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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2020-6-50-56</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-5634</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ИНФЕКЦИИ В ОТОРИНОЛАРИНГОЛОГИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>INFECTIONS IN OTORHINOLARYNGOLOGY</subject></subj-group></article-categories><title-group><article-title>Топические антибиотики при остром риносинусите у детей</article-title><trans-title-group xml:lang="en"><trans-title>Topical antibiotics for acute rhinosinusitis in children</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8292-9635</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Карпова</surname><given-names>Е. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Karpova</surname><given-names>E. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Карпова Елена Петровна, доктор медицинских наук, профессор, заведующая кафедрой детской оториноларингологии</p><p>125993, Москва, ул. Баррикадная, д. 2/1, стр. 1</p></bio><bio xml:lang="en"><p>Elena P. Karpova, Dr. of Sci. (Med.), Professor, Head of Chair for Paediatric Otorhinolaryngology</p><p>2/1, Bldg. 1, Barrikadnaya St., Moscow, 125993</p></bio><email xlink:type="simple">edoctor@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6096-2082</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тулупов</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Tulupov</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Тулупов Денис Андреевич, кандидат медицинских наук, доцент, доцент кафедры детской оториноларингологии</p><p>125993, Москва, ул. Баррикадная, д. 2/1, стр. 1</p></bio><bio xml:lang="en"><p>Denis A. Tulupov, Cand. of Sci. (Med.), Associate Professor, Chair for Pediatric Otorhinolaryngology</p><p>2/1, Bldg. 1, Barrikadnaya St., Moscow, 125993</p></bio><email xlink:type="simple">tulupov-rmapo@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9717-5872</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зябкин</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zyabkin</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Зябкин Илья Владимирович, кандидат медицинских наук, ассистент, доцент кафедры детской оториноларингологии</p><p>125993, Москва, ул. Баррикадная, д. 2/1, стр. 1</p></bio><bio xml:lang="en"><p>Ilya V. Zyabkin, Cand. of Sci. (Med.), Assistant, Associate Professor, Chair for Paediatric Otorhinolaryngology</p><p>2/1, Bldg. 1, Barrikadnaya St., Moscow, 125993</p></bio><email xlink:type="simple">dr.zyabkin@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Российская медицинская академия непрерывного профессионального образования<country>Россия</country></aff><aff xml:lang="en">Russian Medical Academy of Continuous Professional Education<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>25</day><month>05</month><year>2020</year></pub-date><volume>0</volume><issue>6</issue><fpage>50</fpage><lpage>56</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Карпова Е.П., Тулупов Д.А., Зябкин И.В., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Карпова Е.П., Тулупов Д.А., Зябкин И.В.</copyright-holder><copyright-holder xml:lang="en">Karpova E.P., Tulupov D.A., Zyabkin I.V.