<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2014-5-108-111</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-576</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>РЕВМАТОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>RHEUMATOLOGY</subject></subj-group></article-categories><title-group><article-title>Клинико-фармакологические аспекты выбора и безопасности НПВП у пациентов с цереброваскулярной патологией на фоне ревматоидного артрита</article-title><trans-title-group xml:lang="en"><trans-title>Clinico-pharmacological aspects of choice and safety of NSAIDs in patients with cerebrovascular disease against a background of rheumatoid arthritis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Золотовская</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Zolotovskaya</surname><given-names>I. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Повереннова</surname><given-names>И. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Poverennova</surname><given-names>I. E.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Самарский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>City Polyclinic No. 9 in the Samara Region</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Самарский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Samara State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>30</day><month>12</month><year>2014</year></pub-date><volume>0</volume><issue>5</issue><fpage>108</fpage><lpage>111</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Золотовская И.А., Повереннова И.Е., 2014</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="ru">Золотовская И.А., Повереннова И.Е.</copyright-holder><copyright-holder xml:lang="en">Zolotovskaya I.A., Poverennova I.E.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/576">https://www.med-sovet.pro/jour/article/view/576</self-uri><abstract><p>Проведен ретроспективный анализ рисков применения нестероидных противовоспалительных препаратов (НПВП) при лечении болей в спине у пациентов с цереброваскулярной патологией на фоне ревматоидного артрита. Острые кардио- и цереброваскулярные события были зафиксированы у 9,7% лиц, получавших терапию НПВП. Неблагоприятные эффекты в период лечения были связаны с приемом диклофенака и нимесулида. В группе лиц, принимавших эторикоксиб, суммарные риски были низкими, что позволило провести у всех пациентов запланированные курсы терапии НПВП, в т. ч. и при повторных обращениях.</p></abstract><trans-abstract xml:lang="en"><p>The retrospective study evaluated the risk of using non-steroidal antiinflammatory drugs (NSAIDs) for the treatment of back pain in patients with cerebrovascular disease against a background of rheumatoid arthritis. Acute cardio-and cerebrovascular events were reported in 9.7% of subjects treated with NSAIDs. Adverse effects during treatment were associated with diclofenac and nimesulide. Overall risks were low in the group treated with etoricoxib, allowing for all patients to undergo scheduled courses of NSAID therapy, including upon follow-up visits.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>нестероидные противовоспалительные препараты</kwd><kwd>цереброваскулярная патология</kwd><kwd>эторикоксиб</kwd><kwd>nonsteroidal anti-inflammatory drugs</kwd><kwd>cerebrovascular pathology</kwd><kwd>etoricoxib</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Зырянов С.К., Нельга О.Н. Белоусов Ю.В. Терапия боли: как снизить риск развития неблагоприятных побочных реакций. Consilium Medicum, 2007, 9 (2): 65-67.</mixed-citation><mixed-citation xml:lang="en">Зырянов С.К., Нельга О.Н. Белоусов Ю.В. Терапия боли: как снизить риск развития неблагоприятных побочных реакций. Consilium Medicum, 2007, 9 (2): 65-67.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Каратеев А.Е., Яхно Н.Н., Лазебник Л.Б. и др. Применение нестероидных противовоспалительных препаратов. Клинические рекомендации. М.: ИМА-ПРЕСС, 2009: 167.</mixed-citation><mixed-citation xml:lang="en">Каратеев А.Е., Яхно Н.Н., Лазебник Л.Б. и др. Применение нестероидных противовоспалительных препаратов. Клинические рекомендации. М.: ИМА-ПРЕСС, 2009: 167.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Насонов Е.Л., Тов Н.В., Насонова В.А. Нестероидные противовоспалительные препараты и артериальная гипертензия. Клин, медицина, 1999.</mixed-citation><mixed-citation xml:lang="en">Насонов Е.Л., Тов Н.В., Насонова В.А. Нестероидные противовоспалительные препараты и артериальная гипертензия. Клин, медицина, 1999.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Hermann M. Cardiovascular risk associated with nons-teroidal antiinflammatory drugs. Curr Rheumatol Rep., 2009, 11 (1): 31-5.</mixed-citation><mixed-citation xml:lang="en">Hermann M. Cardiovascular risk associated with nons-teroidal antiinflammatory drugs. Curr Rheumatol Rep., 2009, 11 (1): 31-5.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Hochman J, Shah N. What Price Pain Relief? Circulation, 2006, 113: 2868-2870.</mixed-citation><mixed-citation xml:lang="en">Hochman J, Shah N. What Price Pain Relief? Circulation, 2006, 113: 2868-2870.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">McGettingan P. David Henry. Cardiovascular risk and inhibition of cyclooxygenase. A Systematic Review of the Observational Studies of Selective and Nonselective Inhibitors of Cyclooxygenase 2. JAMA, 2006, 296: 1633-1644.</mixed-citation><mixed-citation xml:lang="en">McGettingan P. David Henry. Cardiovascular risk and inhibition of cyclooxygenase. A Systematic Review of the Observational Studies of Selective and Nonselective Inhibitors of Cyclooxygenase 2. JAMA, 2006, 296: 1633-1644.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Krum H, Swergold G, Gammaitoni A et al. Blood pressure and cardiovascular outcomes in patients taking nonsteroidal antiinflammatory drugs. Cardiovasc Ther, 2012, 30: 342-350.</mixed-citation><mixed-citation xml:lang="en">Krum H, Swergold G, Gammaitoni A et al. Blood pressure and cardiovascular outcomes in patients taking nonsteroidal antiinflammatory drugs. Cardiovasc Ther, 2012, 30: 342-350.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
