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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2020-18-163-170</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-5909</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ШКОЛА ПЕДИАТРА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PEDIATRICIAN SCHOOL</subject></subj-group></article-categories><title-group><article-title>Можно ли профилактировать респираторную патологию?</article-title><trans-title-group xml:lang="en"><trans-title>Is it possible to prevent respiratory pathology?</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4200-4598</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Захарова</surname><given-names>И. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Zakharova</surname><given-names>I. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор, заслуженный врач РФ, заведующая кафедрой педиатрии имени академика Г.Н. Сперанского</p><p>125993, Россия, Москва, ул. Баррикадная, д. 2/1, стр. 1 </p></bio><bio xml:lang="en"><p>Dr. of Sci. (Med.), Professor, Honoured Doctor of the Russian Federation, Head of the Department of Pediatrics named after G.N. Speransky</p><p>2/1, Bldg. 1, Barrikadnaya St., Moscow, 125993, Russia </p></bio><email xlink:type="simple">kafedra25@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бережная</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Berezhnaya</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., доцент кафедры педиатрии имени академика Г.Н. Сперанского</p><p>125993, Россия, Москва, ул. Баррикадная, д. 2/1, стр. 1 </p></bio><bio xml:lang="en"><p>Cand. of Sci. (Med.), Associate Professor of the Department of Pediatrics named after G.N. Speransky</p><p>2/1, Bldg. 1, Barrikadnaya St., Moscow, 125993, Russia </p></bio><email xlink:type="simple">berezhnaya-irina26@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное образовательное учреждение дополнительного профессионального образования «Российская медицинская  академия непрерывного профессионального образования» Министерства  здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Budgetary Educational Institution of Additional Professional Education “Russian Medical Academy of Continuing Professional Education” of the Ministry of Health of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное образовательное учреждение дополнительного профессионального образования «Российская медицинская академия непрерывного профессионального образования» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Budgetary Educational Institution of Additional Professional Education “Russian Medical Academy of Continuing Professional Education” of the Ministry of Health of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>28</day><month>11</month><year>2020</year></pub-date><volume>0</volume><issue>18</issue><fpage>163</fpage><lpage>170</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Захарова И.Н., Бережная И.В., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Захарова И.Н., Бережная И.В.</copyright-holder><copyright-holder xml:lang="en">Zakharova I.N., Berezhnaya I.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/5909">https://www.med-sovet.pro/jour/article/view/5909</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>профилактика</kwd><kwd>острые респираторные инфекции</kwd><kwd>дети</kwd><kwd>мультивидовые</kwd><kwd>мультиштаммовые пробиотики</kwd><kwd>иммуносупрессия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>prophylaxis</kwd><kwd>acute respiratory infections</kwd><kwd>children</kwd><kwd>multispecies</kwd><kwd>multistrain probiotics</kwd><kwd>immunosuppression</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Захарова И.Н., Османов И.М., Горяйнова А.Н., Гавеля Н.В., Ручкина Е.В. Современные этиологические и клинические особенности острой респираторной инфекции у детей. Имеются ли предпосылки к проведению антивирусной терапии? Обзор литературы. Фарматека. 2020;(1):14–19. doi: 10.18565/pharmateca.2020.1.14-19.