<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2021-10-164-170</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-6279</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПРАКТИКА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PRACTICE</subject></subj-group></article-categories><title-group><article-title>Практические принципы лечения хронической неспецифической боли в нижней части спины и коморбидной хронической инсомнии: клиническое наблюдение</article-title><trans-title-group xml:lang="en"><trans-title>Practical guidelines for the treatment of chronic nonspecific low back pain and comorbid chronic insomnia: clinical observation</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2752-4109</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Головачева</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Golovacheva</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Головачева Вероника Александровна, кандидат медицинских наук, доцент кафедры нервных болезней и нейрохирургии Института клинической медицины.</p><p>119991, Москва, ул. Трубецкая, д. 8, стр. 2</p></bio><bio xml:lang="en"><p>Veronika A. Golovacheva, Cand. Sci. (Med.), Associate Professor of the Department of Nervous Diseases and Neurosurgery of the Institute of Clinical Medicine.</p><p>8, Bldg. 2, Trubetskaya St., Moscow, 119991</p></bio><email xlink:type="simple">xoxo.veronicka@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2845-7323</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Головачева</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Golovacheva</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Головачева Анжелика Александровна, студентка 6-го курса Института клинической медицины.</p><p>119991, Москва, ул. Трубецкая, д. 8, стр. 2</p></bio><bio xml:lang="en"><p>Anzhelika A. Golovacheva, 6th year Student of the Institute of Clinical Medicine.</p><p>8, Bldg. 2, Trubetskaya St., Moscow, 119991</p></bio><email xlink:type="simple">angelika.golovacheva@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0842-8557</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Голубев</surname><given-names>В. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Golubev</surname><given-names>V. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Голубев Валерий Леонидович - доктор медицинских наук, профессор кафедры нервных болезней Института профессионального образования.</p><p>119991, Москва, ул. Трубецкая, д. 8, стр. 2</p></bio><bio xml:lang="en"><p>Valery L. Golubev, Dr. Sci. (Med.), Professor of the Department of Nervous Diseases and Neurosurgery of the Institute of Clinical Medicine.</p><p>8, Bldg. 2, Trubetskaya St., Moscow, 119991</p></bio><email xlink:type="simple">vlgol_59@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Первый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский Университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Sechenov First Moscow State Medical University (Sechenov University)</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>07</day><month>08</month><year>2021</year></pub-date><volume>0</volume><issue>10</issue><fpage>164</fpage><lpage>170</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Головачева В.А., Головачева А.А., Голубев В.Л., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Головачева В.А., Головачева А.А., Голубев В.Л.</copyright-holder><copyright-holder xml:lang="en">Golovacheva V.A., Golovacheva A.A., Golubev V.L.