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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2020-6-101-106</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-5642</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АКТУАЛЬНЫЕ ВОПРОСЫ ОТОРИНОЛАРИНГОЛОГИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>TOPICAL ISSUES OF OTORHINOLARYNGOLOGY</subject></subj-group></article-categories><title-group><article-title>Современные возможности патогенетической терапии больных аллергическим ринитом</article-title><trans-title-group xml:lang="en"><trans-title>Modern possibilities of pathogenetic therapy of patients with allergic rhinitis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1257-9879</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Свистушкин</surname><given-names>В. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Svistushkin</surname><given-names>V. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Свистушкин Валерий Михайлович, доктор медицинских наук, профессор, заведующий кафедрой болезней уха, горла и носа</p><p>119991,Москва, ул. Трубецкая, д. 8, стр. 2</p></bio><bio xml:lang="en"><p>Valeriy M. Svistushkin, Dr. of Sci. (Med.), professor, Head of the Department of ENT Diseases</p><p>8, Bldg. 2, Trubetskaya St., Moscow, 119991</p></bio><email xlink:type="simple">svvm3@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8617-0179</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Никифорова</surname><given-names>Г. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Nikiforova</surname><given-names>G. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Никифорова Галина Николаевна, доктор медицинских наук, профессор кафедры болезней уха, горла и носа Института клинической медицины им. Н.В. Склифосовского</p><p>119991,Москва, ул. Трубецкая, д. 8, стр. 2</p></bio><bio xml:lang="en"><p>Galina N. Nikiforova, Dr. of Sci. (Med.), professor of the Department of ENT Diseases</p><p>8, Bldg. 2, Trubetskaya St., Moscow, 119991</p></bio><email xlink:type="simple">gn_nik_63@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4506-4599</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Артамонова</surname><given-names>П. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Artamonova</surname><given-names>P. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Артамонова Полина Сергеевна, аспирант кафедры болезней уха, горла и носа Института клинической медицины им. Н.В. Склифосовского</p><p>119991,Москва, ул. Трубецкая, д. 8, стр. 2</p></bio><bio xml:lang="en"><p>Polina S. Artamonova, Postgraduate Student of the Department of Ear, Throat and Nose Diseases of N.V. Sklifosovsky Clinical Medicine Institute </p><p>8, Bldg. 2, Trubetskaya St., Moscow, 119991</p></bio><email xlink:type="simple">polina_lokshina2901@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0051-3792</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шевчик</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Shevchik</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шевчик Елена Александровна, кандидат медицинских наук, ассистент кафедры болезней уха, горла и носа Института клинической медицины им. Н.В. Склифосовского</p><p>119991,Москва, ул. Трубецкая, д. 8, стр. 2</p></bio><bio xml:lang="en"><p>Elena A. Shevchik, Cand. of Sci. (Med), associate professor of the Department of Ear, Throat and Nose Diseases of N.V. Sklifosovsky Clinical Medicine Institute</p><p>8, Bldg. 2, Trubetskaya St., Moscow, 119991</p></bio><email xlink:type="simple">elena.shevchik@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Первый Московский государственный медицинский университет им. И.М. Сеченова Минздрава России (Сеченовский Университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I.M. Sechenov First Moscow State Medical University (Sechenov University)</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>25</day><month>05</month><year>2020</year></pub-date><volume>0</volume><issue>6</issue><fpage>101</fpage><lpage>106</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Свистушкин В.