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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2021-12-238-244</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-6354</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЭНДОКРИНОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ENDOCRINOLOGY</subject></subj-group></article-categories><title-group><article-title>Гликемический контроль – важный инструмент в профилактике сердечно-сосудистого старения у больных сахарным диабетом</article-title><trans-title-group xml:lang="en"><trans-title>Glycemic control as an important tool in the prevention of cardiovascular aging in patients with diabetes mellitus</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1831-8052</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шацкая</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Shatskaya</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., ведущий научный сотрудник отдела кардиологии и сосудистой хирургии,</p><p>117036, Москва, ул. Дмитрия Ульянова, д. 11</p></bio><bio xml:lang="en"><p>Cand. Sci. (Med.), Leading Researcher of the Department of Cardiology and Vascular Surgery,</p><p>11, Dmitry Ulyanov St., Moscow, 117036</p></bio><email xlink:type="simple">shatskaya@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5178-6029</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бондаренко</surname><given-names>И. З.</given-names></name><name name-style="western" xml:lang="en"><surname>Bondarenko</surname><given-names>I. Z.</given-names></name></name-alternatives><bio xml:lang="ru"><p> д.м.н., главный научный сотрудник отдела кардиологии и сосудистой хирургии,</p><p>117036, Москва, ул. Дмитрия Ульянова, д. 11</p></bio><bio xml:lang="en"><p>Dr. Sci. (Med.), Chief Researcher of the Department of Cardiology and Vascular Surgery,</p><p>11, Dmitry Ulyanov St., Moscow, 117036</p></bio><email xlink:type="simple">iz_bondarenko@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1926-0091</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кухаренко</surname><given-names>С. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Kukharenko</surname><given-names>S. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., ведущий научный сотрудник отдела кардиологии и сосудистой хирургии</p><p>117036, Москва, ул. Дмитрия Ульянова, д. 11</p></bio><bio xml:lang="en"><p>Cand. Sci. (Med.), Leading Researcher of the Department of Cardiology and Vascular Surgery,</p><p>11, Dmitry Ulyanov St., Moscow, 117036</p></bio><email xlink:type="simple">sveta_kukharenko@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Национальный медицинский исследовательский центр эндокринологии</institution><country>Россия</country></aff><aff xml:lang="en"><institution>National Medical Research Center for Endocrinology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>17</day><month>09</month><year>2021</year></pub-date><volume>0</volume><issue>12</issue><fpage>238</fpage><lpage>244</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шацкая О.А., Бондаренко И.З., Кухаренко С.С., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Шацкая О.А., Бондаренко И.З., Кухаренко С.С.</copyright-holder><copyright-holder xml:lang="en">Shatskaya O.A., Bondarenko I.Z., Kukharenko S.