medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2021-11-156-164medsovet-6303Research ArticleШКОЛА ПЕДИАТРАPEDIATRICIAN SCHOOLКишечная микробиота и иммунитет. Возможности мультиштаммовых пробиотиков в коррекции иммунного статуса у детейIntestinal microbiota and immunity. Possibilities of multistrain probiotics in the correction of immune status in childrenhttps://orcid.org/0000-0002-6607-3793ЧеботареваТ. А.ChebotarevaT. A.

Чеботарева Татьяна Александровна, доктор медицинских наук, профессор кафедры детских инфекционных болезней.

125373, Москва, ул. Героев Панфиловцев, д. 28

Tatiana A. Chebotareva, Dr. Sci. (Med.), Professor of the Department of Pediatric Infectious Diseases.

28, Geroev Panfilovtsev St., Moscow, 125373

t_sheina@mail.ruРоссийская медицинская академия непрерывного профессионального образованияРоссияMedical Academy of Continuous Professional EducationRussian Federation202110082021011156164Copyright © Чеботарева Т.А., 20212021Чеботарева Т.А.Chebotareva T.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/6303

На основании анализа зарубежных и российских научных исследований представлены современные данные о роли кишечной микробиоты в становлении иммунитета и изменениях ее качественного состава при формировании различных заболеваний. Так, например, снижение или отсутствие Helicobacter pylori ассоциировано с бронхиальной астмой и рефлюксэзофагитом в детском возрасте, при псориазе отмечено изменение соотношения Firmicutes/Actinobacteria, а при ожирении – Bacteroidetes/ Firmicutes в желудочнокишечном тракте, воспалительные заболевания кишечника сопровождаются увеличением содержания Enterobacteriaceae, функциональные нарушения желудочнокишечного тракта – ростом бактерий рода Veillonella. В статье показаны механизмы влияния микробиоты желудочнокишечного и респираторного трактов на снижение частоты повторных инфекций путем индукции генов противовирусной защиты, что в исследованиях терапии пробиотиками подтверждено значимыми клиническими эффектами. Приводится обсуждение преимуществ мультиштаммовых пробиотиков, оказывающих всестороннее воздействие на кишечную микробиоту. Важность включения пробиотических штаммов в комплексную терапию острых респираторных инфекций подтверждена исследованиями, доказавшими их положительное влияние на иммунитет ребенка, снижение тяжести болезни и частоты осложнений и рецидивов. Результаты современных научных исследований доказывают значимость оптимального соотношения пробиотических штаммов в комбинации лактои бифидобактерий, а также их штаммоспецифичность. В статье представлены сведения о синбиотике, созданном с использованием инновационной защитной технологии каждой микрогранулы саше, включающем комбинацию 9  пробиотических штаммов лактои  бифидобактерий. Присутствие в составе пребиотического компонента фруктоолигосахарида усиливает действие пробиотической составляющей.

On the basis of the analysis of foreign and Russian scientific studies the current data on the role of the intestinal microbiota in the formation of immunity and changes in its qualitative composition in the formation of various diseases are presented: For example, a decrease or absence of Helicobacter pylori is associated with bronchial asthma and reflux esophagitis in childhood, a change in Firmicutes/Actinobacteria ratio in psoriasis, and Bacteroidetes/Firmicutes ratio in the gastrointestinal tract in obesity, inflammatory bowel diseases are accompanied by an increase in Enterobacteriaceae, functional disorders of the gastrointestinal tract by a growth of Veillonella bacteria. The article shows the mechanisms of influence of the microbiota of the gastrointestinal and respiratory tracts on reducing the frequency of repeated infections by induction of antiviral defense genes, which in studies of probiotic therapy is confirmed by significant clinical effects. A discussion of the benefits of multistrain probiotics with comprehensive effects on the intestinal microbiota is provided. The importance of including probiotic strains in the complex therapy of acute respiratory infections is confirmed by the studies proving their positive effect on the child’s immunity, reducing the severity of the disease and the frequency of complications and relapses. The results of modern scientific research prove the importance of the optimal ratio of probiotic strains in the combination of lactoand bifidobacteria, as well as their strain specificity. The article presents information on a synbiotic created using an innovative protective technology of each sachet microgranule including a combination of 9 probiotic strains of lactoand bifidobacteria. The presence of fructooligosaccharide in the prebiotic component enhances the effect of the probiotic component.

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The authors declare that there are no conflicts of interest present.