medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2020-6-66-70medsovet-5636Research ArticleАКТУАЛЬНЫЕ ВОПРОСЫ ОТОРИНОЛАРИНГОЛОГИИTOPICAL ISSUES OF OTORHINOLARYNGOLOGYПрименение интраназальных глюкокортикостероидов в комплексном лечении пациентов с хроническими заболеваниями носа и околоносовых пазухIntranasal glucocorticosteroids for the complex treatment of patients with chronic diseases of the nose and paranasal sinuseshttps://orcid.org/0000-0002-5778-629XКочетковП. А.KochetkovP. A.

Кочетков Петр Александрович, кандидат медицинских наук, доцент, кафедра болезней уха, горла и носа

119991, Москва, ул. Трубецкая, д. 8, стр. 2

Pyotr A. Kochetkov, Cand. of Sci. (Med.), Associate Professor, Head of the Department of ENT Diseases

8, Bldg. 2, Trubetskaya St., Moscow, 119991

adenotom@yandex.ruhttps://orcid.org/0000-0002-1257-9879СвистушкинВ. М.SvistushkinV. A.

Свистушкин Валерий Михайлович, доктор медицинских наук, профессор, заведующий кафедрой болезней уха, горла и носа

119991, Москва, ул. Трубецкая, д. 8, стр. 2

Valeriy M. Svistushkin, Dr. of Sci. (Med.), professor, Head of the Department of ENT Diseases

8, Bldg. 2, Trubetskaya St., Moscow, 119991

svvm3@yandex.ruhttps://orcid.org/0000-0003-4755-0205ЩенниковаЕ. С.ShchennikovaE. S.

Щенникова Екатерина Сергеевна, врач-оториноларинголог отделения оториноларингологии Университетской клинической больницы №1

119991, Москва, ул. Трубецкая, д. 8, стр. 2

Ekaterina S. Shchennikova, Otorhinolaryngologist, Department of Otorhinolaryngology, University Clinical Hospital No. 1

8, Bldg. 2, Trubetskaya St., Moscow, 119991

 

katt-she@yandex.ruПервый Московский государственный медицинский университет им. И.М. Сеченова (Сеченовский Университет)РоссияFirst Moscow State Medical University named after I.M. Sechenov (Sechenov University)Russian Federation202025052020066670Copyright © Кочетков П.А., Свистушкин В.М., Щенникова Е.С., 20202020Кочетков П.А., Свистушкин В.М., Щенникова Е.С.Kochetkov P.A., Svistushkin V.A., Shchennikova E.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/5636Введение

Введение. Хронический ринит и риносинусит являются широко распространенными заболеваниями во всем мире, оказывают значительное влияние на качество жизни пациентов и могут приводить к развитию сопутствующей патологии органов верхнего отдела дыхательных путей. Основными целями лечения являются уменьшение или устранение симптомов, предупреждение обострений и профилактика развития осложнений. Оптимально подобранная терапия должна позволить пациенту поддерживать привычный для него образ жизни. Интраназальные глюкокортикостероиды являются препаратами первой линии для лечения острого риносинусита или обострения хронического риносинусита у взрослых (в т. ч. пожилого возраста) и подростков с 12 лет в качестве вспомогательного терапевтического средства при лечении антибиотиками, а также лечения острого риносинусита с легкими и умеренно выраженными симптомами без признаков тяжелой бактериальной инфекции. В свою очередь, по данным большого количества исследований, мометазона фуроат показал свою эффективность в купировании симптомов, не приводя при этом к выраженному развитию побочных эффектов.

Цель

Цель: провести обзор доступной литературы по эффективности применения интраназального глюкокортикостероида мометазона фуроат в лечении различных форм обострений хронического синусита.

Материалы и методы

Материалы и методы: поиск данных для обзора проводился в базе данных РИНЦ и MEDLINE с использованием ключевых слов.

Выводы

Выводы: таким образом, основываясь на доступных в литературе данных, лечение хронического риносинусита и ринита необходимо начинать с консервативной терапии. Обобщая данные проведенных исследований, можно заключить, что применение мометазона фуроата улучшает качество жизни пациентов путем уменьшения клинических проявлений обострений хронического синусита и острого риносинусита.

Intriduction

Intriduction. Chronic rhinitis and rhinosinusitis noticeably deteriorate the patients’ quality of life and lead to the accompanying upper airway pathology development. The main purpose of treatment of this group of patients is to decrease severity of symptoms and the second one to prevent complications. The optimal therapy will help patients to maintain their lifestyle. Intranasal glucocorticosteroids are first-line drugs to treat acute rhinosinusitis or exacerbations of chronic rhinosinusitis in adults (including the elderly) and adolescents aged 12 years and older as an auxiliary therapeutic agent if treated by antibiotics, and to treat acute rhinosinusitis with mild to moderate symptoms without signs of severe bacterial infection. In the number of trials, mometasone furoate effectiveness in regard to decreasing of prominent symptoms with no side effects development has been shown.

Objective

Objective: this article reviews available data on the effectiveness of intranasal corticosteroids – mometasone furoate – in the treatment of different forms of chronic inflammatory diseases of the nose and paranasal sinuses.

Methods

Methods: information for this review was identified through a RISC and MEDLINE databases applying key words.

Conclusions

Conclusions: based on the available data, treatment of chronic rhinosinusites and rhinitis should be initiated by conservative therapy. Summarizing information from the available literature we can conclude that treatment by mometasone furoate improve quality of life decreasing clinical symptoms of chronic rhinosinusitis and rhinitis.

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The authors declare that there are no conflicts of interest present.