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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2020-16-26-35</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-5841</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АКТУАЛЬНЫЕ ВОПРОСЫ ОТОРИНОЛАРИНГОЛОГИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>TOPICAL ISSUES OF OTORHINOLARYNGOLOGY</subject></subj-group></article-categories><title-group><article-title>Актуальная антигистаминная терапия</article-title><trans-title-group xml:lang="en"><trans-title>Actual antihistamine therapy</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2342-8678</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шабанов</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Shabanov</surname><given-names>D. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шабанов Дмитрий Владимирович, врач аллерголог-иммунолог, врач клинической лабораторной диагностики, научный сотрудник лаборатории молекулярных механизмов аллергии, Федеральное государственное бюджетное учреждение «Государственный научный центр «Институт иммунологии» Федерального медико-биологического агентства; cотрудник кафедры клинической иммунологии и аллергологии, Федеральное государственное бюджетное образовательное учреждение высшего образования «Московский государственный медико-стоматологический университет имени А.И. Евдокимова» Министерства здравоохранения Российской Федерации</p><p>115478, Москва, Каширское шоссе, д. 24, </p><p>127473, Москва, ул. Делегатская, д. 20, стр. 1 </p></bio><bio xml:lang="en"><p>Dmitry V. Shabanov, Allergist-Immunologist, Clinical Laboratory Diagnostic Specialist, Research associate at the Laboratory of molecular mechanisms of Allergy, Federal State Budgetary Institute “National Research Center – Institute of Immunology” Federal Medical-Biological Agency of Russia; senior laboratory assistant of the Department of Clinical Allergology and Immunology, Federal State Budgetary Educational Institution of the Higher Education “Yevdokimov Moscow State University of Medicine and Dentistry” of the Ministry of Healthcare of the Russian Federation</p><p>24, Kashirskoye Shosse, Moscow, 115478, </p><p>20, Bldg. 1, Delegatskaya St., Moscow, 127473</p></bio><email xlink:type="simple">dr.shabanov@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8167-9681</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лутковская</surname><given-names>Ю. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Lutkovskaya</surname><given-names>Ju. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лутковская Юлия Евгеньевна, кандидат медицинских наук, врач аллерголог-иммунолог, доцент кафедры клинической аллергологии и иммунологии</p><p>127473, Москва, ул. Делегатская, д. 20, стр. 1 </p></bio><bio xml:lang="en"><p>Julia E. Lutkovskaya, Cand. of Sci. (Med.), Allergist Immunologist, assistant of the Department of Clinical Allergology and Immunology</p><p>20, Bldg. 1, Delegatskaya St., Moscow, 127473</p></bio><email xlink:type="simple">lutkovskaya_je@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Институт иммунологии;&#13;
Московский государственный медико-стоматологический университет им. А.И. Евдокимова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>National Research Center – Institute of Immunology;&#13;
Yevdokimov Moscow State University of Medicine and Dentistry</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Московский государственный медико-стоматологический университет им. А.И. Евдокимова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Yevdokimov Moscow State University of Medicine and Dentistry</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>12</day><month>11</month><year>2020</year></pub-date><volume>0</volume><issue>16</issue><fpage>26</fpage><lpage>35</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шабанов Д.В., Лутковская Ю.Е., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Шабанов Д.В., Лутковская Ю.Е.</copyright-holder><copyright-holder xml:lang="en">Shabanov D.V., Lutkovskaya J.E.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/5841">https://www.med-sovet.pro/jour/article/view/5841</self-uri><abstract><p>Значимость вопросов аллергических заболеваний не вызывает сомнения. Трудно найти человека, не перенесшего хоть какой-нибудь симптом аллергии, не у всех развиваются заболевания, но с симптомами аллергии сталкивается большинство. Распространенность различных аллергических заболеваний увеличивается ежегодно, в настоящее время достигает 30% населения и, по прогнозам Всемирной организации здравоохранения, достигнет 50% в ближайшие несколько десятилетий. Наиболее распространенными нозологиями являются аллергический ринит, бронхиальная астма, атопический дерматит, крапивница, однако существует и много других состояний гиперчувствительности. В данной статье затронуты вопросы воспалительных реакций в целом и аллергического воспаления в частности, рассмотрены основные аспекты патогенеза аллергического ринита и крапивницы, вопросы медикаментозной терапии этих заболеваний. Большинство людей уверены, что от аллергии можно принимать противоаллергические препараты, и чаще всего имеются в виду антигистаминные лекарственные препараты. К сожалению, понимания особенностей терапии антигистаминными лекарствами не хватает даже некоторым медицинским специалистам, до сих пор некоторые уверены в существовании трех или четырех поколений антигистаминных лекарств, а пациенты используют лекарства не по назначению врачей, а по рекомендации знакомых или просто провизоров аптек. Нерациональное использование антигистаминных препаратов приводит к снижение эффективности, и нередко происходит дискредитирование конкретных лекарств и группы препаратов в целом. В настоящей статье продемонстрированы результаты различных европейских и азиатских исследований по эффективности и безопасности антигистаминных препаратов, в частности биластина, а также собственный опыт использования антигистаминных препаратов в практике.</p></abstract><trans-abstract xml:lang="en"><p>The significance of the issues of allergic diseases is not in doubt. It is difficult to find a person who has not suffered at least some Allergy symptom, not everyone develops diseases, but most people face Allergy symptoms. The prevalence of various allergic diseases is increasing every year, currently reaching 30% of the population, and the world health organization predicts it will reach 50% in the next few decades. The most common nosologies are allergic rhinitis, bronchial asthma, atopic dermatitis, urticaria, but there are many other conditions of hypersensitivity. This article addresses the issues of inflammatory reactions in General and specifically allergic inflammation, discusses the main aspects of the pathogenesis of allergic rhinitis and urticaria, and questions of drug therapy for these diseases. Most people are sure that they can take anti-allergic medications for allergies, and most often they are referring to antihistamines. Unfortunately, even some medical specialists lack an understanding of the specifics of antihistamine therapy. some people still believe that there are three or four generations of antihistamines, and patients use drugs not as prescribed by doctors, but on the recommendation of friends or pharmacists. Irrational use of antihistamines leads to a decrease in effectiveness, and it is not uncommon to discredit specific drugs and groups of drugs in General. This article demonstrates the results of various European and Asian studies on the effectiveness and safety of antihistamines and bilastin in particular, as well as their own experience of using antihistamines in practice.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>аллергия</kwd><kwd>аллергическое воспаление</kwd><kwd>гиперчувствительность</kwd><kwd>гистамин</kwd><kwd>аллергический ринит</kwd><kwd>крапивница</kwd><kwd>антигистаминные препараты</kwd><kwd>биластин</kwd></kwd-group><kwd-group xml:lang="en"><kwd>allergy</kwd><kwd>allergic inflammation</kwd><kwd>hypersensitivity</kwd><kwd>histamine</kwd><kwd>allergic rhinitis</kwd><kwd>urticaria</kwd><kwd>antihistamines</kwd><kwd>bilastin</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Yuksel H., Dinc G., Sakar A., Yilmaz O., Yorgancioglu A., Celik P. et al. 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