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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2020-4-60-65</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-5605</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>НЕВРОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>NEUROLOGY</subject></subj-group></article-categories><title-group><article-title>Дискогенная нерадикулярная боль в спине: анализ клинического случая</article-title><trans-title-group xml:lang="en"><trans-title>Discogenic non-radicular low back pain: a clinical case report</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5070-926X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Воробьева</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Vorob’eva</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Воробьева Ольга Владимировна –доктор медицинских наук, профессор кафедры нервных болезней Института последипломного образования.</p><p>119991, Москва, ул. Трубецкая, д. 8, стр. 2.</p></bio><bio xml:lang="en"><p>Olga V. Vorob’eva - Dr. of Sci. (Med.), Professor, Chair for Nervous Diseases, Institute for Graduate Studies, Federal State Autonomous Educational Institution of Higher Education First Moscow State Medical University named after I.M. Sechenov of the Ministry of Health of the Russian Federation (Sechenov University).</p><p>8, p. 2, Trubetskaya St., Moscow, 119991.</p></bio><email xlink:type="simple">ovvorobeva@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Первый Московский государственный медицинский университет им. И.М. Сеченова (Сеченовский Университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>First Moscow State Medical University named after I.M. Sechenov (Sechenov University)</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>21</day><month>05</month><year>2020</year></pub-date><volume>0</volume><issue>4</issue><fpage>60</fpage><lpage>65</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Воробьева О.В., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Воробьева О.В.</copyright-holder><copyright-holder xml:lang="en">Vorob’eva O.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/5605">https://www.med-sovet.pro/jour/article/view/5605</self-uri><abstract><p>Боль в спине часто рассматривается под диагностической рубрикой «неспецифическая боль» в связи с трудностью идентификации первичного источника боли в обыденной клинической практике. Однако, несмотря на трудности в выяснении специфической этиологии хронической боли в спине, диагностические процедуры могут выявить ее источник у 90% пациентов. Мы сообщаем о клиническом случае типичной дискогенной боли.</p><p>Боль длительностью 6 недель, возникшая после упражнений со штангой у 42-летнего мужчины, привела к потере профессиональной занятости. Боль локализовалась по средней линии поясницы (аксиальная боль), усиливалась в положении сидя. Компьютерная томография выявила субхондральные изменения тел позвонков L5-S1 (Модик-1). Комплексный диагностический подход, включая вибротест, позволил диагностировать дегенеративное заболевание дисков (дископатию сегмента L5-S1) с подострой дискогенной болью. Пациент получал Дексалгин®25 в дозе 25 мг x 3 раза в день в сочетании с омепразолом 20 мг в день в течение 5 дней, затем был переведен на Нимесил 200 мг в день в два приема. В качестве адъювантной терапии был использован комплексный препарат из группы SYSADOA, содержащий глюкозамин и хондроитин. После шести недель терапии интенсивность боли снизилась на 70% (2 балла по ВАШ, что соответствует уровню мягкого болевого синдрома) от первоначального уровня.</p><p>Этот клинический случай подчеркивает важность точной диагностики болей в спине и демонстрирует возможности успешного комплексного консервативного лечения дискогенной боли в условиях первичного поликлинического звена.</p></abstract><trans-abstract xml:lang="en"><p>Back pain is often considered under the diagnostic heading “nonspecific pain” because of difficulties in identifying the primary source of pain in everyday clinical practice. However, despite the difficulties in identifying the specific etiology of chronic low back pain, diagnostic procedures can identify its source in 90% of patients. We report a clinical case of typical discogenic pain.