medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2021-3-19-27medsovet-6067Research ArticleРЕПРОДУКТИВНОЕ ЗДОРОВЬЕ И ВРТREPRODUCTIVE HEALTH AND ARTОксидативный стресс сперматозоидов: клиническое значение и коррекцияSperm oxidative stress: clinical significance and managementhttps://orcid.org/0000-0002-9128-2714ГамидовС. И.GamidovS. I.

Гамидов Сафар Исраилович - доктор медицинских наук, заведующий отделением андрологии и урологии, НМИЦАГП имени академика В.И. Кулакова; профессор кафедры урологии и оперативной нефрологии, Первый МГМУ.

117997, Москва, ул. Академика Опарина, д. 4; 119991, Москва, ул. Трубецкая, д. 8, стр. 2

Safail I. Gamidov, Dr. Sci. (Med.), Head of the Department of Andrology and Urology, Kulakov NMRCOGP; Professor of the Department of Urology and Operative Nephrology, Sechenov FMSMU (Sechenov University).

4, Academician Oparin St., Moscow, 117997; 8, Bldg. 2, Trubetskaya St., Moscow, 119991

safargamidov@yandex.ruhttps://orcid.org/0000-0002-3902-9236ШатылкоТ. В.ShatylkoT. V.

Шатылко Тарас Валерьевич - кандидат медицинских наук, врач-уролог отделения андрологии и урологии, SPIN-код: 4129-3649.

117997, Москва, ул. Академика Опарина, д. 4

Taras V. Shatylko - Cand. Sci. (Med.), Urologist of the Department of Andrology and Urology.

4, Academician Oparin St., Moscow, 117997

ialectic.law@gmail.comhttps://orcid.org/0000-0003-1163-5602ПоповаА. Ю.PopovaA. Yu.

Попова Алина Юрьевна - кандидат медицинских наук, старший научный сотрудник отделения андрологии и урологии.

117997, Москва, ул. Академика Опарина, д. 4

Popova - Cand. Sci. (Med.), Senior Research Associate of the Department of Andrology and Urology.

4, Academician Oparin St., Moscow, 117997

alina-dock@yandex.ruhttps://orcid.org/0000-0003-4695-9789ГасановН. Г.GasanovN. G.

Гасанов Натиг Гасанович - 0врач-уролог, андролог отделения урологии и андрологии.

117997, Москва, ул. Академика Опарина, д. 4

Natig G. Gasanov - Urologist, Andrologist of the Department of Andrology and Urology.

4, Academician Oparin St., Moscow, 117997

natiqhasan@gmail.comhttps://orcid.org/0000-0002-1765-4874ГамидовР. С.GamidovR. S.

Гамидов Руслан Сафарович - студент 6-го курса.

119991, Москва, ул. Трубецкая, д. 8, стр. 2

Ruslan S. Gamidov - sixth-year student.

8, Bldg. 2, Trubetskaya St., Moscow, 119991

docand2015@yandex.ruНациональный медицинский исследовательский центр акушерства, гинекологии и перинатологии им. академика В.И. Кулакова; Первый Московский государственный медицинский университет им. И.М. Сеченова (Сеченовский Университет)РоссияKulakov National Medical Research Center of Obstetrics, Gynecology and PerinatologyRussian FederationНациональный медицинский исследовательский центр акушерства, гинекологии и перинатологии им. академика В.И. КулаковаРоссияKulakov National Medical Research Center of Obstetrics, Gynecology and PerinatologyRussian FederationПервый Московский государственный медицинский университет им. И.М. Сеченова (Сеченовский Университет)РоссияSechenov First Moscow State Medical University (Sechenov University)Russian Federation202114042021031927Copyright © Гамидов С.И., Шатылко Т.В., Попова А.Ю., Гасанов Н.Г., Гамидов Р.С., 20212021Гамидов С.И., Шатылко Т.В., Попова А.Ю., Гасанов Н.Г., Гамидов Р.С.Gamidov S.I., Shatylko T.V., Popova A.Y., Gasanov N.G., Gamidov R.S.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/6067

Одной из ведущих причин нарушения функции сперматозоидов является оксидативный стресс. Избыточная концентрация активных форм кислорода приводит к повреждению мембран сперматозоидов и нарушению целостности их ДНК, что отражается не только на вероятности наступления беременности естественным путем, но и на результатах применения вспомогательных репродуктивных технологий и риске невынашивания беременности. Сперматозоиды крайне уязвимы перед оксидативным стрессом, учитывая ограниченный функциональный запас их антиоксидантных систем и аппарата репарации ДНК. Часто причиной появления активных форм кислорода являются факторы образа жизни, большинство из которых являются модифицируемыми. Как модификация образа жизни, так и применение антиоксидантных биологически активных добавок являются адекватными и совместимыми друг с другом способами борьбы с мужским бесплодием, ассоциированным с оксидативным стрессом. Поиск других внутренних и внешних источников активных форм кислорода, выявление этиологии оксидативного стресса и  лечение соответствующих заболеваний необходимы для успешной регуляции окислительно- восстановительных процессов в мужской репродуктивной системе в клинической практике, что необходимо не только для преодоления бесплодия, но и для предотвращения индуцированных эпигенетических нарушений у последующих поколений. В статье проанализированы молекулярные механизмы мужского идиопатического бесплодия. Авторы предлагают обзор способов предотвращения оксидативного стресса как одной из причин субфебрильности. В статье представлен обзор средств современной фармакотерапии, а также возможностей устранения последствий влияния активных форм кислорода на сперматогенез и мужскую репродуктивную систему в целом.

Oxidative stress is one of the leading causes of sperm dysfunction. Excessive amounts of reactive oxygen species can damage sperm membranes and disrupt their DNA integrity, which affects not only the likelihood of getting pregnant naturally, but also the clinical outcomes of assisted reproductive technologies and the risk of miscarriage. Sperm cells are extremely vulnerable to oxidative stress, given the limited functional reserve of their antioxidant systems and the DNA repair apparatus. Lifestyle factors, most of which are modifiable, often trigger generation of reactive oxygen species.  Both the lifestyle modification and use of antioxidant dietary supplements are adequate and compatible ways to combat male oxidative stress-associated infertility. The search for other internal and external sources of reactive oxygen species, the identification of the etiology of oxidative stress and treatment of respective diseases are necessary for the successful regulation of redox processes in the male reproductive system in clinical practice, which is required not only to overcome infertility, but also to prevent induced epigenetic disorders in subsequent generations. The article presents the analysis of the molecular mechanisms of male idiopathic infertility. The authors provide an overview of how to prevent oxidative stress as one of the causes of subfebrile fever. The article provides an overview of modern therapeutics, as well as the options for eliminating the consequences of the effect of reactive oxygen species on spermatogenesis and male reproductive system in general.

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The authors declare that there are no conflicts of interest present.