References

medsovet

Медицинский Совет

Meditsinskiy sovet = Medical Council

2079-701X2658-5790

REMEDIUM GROUP Ltd.

10.21518/2079-701X-2020-21-152-159

medsovet-5979

Research Article

Эндокринология

Endocrinology

Роль Т-регуляторных клеток в аутоиммунном тиреоидите

The role of regulatory T cells in autoimmune thyroiditis

https://orcid.org/0000-0002-4123-8213

Жукова

С. И.

Zhukova

S. I.

студент 3-го курса факультета фундаментальной медицины,

119991, Россия, Москва, Ленинские горы, д. 1

third-year student of the Faculty of Medicine,

1, Lenin Hills, Moscow, 119991

szhukova06@gmail.com

https://orcid.org/0000-0003-4632-0547

Каннер

И. Д.

Kanner

I. D.

студент 3-го курса факультета фундаментальной медицины,

119991, Россия, Москва, Ленинские горы, д. 1

third-year student of the Faculty of Medicine,

1, Lenin Hills, Moscow, 119991

dwilya4@mail.ru

https://orcid.org/0000-0001-5922-0807

Мамонтова

Т. М.

Mamontova

T. M.

студент 3-го курса факультета фундаментальной медицины,

119991, Россия, Москва, Ленинские горы, д. 1

third-year student of the Faculty of Medicine,

1, Lenin Hills, Moscow, 119991

tatianamamontova@inbox.ru

https://orcid.org/0000-0002-9675-3693

Шеломенцева

Е. М.

Shelomentceva

E. M.

студент 3-го курса факультета фундаментальной медицины,

119991, Россия, Москва, Ленинские горы, д. 1

third-year student of the Faculty of Medicine,

1, Lenin Hills, Moscow, 119991

emshelomentseva@gmail.com

https://orcid.org/0000-0002-8979-8084

Максимов

М. Л.

Maximov

M. L.

д.м.н., профессор, заведующий кафедрой клинической фармакологии и фармакотерапии,

420012, Россия, Казань, ул. Бутлерова, д. 36

Dr. of Sci. (Med.), Professor, Head of the Department of Clinical Pharmacology and Pharmacotherapy,

36, Mushtari St., Kazan, 420012

maksim_maksimov@mail.ru

Московский государственный университет им. М.В. ЛомоносоваРоссияLomonosov Moscow State UniversityRussian Federation

Казанская государственная медицинская академияРоссияKazan State Medical AcademyRussian Federation

2020

15012021

021152159

2021

Жукова С.И., Каннер И.Д., Мамонтова Т.М., Шеломенцева Е.М., Максимов М.Л.

Zhukova S.I., Kanner I.D., Mamontova T.M., Shelomentceva E.M., Maximov M.L.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.med-sovet.pro/jour/article/view/5979

Аутоиммунный тиреоидит (АИТ) является органоспецифическим аутоиммунным заболеванием, обусловленным активацией CD4+-аутореактивных Т-клеток. Т-регуляторные клетки (Treg) – популяция Т-клеток, которые играют центральную роль в иммунологической толерантности путем супрессии аутореактивных клеток. CD4+-Тreg делятся на тимические (tTreg) и периферические (pTreg). tTreg осуществляют свои функции путем цитокин-независимых механизмов, pTreg – за счет IL-10, TGF-β и IL-35. Тreg выполняют защитную функцию по отношению к АИТ. Исследования уровня Treg при АИТ показывают различные результаты, в большинстве случаев уровень Treg повышен, при этом нарушена их функция. На функцию Treg при АИТ оказывает влияние множество факторов, например уровень тиреоглобулина, витамина D и др. Кроме уровня непосредственно Treg, при АИТ большое значение имеет соотношение Th17/Treg. Активация Treg и изменение соотношения Th17/Treg могут быть использованы при лечении АИТ.

Autoimmune thyroiditis is an organ-specific autoimmune disease caused by the activation of self-reactive CD4+ T cells. Regulatory T (Treg) cells are a population of T cells that play a central role in immunological tolerance by suppressing selfreactive cells. CD4+ Tregs are divided into thymic (tTreg) and peripheral (pTreg). tTregs perform their functions through cytokine-independent mechanisms, pTregs – through IL-10, TGF-β and IL-35. Tregs perform a protective function against AIT. Studies of Treg level in AIT show different results, in most cases Treg level is increased, and their function is impaired. Treg function in AIT is affected by many factors, such as the level of thyroglobulin, vitamin D etc. Apart from the Treg level itself, the Th17/Treg ratio is also crucial in AIT. Activation of Tregs and modification of the Th17/Treg ratio can be used in AIT treatment.

аутоиммунные заболевания щитовидной железыаутоиммунный тиреоидитТregpTregtTregTh17/TregFOXP3

autoimmune thyroid diseaseautoimmune thyroiditisТregpTregtTregTh17/TregFOXP3

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The authors declare that there are no conflicts of interest present.