М., Никифорова Г.Н., Артамонова П.С., Шевчик Е.А., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Свистушкин В.М., Никифорова Г.Н., Артамонова П.С., Шевчик Е.А.</copyright-holder><copyright-holder xml:lang="en">Svistushkin V.M., Nikiforova G.N., Artamonova P.S., Shevchik E.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/5642">https://www.med-sovet.pro/jour/article/view/5642</self-uri><abstract><p>За последние годы отмечен активный рост заболеваемости аллергическим ринитом во всем мире. Около 40% мирового населения страдает аллергическим воспалением слизистой оболочки полости носа. Клиническими проявлениями аллергического ринита являются отсутствие или затруднение носового дыхания, зуд, чихание, заложенность носа и ринорея, а также отечность лица, наличие дерматита в области крыльев носа, общее недомогание, нарушение обоняния. Проявления аллергии со стороны ЛОР-органов в большинстве своем не несут угрозы для жизни, однако они могут стать причиной развития других патологических процессов, плохого сна, раздражительности, снижения работоспособности, перемен настроения, что, в свою очередь, отрицательно влияет на состояние здоровья человека и снижает его качество жизни.</p><p>В основе патогенеза аллергического ринита лежит аллергическая реакция немедленного типа. Согласно современной классификации, в зависимости от характера течения заболевания принято выделять интермиттирующую и персистирующую формы. В настоящее время препаратами выбора в лечении больных аллергическим ринитом остаются интраназальные глюкокортикостероиды. Однако наличие у пациента сопутствующей патологии полости носа, например искривления носовой перегородки, не только выраженно ухудшает течение назального воспалительного процесса, но и создает препятствия для адекватной доставки топических лекарственных средств во все отделы полости носа, что, в свою очередь, снижает их эффективность. Для пациентов, страдающих аллергическим ринитом в сочетании с другой патологией полости носа, хорошей альтернативой интраназальным спреям могут служить комбинированные пероральные препараты. Определенный интерес для врачей вызывает появление на российском рынке комбинированного противоаллергического препарата, в состав которого входят блокатор лейкотриеновых и блокатор Н1-гистаминовых рецепторов второго поколения – монтелукаст и левоцетиризин. Препарат может применяться как у взрослых, так и у детей c 15 лет для лечения интермиттирующей и персистирующей формы аллергического ринита.</p><p>Своевременная и правильно проведенная терапия аллергического ринита позволяет устранить симптомы заболевания и предотвратить развитие осложнений.</p></abstract><trans-abstract xml:lang="en"><p>The incidence of allergic rhinitis has been increasing rapidly worldwide in recent years. About 40% of the world’s population suffer from allergic inflammation of the nasal mucous membrane. Clinical manifestations of allergic rhinitis are absence or difficulty of nasal breathing, itching, sneezing, nasal congestion and rhinorrhoea, as well as swelling of the face, the presence of dermatitis in the region of the nasal wings, general malaise, smell disturbance. Manifestations of allergies by ENT organs in most cases do not pose a threat to life, but they can cause the development of other pathological processes, bad sleep, irritability, decreased efficiency, mood swings, which, in turn, adversely affects human health and reduces the quality of life. The pathogenesis of allergic rhinitis is based on an immediate hypersensitivity. According to the modern classification, depending on the nature of the course of the disease it is common to identify intermittent and persistent forms.</p><p>At present, the drugs of choice in the treatment of patients with allergic rhinitis are intranasal glucocorticosteroids. However, the presence of a concomitant pathology of the nasal cavity in the patient, such as deviated septum, not only significantly impairs the course of nasal inflammatory process, but also creates obstacles to adequate delivery of topical drugs to all parts of the nasal cavity, which, in turn, reduces their effectiveness.