medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2020-9-102-120medsovet-5714Research ArticleОПУХОЛИ КОЖИSKIN TUMORSНеинвазивные методы диагностики опухолей кожи и их потенциал применения для скрининга меланомы кожи: систематический обзор литературыNon-invasive diagnostic techniques for skin tumors and their potential for use in skin melanoma screening: a systematic literature reviewhttps://orcid.org/0000-0002-7326-7553ГаранинаО. Е.GaraninaO. E.

Гаранина Оксана Евгеньевна, к.м.н., доцент кафедры кожных и венерических болезней; научный сотрудник, врач-онколог отделения реконструктивной и пластической хирургии Университетской клиники

Researcher ID: P-8082-2017; РИНЦ: SPIN: 6758-5913, Author ID: 595215

603005, Нижний Новгород, пл. Минина и Пожарского, д. 10/1

Oxana E. Garanina, Cand. of Sci. (Med.), Associate Professor of the Department of Skin and Venereal Diseases, Researcher, Oncologist of the Department of Reconstructive and Plastic Surgery of the University Hospital

Researcher ID: P-8082-2017

10/1, Minin and Pozharsky Square, Nizhny Novgorod, 603005

oksanachekalkina@yandex.ruhttps://orcid.org/0000-0001-7150-5071СамойленкоИ. В.SamoylenkoI. V.

Самойленко Игорь Вячеславович, к.м.н., старший научный сотрудник отделения онкодерматологии

Researcher ID: AAQ-2321-2020; РИНЦ: SPIN: 3691-8923, Author ID: 520864

115478, Москва, Каширское шоссе, д. 24

Igor V. Samoylenko, Cand. of Sci. (Med.), Senior Researcher of the Oncodermatology Department

Researcher ID: AAQ-2321-2020

24, Kashirskoye Shosse, Moscow, 115478

i.samoylenko@ronc.ruhttps://orcid.org/0000-0001-7253-7091ШливкоИ. Л.ShlivkoI. L.

Шливко Ирена Леонидовна, д.м.н., заведующая кафедрой кожных и венерических болезней

Researcher ID: P-8690-2017; РИНЦ: SPIN: 8301-4815, Author ID: 595212

603005, Нижний Новгород, пл. Минина и Пожарского, д. 10/1

Irena L. Shlivko, Dr. of Sci. (Med), Head of the Department of Skin and Venereal Diseases

Researcher ID: P-8690-2017

10/1, Minin and Pozharsky Square, Nizhny Novgorod, 603005 

irshlivko@gmail.comhttps://orcid.org/0000-0003-1042-8425КлеменоваИ. А.KlemenovaI. A.

Клеменова Ирина Александровна, д.м.н., профессор, первый проректор

Researcher ID: R-7945-2017; РИНЦ: SPIN: 8119-2480, Author ID: 343557

603005, Нижний Новгород, пл. Минина и Пожарского, д. 10/1

Irina A. Klemenova, Dr. of Sci. (Med), Professor, first vice-rector

Researcher ID: R-7945-2017

10/1, Minin and Pozharsky Square, Nizhny Novgorod, 603005 

iklemenova@mail.ruhttps://orcid.org/0000-0002-9034-5437НезнахинаМ. С.NeznakhinaM. S.

Незнахина Мария Сергеевна, к.м.н., ассистент кафедры кожных и венерических болезней

603005, Нижний Новгород, пл. Минина и Пожарского, д. 10/1

Maria S. Neznakhina, Cand. of Sci. (Med.), Assistant Professor of the Department of Skin and Venereal Disease

10/1, Minin and Pozharsky Square, Nizhny Novgorod, 603005 

fm557@yandex.ruhttps://orcid.org/0000-0002-8562-6082ДемидовЛ. В.DemidovL. V.