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/6354">https://www.med-sovet.pro/jour/article/view/6354</self-uri><abstract><p>В последние десятилетия отмечается значительный рост заболеваемости и распространенности сахарного диабета (СД), который характеризуется развитием сосудистых осложнений, ведущих к ранней инвалидизации и снижению продолжительности жизни пациентов. Старение организма неизбежно ведет к возникновению возрастзависимых заболеваний, в т. ч. сердечнососудистой системы, и повышает риск смерти. Метаболические и структурно-функциональные нарушения сердечно-сосудистой системы, возникающие при СД, имеют общие со  старением организма патофизиологические механизмы. Для больных СД, особенно в условиях стойкой гипергликемии, характерны изменение метаболизма в миокарде, усиление окислительного стресса, возникновение структурно-функциональных изменений, нарушение микроциркуляции с последующим развитием диастолической и систолической дисфункций сердца, атеросклероза, клинически значимой сердечной недостаточности. Хроническая гипергликемия может ускорять процессы старения и иметь решающее значение в возникновении и прогнозе кардиоваскулярных событий у  больных СД. Достижение и  поддержание целевых показателей гликемии позволяют снизить риск развития сердечно-сосудистых осложнений у  пациентов с  СД. Оптимальный гликемический контроль включает определение уровня гликированного гемоглобина, непрерывное мониторирование гликемии, флеш-мониторинг глюкозы и самоконтроль гликемии при помощи глюкометра. Усовершенствованные модели глюкометров, оснащенные рядом дополнительных функций, позволяют проводить структурированный самоконтроль гликемии, анализировать полученные данные и проводить своевременную коррекцию терапии, активно вовлекать пациентов в процесс управления СД, что значительно повысит эффективность управления заболеванием, позволит снизить риск осложнений у пациентов и улучшить качество жизни. </p></abstract><trans-abstract xml:lang="en"><p>In recent decades, there has been a significant increase in the incidence and prevalence of diabetes mellitus. Diabetes mellitus is characterized by the development of vascular complications leading to early disability and a decrease in the life expectancy of patients. Aging of the body inevitably leads to the occurrence of age-related diseases, including the cardiovascular system, and increases the risk of death. Metabolic and structural and functional disorders of the cardiovascular system arising in diabetes mellitus have common pathophysiological mechanisms with aging of the body. Chronic hyperglycemia can accelerate the aging process and play a decisive role in the occurrence and prognosis of cardiovascular events in patients with diabetes mellitus. Achieving target glycemic values is an important step towards preventing vascular complications in patients with diabetes mellitus. Improved models of glucometers, equipped with a number of additional functions, allow for structured self-control of glycemia, analyze the data obtained and carry out timely correction of therapy, actively involve patients in the process of diabetes management, which will significantly increase the efficiency of disease management, reduce the risk of complications in patients and improve the quality of life.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>гипергликемия</kwd><kwd>клеточное старение</kwd><kwd>эндотелиальная дисфункция</kwd><kwd>окислительный стресс</kwd><kwd>сосудистые осложнения</kwd><kwd>самоконтроль</kwd><kwd>глюкометр</kwd></kwd-group><kwd-group xml:lang="en"><kwd>hyperglycemia</kwd><kwd>cellular senescence</kwd><kwd>endothelial dysfunction</kwd><kwd>oxidative stress</kwd><kwd>vascular complications</kwd><kwd>self-control</kwd><kwd>blood glucose meter</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Cho N.H., Shaw J.E., Karuranga S., Huang Y., da Rocha Fernandes J.D., Ohlrogge A.W., Malanda B. IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Res Clin Pract. 