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/6279">https://www.med-sovet.pro/jour/article/view/6279</self-uri><abstract><p>Описан клинический случай пациентки с хронической неспецифической болью в нижней части спины и коморбидной хронической инсомнией, показан современный подход к ведению данной категории пациентов. К хронизации БНЧС приводят т. н. желтые флажки - факторы, которые способствуют центральной сенситизации боли. В представленном клиническом случае были выявлены наиболее распространенные «желтые флажки»: инсомния, катастрофизация боли, ограничительное «болевое» поведение, тревожность. В практической деятельности часто не обращают внимания на перечисленные факторы, определяют только наличие боли в спине и назначают обезболивающую терапию, что не позволяет добиться эффективного результата. Инсомния распространена среди пациентов с БНЧС, встречается в 47-64% случаев. В условиях пандемии COVID-19 среди населения увеличилась частота развития инсомнии, тревоги и депрессии. На сегодняшний день выявление и лечение перечисленных нарушений особенно актуально при ведении пациентов с хронической неспецифической БНЧС.</p><p>Пациентке проводилось лечение, которое включало нелекарственные и лекарственные методы и соответствовало российским и зарубежным клиническим рекомендациям по терапии хронической неспецифической БНЧС и по терапии хронической инсомнии. Нелекарственное лечение состояло из образовательных бесед, рекомендаций по повседневной активности и гигиене сна, когнитивно-поведенческой терапии, майндфулнесс, релаксации, лечебной гимнастики. Перечисленные методы были направлены на снижение катастрофизации боли, физическую и социальную активизацию пациентки. В качестве фармакотерапии применялось нестероидное противовоспалительное средство декскетопрофен по ступенчатой схеме приема. Через 5 дней терапии наблюдалось облегчение боли, через 3 мес. терапии боль в спине регрессировала, сон нормализовался, настроение улучшилось. Данный терапевтический подход показал свою эффективность и безопасность в лечении хронической неспецифической БНЧС и коморбидной хронической инсомнии.</p></abstract><trans-abstract xml:lang="en"><p>A clinical case of a patient with chronic nonspecific low back pain and comorbid chronic insomnia is described, and a modern approach to the management of this patient category is shown. So-called yellow flags - factors that contribute to the central sensitization of pain - lead to chronicity of LBP. In the presented clinical case we identified the most common "yellow flags”: insomnia, pain catastrophizing, restrictive ”pain” behavior, anxiety. In practice, they often ignore the aforementioned factors, determine only the presence of back pain and prescribe analgesic therapy, which does not allow for an effective result.</p><p>Insomnia is prevalent among patients with LBP, occurring in 47-64% of cases. With the COVID-19 pandemic among the population, the incidence of insomnia, anxiety and depression has increased. To date, the identification and treatment of these disorders is particularly relevant in the management of patients with chronic nonspecific LBP.</p><p>The patient was treated, which included non-drug and drug methods and complied with Russian and foreign clinical guidelines on the therapy of chronic nonspecific LBP and on the therapy of chronic insomnia. Non-drug treatment consisted of educational talks, recommendations on daily activity and sleep hygiene, cognitive-behavioral therapy, mindfulness, relaxation, and therapeutic gymnastics. The listed methods were aimed at reducing pain catastrophizing, physical and social activation of the patient. The nonsteroidal anti-inflammatory drug dexketoprofen was used as pharmacotherapy according to a step-by-step regimen. After 5 days of therapy pain relief was observed, after 3 months of therapy back pain regressed, sleep normalized, mood improved. This therapeutic approach showed its effectiveness and safety in the treatment of chronic nonspecific LBP and comorbid chronic insomnia.