medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2021-12-130-137medsovet-6341Research ArticleПУЛЬМОНОЛОГИЯ, ЛОРBRONCHOPULMONOLOGY, OTORHINOLARYNGOLOGYМометазона фуроат в лечении аллергического ринита: комплексный терапевтический эффектMometasone furoate in the treatment of allergic rhinitis: a complex therapeutic effecthttps://orcid.org/0000-0001-9322-2689ФассаховР. С.FassakhovR. S.

д.м.н., профессор кафедры фундаментальных основ клинической медицины,

420008, Казань, ул. Кремлевская, д. 18

Dr. Sci. (Med.), Professor of the Department of Fundamentals of Clinical Medicine,

18, Kremlevskaya St., Kazan, 420008

farrus@mail.ruhttps://orcid.org/0000-0003-2583-0599МараповД. И.MarapovD. I.

к.м.н., ассистент учебно-методического центра «Бережливые технологии в здравоохранении»,

420008, Казань, ул. Кремлевская, д. 18

Cand. Sci. (Med.), Assistant of the Educational and Methodological Center “Lean Technologies in Health Care”,

18, Kremlevskaya St., Kazan, 420008

damirov@list.ruКазанский (Приволжский) федеральный университетРоссияKazan Federal UniversityRussian Federation202115092021012130137Copyright © Фассахов Р.С., Марапов Д.И., 20212021Фассахов Р.С., Марапов Д.И.Fassakhov R.S., Marapov D.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/6341

В обзоре рассматривается роль интраназального спрея мометазона фуроата (НсМФ) в терапии аллергического ринита (АР). Отмечается широкая распространенность АР как среди детей, так и  взрослого населения, его неблагоприятное влияние на качество жизни больных. Подчеркивается, что основными средствами терапии при среднетяжелом и тяжелом течении АР в соответствии с международными и российскими рекомендациями по диагностике и лечению АР являются препараты интраназальных глюкокортикостероидов (ИнГКС). Подробно разбираются фармакологические особенности молекулы МФ, лежащие в основе его эффективности и безопасности, включая аффинность, липофильность и вязкость, а также низкую системную биодоступность. Детально рассматриваются терапевтические эффекты НсМФ при лечении сезонного и круглогодичного АР, его влияние на назальные симптомы. Отдельно подчеркивается благоприятное влияние терапии НсМФ на заложенность носа. Отмечается благоприятное действие лечения НсМФ и на другие клинические проявления АР, включая глазные симптомы, влияние на  сон, обонятельную функцию. Подробно рассматриваются вопросы безопасности применения НсМФ, включая системные эффекты, такие как влияние на функцию надпочечников, глазное давление и задержку роста у детей, и местное неблагоприятное воздействие на слизистую носа; отмечается высокий профиль местной и системной безопасности длительного применения НсМФ при лечении АР как у взрослых, так и детей. 

The review examines the role of mometasone furoate (NSMF) intranasal spray (Nasonex) in the treatment of allergic rhinitis (AR). There is a wide prevalence of AR both among children and adults, its adverse effect on the quality of life of patients. It is emphasized that the main means of therapy for moderate and severe course in accordance with international and Russian recommendations for the diagnosis and treatment of AR are intranasal glucocorticosteroids (INGKS). The pharmacological features of the MF molecule that underlie its efficacy and safety, including the affinity, lipophilicity and viscosity of the drug, as well as low systemic bioavailability, are discussed in detail. The therapeutic effects of NSMF in the treatment of seasonal and perennial AR, its effect on nasal symptoms are discussed in detail. The beneficial effect of NSMF therapy on nasal congestion is emphasized separately. The beneficial effect of NSMF treatment on other clinical manifestations of AR, including ocular symptoms, effects on sleep, and olfactory function, has been noted. The safety issues of NSMF use are discussed in detail, including systemic effects, such as effects on adrenal function, eye, and growth retardation in children, and local adverse effects on the nasal mucosa; there is a high profile of local and systemic safety of long-term use of NSMF in the treatment of AR in both adults and children. 

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The authors declare that there are no conflicts of interest present.