2018;138:271–281. https://doi.org/10.1016/j.diabres.2018.02.023.</mixed-citation><mixed-citation xml:lang="en">Cho N.H., Shaw J.E., Karuranga S., Huang Y., da Rocha Fernandes J.D., Ohlrogge A.W., Malanda B. IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Res Clin Pract. 2018;138:271–281. https://doi.org/10.1016/j.diabres.2018.02.023.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Borghetti G., von Lewinski D., Eaton D.M., Sourij H., Houser S.R., Wallner M. Diabetic Cardiomyopathy: Current and Future Therapies. Beyond Glycemic Control. Front Physiol. 2018;9:1514. https://doi.org/10.3389/fphys.2018.01514.</mixed-citation><mixed-citation xml:lang="en">Borghetti G., von Lewinski D., Eaton D.M., Sourij H., Houser S.R., Wallner M. Diabetic Cardiomyopathy: Current and Future Therapies. Beyond Glycemic Control. Front Physiol. 2018;9:1514. https://doi.org/10.3389/fphys.2018.01514.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Di Angelantonio E., Kaptoge S., Wormser D., Willeit P., Butterworth A.S., Bansal N. et al. Association of Cardiometabolic Multimorbidity with Mortality. JAMA. 2015;314(1):52–60. https://doi.org/10.1001/jama.2015.7008.</mixed-citation><mixed-citation xml:lang="en">Di Angelantonio E., Kaptoge S., Wormser D., Willeit P., Butterworth A.S., Bansal N. et al. Association of Cardiometabolic Multimorbidity with Mortality. JAMA. 2015;314(1):52–60. https://doi.org/10.1001/jama.2015.7008.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Jia G., Hill M.A., Sowers J.R. Diabetic Cardiomyopathy: An Update of Mechanisms Contributing to This Clinical Entity. Circ Res. 2018;122(4):624–638. https://doi.org/10.1161/CIRCRESAHA.117.311586.</mixed-citation><mixed-citation xml:lang="en">Jia G., Hill M.A., Sowers J.R. Diabetic Cardiomyopathy: An Update of Mechanisms Contributing to This Clinical Entity. Circ Res. 2018;122(4):624–638. https://doi.org/10.1161/CIRCRESAHA.117.311586.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Lehrke M., Marx N. Diabetes Mellitus and Heart Failure. Am J Cardiol. 2017;120(1S):S37–S47. https://doi.org/10.1016/j.amjcard.2017.05.014.</mixed-citation><mixed-citation xml:lang="en">Lehrke M., Marx N. Diabetes Mellitus and Heart Failure. Am J Cardiol. 2017;120(1S):S37–S47. https://doi.org/10.1016/j.amjcard.2017.05.014.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Van Melle J.P., Bot M., de Jonge P., de Boer R.A., van Veldhuisen D.J., Whooley M.A. Diabetes, Glycemic Control, and New-Onset Heart Failure in Patients with Stable Coronary Artery Disease: Data from the Heart and Soul Study. Diabetes Care. 2010;33(9):2084–2089. https://doi.org/10.2337/dc10-0286.</mixed-citation><mixed-citation xml:lang="en">Van Melle J.P., Bot M., de Jonge P., de Boer R.A., van Veldhuisen D.J., Whooley M.A. Diabetes, Glycemic Control, and New-Onset Heart Failure in Patients with Stable Coronary Artery Disease: Data from the Heart and Soul Study. Diabetes Care. 2010;33(9):2084–2089. https://doi.org/10.2337/dc10-0286.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Maisch B., Alter P., Pankuweit S. Diabetic Cardiomyopathy: Fact or Fiction? Herz. 2011;36(2):102–115. https://doi.org/10.1007/s00059-011-3429-4.</mixed-citation><mixed-citation xml:lang="en">Maisch B., Alter P., Pankuweit S. Diabetic Cardiomyopathy: Fact or Fiction? Herz. 2011;36(2):102–115. https://doi.org/10.1007/s00059-011-3429-4.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Witteles R.M., Fowler M.B. Insulin-Resistant Cardiomyopathy Clinical Evidence, Mechanisms, and Treatment Options. J Am Coll Cardiol. 