medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2021-4-205-211medsovet-6110Research ArticleИНФЕКЦИОННЫЕ БОЛЕЗНИINFECTIOUS DISEASESКомбинированные препараты в терапии острых респираторных вирусных инфекций: обзор результатов исследованийCombined drugs in the treatment of acute respiratory viral infections: a review of research resultshttps://orcid.org/0000-0001-5195-9316ЦветковВ. В.TsvetkovV. V.

Цветков Валерий Владимирович, кандидат медицинских наук, старший научный сотрудник

197376, Санкт-Петербург, ул. профессора Попова, д. 15/17

Valeriy V. Tsvetkov, Cand. Sci. (Med.), Senior Researcher

15/17, Professor Popov St., St Petersburg, 197376

suppcolor@gmail.comНаучно-исследовательский институт гриппа имени А.А. СмородинцеваРоссияSmorodintsev Research Institute of InfluenzaRussian Federation20212004202104205211Copyright © Цветков В.В., 20212021Цветков В.В.Tsvetkov V.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/6110

В Российской Федерации среди всех инфекционных заболеваний наибольшую экономическую значимость представляют острые респираторные инфекции. На сегодняшний день для большинства ОРВИ не существует препаратов с прямым противовирусным действием, эффективность которых была бы доказана в многочисленных клинических исследованиях и подтверждена результатами метаанализов. Использование различных комбинаций жаропонижающих, противовоспалительных и антиоксидантных препаратов является наиболее распространенным методом симптоматической и  патогенетической терапии острых респираторных вирусных инфекций (ОРВИ). Целью обзора стали анализ и систематизация результатов доклинических и клинических исследований, направленных на изучение безопасности и эффективности использования комбинации фиксированных доз парацетамола, фенирамина малеата, фенилэфрина гидрохлорида и аскорбиновой кислоты в терапии ОРВИ. Поиск научных публикаций осуществлялся в базах данных PubMed, ClinicalKey ELSEVIER и Google Scholar. Глубина поиска составила 10  лет. Результаты многочисленных сравнительных и  плацебо-контролируемых исследований свидетельствуют о том, что применение комбинации фиксированных доз парацетамола, фенирамина малеата, фенилэфрина гидрохлорида и аскорбиновой кислоты в терапии ОРВИ является патогенетически обоснованным, безопасным и эффективным в отношении купирования таких симптомов, как лихорадка, ринит, кашель, боль в мышцах и суставах, боль в горле и головная боль. При своевременном использовании комбинированные лекарственные средства облегчают состояние пациента и способствуют сокращению продолжительности болезни. Между тем патогенетические эффекты комбинированных средств, направленные на ограничение очага воспаления и минимизацию риска развития осложнений, требуют дальнейшего изучения.

Acute respiratory infections are of the greatest economic significance among all infectious diseases in the Russian Federation. There are no drugs with a direct antiviral effect for most acute respiratory viral infections, which efficacy would have been proven in the numerous clinical trials and confirmed by the results of meta-analyses today. The use of various combinations of antipyretic, anti-inflammatory and antioxidant drugs is the most common method of symptomatic and pathogenetic therapy of acute respiratory viral infections (ARVI). The purpose of this review is to analyse and systematize the results of preclinical and clinical trials aimed at studying the safety and efficacy of fixed-doses combinations of paracetamol, pheniramine maleate, phenylephrine hydrochloride and ascorbic acid in the ARVI therapy. The search of scientific publications was carried out in the PubMed, ClinicalKey ELSEVIER and Google Scholar databases. The search depth was 10 years. The results of numerous comparative and placebo-controlled trials showed that the use of fixed-dose combinations of paracetamol, pheniramine maleate, phenylephrine hydrochloride and ascorbic acid in the ARVI therapy was pathogenetically justified, safe, and effective in relieving symptoms such as fever, rhinitis, cough, muscle and joint pain, sore throat, and headache. The combination drugs can ease the patient’s condition and help shorten the duration of the illness provided that they are administered in due time. Meanwhile, the pathogenetic effects of combination drugs aimed at localizing the focus of inflammation and minimizing the risk of complications warrant further research.

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The authors declare that there are no conflicts of interest present.