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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2020-18-115-121</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-5903</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АЛЛЕРГОЛОГИЯ И ИММУНОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ALLERGOLOGY AND IMMUNOLOGY</subject></subj-group></article-categories><title-group><article-title>Клиническая эффективность препарата меполизумаб в терапии тяжелой эозинофильной астмы у детей</article-title><trans-title-group xml:lang="en"><trans-title>Clinical efficacy of mepolizumab in the treatment of severe eosinophilic asthma in children</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0535-2916</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дроздов</surname><given-names>В. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Drozdov</surname><given-names>V. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор, профессор кафедры клинической фармакологии и пропедевтики внутренних болезней</p><p>119991, Россия, Москва, ул. Трубецкая, д. 8, стр. 2 </p></bio><bio xml:lang="en"><p>Dr. of Sci. (Med.), Professor of the Department of Clinical Pharmacology and Propaedeutics of Internal Diseases</p><p>8, Bldg. 2, Trubetskaya St., Moscow, 119991, Russia </p></bio><email xlink:type="simple">vndrozdov@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7430-3341</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Астаповский</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Astapovskiy</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>клинический ординатор кафедры клинической фармакологии и пропедевтики внутренних болезней</p><p>119991, Россия, Москва, ул. Трубецкая, д. 8, стр. 2 </p></bio><bio xml:lang="en"><p>Clinical resident of the Department of Clinical Pharmacology and Propaedeutics of Internal Diseases</p><p>8, Bldg. 2, Trubetskaya St., Moscow, 119991, Russia </p></bio><email xlink:type="simple">al.astapovskii@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7163-7119</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сереброва</surname><given-names>С. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Serebrova</surname><given-names>S. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., главный научный сотрудник Центра клинической фармакологии; профессор кафедры  клинической фармакологии и пропедевтики внутренних болезней</p><p>127051, Россия, Москва, Петровский бульвар, д. 8, стр. 2</p><p>119991, Россия, Москва, ул. Трубецкая, д. 8, стр. 2 </p></bio><bio xml:lang="en"><p>Dr. of Sci. (Med.), Chief Researcher of Clinical Pharmacology Centre; Professor of the Department of Clinical Pharmacology and Propaedeutics of Internal Diseases</p><p>8, Bldg. 2, Petrovsky Boulevard, Moscow, 127051, Russia</p><p>8, Bldg. 2, Trubetskaya St., Moscow, 119991, Russia </p></bio><email xlink:type="simple">svetaserebrova@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6589-7654</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ших</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Shikh</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор, заведующая кафедрой клинической фармакологии и пропедевтики внутренних болезней</p><p>119991, Россия, Москва, ул. Трубецкая, д. 8, стр. 2 </p></bio><bio xml:lang="en"><p>Dr. of Sci. (Med.), Chair of the Department of Clinical Pharmacology and Propaedeutics of Internal Diseases</p><p>8, Bldg. 2, Trubetskaya St., Moscow, 119991, Russia </p></bio><email xlink:type="simple">chih@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5621-2721</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Комиссаренко</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Komissarenko</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор кафедры поликлинической терапии</p><p>127473, Россия, Москва, ул. Делегатская, д. 20, стр. 1 </p></bio><bio xml:lang="en"><p>Dr. of Sci. (Med.), Professor of the Department of Polyclinic Therapy</p><p>20, Bldg. 1, Delegateskaya St., Moscow, 127473, Russia </p></bio><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное автономное образовательное учреждение высшего образования «Первый Московский государственный медицинский университет имени И.