</p><p>For patients suffering from allergic rhinitis in combination with other pathology of the nasal cavity, combined oral medications may be a good alternative to intranasal sprays. Certain interest for doctors is caused by the appearance of a combined antihistamine drug on the Russian market, which includes a blocker of leukotrienes and H1-histamine receptors of the second generation – montelukast and levocetirizine. The drug can be used both in adults and children from 15 years old for treatment of intermittent and persistent forms of allergic rhinitis.</p><p>Timely and properly performed therapy of allergic rhinitis allows to eliminate symptoms of the disease and prevent the development of complications.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>аллергический ринит</kwd><kwd>назальная обструкция</kwd><kwd>искривление перегородки носа</kwd><kwd>монтелукаст</kwd><kwd>левоцетиризин</kwd></kwd-group><kwd-group xml:lang="en"><kwd>allergic rhinitis</kwd><kwd>nasal obstruction</kwd><kwd>curvature of the nasal septum</kwd><kwd>montelukast</kwd><kwd>levocetirizine</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Крюков А.И., Туровский А.Б., Бондарева Г.П., Семкина О.В. Принципы лечения аллергического ринита. Медицинский Совет. 2013;(7):42–47. doi: 10.21518/2079-701X-2013-7-42-47.</mixed-citation><mixed-citation xml:lang="en">Kryukov A.I., Turovskiy A.B., Bondareva G.P., Semkina O.V. Principles of allergic rhinitis treatment. Meditsinskiy sovet = Medical Council. 2013;(7):42–47. (In Russ.) doi: 10.21518/2079-701X-2013-7-42-47.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Kakli H.A., Riley T.D. Allergic rhinitis. Primary Care: Clinics in Office Practice. 2016;43(3):465–475. doi: 10.1016/j.pop.2016.04.009.</mixed-citation><mixed-citation xml:lang="en">Kakli H.A., Riley T.D. Allergic rhinitis. Primary Care: Clinics in Office Practice. 2016;43(3):465–475. doi: 10.1016/j.pop.2016.04.009.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Вишнева Е.А., Намазова-Баранова Л.С., Алексеева А.А., Эфендиева К.Е., Левина Ю.Г., Вознесенская Н.И. и соавт. Современные принципы терапии аллергического ринита у детей. Педиатрическая фармакология. 2014;11(1):6–14. doi: 10.15690/pf.v11i1.889.</mixed-citation><mixed-citation xml:lang="en">Vishneva E.A., Namazova-Baranova L.S., Alexeyeva A.A., Ephendiyeva K.E., Levina Y.G., Voznesenskaya N.I. et al. Modern principles of allergic rhinitis therapy in children. Pediatricheskaya farmakologiya = Pediatric pharmacolo­ gy. 2014;11(1):6–14. (In Russ.) doi: 10.15690/pf.v11i1.889.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang Y., Zhang L. Increasing prevalence of allergic rhinitis in China. Allergy, asthma &amp; immunology research. 2019;11(2):156–169. doi: 10.4168/aair.2019.11.2.156</mixed-citation><mixed-citation xml:lang="en">Zhang Y., Zhang L. Increasing prevalence of allergic rhinitis in China. Allergy, asthma &amp; immunology research. 2019;11(2):156–169. doi: 10.4168/aair.2019.11.2.156.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Vandenplas O., Vinnikov D., Blanc P.D., Agache I., Bachert C., Bewick M. et al. Impact of rhinitis on work productivity: a systematic review. J Allergy Clin Immunol Pract. 2018;6(4):1274–1286. doi: 10.1016/j.jaip.2017.09.002.</mixed-citation><mixed-citation xml:lang="en">Vandenplas O., Vinnikov D., Blanc P.D., Agache I., Bachert C., Bewick M. et al. Impact of rhinitis on work productivity: a systematic review. J Allergy Clin Immunol Pract. 2018;6(4):1274–1286. doi: 10.1016/j.jaip.2017.09.002.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Poddighe D., Gelardi M., Licari A., Del Giudice M.M., Marseglia G.L. Nonallergic rhinitis in children: Epidemiological aspects, pathological features, diagnostic methodology and clinical management. World J Methodol. 2016;6(4):200–213. doi: 10.5662/wjm.v6.i4.200.