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/5634">https://www.med-sovet.pro/jour/article/view/5634</self-uri><abstract><p>В данной статье авторами представлен обзор существующих данных по применению топических антибактериальных препаратов при остром риносинусите у детей. Дана общая информация об этиологии острого риносинусита. Отмечены показания к системной и топической антибактериальной терапии при остром риносинусите, указанные в российских и международных согласительных документах. Отдельно рассмотрены преимущества использования комбинированного препарата тиамфеникола и N-ацетилцистеина при остром риносинусите у детей и взрослых. Сделаны выводы, что топическая антибактериальная терапия острого риносинусита, несмотря на все свои преимущества, не является равноценной заменой системной антибактериальной терапии в лечении тяжелых, и особенно осложненных, форм острого риносинусита. Практикующему врачу следует руководствоваться принятыми в российских согласительных документах показаниями к системной и топической антибактериальной терапии. При наличии показаний к системной антибактериальной терапии местные средства являются лишь вспомогательным лечением, действие которого направлено на усиление эффекта системных антибиотиков. В случае проведения монотерапии местными препаратами, содержащими антибактериальные компоненты, обязательно на 2–3-й день лечения повторно оценить состояние пациента и динамику симптомов заболевания и при отсутствии положительных изменений пересмотреть вопрос о необходимости системной антибактериальной терапии. Более перспективным выглядит применение комбинированных препаратов, обеспечивающих, помимо воздействия на возбудителя заболевания, достижение противовоспалительного, противоотечного или муколитического действия. Удобно и рационально использование дозированных назальных спреев, однако с целью улучшения доставки действующего вещества в очаг воспаления при остром риносинусите обоснованно применение компрессорных ингаляторов.</p></abstract><trans-abstract xml:lang="en"><p>In this article, the authors provide an overview of existing data on the use of topical antibacterial drugs in acute rhinosinusitis in children. General information on the etiology of acute rhinosinusitis is given. Indications for systemic and topical antibiotic therapy in acute rhinosinusitis are noted, indicated in Russian and international consensus documents. The advantages of using the combined preparation of thiamphenicol and N-acetylcysteine in acute rhinosinusitis in children and adults are considered separately. It is concluded that the topical antibacterial therapy of acute rhinosinusitis, despite all its advantages, is not an equivalent substitute for systemic antibacterial therapy in the treatment of severe and, especially, complicated forms of acute rhinosinusitis. The practitioner should be guided by the indications for systemic and topical antibacterial therapy adopted in Russian consensus documents. If there are indications for systemic antibiotic therapy, local remedies are only ancillary treatment, the action of which is aimed at enhancing the effect of systemic antibiotics. In the case of monotherapy with local drugs containing antibacterial components, it is mandatory to re-evaluate the patient’s condition and the dynamics of the symptoms of the disease for 2–3 days of treatment, and in the absence of positive changes, reconsider the need for systemic antibacterial therapy. More promising is the use of combined drugs that, in addition to affecting the causative agent of the disease, achieve anti-inflammatory, decongestion or mucolytic effects. It is convenient and rational to use nasal sprays, however, in order to improve the delivery of the active substance to the site of inflammation in acute rhinosinusitis, the use of nebulizer is justified. </p></trans-abstract><kwd-group xml:lang="ru"><kwd>дети</kwd><kwd>острый риносинусит</kwd><kwd>топические антибиотики</kwd><kwd>тиамфеникол</kwd><kwd>N-ацетилцистеин</kwd></kwd-group><kwd-group xml:lang="en"><kwd>children</kwd><kwd>acute rhinosinusistis</kwd><kwd>topical intranasal antibiotics</kwd><kwd>thiamphenicol</kwd><kwd>N-acetylcysteine</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Козлов Р.С., Зырянов С.К., Синопальников А.И., Рязанцев С.В., Стырт Е.