М. Сеченова» Министерства здравоохранения Российской Федерации (Сеченовский Университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Autonomous Educational Institution of Higher Education “Sechenov First Moscow State Medical University” of the Ministry of Health of the Russian Federation (Sechenov University)</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Федеральное государственное автономное образовательное учреждение высшего образования «Первый Московский государственный медицинский университет имени И.М. Сеченова» Министерства здравоохранения Российской Федерации (Сеченовский  Университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Autonomous Educational Institution of Higher Education “Sechenov First Moscow State Medical University” of the Ministry of Health of the Russian Federation (Sechenov University)</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное учреждение «Научный центр экспертизы средств медицинского применения» Министерства здравоохранения Российской Федерации;&#13;
Федеральное государственное автономное образовательное учреждение высшего образования «Первый Московский государственный медицинский университет имени И.М. Сеченова» Министерства здравоохранения Российской Федерации (Сеченовский Университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Budgetary Institution “Scientific Centre for Expert Evaluation of Medicinal Products”;&#13;
Federal State Autonomous Educational Institution of Higher Education “Sechenov First Moscow State Medical University” of the Ministry of Health of the Russian Federation (Sechenov University)</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное образовательное учреждение высшего образования «Московский государственный медико-стоматологический университет имени А.И. Евдокимова» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Budgetary Educational Institution of the Higher Education “Yevdokimov Moscow State University of Medicine and Dentistry” of the Ministry of Healthcare of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>27</day><month>11</month><year>2020</year></pub-date><volume>0</volume><issue>18</issue><fpage>115</fpage><lpage>121</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Дроздов В.Н., Астаповский А.А., Сереброва С.Ю., Ших Е.В., Комиссаренко И.А., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Дроздов В.Н., Астаповский А.А., Сереброва С.Ю., Ших Е.В., Комиссаренко И.А.</copyright-holder><copyright-holder xml:lang="en">Drozdov V.N., Astapovskiy A.A., Serebrova S.Y., Shikh E.V., Komissarenko I.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/5903">https://www.med-sovet.pro/jour/article/view/5903</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>тяжелая бронхиальная астма</kwd><kwd>меполизумаб</kwd><kwd>эозинофилы</kwd><kwd>интерлейкин-5</kwd><kwd>дети</kwd></kwd-group><kwd-group xml:lang="en"><kwd>severe asthma</kwd><kwd>mepolizumab</kwd><kwd>eosinophils</kwd><kwd>interleukin-5</kwd><kwd>children</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Vos T., Flaxman A.D., Naghavi M., Lozano R., Michaud C., Ezzati M. et al. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380(9859):2163–2196. doi: 10.1016/S0140-6736(12)61729-2.</mixed-citation><mixed-citation xml:lang="en">Vos T., Flaxman A.D., Naghavi M., Lozano R., Michaud C., Ezzati M. et al. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380(9859):2163–2196. doi: 10.1016/S0140-6736(12)61729-2.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Chuchalin A., Khaltaev N., Antonov N., Galkin D., Manakov L., Antonini P. et al. Chronic respiratory diseases and risk factors in 12 regions of the Russian Federation. Int J Chron Obstruct Pulmon Dis. 2014;9(1):963–974. doi: 10.2147/copd.s67283.</mixed-citation><mixed-citation xml:lang="en">Chuchalin A., Khaltaev N., Antonov N., Galkin D., Manakov L., Antonini P. et al. Chronic respiratory diseases and risk factors in 12 regions of the Russian Federation. Int J Chron Obstruct Pulmon Dis. 2014;9(1):963–974. doi: 10.2147/copd.s67283.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Авдеев С.