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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2020-16-134-138</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-5858</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ШКОЛА ОТОРИНОЛАРИНГОЛОГА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>THE SCHOOL’S OF OTORHINOLARYNGOLOGIST</subject></subj-group></article-categories><title-group><article-title>Топические деконгестанты длительного действия</article-title><trans-title-group xml:lang="en"><trans-title>Long-acting topical decongestants</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7262-1151</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Овчинников</surname><given-names>А. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Ovchinnikov</surname><given-names>A. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Овчинников Андрей Юрьевич, доктор медицинских наук, профессор, заведующий кафедрой оториноларингологии</p><p>127473, Москва, ул. Делегатская, д. 20, стр. 1 </p></bio><bio xml:lang="en"><p>Andrey Yu. Ovchinnikov, Dr. of Sci. (Med.), Professor, Head of Department of Otorhinolaryngology</p><p>20, Bldg. 1, Delegateskaya St., Moscow, 127473</p></bio><email xlink:type="simple">lorent1@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4213-6435</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мирошниченко</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Miroshnichenko</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мирошниченко Нина Александровна, доктор медицинских наук, профессор кафедры оториноларингологии</p><p>127473, Москва, ул. Делегатская, д. 20, стр. 1 </p></bio><bio xml:lang="en"><p>Nina A. Miroshnichenko, Dr. of Sci. (Med.), Professor of Department of Otorhinolaryngology</p><p>20, Bldg. 1, Delegateskaya St., Moscow, 127473</p></bio><email xlink:type="simple">mirnino@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5227-3145</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рябинин</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Ryabinin</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Рябинин Владлен Алексеевич, кандидат медицинских наук, доцент, профессор кафедры оториноларингологии</p><p>127473, Москва, ул. Делегатская, д. 20, стр. 1 </p></bio><bio xml:lang="en"><p>Vladlen A. Ryabinin, Cand. of Sci. (Med.), Docent of Department of Otorhinolaryngology</p><p>20, Bldg. 1, Delegateskaya St., Moscow, 127473</p></bio><email xlink:type="simple">vladiolus@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7930-8259</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Николаева</surname><given-names>Ю. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Nikolaeva</surname><given-names>Yu. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Николаева Юлия Олеговна, аспирантка кафедры оториноларингологии</p><p>127473, Москва, ул. Делегатская, д. 20, стр. 1 </p></bio><bio xml:lang="en"><p>Yulia O. Nikolaeva, graduate student, Postgraduate of Department of Otorhinolaryngology</p><p>20, Bldg. 1, Delegateskaya St., Moscow, 127473</p></bio><email xlink:type="simple">yu.o.nikolaeva@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Московский государственный медико-стоматологический университет им. А.И. Евдокимова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Yevdokimov Moscow State University of Medicine and Dentistry</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>13</day><month>11</month><year>2020</year></pub-date><volume>0</volume><issue>16</issue><fpage>134</fpage><lpage>138</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Овчинников А.Ю., Мирошниченко Н.А., Рябинин В.А., Николаева Ю.О., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Овчинников А.Ю., Мирошниченко Н.А., Рябинин В.А., Николаева Ю.О.</copyright-holder><copyright-holder xml:lang="en">Ovchinnikov A.Y., Miroshnichenko N.A., Ryabinin V.A., Nikolaeva Y.O.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/5858">https://www.med-sovet.pro/jour/article/view/5858</self-uri><abstract><p>Носовое дыхание играет важную роль для поступления в организм человека необходимого количества воздуха. Полость носа, благодаря сложной структуре слизистой оболочки, подготавливает воздух к взаимодействию с нижними отделами дыхательных путей. При возникновении назальной обструкции дыхание осуществляется главным образом через рот, и происходит нарушение основных функций носа, а также попадание неадаптированного воздуха, агрессивного к чувствительным альвеолярным структурам легких. Это приводит вначале к функциональным, а затем к морфологическим и структурным изменениям. Кроме того, затруднение носового дыхания приводит к нарушению аэрации околоносовых полостей, полости среднего уха и гипоксии всех органов организма. Даже непродолжительные эпизоды назальной обструкции влияют на качество жизни, а затянувшиеся нелеченые или некорректно леченные острые вирусные риносинуситы могут перетечь в затяжные бактериальные заболевания лор-органов. Для ликвидации заложенности носа используются деконгестанты, к которым относится широкий спектр веществ, использующихся местно или системно в форме монотерапии, а также в комбинации с другими веществами. Наиболее популярными препаратами из этой группы являются топические деконгестанты, поскольку они обладают наиболее выраженным эффектом. Основные назальные деконгестанты можно разделить на две группы: симпатомиметические амины: первичные алифатические; фенольные и нефенольные соединения, а также имидазолиновые производные. Из современных сосудосуживающих препаратов хорошо себя зарекомендовал оксиметазолин. Применение его строго по инструкции в течение 3–5 дней гарантирует отсутствие развития местных и системных осложнений.</p></abstract><trans-abstract xml:lang="en"><p>Significant role of getting the required amount of air into the human body belongs to the breathing by the nose. The nasal cavity prepares the air for reciprocity with the lower respiratory tract owing to the complex structure of the mucous membrane. When nasal obstruction occurs, breathing is carried out mainly through the mouth, and there is a violation of the basic functions of the nose, as well as the ingress of unadapted aggressive air to the sensitive alveolar structures of the lungs. This leads first to functional, and then to morphological and structural changes. In addition, difficult nasal breathing leads to impaired aeration of the paranasal cavities, middle ear cavity and hypoxia of all organs of the body. Even short episodes of nasal obstruction affect the quality of life, and prolonged untreated or incorrectly treated acute viral rhinosinusitis can spill over into lingering bacterial diseases of the ENT organs. Decongestants are used to eliminate nasal congestion. Decongestants include a wide range of substances that are used topically or systemically, in the form of monotherapy or in combination with other substances. The most popular drugs in this group are topical decongestants, since they have the most pronounced effect. The main nasal decongestants can be divided into two groups: sympathomimetic amines: primary aliphatic; phenolic and non-phenolic compounds, as well as imidazoline derivatives. Among the modern vasoconstrictor drugs oxymetazoline. Using it strictly according to the instructions within 3–5 days guarantees the absence of the development of local and systemic complications.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ринит</kwd><kwd>заложенность носа</kwd><kwd>назальная обструкция</kwd><kwd>деконгестанты</kwd><kwd>оксиметазолин</kwd></kwd-group><kwd-group xml:lang="en"><kwd>rhinitis</kwd><kwd>nasal congestion</kwd><kwd>nasal obstruction</kwd><kwd>decongestants</kwd><kwd>oxymetazoline</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Van Gerven L., Steelant B., Hellings P.W. Nasal hyperreactivity in rhinitis: A diagnostic and therapeutic challenge. Allergy. 2018;73(9):1784–1791. doi: 10.1111/all.13453.</mixed-citation><mixed-citation xml:lang="en">Van Gerven L., Steelant B., Hellings P.W. Nasal hyperreactivity in rhinitis: A diagnostic and therapeutic challenge. 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