</mixed-citation><mixed-citation xml:lang="en">Poddighe D., Gelardi M., Licari A., Del Giudice M.M., Marseglia G.L. Nonallergic rhinitis in children: Epidemiological aspects, pathological features, diagnostic methodology and clinical management. World J Methodol. 2016;6(4):200–213. doi: 10.5662/wjm.v6.i4.200.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">S. Brożek J.L., Bousquet J., Agache I., Agarwal A., Bachert C., Bosnic-Anticevich et al. Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines 2016 revision. J Allergy Clin Immunol. 2017;140(4):950–958. doi: 10.1016/j.jaci.2017.03.050.</mixed-citation><mixed-citation xml:lang="en">Brożek J.L., Bousquet J., Agache I., Agarwal A., Bachert C., Bosnic-Anticevich S. et al. Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines 2016 revision. J Allergy Clin Immunol. 2017;140(4):950–958. doi: 10.1016/j.jaci.2017.03.050.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Никифорова Г.Н., Свистушкин В.М., Славский А.Н., Пшонкина Д.М. Возможности использования современных антигистаминных препаратов в терапии больных аллергическим ринитом. Медицинский совет. 2017;(8):92–98. doi: 10.21518/2079-701X-2017-8-92-98.</mixed-citation><mixed-citation xml:lang="en">Nikiforova G.N., Svistushkin V.M., Slavsky A.N., Pshonkina D.M. Possibilities of use of the modern antihistamine medecines in therapy of patients with allergic rhinitis. Meditsinskiy sovet = Medical Council. 2017;(8):92–98. (In Russ.) doi: 10.21518/2079-701X-2017-8-92-98.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Астафьева Н., Горячкина Л., Ильина Н., Намазова Л., Огородова Л., Сидоренко И., Смирнова Г., Черняк Б. Аллергический ринит. Педиатрическая фармакология. 2008;5(4):81–87. Режим доступа: https:// www.pedpharma.ru/jour/article/view/839.</mixed-citation><mixed-citation xml:lang="en">Astaf’eva N., Goryachkina L., Il’ina N., Namazova L., Ogorodova L., Sidorenko I., Smirnova G., Chernyak B. Allergic rhinitis. Pediatricheskaya far­ makologiya = Pediatric pharmacology. 2008;5(4):81–87. (In Russ.) Available at: https://www.pedpharma.ru/jour/article/view/839.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Greiner A.N., Hellings P.W., Rotiroti G., Scadding G.K. Allergic rhinitis. Lancet. 2011;378(9809):2112–2122. doi: 10.1016/S0140-6736(11)60130-X.</mixed-citation><mixed-citation xml:lang="en">Greiner A.N., Hellings P.W., Rotiroti G., Scadding G.K. Allergic rhinitis. Lancet. 2011;378(9809):2112–2122. doi: 10.1016/S0140-6736(11)60130-X.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Gani F., Lombardi C., Bonizzoni G., Rolla G., Brussino L., Landi M. et al. The Characteristics of Severe Chronic Upper-Airway Disease (SCUAD) in Patients with Allergic Rhinitis: A Real-Life Multicenter Cross-Sectional Italian Study. Int Arch Allergy Immunol. 2019;178(4):333–337. doi: 10.1159/000495305.</mixed-citation><mixed-citation xml:lang="en">Gani F., Lombardi C., Bonizzoni G., Rolla G., Brussino L., Landi M. et al. The Characteristics of Severe Chronic Upper-Airway Disease (SCUAD) in Patients with Allergic Rhinitis: A Real-Life Multicenter Cross-Sectional Italian Study. Int Arch Allergy Immunol. 2019;178(4):333–337. doi: 10.1159/000495305.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Bousquet J., Khaltaev N., Cruz A.A., Denburg J., Fokkens W.J., Togias A. et al. Allergic rhinitis and its impact on asthma (ARIA) 2008. Allergy. 2008;63(Suppl 86):8–160. doi: 10.1111/j.1398-9995.2007.01620.x.</mixed-citation><mixed-citation xml:lang="en">Bousquet J., Khaltaev N., Cruz A.A., Denburg J., Fokkens W.J., Togias A. et al. Allergic rhinitis and its impact on asthma (ARIA) 2008. Allergy. 2008;63(Suppl 86):8–160. doi: 10.1111/j.1398-9995.2007.01620.x.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Naclerio R.M., Pinto J., deTineo M., Baroody F.M. Elucidating the mechanism underlying the ocular symptoms associated with allergic rhinitis. Allergy Asthma Proc. 2008;29(1):24–28. doi: 10.2500/aap2008.29.3075.</mixed-citation><mixed-citation xml:lang="en">Naclerio R.M., Pinto J., deTineo M., Baroody F.M. Elucidating the mechanism underlying the ocular symptoms associated with allergic rhinitis. Allergy Asthma Proc. 2008;29(1):24–28. doi: 10.2500/aap2008.29.3075.