</mixed-citation><mixed-citation xml:lang="en">Zakharova I.N., Osmanov I.M., Goryainova A.N., Gavelya N.V., Ruchkina E.V. Modern etiological and clinical features of acute respiratory viral infection in children. Are there any prerequisites for antiviral therapy? Literature review. Farmateka = Pharmateca. 2020;(1):14–19. (In Russ.) doi: 10.18565/pharmateca.2020.1.14-19.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Sullivan M., Hallam S.J., Woyke T., Sullivan M.B. Viral dark matter and virushost interactions resolved from publicly available microbial genomes. eLife. 2015;4:e08490. doi: 10.7554/eLife.08490.</mixed-citation><mixed-citation xml:lang="en">Sullivan M., Hallam S.J., Woyke T., Sullivan M.B. Viral dark matter and virushost interactions resolved from publicly available microbial genomes. eLife. 2015;4:e08490. doi: 10.7554/eLife.08490.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Malesker M.A., Callahan-Lyon P., Ireland B., Irwin R.S. Pharmacologic and Nonpharmacologic Treatment for Acute Cough Associated With the Common Cold: CHEST Expert Panel Report. Chest. 2017;152(5):1021–1037. doi: 10.1016/j.chest.2017.08.009.</mixed-citation><mixed-citation xml:lang="en">Malesker M.A., Callahan-Lyon P., Ireland B., Irwin R.S. Pharmacologic and Nonpharmacologic Treatment for Acute Cough Associated With the Common Cold: CHEST Expert Panel Report. Chest. 2017;152(5):1021–1037. doi: 10.1016/j.chest.2017.08.009.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Wishaupt J., van der Ploeg T., de Groot R., Versteegh F.G.A., Hartwig N.G. Single- and multiple viral respiratory infections in children: disease and management cannot be related to a specific pathogen. BMC Infect Dis. 2017;17:62. doi: 10.1186/s12879-016-2118-6.</mixed-citation><mixed-citation xml:lang="en">Wishaupt J., van der Ploeg T., de Groot R., Versteegh F.G.A., Hartwig N.G. Single- and multiple viral respiratory infections in children: disease and management cannot be related to a specific pathogen. BMC Infect Dis. 2017;17:62. doi: 10.1186/s12879-016-2118-6.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Appak Ö., Duman M., Belet N., Sayiner A.A. Viral respiratory infections diagnosed by multiplex polymerase chain reaction in pediatric patients. J Med Virol. 2019;91(5):731–737. doi: 10.1002/jmv.25379.</mixed-citation><mixed-citation xml:lang="en">Appak Ö., Duman M., Belet N., Sayiner A.A. Viral respiratory infections diagnosed by multiplex polymerase chain reaction in pediatric patients. J Med Virol. 2019;91(5):731–737. doi: 10.1002/jmv.25379.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Martínez-Roig A., Salvadó M., Caballero-Rabasco M.A., Sánchez-Buenavidaa A., López-Seguraa N., Bonet-Alcainaa M. Viral coinfection in childhood respiratory tract infections. Arch Bronconeumol. 2015;51(1):5–9. doi: 10.1016/j.arbres.2014.01.018.</mixed-citation><mixed-citation xml:lang="en">Martínez-Roig A., Salvadó M., Caballero-Rabasco M.A., Sánchez-Buenavidaa A., López-Seguraa N., Bonet-Alcainaa M. Viral coinfection in childhood respiratory tract infections. Arch Bronconeumol. 2015;51(1):5–9. doi: 10.1016/j.arbres.2014.01.018.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Fillatre A., François C., Segard C., Duverlie G., Hecquet D., Pannier C. et al. Epidemiology and seasonality of acute respiratory infections in hospitalized children over four consecutive years (2012–2016). J Clin Virol. 2018;102:27–31. doi: 10.1016/j.jcv.2018.02.010.</mixed-citation><mixed-citation xml:lang="en">Fillatre A., François C., Segard C., Duverlie G., Hecquet D., Pannier C. et al. Epidemiology and seasonality of acute respiratory infections in hospitalized children over four consecutive years (2012–2016). J Clin Virol. 2018;102:27–31. doi: 10.1016/j.jcv.2018.02.010.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Ghazaly M., Nadel S. Characteristics of children admitted to intensive care with acute bronchiolitis. Eur J Pediatr. 2018;177(6):913–920. doi: 10.1007/s00431-018-3138-6.