2008;51(2):93–102. https://doi.org/10.1016/j.jacc.2007.10.021.</mixed-citation><mixed-citation xml:lang="en">Witteles R.M., Fowler M.B. Insulin-Resistant Cardiomyopathy Clinical Evidence, Mechanisms, and Treatment Options. J Am Coll Cardiol. 2008;51(2):93–102. https://doi.org/10.1016/j.jacc.2007.10.021.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Wong A.K., AlZadjali M.A., Choy A.M., Lang C.C. Insulin Resistance: A Potential New Target for Therapy in Patients with Heart Failure. Cardiovasc Ther. 2008;26(3):203–213. https://doi.org/10.1111/j.1755-5922.2008.00053.x.</mixed-citation><mixed-citation xml:lang="en">Wong A.K., AlZadjali M.A., Choy A.M., Lang C.C. Insulin Resistance: A Potential New Target for Therapy in Patients with Heart Failure. Cardiovasc Ther. 2008;26(3):203–213. https://doi.org/10.1111/j.1755-5922.2008.00053.x.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">North B.J., Sinclair D.A. The Intersection between Aging and Cardiovascular Disease. Circ Res 2012;110(8):1097–108. https://doi.org/10.1161/CIRCRESAHA.111.246876.</mixed-citation><mixed-citation xml:lang="en">North B.J., Sinclair D.A. The Intersection between Aging and Cardiovascular Disease. Circ Res 2012;110(8):1097–108. https://doi.org/10.1161/CIRCRESAHA.111.246876.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Paneni F., Cañestro C.D., Libby P., Lüscher T.F., Camici G.G. The Aging Cardiovascular System: Understanding It at the Cellular and Clinical Levels. J Am Coll Cardiol. 2017;69(15):1952–1967. https://doi.org/10.1016/j.jacc.2017.01.064.</mixed-citation><mixed-citation xml:lang="en">Paneni F., Cañestro C.D., Libby P., Lüscher T.F., Camici G.G. The Aging Cardiovascular System: Understanding It at the Cellular and Clinical Levels. J Am Coll Cardiol. 2017;69(15):1952–1967. https://doi.org/10.1016/j.jacc.2017.01.064.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Shakeri H., Lemmens K., Gevaert A.B., De Meyer G.R.Y., Segers V.F.M. Cellular Senescence Links Aging and Diabetes in Cardiovascular Disease. Am J Physiol Heart Circ Physiol. 2018;315(3):H448–H462. https://doi.org/10.1152/ajpheart.00287.2018.</mixed-citation><mixed-citation xml:lang="en">Shakeri H., Lemmens K., Gevaert A.B., De Meyer G.R.Y., Segers V.F.M. Cellular Senescence Links Aging and Diabetes in Cardiovascular Disease. Am J Physiol Heart Circ Physiol. 2018;315(3):H448–H462. https://doi.org/10.1152/ajpheart.00287.2018.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Aroor A.R., Mandavia C.H., Sowers J.R. Insulin Resistance and Heart Failure: Molecular Mechanisms. Heart Fail Clin. 2012;8(4):609–617. https://doi.org/10.1016/j.hfc.2012.06.005.</mixed-citation><mixed-citation xml:lang="en">Aroor A.R., Mandavia C.H., Sowers J.R. Insulin Resistance and Heart Failure: Molecular Mechanisms. Heart Fail Clin. 2012;8(4):609–617. https://doi.org/10.1016/j.hfc.2012.06.005.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Mandavia C.H., Pulakat L., DeMarco V., Sowers J.R. Over-Nutrition and Metabolic Cardiomyopathy. Metabolism. 2012;61(9):1205–1210. https://doi.org/10.1016/j.metabol.2012.02.013.</mixed-citation><mixed-citation xml:lang="en">Mandavia C.H., Pulakat L., DeMarco V., Sowers J.R. Over-Nutrition and Metabolic Cardiomyopathy. Metabolism. 2012;61(9):1205–1210. https://doi.org/10.1016/j.metabol.2012.02.013.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Lopaschuk G.D., Ussher J.R., Folmes C.D., Jaswal J.S., Stanley W.C. Myocardial Fatty Acid Metabolism in Health and Disease. Physiol Rev. 2010;90(1):207–258. https://doi.org/10.1152/physrev.00015.2009.