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>боль в нижней части спины</kwd><kwd>люмбалгия</kwd><kwd>инсомния</kwd><kwd>хроническая боль</kwd><kwd>диагностика</kwd><kwd>лечение</kwd><kwd>НПВС</kwd><kwd>когнитивно-поведенческая терапия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>low back pain</kwd><kwd>lumbodynia</kwd><kwd>insomnia</kwd><kwd>chronic pain</kwd><kwd>diagnosis</kwd><kwd>treatment</kwd><kwd>NSAIDs</kwd><kwd>cognitive behavioral therapy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Koes B.W., van TuLder M., Lin C.W., Macedo L.G., McAuley J., Maher C. An updated overview of clinical guidelines for the management of non-specific Low back pain in primary care. Eur Spine J. 2010;19(12):2075-2094. https://doi.org/10.1007/s00586-010-1502-y.</mixed-citation><mixed-citation xml:lang="en">Koes B.W., van TuLder M., Lin C.W., Macedo L.G., McAuLey J., Maher C. An updated overview of cLinicaL guideLines for the management of non-specific Low back pain in primary care. Eur Spine J. 2010;19(12):2075-2094. https://doi.org/10.1007/s00586-010-1502-y.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Подчуфарова Е.В., Яхно Н.Н. Боль в спине. М.: ГЭОТАР-Медиа; 2010. 368 c. Режим доступа: http://www.geotar.ru/Lots/O0113294.htmL.</mixed-citation><mixed-citation xml:lang="en">Podchufarova E.V., Yakhno N.N. Backache. Moscow: GEOTAR-Media; 2010. 368 p. (In Russ.) AvaiLabLe at: http://www.geotar.ru/Lots/O0113294.htmL.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Парфенов ВА., Яхно Н.Н., Давыдов О.С., Кукушкин М.Л., Чурюканов М.В., Головачева В.А. и др. Хроническая неспецифическая (скелетно-мышечная) поясничная боль. Рекомендации Российского общества по изучению боли (РОИБ). Неврология, нейропсихиатрия, психосоматика. 2019;11(2S):7-16. https://doi.org/10.14412/2074-2711-2019-2S-7-16.</mixed-citation><mixed-citation xml:lang="en">Parfenov V.A., Yakhno N.N., Davydov O.S., Kukushkin M.L., Churyukanov M.V., GoLovacheva V.A. et aL. Chronic Nonspecific (MuscuLoskeLetaL) Low Back Pain. GuideLines of the Russian Society for the Study of Pain (RSSPj. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2019;11(2S):7-16. (In Russ.) https://doi.org/10.14412/2074-2711-2019-2S-7-16.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Парфенов ВА., Яхно Н.Н., Кукушкин МЛ., Чурюканов М.В., Давыдов О.С., Головачева ВА. и др. Острая неспецифическая (скелетно-мышечная) поясничная боль. Рекомендации Российского. Неврология, нейропсихиатрия, психосоматика. 2018;10(2):4-11. https://doi.org/10.14412/2074-2711-2018-2-4-11.</mixed-citation><mixed-citation xml:lang="en">Parfenov VA., Yakhno N.N., Kukushkin M.L., Churyukanov M.V., Davydov O.S., Golovacheva VA. et al. Acute Nonspecific (Musculoskeletal) Low Back Pain. Guidelines of the Russian Society for the Study of Pain (RSSP). Nevrologiya, nei-ropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2018;10(2):4-11. (In Russ.) https://doi.org/10.14412/2074-2711-2018-2-4-11.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Парфенов ВА., Исайкин А.И. Боли в нижней части спины: мифы и реальность. М.: ИМА-ПРЕСС; 2016. 104 с. Режим доступа: https://docpLayer.ru/76565256-V-a-parfenov-a-i-isaykin-boL-v-nizhney-chasti-spiny-mify-i-reaLnost.htmL.</mixed-citation><mixed-citation xml:lang="en">Parfenov VA., Isaikin A.I. Pain in the Lower Back: Myths and Reality. Moscow: IMA-PRESS; 2016. 104 p. (In Russ.) Available at: https://docplayer.ru/76565256-V-a-parfenov-a-i-isaykin-bol-v-nizhney-chasti-spiny-mify-i-realnost.html.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Парфенов ВА., Головачева ВА. Хроническая боль и ее лечение в неврологии. М.: ГЭОТАР-Медиа; 2018. 288 с. Режим доступа: https://eLibrary.ru/item.asp?id=32304260.</mixed-citation><mixed-citation xml:lang="en">Parfenov VA., Golovacheva VA. Chronic pain and its treatment in neurology. Moscow: GEOTAR-Media; 2018. 288 p. (In Russ.) Available at: https://elibrary.ru/item.asp?id=32304260.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Bahouq H., ALLaLi F., Rkain H., Hmamouchi I., Hajjaj-Hassouni N. PrevaLence and Severity of Insomnia in Chronic Low Back Pain Patients. Rheumatol Int. 2013;33(5):1277-1281. https://doi.org/10.1007/s00296-012-2550-x.