</mixed-citation><mixed-citation xml:lang="en">Ghazaly M., Nadel S. Characteristics of children admitted to intensive care with acute bronchiolitis. Eur J Pediatr. 2018;177(6):913–920. doi: 10.1007/s00431-018-3138-6.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Jain S., Williams D.J., Arnold S.R., Ampofo K., Bramley A.M. et al. Communityacquired pneumonia requiring hospitalization among U.S. children. N Engl J Med. 2015;372(9):835–845. doi: 10.1056/NEJMoa1405870.</mixed-citation><mixed-citation xml:lang="en">Jain S., Williams D.J., Arnold S.R., Ampofo K., Bramley A.M. et al. Communityacquired pneumonia requiring hospitalization among U.S. children. N Engl J Med. 2015;372(9):835–845. doi: 10.1056/NEJMoa1405870.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Yu C., Fedoric B., Anderson P.H., Lopez A.F., Grimbaldeston M.A. Vitamin D3 signalling to mast cells: A new regulatory axis. Int J Biochem Cell Biol. 2011;43(1):41–46. doi: 10.1016/j.biocel.2010.10.011.</mixed-citation><mixed-citation xml:lang="en">Yu C., Fedoric B., Anderson P.H., Lopez A.F., Grimbaldeston M.A. Vitamin D3 signalling to mast cells: A new regulatory axis. Int J Biochem Cell Biol. 2011;43(1):41–46. doi: 10.1016/j.biocel.2010.10.011.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Vassallo M.F., Camargo C.A.Jr. Potential mechanisms for the hypothesized link between sunshine, vitamin D and food allergy in children. J Allergy Clin Immunol. 2010;126(2):217–222. Available at: https://www.jacionline.org/article/S0091-6749(10)00968-1/pdf.</mixed-citation><mixed-citation xml:lang="en">Vassallo M.F., Camargo C.A.Jr. Potential mechanisms for the hypothesized link between sunshine, vitamin D and food allergy in children. J Allergy Clin Immunol. 2010;126(2):217–222. Available at: https://www.jacionline.org/article/S0091-6749(10)00968-1/pdf.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Abuzeid W.M., Akbar N.A., Zacharek M.A. Vitamin D and chronic rhinitis. Curr Opin Allergy Clin Immunol. 2012;12(1):13–17. doi: 10.1097/ACI.0b013e32834eccdb.</mixed-citation><mixed-citation xml:lang="en">Abuzeid W.M., Akbar N.A., Zacharek M.A. Vitamin D and chronic rhinitis. Curr Opin Allergy Clin Immunol. 2012;12(1):13–17. doi: 10.1097/ACI.0b013e32834eccdb.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Benson A.A., Toh J.A., Vernon N., Jariwala S.P. The role of vitamin D in the immunopathogenesis of allergic skin diseases. Allergy. 2012;67(3):296–301. doi: 10.1111/j.1398-9995.2011.02755.x.</mixed-citation><mixed-citation xml:lang="en">Benson A.A., Toh J.A., Vernon N., Jariwala S.P. The role of vitamin D in the immunopathogenesis of allergic skin diseases. Allergy. 2012;67(3):296–301. doi: 10.1111/j.1398-9995.2011.02755.x.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Захарова И.Н., Скоробогатова Е.В. Коррекция дефицита витаминов у детей. РМЖ. 2006;(1):70–73.</mixed-citation><mixed-citation xml:lang="en">Zakharova I.N., Skorobogatova E.V. Correction of vitamin deficiency in children. RMZH = RMJ. 2006;(1):70–73. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Сейпенова А.Н., Исмагулова А.У., Савельчева И.А. Социально-биологические факторы, способствующие реализации острых респираторных инфекций у часто болеющих детей. Медицинский журнал Западного Казахстана. 2014;(1):12–16. Режим доступа: https://e.lanbook.com/reader/journalArticle/248074/#1.</mixed-citation><mixed-citation xml:lang="en">Seypenova A.N., Ismagulova A.U., Savel’cheva I.A. Social-biological factors, сonducing realizacion of acute respiratory infection affected in ill children. Meditsinskiy zhurnal Zapadnogo Kazakhstana = Medical Journal of West Kazakhstan. 2014;(1):12–16. (In Russ.) Available at: https://e.lanbook.com/reader/journalArticle/248074/#1.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Артюхова Ю.К. Как закалить свой организм. Минск: Недра; 1999. 54 с.</mixed-citation><mixed-citation xml:lang="en">Artyukhova Yu.K. How to temper your body. Minsk: Nedra; 1999. 54 p. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Quigley E.M.M. Gut microbiome as a clinical tool in gastrointestinal disease management: are we there yet? Nat Rev Gastroenterol Hepatol. 