</mixed-citation><mixed-citation xml:lang="en">Lopaschuk G.D., Ussher J.R., Folmes C.D., Jaswal J.S., Stanley W.C. Myocardial Fatty Acid Metabolism in Health and Disease. Physiol Rev. 2010;90(1):207–258. https://doi.org/10.1152/physrev.00015.2009.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Volpe C.M.O., Villar-Delfino P.H., Dos Anjos P.M.F., Nogueira-Machado J.A. Cellular Death, Reactive Oxygen Species (ROS) and Diabetic Complications. Cell Death Dis. 2018;9(2):119. https://doi.org/10.1038/s41419-017-0135-z.</mixed-citation><mixed-citation xml:lang="en">Volpe C.M.O., Villar-Delfino P.H., Dos Anjos P.M.F., Nogueira-Machado J.A. Cellular Death, Reactive Oxygen Species (ROS) and Diabetic Complications. Cell Death Dis. 2018;9(2):119. https://doi.org/10.1038/s41419-017-0135-z.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Giacco F., Brownlee M. Oxidative Stress and Diabetic Complications. Circ Res. 2010;107(9):1058–1070. https://doi.org/10.1161/CIRCRESAHA.110.223545.</mixed-citation><mixed-citation xml:lang="en">Giacco F., Brownlee M. Oxidative Stress and Diabetic Complications. Circ Res. 2010;107(9):1058–1070. https://doi.org/10.1161/CIRCRESAHA.110.223545.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Dillmann W.H. Diabetic Cardiomyopathy: What Is It and Can It Be Fixed? Circ Res. 2019;124(8):1160–1162. https://doi.org/10.1161/CIRCRESAHA.118.314665.</mixed-citation><mixed-citation xml:lang="en">Dillmann W.H. Diabetic Cardiomyopathy: What Is It and Can It Be Fixed? Circ Res. 2019;124(8):1160–1162. https://doi.org/10.1161/CIRCRESAHA.118.314665.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Pereira L., Matthes J., Schuster I., Valdivia H.H., Herzig S., Richard S., Gómez A.M. Mechanisms of [Ca2+]i Transient Decrease in Cardiomyopathy of db/db Type 2 Diabetic Mice. Diabetes. 2006;55(3):608–615. https://doi.org/10.2337/diabetes.55.03.06.db05-1284.</mixed-citation><mixed-citation xml:lang="en">Pereira L., Matthes J., Schuster I., Valdivia H.H., Herzig S., Richard S., Gómez A.M. Mechanisms of [Ca2+]i Transient Decrease in Cardiomyopathy of db/db Type 2 Diabetic Mice. Diabetes. 2006;55(3):608–615. https://doi.org/10.2337/diabetes.55.03.06.db05-1284.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Al Kury L.T. Calcium Homeostasis in Ventricular Myocytes of Diabetic Cardiomyopathy. J. Diabetes Res. 2020; 1942086. https://doi.org/10.1155/2020/1942086.</mixed-citation><mixed-citation xml:lang="en">Al Kury L.T. Calcium Homeostasis in Ventricular Myocytes of Diabetic Cardiomyopathy. J. Diabetes Res. 2020; 1942086. https://doi.org/10.1155/2020/1942086.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Isfort M., Stevens S.C., Schaffer S., Jong C.J., Wold L.E. Metabolic Dysfunction in Diabetic Cardiomyopathy. Heart Fail Rev. 2014;19(1):35–48. https://doi.org/10.1007/s10741-013-9377-8.</mixed-citation><mixed-citation xml:lang="en">Isfort M., Stevens S.C., Schaffer S., Jong C.J., Wold L.E. Metabolic Dysfunction in Diabetic Cardiomyopathy. Heart Fail Rev. 2014;19(1):35–48. https://doi.org/10.1007/s10741-013-9377-8.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">De Jong K.A., Lopaschuk G.D. Complex Energy Metabolic Changes in Heart Failure with Preserved Ejection Fraction and Heart Failure with Reduced Ejection Fraction. Can J Cardiol. 2017;33(7):860–871. https://doi.org/10.1016/j.cjca.2017.03.009.</mixed-citation><mixed-citation xml:lang="en">De Jong K.A., Lopaschuk G.D. Complex Energy Metabolic Changes in Heart Failure with Preserved Ejection Fraction and Heart Failure with Reduced Ejection Fraction. Can J Cardiol. 