</p><p>The 6-week pain, which developed after barbell exercising in a 42-year-old man, resulted in the loss of professional employment. The pain was localized to the midline of the lower back (axial pain) and intensified in a sitting position. Computed tomography images demonstrated subchondral changes in L5-S1 vertebral bodies (Modic-1). A holistic diagnostic approach, including a vibration test, made it possible to diagnose the degenerative disc disease (L5-S1 intervertebral disk disease) with subacute discogenic pain. The patient received Dexalgin®25 at a dose of 25 mg x 3 times a day in combination with omeprazole 20 mg per day for 5 days, then the patient was switched to Nimesil 200 mg per day in two divided doses. A complex drug of the SYSADOA group containing glucosamine and chondroitin was used as adjuvant therapy. Pain intensity was reduced by 70 % at 6 weeks (2 points on VAS scale, which corresponds to the level of mild pain syndrome) as compared to the baseline level.</p><p>This clinical case stresses the importance of accurate diagnosis of back pain and demonstrates the potential for successful combination non-surgical treatment of discogenic pain in primary outpatient settings.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>дегенеративные изменения межпозвонковых дисков</kwd><kwd>дискогенные боли</kwd><kwd>концепция «активной» дископатии</kwd><kwd>субдиагноз боли в спине</kwd><kwd>терапевтические стратегии</kwd></kwd-group><kwd-group xml:lang="en"><kwd>degenerative changes in the intervertebral discs</kwd><kwd>discogenic pain</kwd><kwd>concept of active discopathy</kwd><kwd>subdiagnosis of back pain</kwd><kwd>therapeutic strategies</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Nijs J., Clark J., MaLfLiet A., Ickmans K., Voogt L., Don S. et al. In the spine or in the brain? Recent advances in pain neuroscience applied in the intervention for Low back pain. Clin Exp Rheumatol. 2017;35(Suppl 107(5)):108-115. Available at: https://www.ncbi.nlm.nih.gov/pubmed/28967357.</mixed-citation><mixed-citation xml:lang="en">Nijs J., Clark J., MaLfLiet A., Ickmans K., Voogt L., Don S. et al. In the spine or in the brain? Recent advances in pain neuroscience applied in the intervention for Low back pain. Clin Exp Rheumatol. 2017;35(Suppl 107(5)):108-115. Available at: https://www.ncbi.nlm.nih.gov/pubmed/28967357.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Dudli S., Fields AJ., Samartzis D., Karppinen J., Lotz J.C. Pathobiology of Modic changes. Eur Spine J. 2016;25(11):3723-3734. doi: 10.1007/s00586-016-4459-7.</mixed-citation><mixed-citation xml:lang="en">Dudli S., Fields AJ., Samartzis D., Karppinen J., Lotz J.C. Pathobiology of Modic changes. Eur Spine J. 2016;25(11):3723-3734. doi: 10.1007/s00586-016-4459-7.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Yrjama M., Vanharanta H. Bony vibration stimulation: a new, non-invasive method for examining intradiscal pain. Eur Spine J. 1994;3(4):233-235. doi: 10.1007/bf02221600.</mixed-citation><mixed-citation xml:lang="en">Yrjama M., Vanharanta H. Bony vibration stimulation: a new, non-invasive method for examining intradiscal pain. Eur Spine J. 1994;3(4):233-235. doi: 10.1007/bf02221600.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Boisson M., Lefevre-Colau M., Rannou F., Nguyen Ch. Active discopathy: a clinical reality. RMD Open. 2018;4(1):e000660. doi: 10.1136/rmdopen-2018-000660.</mixed-citation><mixed-citation xml:lang="en">Boisson M., Lefevre-Colau M., Rannou F., Nguyen Ch. Active discopathy: a clinical reality. RMD Open. 2018;4(1):e000660. doi: 10.1136/rmdopen-2018-000660.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Vo N.V., Hartman R.A., Patil P.R., Risbud M.V., Kletsas D., latridis J.C. et al. Molecular mechanisms of biological aging in intervertebral discs. J Orthop Res. 2016;34(8):1289-1306. doi: 10.1002/jor.23195.</mixed-citation><mixed-citation xml:lang="en">Vo N.V., Hartman R.A., Patil P.R., Risbud M.V., Kletsas D., latridis J.C. et al. Molecular mechanisms of biological aging in intervertebral discs. J Orthop Res. 2016;34(8):1289-1306. doi: 10.1002/jor.23195.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Huang Z.Y., Xu H.C., Lei T., Li O.L., Wu A.M., Ni W.F. The location of Modic changes in the lumbar spine: a meta-analysis. Eur Spine J. 2016;25(11):3746-3759. doi: 10.1007/s00586-016-4456-x.</mixed-citation><mixed-citation xml:lang="en">Huang Z.Y., Xu H.C., Lei T., Li O.L., Wu A.M., Ni W.F. The location of Modic changes in the lumbar spine: a meta-analysis. Eur Spine J. 2016;25(11):3746-3759. doi: 10.1007/s00586-016-4456-x.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Nguyen C., Jousse M., Poiraudeau S., Feydy A., Rannou F. Intervertebral disc and vertebral endplate subchondral changes associated with Modic 1 changes of the lumbar spine: a cross-sectional study. BMC Musculoskelet Disord. 2017;18(1):34. doi: 10.1186/s12891-017-1407-6.