medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2020-4-85-92medsovet-5615Research ArticleОториноларингологияOtorhinolaryngologyВозможности использования синбиотика при ЛОР-заболеванияхPotential use of synbiotics in ENT diseaseshttps://orcid.org/0000-0002-5024-6135ГаращенкоТ. И.GarashchenkoT. I.

Гаращенко Татьяна Ильинична - доктор медицинских наук, профессор, ученый секретарь, Федеральное государственное бюджетное учреждение «Научно-клинический центр оториноларингологии» ФМБА РФ; профессор кафедры оториноларингологии факультета дополнительного профессионального образования, Федеральное государственное автономное образовательное учреждение высшего образования РНИМУ им. Н.И. Пирогова МЗ РФ.

123182, Москва, Волоколамское шоссе, д. 30, стр. 2; 117997, Москва, ул. Островитянова, д. 1.

Tatiana I. Garashchenko - Dr. of Sci. (Med.), professor, academic secretary, Federal State Budgetary Institution “Scientific and Clinical Center of Otorhinolaryngology” of the Federal Medico-Biological Agency of Russia; Professor of the Department of Otorhinolaryngology, Faculty of Continuing Professional Education, Federal State Autonomous Educational Institution of Higher Education “N.I. Pirogov Russian National Research Medical University” of the Ministry of Health of the Russian Federation.

30, bldg. 2, Volokolamskoe shosse, Moscow, 123182; 1, Ostrovityanova St., Moscow, 117997.

9040100@mail.ruhttps://orcid.org/0000-0002-7645-5437ТарасоваГ. Д.TarasovaG. D.

Тарасова Галина Дмитриевна - доктор медицинских наук, главный научный сотрудник.

123182, Москва, Волоколамское шоссе, д. 30, стр. 2.

Galina D. Tarasova - Dr. of Sci. (Med.), chief researcher, Federal State Budgetary Institution “Scientific and Clinical Center of Otorhinolaryngology” of the Federal Medico-Biological Agency of Russia.

30, bldg. 2, Volokolamskoe shosse, Moscow, 123182.

gtarasova@yandex.ruНаучно-клинический центр оториноларингологии; Российский национальный исследовательский медицинский университет им. Н.И. ПироговаРоссияScientific and Clinical Center of Otorhinolaryngology; N.I. Pirogov Russian National Research Medical UniversityRussian FederationНаучно-клинический центр оториноларингологииРоссияScientific and Clinical Center of OtorhinolaryngologyRussian Federation202021052020048592Copyright © Гаращенко Т.И., Тарасова Г.Д., 20202020Гаращенко Т.И., Тарасова Г.Д.Garashchenko T.I., Tarasova G.D.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/5615

Профилактика рецидивирования острой респираторной вирусной инфекции (ОРВИ) является актуальной медицинской и социальной проблемой, особенно в детском возрасте. У детей этой группы выявлен дисбаланс кишечной флоры, который может нивелироваться путем перорального приема пробиотиков, которые вызывают иммуномодулирующие эффекты.

Нормальная микрофлора выполняет важные физиологические функции и активна против патогенной и условно-патогенной микрофлоры. На микробиоту (совокупность микробов, колонизирующих тело человека) воздействует окружающая среда, нередко приводя к развитию ОРВИ. При этом нормальная микрофлора обладает антагонистической активностью по отношению к патогенной. Полезные бактерии называют пробиотиками (лактобациллы и бифидобактерии), они представляют вариант лечения хронических заболеваний дыхательных путей.

Во время рецидивирования острых инфекций дыхательных путей (РОИДП) выявляют дисбиоз кишечной флоры, улучшить которую может использование пробиотиков.

Известны заболевания, которые нарушают функцию нормальной микрофлоры, вызывая дисбиоз.

Существуют микроорганизмы, нарушающие проницаемость эпителиального барьера слизистой оболочки. Регуляцию дисбиоза могут осуществлять пробиотики, которые вводят как перорально, так и назально. Они способны оказывать различные иммуномодулирущие эффекты. Пребиотики представляют собой неперевариваемую форму клетчатки. А комбинация про- и пре-биотиков представляет собой синбиотики, обладающие синергетическим эффектом в отношении многих заболеваний и уменьшающие частоту всех инфекционных заболеваний.

Новая синбиотическая биодобавка способствует улучшению показателей иммунологических механизмов, мукозального иммунитета, усилению противовирусного иммунитета и др. Она содержит 5 пробиотиков и один пребиотик и разрешена к применению у детей с первого месяца жизни. Эта добавка при лечении часто болеющих детей оказывает положительное влияние на некоторые показатели иммунной системы. Средство может быть рекомендовано при дисбиозе, диабете, целиакии и для профилактики гриппа и гриппоподобных синдромов.

Prevention of recurrent ARVI is an urgent medical and social problem, especially in children. In children of this group, an imbalance of the intestinal flora was detected, which can be leveled by oral administration of probiotics, which cause immunomodulatory effects.

Normal micro-flora performs important physiological functions and are active against pathogenic and conditionally pathogenic microflora. The microbiota (a collection of microbes that colonize the human body) is affected by the environment, often leading to the development of SARS. In this case, the normal microflora has an antagonistic activity in relation to the pathogenic one. Useful bacteria are called probiotics (lactobacilli and bifidobacteria) and represent a treatment option for chronic respiratory diseases.

During the recurrence of acute respiratory infections (ROIDP), intestinal flora dysbiosis is detected, which can be improved by the use of probiotics.

Known diseases that disrupt the function of normal microflora, causing dysbiosis.

There are microorganisms that violate the permeability of the epithelial barrier of the mucous membrane. Dysbiosis can be regulated by probiotics that are administered both orally and nasally. They can have various immunomodulatory effects. Prebiotics are an indigestible form of fiber. A combination of Pro-and prebiotics is a synbiotic that has a synergistic effect in the treatment of many diseases and reduces the frequency of all infectious diseases.

New synbiotic dietary supplement contributes to the improvement of immunological mechanisms, mucosal immunity, enhancement of antiviral immunity, etc. It contains 5 probiotics and one prebiotic and is approved for use in children from the first month of life. This supplement has a positive effect on several immune system indicators in the treatment of sickly children. It may be recommended for dysbiosis, diabetes, coeliac disease and for the prevention of influenza and flu-like syndromes.

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The authors declare that there are no conflicts of interest present.