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Callebaut I., Spielberg L., Hox V., Bobic S., Jorissen M., Stalmans I. et al. Conjunctival effects of a selective nasal pollen provocation. Allergy. 2010;65(9):1173–1181. doi: 10.1111/j.1398-9995.2010.02360.x.</mixed-citation><mixed-citation xml:lang="en">Callebaut I., Spielberg L., Hox V., Bobic S., Jorissen M., Stalmans I. et al. Conjunctival effects of a selective nasal pollen provocation. Allergy. 2010;65(9):1173–1181. doi: 10.1111/j.1398-9995.2010.02360.x.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">van den Oord R.A., Sheikh A. Filaggrin gene defects and risk of developing allergic sensitisation and allergic disorders: systematic review and metaanalysis. BMJ. 2009;339:b2433. doi: 10.1136/bmj.b2433.</mixed-citation><mixed-citation xml:lang="en">van den Oord R.A., Sheikh A. Filaggrin gene defects and risk of developing allergic sensitisation and allergic disorders: systematic review and metaanalysis. BMJ. 2009;339:b2433. doi: 10.1136/bmj.b2433.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Zhu D., Zhu X.W., Jiang X.D., Dong Z. Thymic stromal lymphopoietin expression is increased in nasal epithelial cells of patients with mugwort pollen sensitive-seasonal allergic rhinitis. Chin Med J (Engl). 2009;122(19):2303–2307. Available at: https://www.ncbi.nlm.nih.gov/pubmed/20079130.</mixed-citation><mixed-citation xml:lang="en">Zhu D., Zhu X.W., Jiang X.D., Dong Z. Thymic stromal lymphopoietin expression is increased in nasal epithelial cells of patients with mugwort pollen sensitive-seasonal allergic rhinitis. Chin Med J (Engl). 2009;122(19):2303– 2307. Available at: https://www.ncbi.nlm.nih.gov/pubmed/20079130.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Smurthwaite L., Durham S.R. Local IgE synthesis in allergic rhinitis and asthma. Curr Allergy Asthma Rep. 2002;2(3):231–238. doi: 10.1007/s11882- 002-0024-z.</mixed-citation><mixed-citation xml:lang="en">Smurthwaite L., Durham S.R. Local IgE synthesis in allergic rhinitis and asthma. Curr Allergy Asthma Rep. 2002;2(3):231–238. doi: 10.1007/s11882-002-0024-z.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Li H., Sha Q., Zuo K., Jiang H., Cheng L., Shi J., Xu G. Nasal saline irrigation facilitates control of allergic rhinitis by topical steroid in children. ORL J Otorhinolaryngol Relat Spec. 2009;71(1):50–55. doi: 10.1159/000178165.</mixed-citation><mixed-citation xml:lang="en">Li H., Sha Q., Zuo K., Jiang H., Cheng L., Shi J., Xu G. Nasal saline irrigation facilitates control of allergic rhinitis by topical steroid in children. ORL J Otorhinolaryngol Relat Spec. 2009;71(1):50–55. doi: 10.1159/000178165.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Roberts G., Xatzipsalti M., Borrego L.M., Custovic A., Halken S., Hellings P.W. et al. Paediatric rhinitis: position paper of the European Academy of Allergy and Clinical Immunology. Allergy. 2013;68(9):1102–1116. doi: 10.1111/all.12235.</mixed-citation><mixed-citation xml:lang="en">Roberts G., Xatzipsalti M., Borrego L.M., Custovic A., Halken S., Hellings P.W. et al. Paediatric rhinitis: position paper of the European Academy of Allergy and Clinical Immunology. Allergy. 2013;68(9):1102–1116. doi: 10.1111/all.12235.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Calderon M.A., Gerth van Wijk R., Eichler I., Matricardi P.M., Varga E.M., Kopp M.V. et al. European Academy of Allergy and Clinical Immunology. Perspectives on allergen specific immunotherapy in childhood: an EAACI position statement. Pediatr Allergy Immunol. 2012;23(4):300–306. doi: 10.1111/j.1399-3038.2012.01313.x.</mixed-citation><mixed-citation xml:lang="en">Calderon M.A., Gerth van Wijk R., Eichler I., Matricardi P.M., Varga E.M., Kopp M.V. et al. European Academy of Allergy and Clinical Immunology. Perspectives on allergen specific immunotherapy in childhood: an EAACI position statement. Pediatr Allergy Immunol. 2012;23(4):300–306. doi: 10.1111/j.1399-3038.2012.01313.x.