</mixed-citation><mixed-citation xml:lang="en">Bahouq H., Allali F., Rkain H., Hmamouchi I., Hajjaj-Hassouni N. Prevalence and Severity of Insomnia in Chronic Low Back Pain Patients. Rheumatol Int. 2013;33(5):1277-1281. https://doi.org/10.1007/s00296-012-2550-x.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Purushothaman B., Singh A., LingutLa K., Bhatia C., PoLLock R., Krishna M. PrevaLence of Insomnia in Patients with Chronic Back Pain. J Orthop Surg (Hong Kong). 2013;21(1):68-70. https://doi.org/10.1177/230949901302100118.</mixed-citation><mixed-citation xml:lang="en">Purushothaman B., Singh A., Lingutla K., Bhatia C., Pollock R., Krishna M. Prevalence of Insomnia in Patients with Chronic Back Pain. J Orthop Surg (Hong Kong). 2013;21(1):68-70. https://doi.org/10.1177/230949901302100118.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Tang N.K., Wright KJ., SaLkovskis P.M. PrevaLence and CorreLates of CLinicaL Insomnia Co-Occurring with Chronic Back Pain. J Sleep Res. 2007;16(1):85-95. https://doi.org/10.1111/j.1365-2869.2007.00571.x.</mixed-citation><mixed-citation xml:lang="en">Tang N.K., Wright KJ., Salkovskis P.M. Prevalence and Correlates of Clinical Insomnia Co-Occurring with Chronic Back Pain. J Sleep Res. 2007;16(1):85-95. https://doi.org/10.1111/j.1365-2869.2007.00571.x.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Edwards R.R., ALmeida D.M., KLick B., Haythornthwaite JA., Smith M.T. Duration of SLeep Contributes to Next-Day Pain Report in the GeneraL PopuLation. Pain. 2008;137(1):202-207. https://doi.org/10.1016/j.pain.2008.01.025.</mixed-citation><mixed-citation xml:lang="en">Edwards R.R., Almeida D.M., Klick B., Haythornthwaite JA., Smith M.T. Duration of Sleep Contributes to Next-Day Pain Report in the General Population. Pain. 2008;137(1):202-207. https://doi.org/10.1016/j.pain.2008.01.025.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Siengsukon C., EmmanueL N.M., Sharma N.K. ReLationship between Low Back Pain and SLeep OuaLity. J NovPhysiother. 2013;3(4):168. https://doi.org/10.4172/2165-7025.1000168.</mixed-citation><mixed-citation xml:lang="en">Siengsukon C., Emmanuel N.M., Sharma N.K. Relationship between Low Back Pain and Sleep Ouality. J NovPhysiother. 2013;3(4):168. https://doi.org/10.4172/2165-7025.1000168.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Wang H., Fu T., Hsu S., Hung C. Association of Depression with SLeep OuaLity Might Be Greater Than That of Pain Intensity among Outpatients with Chronic Low Back Pain. Neuropsychiatr Dis Treat. 2016;12:1993-1998. https://doi.org/10.2147/ndt.s110162.</mixed-citation><mixed-citation xml:lang="en">Wang H., Fu T., Hsu S., Hung C. Association of Depression with Sleep Ouality Might Be Greater Than That of Pain Intensity among Outpatients with Chronic Low Back Pain. Neuropsychiatr Dis Treat. 2016;12:1993-1998. https://doi.org/10.2147/ndt.s110162.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">KeLLy G.A., BLake C., Power C.K, O'keeffe D., FuLLen B.M. The Association between Chronic Low Back Pain and SLeep: A Systematic Review. Clin J Pain. 2011;27(2):169-181. https://doi.org/10.1097/AJP.0b013e3181f3bdd5.</mixed-citation><mixed-citation xml:lang="en">Kelly G.A., Blake C., Power C.K, O'keeffe D., Fullen B.M. The Association between Chronic Low Back Pain and Sleep: A Systematic Review. Clin J Pain. 2011;27(2):169-181. https://doi.org/10.1097/AJP.0b013e3181f3bdd5.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Полуэктов М.Г, Бузунов Р.В., Авербух В.М., Вербицкий Е.В., Захаров А.В., Кельмансон ИА. и др. Проект клинических рекомендаций по диагностике и лечению хронической инсомнии у взрослых. Consilium Medicum. Неврология и ревматология (Прил.). 