2017;33(7):860–871. https://doi.org/10.1016/j.cjca.2017.03.009.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Brindley D.N., Kok B.P., Kienesberger P.C., Lehner R., Dyck J.R. Shedding Light on the Enigma of Myocardial Lipotoxicity: the Involvement of Known and Putative Regulators of Fatty acid Storage and Mobilization. Am J Physiol Endocrinol Metab. 2010;298(5):E897–E908. https://doi.org/10.1152/ajpendo.00509.2009.</mixed-citation><mixed-citation xml:lang="en">Brindley D.N., Kok B.P., Kienesberger P.C., Lehner R., Dyck J.R. Shedding Light on the Enigma of Myocardial Lipotoxicity: the Involvement of Known and Putative Regulators of Fatty acid Storage and Mobilization. Am J Physiol Endocrinol Metab. 2010;298(5):E897–E908. https://doi.org/10.1152/ajpendo.00509.2009.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Koves T.R., Ussher J.R., Noland R.C., Slentz D., Mosedale M., Ilkayeva O. et al. Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance. Cell Metab. 2008;7(1): 45–56. https://doi.org/10.1016/j.cmet.2007.10.013.</mixed-citation><mixed-citation xml:lang="en">Koves T.R., Ussher J.R., Noland R.C., Slentz D., Mosedale M., Ilkayeva O. et al. Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance. Cell Metab. 2008;7(1): 45–56. https://doi.org/10.1016/j.cmet.2007.10.013.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Kim J.A., Wei Y., Sowers J.R. Role of Mitochondrial Dysfunction in Insulin Resistance. Circ Res. 2008;102(4):401–414. https://doi.org/10.1161/CIRCRESAHA.107.165472.</mixed-citation><mixed-citation xml:lang="en">Kim J.A., Wei Y., Sowers J.R. Role of Mitochondrial Dysfunction in Insulin Resistance. Circ Res. 2008;102(4):401–414. https://doi.org/10.1161/CIRCRESAHA.107.165472.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Bugger H., Abel E.D. Mitochondria in the Diabetic Heart. Cardiovasc Res. 2010;88(2):229–240. https://doi.org/10.1093/cvr/cvq239.</mixed-citation><mixed-citation xml:lang="en">Bugger H., Abel E.D. Mitochondria in the Diabetic Heart. Cardiovasc Res. 2010;88(2):229–240. https://doi.org/10.1093/cvr/cvq239.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Palomer X., Salvadó L., Barroso E., Vázquez-Carrera M. An Overview of the Crosstalk between Inflammatory Processes and Metabolic Dysregulation during Diabetic Cardiomyopathy. Int J Cardiol. 2013;168(4):3160–3172. https://doi.org/10.1016/j.ijcard.2013.07.150.</mixed-citation><mixed-citation xml:lang="en">Palomer X., Salvadó L., Barroso E., Vázquez-Carrera M. An Overview of the Crosstalk between Inflammatory Processes and Metabolic Dysregulation during Diabetic Cardiomyopathy. Int J Cardiol. 2013;168(4):3160–3172. https://doi.org/10.1016/j.ijcard.2013.07.150.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Aronson D. Cross-Linking of Glycated Collagen in the Pathogenesis of Arterial and Myocardial Stiffening of Aging and Diabetes. J Hypertens. 2003;21(1):3–12. https://doi.org/10.1097/00004872-200301000-00002.</mixed-citation><mixed-citation xml:lang="en">Aronson D. Cross-Linking of Glycated Collagen in the Pathogenesis of Arterial and Myocardial Stiffening of Aging and Diabetes. J Hypertens. 2003;21(1):3–12. https://doi.org/10.1097/00004872-200301000-00002.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Jia G., DeMarco V.G., Sowers J.R. Insulin Resistance and Hyperinsulinaemia in Diabetic Cardiomyopathy. Nat Rev Endocrinol. 2016;12(3):144–153. https://doi.org/10.1038/nrendo.2015.216.</mixed-citation><mixed-citation xml:lang="en">Jia G., DeMarco V.G., Sowers J.R. Insulin Resistance and Hyperinsulinaemia in Diabetic Cardiomyopathy. Nat Rev Endocrinol. 