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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2020-14-26-32</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-5807</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ДИСЛИПИДЕМИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>DISLIPIDEMIA</subject></subj-group></article-categories><title-group><article-title>Особенности применения фиксированной комбинации розувастатина и эзетимиба для эффективной гиполипидемической терапии</article-title><trans-title-group xml:lang="en"><trans-title>Features of using of a fixed combination of rosuvastatin and ezetimibe for effective hypolipidemic therapy</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9685-4569</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Алексеева</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Alekseeva</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Алексеева Ирина Александровна - кандидат медицинских наук, научный сотрудник лаборатории нарушений липидного обмена Научно-исследовательского института клинической кардиологии имени А.Л. Мясникова.</p><p>121552, Москва, ул. 3-я Черепковская, д. 15а</p></bio><bio xml:lang="en"><p>Irina A. Alekseeva - Cand. of Sci. (Med.), Researcher, Laboratory of Lipid Metabolism Disorders, Myasnikov Research Institute of Clinical Cardiology. </p><p>15а, 3 Cherepkovskaya St., Moscow, 121552</p></bio><email xlink:type="simple">iralex66@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1518-6552</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ежов</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Ezhov</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ежов Марат Владиславович - доктор медицинских наук, профессор, главный научный сотрудник, руководитель лаборатории нарушений липидного обмена Научно-исследовательского института клинической кардиологии имени А.Л. Мясникова.</p><p>121552, Москва, ул. 3-я Черепковская, д. 15а</p></bio><bio xml:lang="en"><p>Marat V. Ezhov - Dr. of Sci. (Med.), Professor, Chief Researcher, Laboratory of Lipid Metabolism Disorders, Myasnikov Research Institute of Clinical Cardiology.</p><p>15а, 3 Cherepkovskaya St., Moscow, 121552</p></bio><email xlink:type="simple">marat_ezhov@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Научно-исследовательский институт клинической кардиологии им. А.Л. Мясникова<country>Россия</country></aff><aff xml:lang="en">Myasnikov Research Institute of Clinical Cardiology, National Medical Research Center of Cardiology<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>14</day><month>10</month><year>2020</year></pub-date><volume>0</volume><issue>14</issue><fpage>26</fpage><lpage>32</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Алексеева И.А., Ежов М.В., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Алексеева И.А., Ежов М.В.</copyright-holder><copyright-holder xml:lang="en">Alekseeva I.A., Ezhov M.V.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/5807">https://www.med-sovet.pro/jour/article/view/5807</self-uri><abstract><p>Смертность от сердечно-сосудистых заболеваний в Российской Федерации остается одной из самых высоких в мире. По сравнению с 2003 г. смертность от сердечно-сосудистых заболеваний в РФ в 2018 г. снизилась на 37%, однако при сравнении с большинством стран Европы она выше в три раза. Большинство случаев смертности от сердечно-сосудистых заболеваний (53%) приходится на ишемическую болезнь сердца, 31% - на цереброваскулярную болезнь. Анализ смертности в РФ демонстрирует существенный вклад гиперхолестеринемии в экономику страны с суммарными потерями в 1,3 трлн руб. ежегодно. Распространенность гиперхолестеринемии в РФ превышает 50% среди трудоспособного населения. По данным исследования «АЙСБЕРГ», частота гиперхолестеринемии на амбулаторном приеме по РФ составляет 84%, при применении гиполипидемической терапии частота достижения целевого уровня общего холестерина крови в амбулаторной практике не превышает 12%. Для снижения смертности от сердечно-сосудистых заболеваний нужны активные мероприятия по их первичной и вторичной профилактике, включая пропаганду здорового образа жизни и назначение по показаниям гиполипидемической терапии. В статье отражена значимость целевого уровня холестерина липопротеидов низкой плотности как основной мишени гиполипидемической терапии в соответствии с современными рекомендациями. Комбинированная гиполипидемическая терапия с использованием наиболее мощного статина - розувастатина и эзетимиба является наиболее эффективной и безопасной стратегией достижения целевых значений липидов в различных популяциях пациентов. В РФ доступен препарат Розулип® Плюс - качественная и проверенная комбинация розувастатина и эзетимиба.</p></abstract><trans-abstract xml:lang="en"><p>Mortality from cardiovascular diseases (CVD) in Russian Federation (RF) remains one of the highest in the world. Compared to 2003, the mortality from CVD decreased by 37%, but when compared with most European countries, it is 3 times higher. Most deaths (53%) occur due to coronary heart disease. While analyzing reasons of mortality, total economic impact due to hypercholesterolemia in RF is estimated as 1,3 trillion RUR annually. The prevalence of hypercholesterolemia is in more than 50% of working-age population in RF. Due to AISBERG study, the prevalence of HCE in ambulatory practice in RF is 84%. When using lipid-lowering medications, the frequency of reaching of target total cholesterol level does not exceed 12%. Active actions on primary and secondary prevention are needed to low mortality rate from CVD, including active promoting of healthy lifestyle, and prescribing if necessary of lipid-lowering therapy (LLT) regimens. The paper deals with significance of target low density lipoprotein cholesterol level in accordance with the latest recommendations as the main aim for LLT. Combined LLT with one of the most potent statins rosuvastatin and ezetimibe seems to be effective and safe strategy for achieving target lipid level in different populations of patients. At present, Rosulip Plus is available in Russia - an quantitative and proven combination of rosuvastatin and ezetimibe.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>сердечно-сосудистые заболевания</kwd><kwd>смертность</kwd><kwd>гиперлипидемия</kwd><kwd>гиперхолестеринемия</kwd><kwd>холестерин липопротеидов низкой плотности</kwd><kwd>розувастатин</kwd><kwd>эзетимиб</kwd><kwd>целевой уровень</kwd></kwd-group><kwd-group xml:lang="en"><kwd>coronary vascular diseases</kwd><kwd>mortality</kwd><kwd>hyperlipidemia</kwd><kwd>hypercholesterolemia</kwd><kwd>low density lipoprotein cholesterol</kwd><kwd>rosuvastatin</kwd><kwd>ezetimibe</kwd><kwd>target level</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Mach F., Baigent C., Catapano A., Koskinas K., Casula M., Badimon L. et al. 2019 ESC/EAS guidelines for the management of dyslipidaemias: lipid modification to reduce cardio vascular risk: The task force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and European Atherosclerosis Society (EAS). 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