Н., Ненашева Н.М., Жуденков К.В., Петраковская В.А., Изюмова Г.В. Распространенность, заболеваемость, фенотипы и другие характеристики тяжелой бронхиальной астмы в Российской Федерации. Пульмонология. 2018;28(3):341–358. doi: 10.18093/0869-0189-2018-28-3-341-358.</mixed-citation><mixed-citation xml:lang="en">Avdeev S.N., Nenasheva N.M., Zhudenkov K.V., Petrakovskaya V.A., Izyumova G.V. Prevalence, morbidity, phenotypes and other characteristics of severe bronchial asthma in Russian Federation. Pulmonologiya = Russian Pulmonology Journal. 2018;28(3):341–358. (In Russ.) doi: 10.18093/0869-0189-2018-28-3-341-358.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Поликарпов А.В., Александрова Г.А., Голубева Н.А., Тюрина Е.М., Оськов Ю.И., Шелепова Е.А. Общая заболеваемость детского населения России (0–14 лет) в 2017 году: cтатистические материалы. Ч. VI. 2018. 144 с. Режим доступа: https://minzdrav.gov.ru/ministry/61/22/stranitsa-979/statisticheskie-i-informatsionnye-materialy/statisticheskiy-sbornik-2017-god.</mixed-citation><mixed-citation xml:lang="en">https://minzdrav.gov.ru/ministry/61/22/stranitsa-979/statisticheskie-i-informatsionnye-materialy/statisticheskiy-sbornik-2017-god.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Moore W.С., Meyers D.A., Wenzel S.E., Teague W.G., Li H., Li X. et al. Identification of Asthma Phenotypes Using Cluster Analysis in the Severe Asthma Research Program. Am J Respir Critic Care Med. 2010;181(4):315–323. doi: 10.1164/rccm.200906-0896oc.</mixed-citation><mixed-citation xml:lang="en">Moore W.С., Meyers D.A., Wenzel S.E., Teague W.G., Li H., Li X. et al. Identification of Asthma Phenotypes Using Cluster Analysis in the Severe Asthma Research Program. Am J Respir Critic Care Med. 2010;181(4):315–323. doi: 10.1164/rccm.200906-0896oc.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Chung K.F. Asthma phenotyping: a necessity for improved therapeutic precision and new targeted therapies. J Int Med. 2015;279(2):192–204. doi: 10.1111/joim.12382.</mixed-citation><mixed-citation xml:lang="en">Chung K.F. Asthma phenotyping: a necessity for improved therapeutic precision and new targeted therapies. J Int Med. 2015;279(2):192–204. doi: 10.1111/joim.12382.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Fitzpatrick A.M., Jackson D.J., Mauger D.T., Boehmer S.J., Phipatanakul W., Sheehan W.J. et al. Individualized therapy for persistent asthma in young children. J Allergy Clin Immunol. 2016;138(6):1608–1618.e12. doi: 10.1016/j.jaci.2016.09.028.</mixed-citation><mixed-citation xml:lang="en">Fitzpatrick A.M., Jackson D.J., Mauger D.T., Boehmer S.J., Phipatanakul W., Sheehan W.J. et al. Individualized therapy for persistent asthma in young children. J Allergy Clin Immunol. 2016;138(6):1608–1618.e12. doi: 10.1016/j.jaci.2016.09.028.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Guilbert T.W., Bacharier L.B., Fitzpatrick A.M. Severe Asthma in Children. J Allergy Clin Immunol Pract. 2014;2(5):489–500. doi: 10.1016/j.jaip.2014.06.022.</mixed-citation><mixed-citation xml:lang="en">Guilbert T.W., Bacharier L.B., Fitzpatrick A.M. Severe Asthma in Children. J Allergy Clin Immunol Pract. 2014;2(5):489–500. doi: 10.1016/j.jaip.2014.06.022.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Chung K.F., Wenzel S.E., Brozek J.L., Bush A., Castro M., Sterk P.J. et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J. 2013;43(2):343–373. doi: 10.1183/09031936.00202013.</mixed-citation><mixed-citation xml:lang="en">Chung K.F., Wenzel S.E., Brozek J.L., Bush A., Castro M., Sterk P.J. et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J. 2013;43(2):343–373. doi: 10.1183/09031936.00202013.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Vottero A., Kino T., Combe H., Lecomte P., Chrousos G.P. A Novel, C-Terminal Dominant Negative Mutation of the GR Causes Familial Glucocorticoid Resistance through Abnormal Interactions with p160 Steroid Receptor Coactivators. J Clin Endocrinol Metab. 2002;87(6):2658–2667. doi: 10.1210/jcem.87.6.8520.