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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2021-10-154-162</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-6278</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПРАКТИКА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PRACTICE</subject></subj-group></article-categories><title-group><article-title>Двигательные и речевые нарушения у пациента с инсультом в вертебробазилярном бассейне на фоне коронавирусной инфекции (клиническое наблюдение)</article-title><trans-title-group xml:lang="en"><trans-title>Motor-speech disorders in a patient with a vertebrobasilar stroke affected by coronavirus infection (clinical observation)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5576-1649</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Обухова</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Obukhova</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Обухова Анастасия Васильевна - кандидат медицинских наук, ассистент кафедры нервных болезней и нейрохирургии Института клинической медицины им. В.Н. Склифосовского.</p><p>119991, Москва, ул. Трубецкая, д. 8, стр. 2</p></bio><bio xml:lang="en"><p>Anastasia V. Obukhova, Cand. Sci. (Med.), Teaching Assistant, Department of Nervous System Diseases and Neurosurgery, Sklifosovsky Institute of Clinical Medicine, Sechenov FMSMU (Sechenov University).</p><p>8, Bldg. 2, Trubetskaya St., Moscow, 119991</p></bio><email xlink:type="simple">nasta-duk@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3110-4764</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Коберская</surname><given-names>Н. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Koberskaya</surname><given-names>N. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Коберская Надежда Николаевна - кандидат медицинских наук, доцент кафедры нервных болезней и нейрохирургии Института клинической медицины им. В.Н. Склифосовского, Первый МГМУ имени И.М. Сеченова (Сеченовский Университет); старший научный сотрудник, Российский геронтологический научно-клинический центр, РНИМУ имени Н.И. Пирогова.</p><p>129226, Москва, ул. 1-я Леонова, д. 16</p></bio><bio xml:lang="en"><p>Nadejda N. Koberskaya, Cand. Sci. (Med.), Associate Professor, Department of Nervous System Diseases and Neurosurgery, Sklifosovsky Institute of Clinical Medicine, Sechenov FMSMU (Sechenov University); Senior Researcher, Russian Clinical and Research Center of Gerontology, Pirogov RNRMU.</p><p>8, Bldg. 2, Trubetskaya St., Moscow, 119991; 16, 1s Leonov St., Moscow, 129226</p></bio><email xlink:type="simple">koberskaya_n_n@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4852-0588</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Артемьев</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Artemev</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Артемьев Дмитрий Валерьевич - кандидат медицинских наук, доцент кафедры неврологии с курсом рефлексологии и мануальной терапии.</p><p>125993, Москва, ул. Баррикадная, д. 2/1, стр. 1</p></bio><bio xml:lang="en"><p>Dmitriy V. Artemev, Cand. Sci. (Med.), Associate Professor, Department of Neurology with Reflexology and Manual Therapy Module.</p><p>2/1, Bldg. 1, Barrikadnaya St., Moscow, 1125993</p></bio><email xlink:type="simple">artemev1966@yandex.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Первый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский Университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Sechenov First Moscow State Medical University (Sechenov University)</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Первый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский Университет); Российский национальный исследовательский медицинский университет имени Н.И. Пирогова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Sechenov First Moscow State Medical University (Sechenov University); Pirogov Russian National Research Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Российская медицинская академия непрерывного профессионального образования</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Medical Academy of Continuous Professional Education</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>07</day><month>08</month><year>2021</year></pub-date><volume>0</volume><issue>10</issue><fpage>154</fpage><lpage>162</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Обухова А.В., Коберская Н.Н., Артемьев Д.В., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Обухова А.В., Коберская Н.Н., Артемьев Д.В.