medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2020-10-134-142medsovet-5732Research ArticleШКОЛА ПЕДИАТРАPEDIATRICIAN SCHOOLМикробиота кишечника у детей с ожирением. Роль пробиотиковIntestinal microbiota in children with obesity. Role of probioticshttps://orcid.org/0000-0003-4200-4598ЗахароваИ. Н.ZakharovaI. N.

Захарова Ирина Николаевна, д.м.н., профессор, заслуженный врач РФ, заведующая кафедрой педиатрии имени академика Г.Н. Сперанского

125993, Москва, ул. Баррикадная, д. 2/1, стр. 1

Irina N. Zakharova, Honoured Doctor of the Russian Federation, Dr. of Sci. (Med.), Professor, Head of the Department of Pediatrics named after Academician G.N. Speransky

2/1, Bldg. 1, Barrikadnaya St., Moscow, 125993

79166020368@yandex.ruБережнаяИ. В.BerezhnayaI. V.

Бережная Ирина Владимировна, к.м.н., доцент кафедры педиатрии имени академика Г.Н. Сперанского

125993, Москва, ул. Баррикадная, д. 2/1, стр. 1

Irina V. Berezhnaya, Cand. of Sci. (Med.), Associate Professor of the Department of Pediatrics named after Academician G.N. Speransky

2/1, Bldg. 1, Barrikadnaya St., Moscow, 125993

berezhnaya-irina26@yandex.ruСкоробогатоваЕ. В.SkorobogatovaE. V.

Скоробогатова Екатерина Владимировна, к.м.н., заведующая отделением педиатрии № 2

125373, Москва, ул. Героев Панфиловцев, д. 28

Ekaterina V. Skorobogatova, Cand. of Sci. (Med.), head of the Department of Pediatrics No. 2

28, Geroev Panfilovtsev St., Moscow, 125373

katrinscor@mail.ruАйсановаМ. Р.AysanovaM. R.

Айсанова Марьят Романовна, аспирантка кафедры педиатрии имени академика Г.Н. Сперанского

125993, Москва, ул. Баррикадная, д. 2/1, стр. 1

Maryat R. Aysanova, Postgraduate Student of the Department of Pediatrics named after Academician G.N. Speransky

2/1, Bldg. 1, Barrikadnaya St., Moscow, 125993

maryat@inbox.ruБочароваТ. И.BocharovaT. I.

Бочарова Татьяна Ивановна, врач отделения педиатрии № 2

125373, Москва, ул. Героев Панфиловцев, д. 28

Tatyana I. Bocharova, physician of the Department of Pediatrics No. 2

28, Geroev Panfilovtsev St., Moscow, 125373

dr.bocharova@yandex.ruРоссийская медицинская академия непрерывного профессионального образованияРоссияRussian Medical Academy of Continuous Professional EducationRussian FederationДетская городская клиническая больница им. З.А. БашляевойРоссияZ.A. Bashlyaeva City Children’s Clinical HospitalRussian Federation202029072020010134142Copyright © Захарова И.Н., Бережная И.В., Скоробогатова Е.В., Айсанова М.Р., Бочарова Т.И., 20202020Захарова И.Н., Бережная И.В., Скоробогатова Е.В., Айсанова М.Р., Бочарова Т.И.Zakharova I.N., Berezhnaya I.V., Skorobogatova E.V., Aysanova M.R., Bocharova T.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/5732

Ожирение является глобальной проблемой современного здравоохранения. В 2016 г. Всемирная организация здравоохранения подсчитала, что 39% лиц старше 18 лет имеют избыточный вес, а за период с 1975 по 2016 г. количество лиц, страдающих ожирением, во всем мире почти утроилось. Количество детей с избыточной массой и ожирением растет тревожными темпами, причем, по оценкам Всемирной организации здравоохранения, в 2016 г. их число в возрасте до 5 лет превысило 41 млн человек. Научные данные подтверждают гипотезу о том, что развитие ожирения тесно связано с изменениями как функции, так и состава микробиоты кишечника, играющей существенную роль в контроле энергетического обмена и изменения индекса массы тела. Основной терапией ожирения и опосредованных с ним метаболических нарушений до настоящего времени остается корригированная диета в сочетании с физической активностью. Новая терапевтическая стратегия лечения и профилактики ожирения основана на изменении метаболической активности микробиоты кишечника с помощью пробиотиков. Исследования, посвященные изменениям метаболической активности и ожирения, проведенные на грызунах, показали обнадеживающие результаты. Благотворное влияние пробиотиков на здоровье человека сегодня уже не требует доказательств. Пробиотики оказывают комплексное воздействие на физические, биохимические и метаболические параметры, связанные с ожирением, в сочетании с адекватным питанием и коррекцией образа жизни. Пробиотики в присутствии пребиотиков обладают более выраженными метаболическими функциями, способствуют стабилизации состава кишечной микробиоты, поддержанию здоровой массы тела и контролю факторов, связанных с накоплением жира и хроническим воспалением.

Obesity is a global problem of modern healthcare. In 2016, the World Health Organization estimated that 39% of people over 18 were overweight, and the number of obese people worldwide almost tripled over the period from 1975 to 2016. The number of overweight and obese children is growing at an alarming rate, with the World Health Organization estimating that in 2016 the number of overweight children under the age of 5 will exceed 41 million. Scientific evidence supports the hypothesis that the development of obesity is closely related to changes in both the function and composition of the intestinal microbiota, which plays a significant role in controlling energy metabolism and changes in body mass index. The main therapy for obesity and associated metabolic disorders to date has been a corrected diet combined with physical activity. The new therapeutic strategy for the treatment and prevention of obesity is based on changing the metabolic activity of the intestinal microbiota using probiotics. Studies on changes in metabolic activity and obesity in rodents have shown encouraging results. The beneficial effects of probiotics on human health today no longer require proof. Probiotics have an integrated effect on the physical, biochemical and metabolic parameters associated with obesity, combined with adequate nutrition and lifestyle correction. Probiotics in the presence of prebiotics have more pronounced metabolic functions, help stabilize the intestinal microbiota, maintain a healthy body weight and control factors associated with fat accumulation and chronic inflammation.

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The authors declare that there are no conflicts of interest present.