2016;(2):41-51. Режим доступа: https://www.mmot.ru/pubLic/upLoads/2020/RNMOT/Клинические%20рекомендации%20по%20инсомнии.pdf.</mixed-citation><mixed-citation xml:lang="en">Poluektov M.G., Buzunov R.V., Averbukh V.M., Verbitskiy E.V., Zakharov A.V., Kel’manson I.A. et al. Project of Clinical Recommendations on Diagnosis and Treatment of Chronic Insomnia in Adults. Consilium Medicum. Nevrologiya i Revmato logiya (Pril.) = Consilium Medicum. Neurology and Rheumatology (Suppl.). 2016;(2):41–51. (In Russ.) Available at: https://www.rnmot.ru/public/uploads/2020/RNMOT/Клинические%20рекомендации%20по%20инсомнии.pdf</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">OLiveira C.B., Maher C.G., Pinto R.Z., Traeger A.C., Lin C.C., Chenot J.F. et aL. CLinicaL Practice GuideLines for the Management of Non-Specific Low Back Pain in Primary Care: An Updated Overview. Eur Spine J. 2018;27(11):2791-2803. https://doi.org/10.1007/s00586-018-5673-2.</mixed-citation><mixed-citation xml:lang="en">Oliveira C.B., Maher C.G., Pinto R.Z., Traeger A.C., Lin C.C., Chenot J.F. et al. Clinical Practice Guidelines for the Management of Non-Specific Low Back Pain in Primary Care: An Updated Overview. Eur Spine J. 2018;27(11):2791-2803. https://doi.org/10.1007/s00586-018-5673-2.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Schutte-Rodin S., Broch L., Buysse D., Dorsey C., Sateia M. CLinicaL GuideLine for the EvaLuation and Management of Chronic Insomnia in AduLts. J Clin Sleep Med. 2008;4(5):487-504. AvaiLabLe at: https://pubmed.ncbi.nLm.nih.gov/18853708.</mixed-citation><mixed-citation xml:lang="en">Schutte-Rodin S., Broch L., Buysse D., Dorsey C., Sateia M. Clinical Guideline for the Evaluation and Management of Chronic Insomnia in Adults. J Clin Sleep Med. 2008;4(5):487-504. Available at: https://pubmed.ncbi.nlm.nih.gov/18853708.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Sateia MJ. InternationaL CLassification of SLeep Disorders - Third Edition: HighLights and Modifications. Chest. 2014;146(5):1387-1394. https://doi.org/10.1378/chest.14-0970.</mixed-citation><mixed-citation xml:lang="en">Sateia MJ. International Classification of Sleep Disorders - Third Edition: Highlights and Modifications. Chest. 2014;146(5):1387-1394. https://doi.org/10.1378/chest.14-0970.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Oaseem A., WiLt TJ., McLean R.M., Forciea MA. Noninvasive Treatments for Acute, Subacute, and Chronic Low Back Pain: A CLinicaL Practice GuideLine from the American CoLLege of Physicians. Ann Intern Med. 2017;166(7): 514-530. https://doi.org/10.7326/M16-2367.</mixed-citation><mixed-citation xml:lang="en">Oaseem A., Wilt TJ., McLean R.M., Forciea MA. Noninvasive Treatments for Acute, Subacute, and Chronic Low Back Pain: A Clinical Practice Guideline from the American College of Physicians. Ann Intern Med. 2017;166(7): 514-530. https://doi.org/10.7326/M16-2367.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">StochkendahL MJ., Kjaer P, Hartvigsen J., Kongsted A., Aaboe J., Andersen M. et aL. NationaL CLinicaL GuideLines for Non-SurgicaL Treatment of Patients with Recent Onset Low Back Pain or Lumbar RadicuLopathy. Eur Spine J. 2018;27(1):60-75. https://doi.org/10.1007/s00586-017-5099-2.</mixed-citation><mixed-citation xml:lang="en">Stochkendahl MJ., Kjaer P., Hartvigsen J., Kongsted A., Aaboe J., Andersen M. et al. National Clinical Guidelines for Non-Surgical Treatment of Patients with Recent Onset Low Back Pain or Lumbar Radiculopathy. Eur Spine J. 2018;27(1):60-75. https://doi.org/10.1007/s00586-017-5099-2.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Медведев В.Э. Расстройства тревожно-депрессивного спектра на фоне COVID-19: возможности терапии. Неврология, нейропсихиатрия, психосоматика. 2021;13(2):111-116. https://doi.org/10.14412/2074-2711-2021-2-111-116.</mixed-citation><mixed-citation xml:lang="en">Medvedev V.E. Anxiety and Depression in COVID-19: Treatment Options. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2021;13(2):111-116. (In Russ.) https://doi.org/10.14412/2074-2711-2021-2-111-116.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Pappa S., NteLLa V., Giannakas T., GiannakouLis V.G., Papoutsi E., Katsaounou P PrevaLence of Depression, Anxiety, and Insomnia among HeaLthcare Workers during the COVID-19 Pandemic: A Systematic Review and Meta-AnaLysis. Brain BehavImmun. 2020;88:901-907. https://doi.org/10.1016/j.bbi.2020.05.026.</mixed-citation><mixed-citation xml:lang="en">Pappa S., Ntella V., Giannakas T., Giannakoulis V.G., Papoutsi E., Katsaounou P. Prevalence of Depression, Anxiety, and Insomnia among Healthcare Workers during the COVID-19 Pandemic: A Systematic Review and Meta-Analysis. Brain BehavImmun. 2020;88:901-907. https://doi.org/10.1016/j.bbi.2020.05.026.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Li Y., Oin O., Sun O., Sanford L.D., Vgontzas A.N., Tang X. Insomnia and PsychoLogicaL Reactions during the COVID-19 Outbreak in China. J Clin Sleep Med. 2020;16(8):1417-1418. https://doi.org/10.5664/jcsm.8524.</mixed-citation><mixed-citation xml:lang="en">Li Y., Oin O., Sun O., Sanford L.D., Vgontzas A.N., Tang X. Insomnia and Psychological Reactions during the COVID-19 Outbreak in China. J Clin Sleep Med. 2020;16(8):1417-1418. https://doi.org/10.5664/jcsm.8524.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Cenat J.M., BLais-Rochette C., Kokou-KpoLou C.K., Noorishad P.G., Mukunzi J.N., McIntee S.E. et aL. PrevaLence of Symptoms of Depression, Anxiety, Insomnia, Posttraumatic Stress Disorder, and PsychoLogicaL Distress among PopuLations Affected by the COVID-19 Pandemic: A Systematic Review and Meta-AnaLysis. Psychiatry Res. 2021;295:113599. https://doi.org/10.1016/j.psychres.2020.113599.</mixed-citation><mixed-citation xml:lang="en">Cenat J.M., Blais-Rochette C., Kokou-Kpolou C.K., Noorishad P.G., Mukunzi J.N., McIntee S.E. et al. Prevalence of Symptoms of Depression, Anxiety, Insomnia, Posttraumatic Stress Disorder, and Psychological Distress among Populations Affected by the COVID-19 Pandemic: A Systematic Review and Meta-Analysis. Psychiatry Res. 2021;295:113599. https://doi.org/10.1016/j.psy-chres.2020.113599.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Соловьева Э., Карнеев А., Федин А. Сочетанное применение Дексалгина и Нимесила в стадии обострения дорсопатии. Врач. 2007;(3):67-71. Режим доступа: https://www.eLibrary.ru/item.asp?id=12974322.</mixed-citation><mixed-citation xml:lang="en">Solov'eva E., Karneev A., Fedin A. Combined Use of Dexalgin and Nimesil in the Stage of Exacerbation of Dorsopathy. Vrach = The Doctor. 2007;(3):67-71. (In Russ.) Available at: https://www.elibrary.ru/item.asp?id=12974322.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Соловьева Э.Ю., Карнеев А.Н., Иваноков А.Н., Джутова ЭД. Декскетопрофен в лечении острой боли в спине. Эффективная фармакотерапия. Неврология и психиатрия. 2012;(5):36-40. Режим доступа: https://www.umedp.ru/upLoad/ibLock/8c1/8c182cde09801d0367615e2c18fb49a1.pdf.</mixed-citation><mixed-citation xml:lang="en">Solov'eva E.Yu., Karneev A.N., Ivanokov A.N., Dzhutova E.D. Dexketoprofen in the Treatment of Acute Back Pain. Effektivnaya farmakoterapiya. Nevrologiya i psihiatriya = Effective Pharmacotherapy. Neurology and Psychiatry. 2012;(5):36-40. (In Russ.) Available at: https://www.umedp.ru/upload/iblock/8c1/8c182cde09801d0367615e2c18fb49a1.pdf.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Moore R.A., Barden J. Systematic Review of Dexketoprofen in Acute and Chronic Pain. BMC Clinical Pharmacology. 2008;8:11. https://doi.org/10.1186/1472-6904-8-11.</mixed-citation><mixed-citation xml:lang="en">Moore R.A., Barden J. Systematic Review of Dexketoprofen in Acute and Chronic Pain. BMC Clinical Pharmacology. 