2016;12(3):144–153. https://doi.org/10.1038/nrendo.2015.216.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Pacher P., Beckman J.S., Liaudet L. Nitric Oxide and Peroxynitrite in Health and Disease. Physiol Rev. 2007;87(1):315–424. https://doi.org/10.1152/physrev.00029.2006.</mixed-citation><mixed-citation xml:lang="en">Pacher P., Beckman J.S., Liaudet L. Nitric Oxide and Peroxynitrite in Health and Disease. Physiol Rev. 2007;87(1):315–424. https://doi.org/10.1152/physrev.00029.2006.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Daiber A., Steven S., Vujacic-Mirski K., Kalinovic S., Oelze M., Di Lisa F., Münzel T. Regulation of Vascular Function and Inflammation via Cross Talk of Reactive Oxygen and Nitrogen Species from Mitochondria or NADPH Oxidase-Implications for Diabetes Progression. Int J Mol Sci. 2020;21(10):3405. https://doi.org/10.3390/ijms21103405.</mixed-citation><mixed-citation xml:lang="en">Daiber A., Steven S., Vujacic-Mirski K., Kalinovic S., Oelze M., Di Lisa F., Münzel T. Regulation of Vascular Function and Inflammation via Cross Talk of Reactive Oxygen and Nitrogen Species from Mitochondria or NADPH Oxidase-Implications for Diabetes Progression. Int J Mol Sci. 2020;21(10):3405. https://doi.org/10.3390/ijms21103405.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Gamrat A., Surdacki M.A., Chyrchel B., Surdacki A. Endothelial Dysfunction: A Contributor to Adverse Cardiovascular Remodeling and Heart Failure Development in Type 2 Diabetes beyond Accelerated Atherogenesis. J Clin Med. 2020;9(7):2090. https://doi.org/10.3390/jcm9072090.</mixed-citation><mixed-citation xml:lang="en">Gamrat A., Surdacki M.A., Chyrchel B., Surdacki A. Endothelial Dysfunction: A Contributor to Adverse Cardiovascular Remodeling and Heart Failure Development in Type 2 Diabetes beyond Accelerated Atherogenesis. J Clin Med. 2020;9(7):2090. https://doi.org/10.3390/jcm9072090.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Goligorsky M.S. Vascular Endothelium in Diabetes. Am J Physiol Renal Physiol. 2017;312(2):F266–F275. https://doi.org/10.1152/ajprenal.00473.2016.</mixed-citation><mixed-citation xml:lang="en">Goligorsky M.S. Vascular Endothelium in Diabetes. Am J Physiol Renal Physiol. 2017;312(2):F266–F275. https://doi.org/10.1152/ajprenal.00473.2016.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Sprague A.H., Khalil R.A. Inflammatory Cytokines in Vascular Dysfunction and Vascular Disease. Biochem Pharmacol. 2009;78(6):539–552. https://doi. org/10.1016/j.bcp.2009.04.029.</mixed-citation><mixed-citation xml:lang="en">Sprague A.H., Khalil R.A. Inflammatory Cytokines in Vascular Dysfunction and Vascular Disease. Biochem Pharmacol. 2009;78(6):539–552. https://doi. org/10.1016/j.bcp.2009.04.029.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Johnson J.L. Emerging Regulators of Vascular Smooth Muscle Cell Function in the Development and Progression of Atherosclerosis. Cardiovasc Res. 2014;103(4):452–460. https://doi.org/10.1093/cvr/cvu171.</mixed-citation><mixed-citation xml:lang="en">Johnson J.L. Emerging Regulators of Vascular Smooth Muscle Cell Function in the Development and Progression of Atherosclerosis. Cardiovasc Res. 2014;103(4):452–460. https://doi.org/10.1093/cvr/cvu171.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Obermannova B., Petruzelkova L., Sulakova T., Sumnik Z. HbA1c but not Diabetes Duration Predicts Increased Arterial Stiffness in Adolescents with Poorly Controlled Type 1 Diabetes. Pediatr Diabetes. 