</mixed-citation><mixed-citation xml:lang="en">Vottero A., Kino T., Combe H., Lecomte P., Chrousos G.P. A Novel, C-Terminal Dominant Negative Mutation of the GR Causes Familial Glucocorticoid Resistance through Abnormal Interactions with p160 Steroid Receptor Coactivators. J Clin Endocrinol Metab. 2002;87(6):2658–2667. doi: 10.1210/jcem.87.6.8520.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Israel E., Drazen J.M., Liggett S.B., Boushey H.A., Cherniack R.M., Chinchilli V.M. et al. Effect of Polymorphism of the β(2)-Adrenergic Receptor on Response to Regular Use of Albuterol in Asthma. Int Arch Allergy Immunol. 2001;124(1–3):183–186. doi: 10.1159/000053705.</mixed-citation><mixed-citation xml:lang="en">Israel E., Drazen J.M., Liggett S.B., Boushey H.A., Cherniack R.M., Chinchilli V.M. et al. Effect of Polymorphism of the β(2)-Adrenergic Receptor on Response to Regular Use of Albuterol in Asthma. Int Arch Allergy Immunol. 2001;124(1–3):183–186. doi: 10.1159/000053705.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Barnes P.J. Corticosteroid resistance in patients with asthma and chronic obstructive pulmonary disease. J Allergy Clin Immunol. 2013;131(3):636–645. doi: 10.1016/j.jaci.2012.12.1564.</mixed-citation><mixed-citation xml:lang="en">Barnes P.J. Corticosteroid resistance in patients with asthma and chronic obstructive pulmonary disease. J Allergy Clin Immunol. 2013;131(3):636–645. doi: 10.1016/j.jaci.2012.12.1564.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Gagliardo R., Chanez P., Vignola A.M., Bousquet J., Vachier I., Godard P. et al. Glucocorticoid Receptor α and β in Glucocorticoid Dependent Asthma. Am J Respir Crit Care Med. 2000;162(1):7–13. doi: 10.1164/ajrccm.162.1.9911032.</mixed-citation><mixed-citation xml:lang="en">Gagliardo R., Chanez P., Vignola A.M., Bousquet J., Vachier I., Godard P. et al. Glucocorticoid Receptor α and β in Glucocorticoid Dependent Asthma. Am J Respir Crit Care Med. 2000;162(1):7–13. doi: 10.1164/ajrccm.162.1.9911032.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Gupta A., Sjoukes A., Richards D., Banya W., Hawrylowicz C., Bush A., Saglani S. Relationship between Serum Vitamin D, Disease Severity, and Airway Remodeling in Children with Asthma. Am J Respir Crit Care Med. 2011;184(12):1342–1349. doi: 10.1164/rccm.201107-1239oc.</mixed-citation><mixed-citation xml:lang="en">Gupta A., Sjoukes A., Richards D., Banya W., Hawrylowicz C., Bush A., Saglani S. Relationship between Serum Vitamin D, Disease Severity, and Airway Remodeling in Children with Asthma. Am J Respir Crit Care Med. 2011;184(12):1342–1349. doi: 10.1164/rccm.201107-1239oc.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Saglani S., Lloyd C.M. Novel concepts in airway inflammation and remodelling in asthma. Eur Respir J. 2015;46(6):1796–1804. doi: 10.1183/13993003.01196-2014.</mixed-citation><mixed-citation xml:lang="en">Saglani S., Lloyd C.M. Novel concepts in airway inflammation and remodelling in asthma. Eur Respir J. 2015;46(6):1796–1804. doi: 10.1183/13993003.01196-2014.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Bossley C.J., Fleming L., Ullmann N., Gupta A., Adams A., Nagakumar P. et al. Assessment of corticosteroid response in pediatric patients with severe asthma by using a multidomain approach. J Allergy Clin Immunol. 2016;138(2):413–420.e6. doi: 10.1016/j.jaci.2015.12.1347.</mixed-citation><mixed-citation xml:lang="en">Bossley C.J., Fleming L., Ullmann N., Gupta A., Adams A., Nagakumar P. et al. Assessment of corticosteroid response in pediatric patients with severe asthma by using a multidomain approach. J Allergy Clin Immunol. 2016;138(2):413–420.e6. doi: 10.1016/j.jaci.2015.12.1347.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Hossny E., Rosario N., Lee B.W., Singh M., El-Ghoneimy D., Soh J., Le Souef P. The use of inhaled corticosteroids in pediatric asthma: update. World Allergy Organ J. 2016;9:26. doi: 10.1186/s40413-016-0117-0.</mixed-citation><mixed-citation xml:lang="en">Hossny E., Rosario N., Lee B.W., Singh M., El-Ghoneimy D., Soh J., Le Souef P. The use of inhaled corticosteroids in pediatric asthma: update. World Allergy Organ J. 2016;9:26. doi: 10.1186/s40413-016-0117-0.