А. Резолюция совета экспертов «Эмпирическая антибактериальная терапия инфекций дыхательных путей с учетом факторов риска резистентной флоры». Справочник поликлинического врача. 2018;(1):28–32. Режим доступа: https://elibrary.ru/item.asp?id=32706819.</mixed-citation><mixed-citation xml:lang="en">Kozlov R.S., Zyrianov S.K., Sinopalnikov A.I., Riazantsev S.V., Styrt E.A. Expert Council Resolution Empirical antibacterial treatment of respiratory tract infections taking into account risk factors for resistant flora. Spravochnik poliklinicheskogo vracha = Polyclinic Practitioner’s Reference. 2018;(1):28–32. (In Russ.) Available at: https://elibrary.ru/item.asp?id=32706819.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Harris A.M., Hicks L.A., Qaseem A. High Value Care Task Force of the American College of Physicians and for the Centers for Disease Control and Prevention. Appropriate antibiotic use for acute respiratory tract infection in adults: advice for high-value care from the American College of Physicians and the Centers for Disease Control and prevention. Ann Intern Med. 2016;164(6):425–434. doi: 10.7326/M15-1840.</mixed-citation><mixed-citation xml:lang="en">Harris A.M., Hicks L.A., Qaseem A. High Value Care Task Force of the American College of Physicians and for the Centers for Disease Control and Prevention. Appropriate antibiotic use for acute respiratory tract infection in adults: advice for high-value care from the American College of Physicians and the Centers for Disease Control and prevention. Ann Intern Med. 2016;164(6):425–434. doi: 10.7326/M15-1840.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Fokkens W., Lund V., Mullol J., Bachert C., Alobid I., Baroody F. et al. European position paper on rhinosinusitis and nasal polyps 2012 (EP3OS). Rhinology. 2012;50(23):1–299. doi: 10.4193/Rhino50E2.</mixed-citation><mixed-citation xml:lang="en">Fokkens W., Lund V., Mullol J., Bachert C., Alobid I., Baroody F. et al. European position paper on rhinosinusitis and nasal polyps 2012 (EP3OS). Rhinology. 2012;50(23):1–299. doi: 10.4193/Rhino50E2.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Herløv-Nielsen H., Højby N. Sinusitis is common in small children. Ugeskr Laeger. 2010;172(48):3320–3325. Available at: https://www.ncbi.nlm.nih.gov/pubmed/21118660.</mixed-citation><mixed-citation xml:lang="en">Herlø Herløv-Nielsen H., Højby N. Sinusitis is common in small children. Ugeskr Laeger. 2010;172(48):3320–3325. Available at: https://www.ncbi.nlm.nih.gov/pubmed/21118660.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Cronin M.J., Khan S., Saeed S. The role of antibiotics in the treatment of acute rhinosinusitis in children: a systematic review. Arch Dis Child. 2013;98(4):299–303. doi: 10.1136/archdischild-2012-302983.</mixed-citation><mixed-citation xml:lang="en">Cronin M.J., Khan S., Saeed S. The role of antibiotics in the treatment of acute rhinosinusitis in children: a systematic review. Arch Dis Child. 2013;98(4):299–303. doi: 10.1136/archdischild-2012-302983.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Babar-Craig H., Gupta Y., Lund V.J. British Rhinological Society audit of the role of antibiotics in complications of acute rhinosinusitis: a national prospective audit. Rhinology. 2010;48(3):344–347. doi: 10.4193/rhin09.130.</mixed-citation><mixed-citation xml:lang="en">Babar-Craig H., Gupta Y., Lund V.J. British Rhinological Society audit of the role of antibiotics in complications of acute rhinosinusitis: a national prospective audit. Rhinology. 2010;48(3):344–347. doi: 10.4193/rhin09.130.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Hansen F.S., Hoffmans R., Georgalas C., Fokkens W.J. Complications of acute rhinosinusitis in The Netherlands. Fam Pract. 2012;29(2):147–153. doi: 10.1093/fampra/cmr062.