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Scadding G.K., Durham S.R., Mirakian R., Jones N.S., Leech S.C., Farooque S. et al. British Society for Allergy and Clinical Immunology. BSACI guidelines for the management of allergic and non allergic rhinitis. Clin Exp Allergy. 2008;38(1):19–42. doi: 10.1111/j.1365-2222.2007.02888.x.</mixed-citation><mixed-citation xml:lang="en">Scadding G.K., Durham S.R., Mirakian R., Jones N.S., Leech S.C., Farooque S. et al. British Society for Allergy and Clinical Immunology. BSACI guidelines for the management of allergic and non allergic rhinitis. Clin Exp Allergy. 2008;38(1):19–42. doi: 10.1111/j.1365-2222.2007.02888.x.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Church M.K., Church D.S. Pharmacology of antihistamines Indian J Dermatol. 2013;58(3):219–224. doi: 10.4103/0019-5154.110832.</mixed-citation><mixed-citation xml:lang="en">Church M.K., Church D.S. Pharmacology of antihistamines Indian J Dermatol. 2013;58(3):219–224. doi: 10.4103/0019-5154.110832.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Simons F.E., Simons K.J. Histamine and H1-antihistamines: celebrating a century of progress. J Allergy Clin Immunol. 2011;128(6):1139–1150.e4. doi: 10.1016/j.jaci.2011.09.005.</mixed-citation><mixed-citation xml:lang="en">Simons F.E., Simons K.J. Histamine and H1-antihistamines: celebrating a century of progress. J Allergy Clin Immunol. 2011;128(6):1139–1150.e4. doi: 10.1016/j.jaci.2011.09.005.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Ng K.H., Chong D., Wong C.K., Ong H.T., Lee C.Y., Lee B.W., Shek L.P. Central nervous system side effects of first-and second-generation antihistamines in school children with perennial allergic rhinitis: a randomized, doubleblind, placebo-controlled comparative study. Pediatrics. 2004;113(2):116– 121. doi: 10.1542/peds.113.2.e116.</mixed-citation><mixed-citation xml:lang="en">Ng K.H., Chong D., Wong C.K., Ong H.T., Lee C.Y., Lee B.W., Shek L.P. Central nervous system side effects of first-and second-generation antihistamines in school children with perennial allergic rhinitis: a randomized, doubleblind, placebo-controlled comparative study. Pediatrics. 2004;113(2):116– 121. doi: 10.1542/peds.113.2.e116.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Di Lorenzo G., Pacor M.L., Pellitteri M.E., Morici G., Di Gregoli A., Lo Bianco C. et al. Randomized placebo-controlled trial comparing fluticasone aqueous nasal spray in monotherapy, fluticasone plus cetirizine, fluticasone plus montelukast and cetirizine plus montelukast for seasonal allergic rhinitis. Clin Exp Allergy. 2004;34(2):259–267. doi: 10.1111/j.1365-2222.2004.01877.x.</mixed-citation><mixed-citation xml:lang="en">Di Lorenzo G., Pacor M.L., Pellitteri M.E., Morici G., Di Gregoli A., Lo Bianco C. et al. Randomized placebo-controlled trial comparing fluticasone aqueous nasal spray in monotherapy, fluticasone plus cetirizine, fluticasone plus montelukast and cetirizine plus montelukast for seasonal allergic rhinitis. Clin Exp Allergy. 2004;34(2):259–267. doi: 10.1111/j.1365-2222.2004.01877.x.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Асманов А.И. Роль хирургических методов в комплексном лечении аллергического ринита у детей: дис. Научно-клинический центр оториноларингологии МЗ РФ, 2012. Режим доступа: https://elibrary.ru/item.asp?id=19383399.</mixed-citation><mixed-citation xml:lang="en">Asmanov A.I. The role of surgical methods in the complex treatment of allergic rhinitis in children: dis. – Scientific and Clinical Center of Otorhinolaryngology, Ministry of Health of the Russian Federation, 2012. (In Russ.) Available at: https://elibrary.ru/item.asp?id=19383399.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Frank D.O., Kimbell J.S., Cannon D., Pawar S.S., Rhee J.S. Deviated nasal septum hinders intranasal sprays: a computer simulation study. Rhinology. 2012;50(3):311–318. doi: 10.4193/Rhino12.053.