medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2014-7-26-29medsovet-595Research ArticleКАРДИОЛОГИЯCARDIOLOGYИнгибитор АПФ фозиноприл в лечении артериальной гипертензии - потенциальные преимуществаACE inhibitor fosinopril in the treatment of hypertension: potential benefitsКонрадиА. О.KonradiAOnoemail@neicon.ruФедеральный медицинский исследовательский центр им. В.А. Алмазова Минздрава России, Санкт-ПетербургРоссияV.A. Almazov Federal Medical Research Centre, Ministry of Health of Russia, St. PetersburgRussian Federation201430122014072629Copyright © Конради А.О., 20142014Конради А.О.Konradi A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/595

Фозиноприл, имея двойное выведение, может быть использован при почечной недостаточности без коррекции дозировки, что может быть необходимо для пациентов с сахарным диабетом или пожилого возраста даже при нормальном уровне креатинина в плазме крови. Это может служить показанием для применения фозиноприла в качестве препарата выбора у пациентов с почечной недостаточностью и высоким риском заболеваний почек. Фозиноприл может использоваться в качестве монотерапии или в комбинации с гидрохлортиазидом, включая фиксированные комбинации.

Fosinopril with dual clearance can be used in renal failure without dose correction, which may be required in diabetes or elderly patients even with normal creatinine level in blood plasma. Therefore, fosinopril can be indicated as the drug of choice in patients with renal failure and high risk of kidney disease. Fosinopril can be used either as monotherapy or in combination with hydrochlorothiazide, including fixed combinations.

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The authors declare that there are no conflicts of interest present.