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Milburn M., Hassell A.M., Lambert M.H., Jordan S.R., Proudfoot A.E., Graber P., Wells T.N. A novel dimer configuration revealed by the crystal structure at 2.4 A resolution of human interleukin-5. Nature. 1993;363(6425):172–176. doi: 10.1038/363172a0.</mixed-citation><mixed-citation xml:lang="en">Milburn M., Hassell A.M., Lambert M.H., Jordan S.R., Proudfoot A.E., Graber P., Wells T.N. A novel dimer configuration revealed by the crystal structure at 2.4 A resolution of human interleukin-5. Nature. 1993;363(6425):172–176. doi: 10.1038/363172a0.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Kouro T., Takatsu K. IL-5- and eosinophil-mediated inflammation: from discovery to therapy. Int Immunol. 2009;21(12):1303–1309. doi: 10.1093/intimm/dxp102.</mixed-citation><mixed-citation xml:lang="en">Kouro T., Takatsu K. IL-5- and eosinophil-mediated inflammation: from discovery to therapy. Int Immunol. 2009;21(12):1303–1309. doi: 10.1093/intimm/dxp102.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Dent L.A., Strath M., Mellor A.L., Sanderson C.J. Eosinophilia in transgenic mice expressing interleukin 5. J Exp Med. 1990;172(5):1425–1431. doi: 10.1084/jem.172.5.1425.</mixed-citation><mixed-citation xml:lang="en">Dent L.A., Strath M., Mellor A.L., Sanderson C.J. Eosinophilia in transgenic mice expressing interleukin 5. J Exp Med. 1990;172(5):1425–1431. doi: 10.1084/jem.172.5.1425.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Azzawi M., Bradley B., Jeffery P.K., Frew A.J., Wardlaw A.J., Knowles G. et al. Identification of Activated T Lymphocytes and Eosinophils in Bronchial Biopsies in Stable Atopic Asthma. Am Rev Respir Dis. 1990;142(6 Pt 1): 1407–1413. doi: 10.1164/ajrccm/142.6_pt_1.1407.</mixed-citation><mixed-citation xml:lang="en">Azzawi M., Bradley B., Jeffery P.K., Frew A.J., Wardlaw A.J., Knowles G. et al. Identification of Activated T Lymphocytes and Eosinophils in Bronchial Biopsies in Stable Atopic Asthma. Am Rev Respir Dis. 1990;142(6 Pt 1): 1407–1413. doi: 10.1164/ajrccm/142.6_pt_1.1407.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Foster P.S., Hogan S.P., Ramsay A.J., Matthaei K.I., Young I.G. Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model. J Exp Med. 1996;183(1):195–201. doi: 10.1084/jem.183.1.195.</mixed-citation><mixed-citation xml:lang="en">Foster P.S., Hogan S.P., Ramsay A.J., Matthaei K.I., Young I.G. Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model. J Exp Med. 1996;183(1):195–201. doi: 10.1084/jem.183.1.195.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Leckie M.J., ten Brinke A., Khan J., Diamant Z., O’Connor B.J., Walls C.M. et al. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet. 2000;356(9248):2144–2148. doi: 10.1016/s0140-6736(00)03496-6.</mixed-citation><mixed-citation xml:lang="en">Leckie M.J., ten Brinke A., Khan J., Diamant Z., O’Connor B.J., Walls C.M. et al. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet. 2000;356(9248):2144–2148. doi: 10.1016/s0140-6736(00)03496-6.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Flood-Page P., Swenson C., Faiferman I., Matthews J., Williams M., Brannick L. et al. A Study to Evaluate Safety and Efficacy of Mepolizumab in Patients with Moderate Persistent Asthma. Am J Respir Crit Care Med. 2007;176(11):1062–1071. doi: 10.1164/rccm.200701-085oc.</mixed-citation><mixed-citation xml:lang="en">Flood-Page P., Swenson C., Faiferman I., Matthews J., Williams M., Brannick L. et al. A Study to Evaluate Safety and Efficacy of Mepolizumab in Patients with Moderate Persistent Asthma. Am J Respir Crit Care Med. 2007;176(11):1062–1071. doi: 10.1164/rccm.200701-085oc.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Powell C., Milan S.J., Dwan K., Bax L., Walters N. Mepolizumab versus placebo for asthma. Cochrane Database Syst Rev. 2015; (7):CD010834. doi: 10.1002/14651858.cd010834.pub2.</mixed-citation><mixed-citation xml:lang="en">Powell C., Milan S.J., Dwan K., Bax L., Walters N. Mepolizumab versus placebo for asthma. Cochrane Database Syst Rev. 2015; (7):CD010834. doi: 10.1002/14651858.cd010834.pub2.