2017;14(5):315–320. doi: 10.1038/nrgastro.2017.29.</mixed-citation><mixed-citation xml:lang="en">Quigley E.M.M. Gut microbiome as a clinical tool in gastrointestinal disease management: are we there yet? Nat Rev Gastroenterol Hepatol. 2017;14(5):315–320. doi: 10.1038/nrgastro.2017.29.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Li T., Chiang J.Y. Bile acids as metabolic regulators. Curr Opin Gastroenterol. 2015;31(2):159–165. doi: 10.1097/MOG.0000000000000156.</mixed-citation><mixed-citation xml:lang="en">Li T., Chiang J.Y. Bile acids as metabolic regulators. Curr Opin Gastroenterol. 2015;31(2):159–165. doi: 10.1097/MOG.0000000000000156.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Jensen H., Grimmer S., Naterstad K., Axelsson L. In vitro testing of commercial and potential probiotic lactic acid bacteria. Int J Food Microbiol. 2012;153(1–2):216–222. doi: 10.1016/j.ijfoodmicro.2011.11.020.</mixed-citation><mixed-citation xml:lang="en">Jensen H., Grimmer S., Naterstad K., Axelsson L. In vitro testing of commercial and potential probiotic lactic acid bacteria. Int J Food Microbiol. 2012;153(1–2):216–222. doi: 10.1016/j.ijfoodmicro.2011.11.020.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Ouwehand A., Isolauri E., Salminen S. The role of intestinal microflora for development of the immune system in early childhood. Eur J Nutr. 2002;41:132–137. doi: 10.1007/s00394-002-1105-4.</mixed-citation><mixed-citation xml:lang="en">Ouwehand A., Isolauri E., Salminen S. The role of intestinal microflora for development of the immune system in early childhood. Eur J Nutr. 2002;41:132–137. doi: 10.1007/s00394-002-1105-4.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Yan F., Polk D.B. Probiotic bacterium prevents cytokine-induced apoptosis in intestinal epithelial cells. J Biol Chem. 2002;277(52):50959–50965. doi: 10.1074/jbc.M207050200.</mixed-citation><mixed-citation xml:lang="en">Yan F., Polk D.B. Probiotic bacterium prevents cytokine-induced apoptosis in intestinal epithelial cells. J Biol Chem. 2002;277(52):50959–50965. doi: 10.1074/jbc.M207050200.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Сугян Н.Г., Захарова И.Н. Мультипробиотик Бак-Сет: результаты российских и зарубежных клинических исследований. Медицинский совет. 2017;(19):104–110. doi: 10.21518/2079-701X-2017-19-104-110.</mixed-citation><mixed-citation xml:lang="en">Sugyan N.G., Zakharova I.N. Вac-Set multiprobiotic: results of russian and foreign clinical research. Meditsinskiy sovet = Medical Council. 2017;(19):104–110. (In Russ.) doi: 10.21518/2079-701X-2017-19-104-110.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Leyer G.J., Li S., Mubasher M.E., Reifer C., Ouwehand A.C. Probiotic effects on cold and influenza-like symptom incidence and duration in children. Pediatrics. 2009;124(2):e172–179. doi: 10.1542/peds.2008-2666.</mixed-citation><mixed-citation xml:lang="en">Leyer G.J., Li S., Mubasher M.E., Reifer C., Ouwehand A.C. Probiotic effects on cold and influenza-like symptom incidence and duration in children. Pediatrics. 2009;124(2):e172–179. doi: 10.1542/peds.2008-2666.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Smith T.J., Rigassio-Radler D., Denmark R., Haley T., Touger-Decker R. Effect of Lactobacillus rhamnosus LGG® and Bifidobacterium animalis ssp. lactis BB-12® on health-related quality of life in college students affected by upper respiratory infections. Br J Nutr. 2013;109(11):1999–2007. Available at: https://pubmed.ncbi.nlm.nih.gov/23020819.</mixed-citation><mixed-citation xml:lang="en">Smith T.J., Rigassio-Radler D., Denmark R., Haley T., Touger-Decker R. Effect of Lactobacillus rhamnosus LGG® and Bifidobacterium animalis ssp. lactis BB-12® on health-related quality of life in college students affected by upper respiratory infections. Br J Nutr. 2013;109(11):1999–2007. Available at: https://pubmed.ncbi.nlm.nih.gov/23020819.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