Демидов Лев Вадимович, д.м.н., профессор, заведующий отделением онкодерматологии

РИНЦ: SPIN: 5362-6386, Author ID: 173317

115478, Москва, Каширское шоссе, д. 24 

Lev V. Demidov, Dr. of Sci. (Med), Professor, Head of the Department of Oncodermatology

24, Kashirskoye Shosse, Moscow, 115478

demdiov.lev@gmail.comПриволжский исследовательский медицинский университетРоссияPrivolzhsky Research Medical UniversityRussian FederationНациональный медицинский исследовательский центр онкологии им. Н.Н. БлохинаРоссияN.N. Blokhin National Medical Research Center of OncologyRussian Federation20202807202009102120Copyright © Гаранина О.Е., Самойленко И.В., Шливко И.Л., Клеменова И.А., Незнахина М.С., Демидов Л.В., 20202020Гаранина О.Е., Самойленко И.В., Шливко И.Л., Клеменова И.А., Незнахина М.С., Демидов Л.В.Garanina O.E., Samoylenko I.V., Shlivko I.L., Klemenova I.A., Neznakhina M.S., Demidov L.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/5714

Введение. В настоящее время публикуются многочисленные исследования авторов разных стран, демонстрирующие эффективность неинвазивных методов диагностики меланомы. Цель: систематизировать и сравнить данные о доступных неинвазивных технологиях в диагностике меланомы кожи, их механизмы, диагностическую эффективность, ограничения. Материал и методы. Систематический поиск был проведен независимо в электронных базах данных PubMed и Cochrane Central Register of Controlled Trials (CENTRAL) до апреля 2020 г. согласно определенным критериям включения. Извлечение данных было проведено независимо с последующим обобщением с использованием описательных таблиц. Из-за неоднородности включенных исследований и ввиду этого невозможности проведения метаанализа мы выполнили повествовательное описание. Результаты. Всего было найдено и проверено 765 потенциальных для включения публикаций, из которых в исследование были включены 53. По дизайну исследования были отнесены к исследованиям одномоментного дизайна – 40, к рандомизированным клиническим исследованиям – 7, к метаанализу – 6. Во включенных публикациях сообщались данные о 76 802 новообразованиях кожи, из которых 9070 – меланомы. Извлеченные данные были обобщены в описательных таблицах. Заключение. С продолжающимся технологическим прогрессом развитие технологий вспомогательной визуализации в диагностике меланомы кожи должно идти по пути эффективной, экономически выгодной, простой диагностики.

Introduction. Currently, numerous studies are published by authors of different countries to demonstrate the effectiveness of noninvasive methods in the diagnosis of melanoma. Methods. A systematic search was conducted independently in the databases PubMed and Cochrane Central Register of Controlled Trials (CENTRAL) until April 2020 according to certain inclusion criteria. Data extraction was carried out independently, followed by generalization using descriptive tables. Due to the heterogeneity of the included studies and the impossibility of carrying out a meta-analysis in view of this, we performed a narrative description. Results. A total of 765 potential publications for inclusion were found and checked, of which 53 were included. By design, the studies were assigned to studies of simultaneous design – 40, to randomized clinical trials – 7, to meta-analysis – 6. Data in the included publications on 76802 skin neoplasms were reported, of which 9070 were melanomas. The extracted data were summarized in descriptive tables. Conclusion. With continuing technological progress, the development of noninvasive imaging technologies in the diagnosis of skin melanoma should follow the path of cost-effective, simple and accurate diagnosis.

неинвазивные методы диагностикимеланомачувствительность и специфичностьдерматоскопияспектрофотометрический внутрикожный анализавтоматизированный мультиспектральный цифровой анализрамановская спектроскопияоптическая когерентная томографияконфокальная лазерная микроскопиямультифотонная томографияступенчатая двухфотонная лазерная спектроскопиявысокочастотное ультразвуковое исследованиеэлектроимпедансная спектроскопияnoninvasive diagnostic methodsmelanomasensitivity and specificitydermoscopyspectrophotometric intradermal analysisautomated multispectral digital analysisRaman spectroscopyoptical coherence tomographyconfocal laser microscopymultiphoton tomographytwo-photon laser spectroscopyhigh-frequency ultrasoundelectrical impedance spectroscopyReferencesКаприн А.Д., Старинский В.В., Петрова Г.В. (ред.). Злокачественные новообразования в России в 2018 году (заболеваемость и смертность). М.: МНИОИ им. П.А. Герцена – филиал ФГБУ «НМИЦ радиологии» Минздрава России; 2019. 250 с. 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The authors declare that there are no conflicts of interest present.