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Haldar P., Brightling C.E., Hargadon B., Gupta S., Monteiro W., Sousa A. et al. Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma. N Engl J Med. 2009;360(10):973–984. doi: 10.1056/nejmoa0808991.</mixed-citation><mixed-citation xml:lang="en">Haldar P., Brightling C.E., Hargadon B., Gupta S., Monteiro W., Sousa A. et al. Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma. N Engl J Med. 2009;360(10):973–984. doi: 10.1056/nejmoa0808991.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Nair P., Pizzichini M.M., Kjarsgaard M., Inman M.D., Efthimiadis A., Pizzichini E. et al. Mepolizumab for Prednisone-Dependent Asthma with Sputum Eosinophilia. N Engl J Med. 2009;360(10):985–993. doi: 10.1056/nejmoa0805435.</mixed-citation><mixed-citation xml:lang="en">Nair P., Pizzichini M.M., Kjarsgaard M., Inman M.D., Efthimiadis A., Pizzichini E. et al. Mepolizumab for Prednisone-Dependent Asthma with Sputum Eosinophilia. N Engl J Med. 2009;360(10):985–993. doi: 10.1056/nejmoa0805435.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Pavord I., Korn S., Howarth P., Bleecker E.R., Buhl R., Keene O.N. et al. Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial. Lancet. 2012;380(9842):651–659. doi: 10.1016/s0140-6736(12)60988-x.</mixed-citation><mixed-citation xml:lang="en">Pavord I., Korn S., Howarth P., Bleecker E.R., Buhl R., Keene O.N. et al. Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial. Lancet. 2012;380(9842):651–659. doi: 10.1016/s0140-6736(12)60988-x.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Bel E.H., Wenzel S.E., Thompson P.J., Prazma C.M., Keene O.N., Yancey S.W. et al. Oral Glucocorticoid-Sparing Effect of Mepolizumab in Eosinophilic Asthma. N Engl J Med. 2014;371(13):1189–1197. doi: 10.1056/nejmoa1403291.</mixed-citation><mixed-citation xml:lang="en">Bel E.H., Wenzel S.E., Thompson P.J., Prazma C.M., Keene O.N., Yancey S.W. et al. Oral Glucocorticoid-Sparing Effect of Mepolizumab in Eosinophilic Asthma. N Engl J Med. 2014;371(13):1189–1197. doi: 10.1056/nejmoa1403291.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Ortega H.G., Liu M.C., Pavord I.D., Brusselle G.G., FitzGerald J.M., Chetta A. et al. Mepolizumab Treatment in Patients with Severe Eosinophilic Asthma. N Engl J Med. 2014;371(13):1198–1207. doi: 10.1056/nejmoa1403290.</mixed-citation><mixed-citation xml:lang="en">Ortega H.G., Liu M.C., Pavord I.D., Brusselle G.G., FitzGerald J.M., Chetta A. et al. Mepolizumab Treatment in Patients with Severe Eosinophilic Asthma. N Engl J Med. 2014;371(13):1198–1207. doi: 10.1056/nejmoa1403290.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Ferguson G., FitzGerald J.M., Bleecker E.R., Laviolette M., Bernstein D., LaForce C. et al. Benralizumab for patients with mild to moderate, persistent asthma (BISE): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Respir Med. 2017;5(7):568–576. doi: 10.1016/s2213-2600(17)30190-x.</mixed-citation><mixed-citation xml:lang="en">Ferguson G., FitzGerald J.M., Bleecker E.R., Laviolette M., Bernstein D., LaForce C. et al. Benralizumab for patients with mild to moderate, persistent asthma (BISE): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Respir Med. 2017;5(7):568–576. doi: 10.1016/s2213-2600(17)30190-x.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Varricchi G., Bagnasco D., Ferrando M., Puggioni F., Passalacqua G., Canonica G.W. Mepolizumab in the management of severe eosinophilic asthma in adults: current evidence and practical experience. Ther Adv Respir Dis. 2017;11(1):40–45. doi: 10.1177/1753465816673303.</mixed-citation><mixed-citation xml:lang="en">Varricchi G., Bagnasco D., Ferrando M., Puggioni F., Passalacqua G., Canonica G.W. Mepolizumab in the management of severe eosinophilic asthma in adults: current evidence and practical experience. Ther Adv Respir Dis. 2017;11(1):40–45. doi: 10.1177/1753465816673303.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Tsukamoto N., Takahashi N., Itoh H., Pouliquen I. Pharmacokinetics and pharmacodynamics of mepolizumab, an anti-interleukin 5 monoclonal antibody, in healthy Japanese male subjects. Clin Pharmacol Drug Dev. 2016;5(2):102–108. doi: 10.1002/cpdd.205.