</copyright-holder><copyright-holder xml:lang="en">Obukhova A.V., Koberskaya N.N., Artemev D.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/6278">https://www.med-sovet.pro/jour/article/view/6278</self-uri><abstract><p>С развитием пандемии коронавирусной инфекции (COVID-19) стало появляться все больше свидетельств о развитии неврологических осложнений этого заболевания и, в частности, острых нарушений мозгового кровообращения, причем отмечается рост количества инсультов у пациентов младше 50 лет, не имевших факторов риска цереброваскулярных заболеваний. В статье рассматривается несколько потенциальных механизмов, определяющих взаимосвязь ишемического инсульта и COVID-19. Представлен клинический случай развития ишемического инсульта в вертебробазилярном бассейне на фоне коронавирусной инфекции. Обсуждается причинно-следственная связь коронавирусной инфекции и сосудистой катастрофы. В описанном случае COVID-19 способствовал декомпенсации сопутствующих факторов риска, имевшихся у больного. Особенностью описанного случая является отставленное развитие у пациента редкого двигательного расстройства в виде тремора Холмса и сочетанных речевых нарушений (дизартрии и остаточных явлений моторной афазии). Тремор Холмса - необычный вид тремора, характеризующийся сочетанием тремора покоя, постурального и интенционного тремора, который вовлекает преимущественно проксимальные отделы конечностей. Этот симптом назван в честь британского невролога Гордона Холмса, описавшего в 1904 г. серию случаев необычного варианта дрожательного гиперкинеза. В статье рассматриваются вопросы патогенеза развития этого состояния и приводятся клинические критерии тремора Холмса. Это достаточно редкий симптом, в литературе отсутствуют данные по крупным исследованиям этого расстройства, и в основном он описывается в небольших сериях клинических случаев. Обсуждается эффективность Акатинола Мемантина при лечении постинсультных речевых нарушений, приводятся обоснования назначения этого препарата при ведении пациентов с постинсультными речевыми нарушениями.</p></abstract><trans-abstract xml:lang="en"><p>Amidst the growing coronavirus infection (COVID-19) pandemic, there is increasing evidence of the development of neurological complications of this disease and, especially, acute cerebrovascular accidents, and what is more, an increase in incidence rates of strokes is noted in the patients under the age of 50, who did not have risk factors for cerebrovascular diseases. The article examines several potential mechanisms that determine the relationships between ischemic stroke and COVID-19. A clinical case of the development of ischemic stroke in the vertebrobasilar system affected by the coronavirus infection is presented. The causal relationship between coronavirus infection and vascular catastrophe is discussed. In the described case, COVID-19 contributed to the decompensation of the patient’s associated risk factors. A feature of the described case is the delayed development of a rare motor disorder in the form of Holmes tremor and combined speech disorders (dysarthria and aftereffects of motor aphasia) in the patient. Holmes tremor is an unusual type of tremor characterized by a combination of rest, postural, and action tremors that predominantly affects the proximal limbs. This symptom is named after the British neurologist Gordon Holmes, who described a series of cases of an unusual variant of tremulous hyperkinesis in 1904. The article discusses the pathogenesis issues of the development of this condition and provides clinical criteria for Holmes tremor. This is a rather rare symptom, there are no data on large studies of this disorder in the literature, and it is mainly described in small series of clinical cases. The efficacy of Akatinol Memantine in the treatment of post-stroke speech disorders is discussed, and the rationale for prescribing this drug in the management of patients with post-stroke speech disorders is presented.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>коронавирусная инфекция</kwd><kwd>COVID-19</kwd><kwd>инсульт</kwd><kwd>тремор Холмса</kwd><kwd>дизартрия</kwd><kwd>афазия</kwd><kwd>мемантин</kwd></kwd-group><kwd-group xml:lang="en"><kwd>coronavirus infection</kwd><kwd>COVID-19</kwd><kwd>stroke</kwd><kwd>Holmes tremor</kwd><kwd>dysarthria</kwd><kwd>aphasia</kwd><kwd>memantine</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ellul M.A., Benjamin L., Singh B., Lant S., Michael B.D., Easton A. et al. Neurological associations of COVID-19. 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