</mixed-citation><mixed-citation xml:lang="en">Hansen F.S., Hoffmans R., Georgalas C., Fokkens W.J. Complications of acute rhinosinusitis in The Netherlands. Fam Pract. 2012;29(2):147–153. doi: 10.1093/fampra/cmr062.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Рязанцев С.В., Карнеева О.В., Гаращенко Т.И., Гуров А.В., Свистушкин В.М., Сапова К.И. и соавт. Острый синусит. Клинические рекомендации. 2016. Режим доступа: http://www.nmaoru.org/files/KR313%20Ostryj%20sinusit.pdf.</mixed-citation><mixed-citation xml:lang="en">Riazantsev S.V., Karneeva O.V., Garashenko T.I., Gurov A.V., Svistushkin V.M., Sapova K.I. et al. Acute sinusitis. Practice Guideline. 2016. (In Russ.) Available at: http://www.nmaoru.org/files/KR313%20Ostryj%20sinusit.pdf.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Benninger M.S., Holy C.E., Trask D.K. Acute Rhinosinusitis: Prescription Patterns in a Real-World Setting. Otolaryngol Head Neck Surg. 2016;154(5):957–962. doi: 10.1177/0194599816630310.</mixed-citation><mixed-citation xml:lang="en">Benninger M.S., Holy C.E., Trask D.K. Acute Rhinosinusitis: Prescription Patterns in a Real-World Setting. Otolaryngol Head Neck Surg. 2016;154(5):957–962. doi: 10.1177/0194599816630310.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Рачина С.А., Козлов Р.С., Таточенко В.К., Жаркова Л.П., Дудникова Э.В., Сакулина И.Б. и соавт. Практика лечения острых респираторных инфекций у детей в амбулаторно-поликлинических учреждениях РФ: результаты многоцентрового фармакоэпидемиологического исследования. Клиническая фармакология и терапия. 2016;(2):20–27. Режим доступа: https://clinpharm-journal.ru/articles/2016-2/praktika-lecheniya-ostryh-respiratornyh-infektsij-u-detej-v-ambulatorno-poliklinicheskih-uchrezhdeniyah-rf-rezultaty-mnogotsentrovogo-farmakoepidemiologicheskogo-issledovaniya/.</mixed-citation><mixed-citation xml:lang="en">Rachina S.A., Kozlov R.S., Tatochenko V.K., Zharova L.P., Dudnikova E.V., Sakulina I.B. et al. Paediatricians approach to prescribing of systemic antimicrobials in outpatient children with upper respiratory tract and ENT infections: data from multicenter survey. Klinicheskaya farmakologiya i terapiya = Clinical Pharmacology and Therapy. 2016;(2):20–27. (In Russ.) Available at: https://clinpharm-journal.ru/articles/2016-2/praktika-lecheniya-ostryh-respiratornyh-infektsij-u-detej-v-ambulatorno-poliklinicheskih-uchrezhdeniyah-rf-rezultaty-mnogotsentrovogo-farmakoepidemiologicheskogo-issledovaniya/</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Shehab N., Patel P.R., Srinivasan A., Budnitz D.S. Emergency department visits for antibiotic-associated adverse events. Clin Infect Dis. 2008;47(6):735–743. doi: 10.1086/591126.</mixed-citation><mixed-citation xml:lang="en">.Shehab N., Patel P.R., Srinivasan A., Budnitz D.S. Emergency department visits for antibiotic-associated adverse events. Clin Infect Dis. 2008;47(6):735–743. doi: 10.1086/591126.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Геппе Н.А., Малявина У.С., Дронов И.А., Титова Е.Л. Новая технология в лечении риносинуситов у детей. Доктор.Ру. 2010;52(1):7–10. Режим доступа: https://elibrary.ru/item.asp?id=14981930.</mixed-citation><mixed-citation xml:lang="en">Geppe N.A., Malyavina U.S., Dronov I.A., Titova E.L. A new technology in the treatment of rhinosinusitis in children. Doktor.Ru = Doctor.Ru. 2010;1(52):7–10. (In Russ.) Available at: https://elibrary.ru/item.asp?id=14981930.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Иванчик Н.В., Чагарян А.Н., Сухорукова М.В., Козлов Р.С., Дехнич А.В., Кречикова О.И. и соавт. Антибиотикорезистентность клинических штаммов Streptococcus pneumoniae в России: результаты многоцентрового эпидемиологического исследования «ПеГАС 2014–2017». Клиническая микробиология и антимикробная химиотерапия. 