medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2016-3-24-29medsovet-55Research ArticleСАХАРНЫЙ ДИАБЕТDIABETES MELLITUSКлиническая эффективность и безопасность линаглиптина у пациентов с сахарным диабетом 2-го типаClinical efficacy and safety of linagliptin in patients with diabetes type 2БирюковаЕ. В.BiryukovaE. V.noemail@neicon.ruМкртумянА. М.MkrtumyanA. M.noemail@neicon.ruМосковский государственный медико-стоматологический университет им. А.И. ЕвдокимоваРоссияFirst Moscow State University of Medicine and Dentistry named after A.I. EvdokimovRussian Federation201630122016032429Copyright © Бирюкова Е.В., Мкртумян А.М., 20162016Бирюкова Е.В., Мкртумян А.М.Biryukova E.V., Mkrtumyan A.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/55

Лечение сахарного диабета 2-го типа (СД2) - это серьезная проблема, заставляющая искать новые подходы к улучшению результатов фармакотерапии заболевания. Последние успехи в области диа-бетологии связаны с инкретин-направленной терапией. Наряду с традиционными дефектами (инсу-линорезистентность, дисфункция р-клеток), существенный вклад в развитие и прогрессирование заболевания вносит сниженный «эффект инкретинов». Концепция сниженного «эффекта инкрети-нов» послужила основанием для разработки и внедрения в клиническую практику инновационного направления - применение лекарственных средств, действие которых основано на «эффектах инкретинов», - глюкагоноподобного пептида-1 (ГПП-1) и глюкозозависимого инсулинотропного полипептида (ГИП) [12, 17].

Treatment of diabetes mellitus type 2 (T2DM) is a serious challenge which forces to search for new approaches in order to improve the results of pharmacotherapy. Recent advances in diabetology pertain to incretin-directed therapies. Along with traditional defects (insulin resistance, β-cell dysfunction), a significant contribution to the development and progression of the disease is made by a reduction of "incretin effect" (Fig. 1). The concept of reduced "incretin effect" served as the basis for the development and introduction into clinical practice of the innovative medications the action of which is based on the "incretin effect" - glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP). [12, 17].

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