</mixed-citation><mixed-citation xml:lang="en">Tsukamoto N., Takahashi N., Itoh H., Pouliquen I. Pharmacokinetics and pharmacodynamics of mepolizumab, an anti-interleukin 5 monoclonal antibody, in healthy Japanese male subjects. Clin Pharmacol Drug Dev. 2016;5(2):102–108. doi: 10.1002/cpdd.205.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Pouliquen I.J., Kornmann O., Barton S.V., Price J.A., Ortega H.G. Characterization of the relationship between dose and blood eosinophil response following subcutaneous administration of mepolizumab. Int J Clin Pharmacol Ther. 2015;53(12):1015–1027. doi: 10.5414/cp202446.</mixed-citation><mixed-citation xml:lang="en">Pouliquen I.J., Kornmann O., Barton S.V., Price J.A., Ortega H.G. Characterization of the relationship between dose and blood eosinophil response following subcutaneous administration of mepolizumab. Int J Clin Pharmacol Ther. 2015;53(12):1015–1027. doi: 10.5414/cp202446.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Licari A., Manti S., Castagnoli R., Parisi G.F., Salpietro C., Leonardi S., Marseglia G.L. Targeted Therapy for Severe Asthma in Children and Adolescents: Current and Future Perspectives. Pediatric Drugs. 2019;21(4):215–237. doi: 10.1007/s40272-019-00345-7.</mixed-citation><mixed-citation xml:lang="en">Licari A., Manti S., Castagnoli R., Parisi G.F., Salpietro C., Leonardi S., Marseglia G.L. Targeted Therapy for Severe Asthma in Children and Adolescents: Current and Future Perspectives. Pediatric Drugs. 2019;21(4):215–237. doi: 10.1007/s40272-019-00345-7.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Logan J.K., Harinstein L., Muñoz M. Pediatric Postmarketing Pharmacovigilance Review: Cinqair (Reslizumab). Available at: https://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/PediatricAdvisoryCommittee/UCM610723.pdf.</mixed-citation><mixed-citation xml:lang="en">Logan J.K., Harinstein L., Muñoz M. Pediatric Postmarketing Pharmacovigilance Review: Cinqair (Reslizumab). Available at: https://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/PediatricAdvisoryCommittee/UCM610723.pdf.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Corren J., Weinstein S., Janka L., Zangrilli J., Garin M. Phase 3 Study of Reslizumab in Patients With Poorly Controlled Asthma: Effects Across a Broad Range of Eosinophil Counts. Chest. 2016;150(4):799–810. doi: 10.1016/j.chest.2016.03.018.</mixed-citation><mixed-citation xml:lang="en">Corren J., Weinstein S., Janka L., Zangrilli J., Garin M. Phase 3 Study of Reslizumab in Patients With Poorly Controlled Asthma: Effects Across a Broad Range of Eosinophil Counts. Chest. 2016;150(4):799–810. doi: 10.1016/j.chest.2016.03.018.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Bleecker E.R., FitzGerald J.M., Chanez P., Papi A., Weinstein S.F., Barker P. et al. Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with high-dosage inhaled corticosteroids and long-acting β2-agonists (SIROCCO): a randomised, multicentre, placebo-controlled phase 3 trial. Lancet. 2016;388(10056):2115–2127. doi: 10.1016/s0140-6736(16)31324-1.</mixed-citation><mixed-citation xml:lang="en">Bleecker E.R., FitzGerald J.M., Chanez P., Papi A., Weinstein S.F., Barker P. et al. Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with high-dosage inhaled corticosteroids and long-acting β2-agonists (SIROCCO): a randomised, multicentre, placebo-controlled phase 3 trial. Lancet. 2016;388(10056):2115–2127. doi: 10.1016/s0140-6736(16)31324-1.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Gupta A., Pouliquen I., Austin D., Price R.G., Kempsford R., Steinfeld J. et al. Subcutaneous mepolizumab in children aged 6 to 11 years with severe eosinophilic asthma. Pediatr Pulmonol. 2019;54(12):1957–1967. doi: 10.1002/ppul.24508.</mixed-citation><mixed-citation xml:lang="en">Gupta A., Pouliquen I., Austin D., Price R.G., Kempsford R., Steinfeld J. et al. Subcutaneous mepolizumab in children aged 6 to 11 years with severe eosinophilic asthma. Pediatr Pulmonol. 2019;54(12):1957–1967. doi: 10.1002/ppul.24508.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