2019;21(3):230–238. doi: 10.36488/cmac.2019.3.230-237.</mixed-citation><mixed-citation xml:lang="en">Ivanchik N.V., Chagaryan А.N., Sukhorukova М.V., Kozlov R.S., Dekhnich А.V., Krechikova О.I. et. al. Antimicrobial resistance of clinical Streptococcus pneumoniae isolates in Russia: the results of multicenter epidemiological study PEHASus 2014–2017. Klinicheskaya mikrobiologiya i antimikrobnaya khimioterapiya = Clinical Microbiology and Antimicrobial Chemotherapy. 2019;21(3):230–238. (In Russ.) doi: 10.36488/cmac.2019.3.230-237.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Сивая О.В., Козлов Р.С., Кречикова О.И., Иванчик Н.В., Катосова Л.К., Гудкова Л.В. и группа исследователей проекта ПеГАС. Антибиотикорезистентность Haemophilus influenzae в России: результаты многоцентрового проспективного исследования ПеГАС. Клиническая микробиология и антимикробная химиотерапия. 2014;16(1):57–69. Режим доступа: https://cmac-journal.ru/publication/2014/1/cmac-2014t16-n1-p057/cmac-2014-t16-n1-p057.pdf.</mixed-citation><mixed-citation xml:lang="en">Sivaya O.V., Kozlov R.S., Krechikova O.I., Ivanchik N.V., Katosova L.K., Gudkova L.V. and PeGASus Study Group. Antimicrobial Resistance of Haemophilus influenzae in Russia: Results of Multicenter Study PeGASus. Klinicheskaya mikrobiologiya i antimikrobnaya khimioterapiya = Clinical Microbiology and Antimicrobial Chemotherapy. 2014;16(1):57–69. (In Russ.) Available at: https://cmac-journal.ru/publication/2014/1/cmac-2014-t16n1-p057/cmac-2014-t16-n1-p057.pdf.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Pérez-Giraldo C., Rodríguez-Benito A., Morán F.J., Hurtado C., Blanco M.T., Gómez-García A.C. Influence of N-acetylcysteine on the formation of biofilm by Staphylococcus epidermidis. J Antimicrob Chemother. 1997;39(5):643–646. doi: 10.1093/jac/39.5.643.</mixed-citation><mixed-citation xml:lang="en">Pérez-Giraldo C., Rodríguez-Benito A., Morán F.J., Hurtado C., Blanco M.T., Gómez-García A.C. Influence of N-acetylcysteine on the formation of biofilm by Staphylococcus epidermidis. J Antimicrob Chemother. 1997;39(5):643–646. doi: 10.1093/jac/39.5.643.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Aslam S., Darouiche R.O. Role of antibiofilm-antimicrobial agents in controlling device-related infections. Int J Artif Organs. 2011;34(9):752–758. doi: 10.5301/ijao.5000024.</mixed-citation><mixed-citation xml:lang="en">Aslam S., Darouiche R.O. Role of antibiofilm-antimicrobial agents in controlling device-related infections. Int J Artif Organs. 2011;34(9):752–758. doi: 10.5301/ijao.5000024.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Orlandi R.R., Kingdom T.T., Hwang P.H., Smith T.L., Alt J.A., Baroody F.M. et al. International Consensus Statement on Allergy and Rhinology: Rhinosinusitis. Int Forum Allergy Rhinol. 2016;6(1):22–209. doi: 10.1002/alr.21695.</mixed-citation><mixed-citation xml:lang="en">Orlandi R.R., Kingdom T.T., Hwang P.H., Smith T.L., Alt J.A., Baroody F.M. et al. International Consensus Statement on Allergy and Rhinology: Rhinosinusitis. Int Forum Allergy Rhinol. 2016;6(1):22–209. doi: 10.1002/alr.21695.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Serra A., Schito G.C., Nicoletti G., Fadda G. A therapeutic approach in the treatment of infections of the upper airways: thiamphenicol glycinate acetylcysteinate in sequential treatment (systemic-inhalatory route). Int J Immunopathol Pharmacol. 2007;20(3):607–617. doi: 10.1177/039463200702000319.</mixed-citation><mixed-citation xml:lang="en">Serra A., Schito G.C., Nicoletti G., Fadda G. A therapeutic approach in the treatment of infections of the upper airways: thiamphenicol glycinate acetylcysteinate in sequential treatment (systemic-inhalatory route). Int J Immunopathol Pharmacol. 