</mixed-citation><mixed-citation xml:lang="en">Nguyen C., Jousse M., Poiraudeau S., Feydy A., Rannou F. Intervertebral disc and vertebral endplate subchondral changes associated with Modic 1 changes of the lumbar spine: a cross-sectional study. BMC Musculoskelet Disord. 2017;18(1):34. doi: 10.1186/s12891-017-1407-6.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Johnson Z.I., Schoepflin Z.R., Choi H., Shapiro I.M., Risbud M.V. Disc in flames: Roles of TNF-a and IL-1(3 in intervertebral disc degeneration. Eur Cell Mater. 2015;30:104-117. doi: 10.22203/ecm.v030a08.</mixed-citation><mixed-citation xml:lang="en">Johnson Z.I., Schoepflin Z.R., Choi H., Shapiro I.M., Risbud M.V. Disc in flames: Roles of TNF-a and IL-1(3 in intervertebral disc degeneration. Eur Cell Mater. 2015;30:104-117. doi: 10.22203/ecm.v030a08.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Anderson D.G., Tannoury C. Molecular pathogenic factors in symptomatic disc degeneration. Spine J. 2005;5(6 Suppl):260-266. doi: 10.1016/j.spinee.2005.02.010.</mixed-citation><mixed-citation xml:lang="en">Anderson D.G., Tannoury C. Molecular pathogenic factors in symptomatic disc degeneration. Spine J. 2005;5(6 Suppl):260-266. doi: 10.1016/j.spinee.2005.02.010.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Navone S.E., Marfia G., Canzi L., Ciusani E., Canazza A., Visintini S., Campa-nella R., Parati E.A. Expression of neural and neurotrophic markers in nucleus pulposus cells isolated from degenerated intervertebral disc. J Orthop Res. 2012;30(9):1470-1477. doi: 10.1002/jor.22098.</mixed-citation><mixed-citation xml:lang="en">Navone S.E., Marfia G., Canzi L., Ciusani E., Canazza A., Visintini S., Campa-nella R., Parati E.A. Expression of neural and neurotrophic markers in nucleus pulposus cells isolated from degenerated intervertebral disc. J Orthop Res. 2012;30(9):1470-1477. doi: 10.1002/jor.22098.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Metscher B., Kubler U., Jahnel-Kracht H. Dexketoprofen-trometamol and tramadol in acute lumbago. Fortschr Med Orig. 2001;118(4):147-151. Available at: https//www.ncbi.nlm.nih.gov/pubmed/11217678.</mixed-citation><mixed-citation xml:lang="en">Metscher B., Kubler U., Jahnel-Kracht H. Dexketoprofen-trometamol and tramadol in acute lumbago. Fortschr Med Orig. 2001;118(4):147-151. Available at: https//www.ncbi.nlm.nih.gov/pubmed/11217678.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Carne X., Rios J., Torres F. Postmarketing cohort study to assess the safety profile of oral dexketoprofen trometamol for mild to moderate acute pain treatment in primary care. Methods Find Exp Clin Pharmacol. 2009;31(8):533-540. doi: 10.1358/mf.2009.31.8.1419070.</mixed-citation><mixed-citation xml:lang="en">Carne X., Rios J., Torres F. Postmarketing cohort study to assess the safety profile of oral dexketoprofen trometamol for mild to moderate acute pain treatment in primary care. Methods Find Exp Clin Pharmacol. 2009;31(8):533-540. doi: 10.1358/mf.2009.31.8.1419070.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Marbet G.A., Yasikoff Strub M.L., Maccioccbi A., Tsakiris D.A. The effect of nimesulide versus placebo on hemostasis in healthy volunteers. Eur J Clin Pharmacol. 1998;54(5):383-387. doi: 10.1007/s002280050479.</mixed-citation><mixed-citation xml:lang="en">Marbet G.A., Yasikoff Strub M.L., Maccioccbi A., Tsakiris D.A. The effect of nimesulide versus placebo on hemostasis in healthy volunteers. Eur J Clin Pharmacol. 1998;54(5):383-387. doi: 10.1007/s002280050479.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Rainsford K.D. Members of the Consensus Report Group on Nimesulide. Nimesulide - a multifactorial approach to inflammation and pain: scientific and clinical consensus. Curr Med Res Opin. 2006;22(6):1161-1170. doi: 10.1185/030079906X104849.</mixed-citation><mixed-citation xml:lang="en">Rainsford K.D. Members of the Consensus Report Group on Nimesulide. Nimesulide - a multifactorial approach to inflammation and pain: scientific and clinical consensus. Curr Med Res Opin. 2006;22(6):1161-1170. doi: 10.1185/030079906X104849.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Соловьева Э.Ю., Карнеев А.Н., Федин А.И. Дорсопатия: совместное применение декскетопрофена и нимесулида в стадии обострения. Consilium Medicum. 2007;9(2):42-46. Режим доступа: https://www.elibrary.ru/item.asp?id=20307786.</mixed-citation><mixed-citation xml:lang="en">Soloveva E.Yu., Karneev A.N., Fedin A. I. Dorsopathy: co-use of dexketoprofen and nimesulide during the exacerbation phase. Consilium medicum. 2007;9(2):42-46. (In Russ.) Available at: https://www.elibrary.ru/item.asp?id=20307786.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