2008;8:11. https://doi.org/10.1186/1472-6904-8-11.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Rainsford K.D. Current Status of the Therapeutic Uses and Actions of the PreferentiaL CycLo-Oxygenase-2 NSAID, NimesuLide. Inflammopharmacology. 2006;14(3-4):120-137. https://doi.org/10.1007/s10787-006-1505-9.</mixed-citation><mixed-citation xml:lang="en">Rainsford K.D. Current Status of the Therapeutic Uses and Actions of the Preferential Cyclo-Oxygenase-2 NSAID, Nimesulide. Inflammopharmacology. 2006;14(3-4):120-137. https://doi.org/10.1007/s10787-006-1505-9.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Алексеева Л.И., Каратеев А.Е., Попкова Т.В., Новикова Д.С., Шарапова Е.Н., Маркелова Е.П., Насонов ЕЛ. Эффективность и безопасность длительного применения нимесулида у больных остеоартрозом: результаты 12-месячного открытого контролируемого исследования ДИНАМО (Длительное Использование Нимесулида при Артрозе Многофакторная Оценка). Научнопрактическая ревматология. 2009;47(4):64-72. https://doi.org/10.14412/1995-4484-2009-1152.</mixed-citation><mixed-citation xml:lang="en">Alexeeva L.I., Karateev A.E., Popkova T.V., Novikova D.S., Sharapova E.N., Markelova E.P., Nasonov E.L. Efficacy and Safety of Nimesulide Long Term Administration in Patients with Osteoarthritis: Results of 12-Months Open Controlled Study DINAMO (Long Term Administration of Nimesulide in Osteoarthritis Multifactor Assessment). Nauchno-prakticheskaya revmatologi-ya = Rheumatology Science and Practice. 2009;47(4):64-72. (In Russ.) https://doi.org/10.14412/1995-4484-2009-1152.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Laporte J.R., Ibanez L., VidaL X., VendreLL L., Leone R. Upper GastrointestinaL BLeeding Associated with the Use of NSAIDs: Newer versus OLder Agents. Drug Saf. 2004;27(6):411-420. https://doi.org/10.2165/00002018-200427060-00005.</mixed-citation><mixed-citation xml:lang="en">Laporte J.R., Ibanez L., Vidal X., Vendrell L., Leone R. Upper Gastrointestinal Bleeding Associated with the Use of NSAIDs: Newer versus Older Agents. Drug Saf. 2004;27(6):411-420. https://doi.org/10.2165/00002018-200427060-00005.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Conforti A., Leone R., Moretti U., Mozzo F., VeLo G. Adverse Drug Reactions ReLated to the Use of NSAIDs with a Focus on NimesuLide: ResuLts of Spontaneous Reporting from a Northern ItaLian Area. Drug Saf. 2001;24(14):1081-1090. https://doi.org/10.2165/00002018-200124140-00006.</mixed-citation><mixed-citation xml:lang="en">Conforti A., Leone R., Moretti U., Mozzo F., Velo G. Adverse Drug Reactions Related to the Use of NSAIDs with a Focus on Nimesulide: Results of Spontaneous Reporting from a Northern Italian Area. Drug Saf. 2001;24(14):1081-1090. https://doi.org/10.2165/00002018-200124140-00006.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Подчуфарова Е.В. Боль в пояснично-крестцовой области: диагностика и лечение. РМЖ. 2005;(27):1893-1899. Режим доступа: https://www.rmj.ru/articLes/obshchie-stati/BoLy_v_poyasnichnokrestcovoy_obLasti_diagnostika_i_Lechenie.</mixed-citation><mixed-citation xml:lang="en">Podchufarova E.V. Lumbosacral Pain: Diagnosis and Treatment. RMZH = RMJ. 2005;(27):1893-1899. (In Russ.) Available at: https://www.rmj.ru/articles/obshchie-stati/Boly_v_poyasnichnokrestcovoy_oblasti_diagnostika_i_lechenie.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Виноградов Д.К., Доронина О.Б. Особенности нарушений сна у пациентов с хронической болью в спине. Клиническая практика. 2019;10(2):46-52. https://doi.org/10.17816/cLinpract10246-52.</mixed-citation><mixed-citation xml:lang="en">Vinogradov D.K., Doronina O.B. Features of Sleep Disorders in Patients with Chronic Back Pain. Klinicheskaya praktika = Journal of Clinical Practice. 2019;10(2):46-52. (In Russ.) https://doi.org/10.17816/clinpract10246-52.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
