medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2020-20-90-99medsovet-5941Research ArticleОНКОУРОЛОГИЯONCOUROLOGYВыбор варианта лечения при метастатическом гормоночувствительном раке предстательной железыChoice of treatment options for metastatic hormone-sensitive prostate cancerhttps://orcid.org/0000-0002-7592-0392ГафановР. А.GafanovR. A.

Гафанов Рустем Айратович, кандидат медицинских наук, старший научный сотрудник отделения онкоурологии

117485, Россия, Москва, ул. Профсоюзная, д. 86

Rustem A. Gafanov, Cand. of Sci. (Med.), Senior Research Associate, Oncourology Department

86, Profsoyuznaya St., Moscow, 117485, Russia

docgra@mail.ruhttps://orcid.org/0000-0001-5789-375XДзидзарияА. Г.DzidzariaA. G.

Дзидзария Александр Гудисович, кандидат медицинских наук, заведующий урологическим отделением

117485, Россия, Москва, ул. Профсоюзная, д. 86

Alexander G. Dzidzaria, Cand. of Sci. (Med.), Senior Research Associate, Oncourology Department

86, Profsoyuznaya St., Moscow, 117485, Russia

dzidzariamd@gmail.comhttps://orcid.org/0000-0003-1671-369XКравцовИ. Б.KravtsovI. B.

Кравцов Игорь Борисович, кандидат медицинских наук, младший научный сотрудник отделения онкоурологии

117485, Россия, Москва, ул. Профсоюзная, д. 86

Sergey V. Fastovets, Cand. of Sci. (Med.), Junior Research Associate, Oncourology Department

86, Profsoyuznaya St., Moscow, 117485, Russia

kravtsov1985@yandex.ruhttps://orcid.org/0000-0002-8665-3103ФастовецС. В.FastovetsS. V.

Фастовец Сергей Владимирович, кандидат медицинских наук, младший научный сотрудник отделения онкоурологии

117485, Россия, Москва, ул. Профсоюзная, д. 86

Sergey V. Fastovets, Cand. of Sci. (Med.), Junior Research Associate, Oncourology Department

86, Profsoyuznaya St., Moscow, 117485, Russia

sega14@mail.ruРоссийский научный центр рентгенорадиологииРоссияRussian Scientific Center of RoentgenoradiologyRussian Federation2020191220200209099Copyright © Гафанов Р.А., Дзидзария А.Г., Кравцов И.Б., Фастовец С.В., 20202020Гафанов Р.А., Дзидзария А.Г., Кравцов И.Б., Фастовец С.В.Gafanov R.A., Dzidzaria A.G., Kravtsov I.B., Fastovets S.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/5941

Арсенал имеющихся средств и методов лечения метастатического гормоночувствительного рака предстательной железы существенно увеличился за последние 5 лет. Хотя андроген-депривационная терапия по-прежнему остается основой лечения, добавление доцетаксела, абиратерона, энзалутамида, апалутамида или локальной дистанционной лучевой терапии улучшает результаты лечения пациентов с метастатическим гормоночувствительным раком предстательной железы (мГЧРПЖ) и становится стандартом лечения. Выбор терапии для улучшения результатов лечения пациентов с мГЧРПЖ становится все более сложной задачей, поскольку появились различные варианты для этой стадии заболевания. В настоящей статье представлен обзор клинических исследований, включавших андроген-депривационную терапию (АДТ) в сочетании с химиотерапией, новой гормональной и лучевой терапией. Также мы рассмотрим последние достижения в выборе лечения мужчин с диагностированным мГЧРПЖ и влияние предшествующей терапии на последующую биологию заболевания. Варианты включают химиогормональную терапию, терапию, направленную на андрогенные рецепторы (АР), в дополнение к АДТ или – реже – только АДТ. Выбор лечения должен основываться на рассмотрении клинических характеристик и характеристик заболевания, а также учете предпочтений пациента, территориальных ограничений и финансовых возможностей.

The arsenal of available treatments and treatments for metastatic hormone-sensitive prostate cancer (mHRPC) has increased significantly over the past 5 years. Although androgen-preferential therapy (ADT) remains the mainstay of treatment, the addition of docetaxel, abiraterone, enzalutamide, apalutamide, or local external beam radiation therapy improves the outcome of patients with mHRPC and becomes the standard of care. Choosing a therapy to improve treatment outcomes for patients with mHRPC is becoming increasingly challenging as there are different options for this stage of the disease. This article provides an overview of clinical trials that included ADT in combination with chemotherapy, new hormonal therapy, and radiation therapy. We will also consider recent advances in the choice of treatment for men diagnosed with mHPCR and the impact of previous therapy on the subsequent biology of the disease. Options include chemohormone therapy, androgen receptor (AR) targeted therapy in addition to ADT or, less commonly, ADT alone. The choice of treatment should be based on a consideration of the clinical characteristics and characteristics of the disease, as well as taking into account the patient’s preferences, territorial constraints and financial resources.

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The authors declare that there are no conflicts of interest present.