</mixed-citation><mixed-citation xml:lang="en">Frank D.O., Kimbell J.S., Cannon D., Pawar S.S., Rhee J.S. Deviated nasal septum hinders intranasal sprays: a computer simulation study. Rhinology. 2012;50(3):311–318. doi: 10.4193/Rhino12.053.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Aggarwal R., Cardozo A., Homer J.J. The assessment of topical nasal drug distribution. Clin Otolaryngol Allied Sci. 2004;29(3):201–205. doi: 10.1111/j.1365-2273.2004.00797.x.</mixed-citation><mixed-citation xml:lang="en">Aggarwal R., Cardozo A., Homer J.J. The assessment of topical nasal drug distribution. Clin Otolaryngol Allied Sci. 2004;29(3):201–205. doi: 10.1111/j.1365-2273.2004.00797.x.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Benninger M.S., Hadley J.A., Osguthorpe J.D., Marple B.F., Leopold D.A., Derebery M.J., Hannley M. Techniques of intranasal steroid use Otolaryngol Head Neck Surg. 2004;130(1):5–24. doi: 10.1016/j.otohns.2003.10.007.</mixed-citation><mixed-citation xml:lang="en">Benninger M.S., Hadley J.A., Osguthorpe J.D., Marple B.F., Leopold D.A., Derebery M.J., Hannley M. Techniques of intranasal steroid use Otolaryngol Head Neck Surg. 2004;130(1):5–24. doi: 10.1016/j.otohns.2003.10.007.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Леонова М.В., Алимова Э.Э., Дворников А.С. Антагонисты лейкотриеновых рецепторов в лечении аллергических заболеваний: обзор эффективности монтелукаста. Фарматека. 2017;(s4-17):15–20. Режим доступа: https://pharmateca.ru/ru/archive/article/35333.</mixed-citation><mixed-citation xml:lang="en">Leonova M.V., Alimova E.E., Dvornikov A.S. Leukotriene receptor antagonists in the treatment of allergic diseases: the review of the effectiveness of montelukast. Pharmateсa = Farmateca. 2017;(s4-17):15–20. (In Russ.) Available at: https://pharmateca.ru/ru/archive/article/35333.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Li L., Wang R., Cui L., Guan K. Efficacy of montelukast as prophylactic treatment for seasonal allergic rhinitis. Ear Nose Throat J. 2018;97(7):1–16. Available at: https://www.ncbi.nlm.nih.gov/pubmed/30036440.</mixed-citation><mixed-citation xml:lang="en">Li L., Wang R., Cui L., Guan K. Efficacy of montelukast as prophylactic treatment for seasonal allergic rhinitis. Ear Nose Throat J. 2018;97(7):1–16. Available at: https://www.ncbi.nlm.nih.gov/pubmed/30036440.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Жарких М.А., Яблонский С.В., Мокроносова М.А. Значение лейкотриенов и антилейкотриеновых препаратов при аллергическом рините. Педиатрическая фармакология. 2009;6(5):20–29. Режим доступа: https://www.pedpharma.ru/jour/article/view/959.</mixed-citation><mixed-citation xml:lang="en">Zharkikh M., Yablonsky S., Mokronosova M. Leukotriens and antileucotriene drugs in allergic rhinitis. Pediatricheskaya farmakologiya = Pediatric pharmacology. 2009;6(5):20–29. (In Russ.) Available at: https://www.pedpharma.ru/jour/article/view/959.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Knorr B., Holland S., Rogers .J.D, Nguyen H.H., Reiss T.F. Montelukast adult (10-mg film-coated tablet) and pediatric (5-mg chewable tablet) dose selections. J Allergy Clin Immunol. 2000;106(3 Suppl):171–178. doi: 10.1067/mai.2000.109424.</mixed-citation><mixed-citation xml:lang="en">Knorr B., Holland S., Rogers .J.D, Nguyen H.H., Reiss T.F. Montelukast adult (10-mg film-coated tablet) and pediatric (5-mg chewable tablet) dose selections. J Allergy Clin Immunol. 2000;106(3 Suppl):171–178. doi: 10.1067/mai.2000.109424.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Щербак И.Б. Акценты антигистаминной терапии: левоцетиризин. Укра їнський медичний часопис. 2012;(3):84–85. Режим доступа: https://www.umj.com.ua/article/35126/akcenty-antigistaminnoj-terapii-levocetirizin.</mixed-citation><mixed-citation xml:lang="en">Shsherbak I.B. Emphasis of antihistamine therapy: levocetirizine. Ukrainskij medicinskij zhurnal = Ukrainian medical journal. 2012;(3):84–85. (In Russ.) Available at: https://www.umj.com.ua/article/35126/akcenty-antigistaminnoj-terapii-levocetirizin.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