2007;20(3):607–617. doi: 10.1177/039463200702000319.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Wei J.L., Sykes K.J., Johnson P., He J., Mayo M.S. Safety and efficacy of oncedaily nasal irrigation for the treatment of pediatric chronic rhinosinusitis. Laryngoscope. 2011;121(9):1989–2000. doi: 10.1002/lary.21923.</mixed-citation><mixed-citation xml:lang="en">Wei J.L., Sykes K.J., Johnson P., He J., Mayo M.S. Safety and efficacy of oncedaily nasal irrigation for the treatment of pediatric chronic rhinosinusitis. Laryngoscope. 2011;121(9):1989–2000. doi: 10.1002/lary.21923.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Barazi R., Bawab I., Dunia G., Bitar M.A. The Use of Topical Intranasal Antibiotics in Pediatric Chronic Rhinosinusitis. Ann Otolaryngol Rhinol. 2016;3(12):1150. Available at: https://www.researchgate.net/publication/314465071_The_Use_of_Topical_Intranasal_Antibiotics_in_Pediatric_ Chronic_Rhinosinusitis.</mixed-citation><mixed-citation xml:lang="en">Barazi R., Bawab I., Dunia G., Bitar M.A. The Use of Topical Intranasal Antibiotics in Pediatric Chronic Rhinosinusitis. Ann Otolaryngol Rhinol. 2016;3(12):1150. Available at: https://www.researchgate.net/publication/314465071_The_Use_of_Topical_Intranasal_Antibiotics_in_Pediatric_Chronic_Rhinosinusitis.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Карпова Е.П., Тулупов Д.А. О возможностях небулайзерной терапии в лечении острых риносинуситов у детей. Российская оториноларингология. 2013;(4):160–163. Режим доступа: http://entru.org/files/preview/2013/04/j_rus_LOR_4_2013.pdf.</mixed-citation><mixed-citation xml:lang="en">Karpova E.P., Tulupov D.A. About the possibilities of nebulizer therapy in the treatment of acute rhinosinusitis in children. Rossiyskaya otorinolaringologiya = Russian Otorhinolaryngology. 2013;(4):160–163. (In Russ.) Available at: http://entru.org/files/preview/2013/04/j_rus_LOR_4_2013.pdf.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Кунельская Н.Л., Туровский А.Б., Изотова Г.Н., Талалайко Ю.В., Киселева О.А. Возможности ингаляционного применения комбинированных препаратов в лечении острого синусита. Медицинский совет. 2014;(1):28–31. doi: 10.21518/2079-701X-2014-3-28-31.</mixed-citation><mixed-citation xml:lang="en">Kunel’skaja N.L., Turovskij A.B., Izotova G.N., Talalajko Ju.V., Kiseljova O.A. Possibilities of inhaled use of combination drugs in the treatment of acute sinusitis. Meditsinskiy sovet = Medical Council 2014;(1):28–31. (In Russ.) doi: 10.21518/2079-701X-2014-3-28-31.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Анготоева И.Б., Пшенников Д.С. Ингаляционная терапия нетяжелых форм острого бактериального риносинусита. Медицинский совет. 2018;(6):84–88. doi: 10.21518/2079-701X-2018-6-84-88.</mixed-citation><mixed-citation xml:lang="en">Angotoeva I.B., Pshennikov D.S. The inhalation therapy of moderate forms of acute bacterial rhinosinusitis. Meditsinskiy sovet = Medical Council. 2018;(6):84–88. (In Russ.) doi: 10.21518/2079-701X-2018-6-84-88.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Янов Ю.К., Дайхес Н.А., Абдулкеримов Х.Т., Артюшкин С.А., Асланов Б.И., Вахрушев С.Г. и соавт. Резолюция совета экспертов НМАО по проблеме антибиотикотерапии в оториноларингологии от 4 ноября 2018 года. Российская оториноларингология. 2019;18(1):135–138.</mixed-citation><mixed-citation xml:lang="en">Yanov Yu.K., Daikhes N.A., Abdulkerimov Kh.T., Artyushkin S.A., Aslanov B.I., Vakhrushev S.G. et. al. Resolution of the council of experts of the NMAO on the problem of antibiotic therapy in otorhinolaryngology of november 4, 2018. Rossiyskaya otorinolaringologiya = Russian Otorhinolaryngology. 2019;18(1):135–138. (In Russ.)</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
