, К.М. Тарасов М.: МГ, 1998.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Kalloo AN, Kantsevoy SV. Gallstones and biliary disease. Prim Care, 2001, 28: 591-606.</mixed-citation><mixed-citation xml:lang="en">Kalloo AN, Kantsevoy SV. Gallstones and biliary disease. Prim Care, 2001, 28: 591-606.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Лейшнер У. Практическое руководство по заболеваниям желчных путей. М.: ГЭОТАР-МЕД, 2001.</mixed-citation><mixed-citation xml:lang="en">Лейшнер У. Практическое руководство по заболеваниям желчных путей. М.: ГЭОТАР-МЕД, 2001.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Johnson AG, Fried M, Tytgat GNJ, Krabshuis JH. Asymptomatic Gallstone Disease Practice Guideline / WGO Practice Guideline. http://www.worldgastroenterology.org/asymptomatic-gallstone-disease.html.</mixed-citation><mixed-citation xml:lang="en">Johnson AG, Fried M, Tytgat GNJ, Krabshuis JH. Asymptomatic Gallstone Disease Practice Guideline / WGO Practice Guideline. http://www.worldgastroenterology.org/asymptomatic-gallstone-disease.html.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Duca S. Sindromul biliarilor operati. Ed. Genesis Cluj, 1992.</mixed-citation><mixed-citation xml:lang="en">Duca S. Sindromul biliarilor operati. Ed. Genesis Cluj, 1992.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Blumgart TM, Lygidakis NJ. The post-cholecystectomy patient. In: The Biliary Tract. Blumgart LM (ed.). Edinburgh: Churchill Livingstone, 1982: 143-156.</mixed-citation><mixed-citation xml:lang="en">Blumgart TM, Lygidakis NJ. The post-cholecystectomy patient. In: The Biliary Tract. Blumgart LM (ed.). Edinburgh: Churchill Livingstone, 1982: 143-156.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Paun R. Tratat de medicina interna. Bolile aparatului digestive. Ed Med Bucuresti, 1984, 2: 527-587.</mixed-citation><mixed-citation xml:lang="en">Paun R. Tratat de medicina interna. Bolile aparatului digestive. Ed Med Bucuresti, 1984, 2: 527-587.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Terhaar OA, Abbas S, Thornton FJ, Duke D, O'Kelly P, Abdullah K. Imaging patients with "post-cholecystectomy syndrome": an algorithmic approach. Clin Radiol, 2005, 60: 78-84.</mixed-citation><mixed-citation xml:lang="en">Terhaar OA, Abbas S, Thornton FJ, Duke D, O'Kelly P, Abdullah K. Imaging patients with "post-cholecystectomy syndrome": an algorithmic approach. Clin Radiol, 2005, 60: 78-84.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Schofer JM. Biliary causes of postcholecystectomy syndrome.JEmergMed, 2008, Aug. 22.</mixed-citation><mixed-citation xml:lang="en">Schofer JM. Biliary causes of postcholecystectomy syndrome.JEmergMed, 2008, Aug. 22.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