2017;18(4):304– 310. https://doi.org/10.1111/pedi.12385.</mixed-citation><mixed-citation xml:lang="en">Obermannova B., Petruzelkova L., Sulakova T., Sumnik Z. HbA1c but not Diabetes Duration Predicts Increased Arterial Stiffness in Adolescents with Poorly Controlled Type 1 Diabetes. Pediatr Diabetes. 2017;18(4):304– 310. https://doi.org/10.1111/pedi.12385.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Bebu I., Schade D., Braffett B., Kosiborod M., Lopes-Virella M., Soliman E.Z. et al. Risk Factors for First and Subsequent CVD Events in Type 1 Diabetes: The DCCT/EDIC Study. Diabetes Care. 2020;43(4):867–874. https://doi.org/10.2337/dc19-2292.</mixed-citation><mixed-citation xml:lang="en">Bebu I., Schade D., Braffett B., Kosiborod M., Lopes-Virella M., Soliman E.Z. et al. Risk Factors for First and Subsequent CVD Events in Type 1 Diabetes: The DCCT/EDIC Study. Diabetes Care. 2020;43(4):867–874. https://doi.org/10.2337/dc19-2292.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Roussel R., Steg P.G., Mohammedi K., Marre M., Potier L. Prevention of Cardiovascular Disease through Reduction of Glycaemic Exposure in Type 2 Diabetes: A Perspective on Glucose-Lowering Interventions. Diabetes Obes Metab. 2018;20(2):238–244. https://doi.org/10.1111/dom.13033.</mixed-citation><mixed-citation xml:lang="en">Roussel R., Steg P.G., Mohammedi K., Marre M., Potier L. Prevention of Cardiovascular Disease through Reduction of Glycaemic Exposure in Type 2 Diabetes: A Perspective on Glucose-Lowering Interventions. Diabetes Obes Metab. 2018;20(2):238–244. https://doi.org/10.1111/dom.13033.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Дедов И.И., Шестакова М.В., Майоров А.Ю. (ред.) Алгоритмы специализированной медицинской помощи больным сахарным диабетом. 9-й вып. Сахарный диабет. 2019;22(1S1):1–144. https://doi.org/10.14341/DM221S1.</mixed-citation><mixed-citation xml:lang="en">Dedov I.I., Shestakova M.V., Mayorov A.Yu. (eds.). Standards of Specialized Diabetes Care. 9th ed. Sakharnyy diabet = Diabetes Mellitus. 2019;22(1S1):1–144. (In Russ.) https://doi.org/10.14341/DM221S1.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Polonsky W.H., Fisher L., Schikman C.H., Hinnen D.A., Parkin C.G., Jelsovsky Z. et al. Structured Self-Monitoring of Blood Glucose Significantly Reduces A1C Levels in Poorly Controlled, Noninsulin-Treated Type 2 Diabetes: Results from the Structured Testing Program Study. Diabetes Care. 2011;34(2):262–267. https://doi.org/10.2337/dc10-1732.</mixed-citation><mixed-citation xml:lang="en">Polonsky W.H., Fisher L., Schikman C.H., Hinnen D.A., Parkin C.G., Jelsovsky Z. et al. Structured Self-Monitoring of Blood Glucose Significantly Reduces A1C Levels in Poorly Controlled, Noninsulin-Treated Type 2 Diabetes: Results from the Structured Testing Program Study. Diabetes Care. 2011;34(2):262–267. https://doi.org/10.2337/dc10-1732.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Otto E., Tannan V. Evaluation of the Utility of a Glycemic Pattern Identification System. J Diabetes Sci Technol. 2014;8(4):830–838. https://doi.org/10.1177/1932296814532210.</mixed-citation><mixed-citation xml:lang="en">Otto E., Tannan V. Evaluation of the Utility of a Glycemic Pattern Identification System. J Diabetes Sci Technol. 2014;8(4):830–838. https://doi.org/10.1177/1932296814532210.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Jendrike N., Baumstark A., Kamecke U., Haug C., Freckmann G. ISO 15197:2013 Evaluation of a Blood Glucose Monitoring System’s Measurement Accuracy. J Diabetes Sci Technol. 2017;11(6):1275–1276. https://doi.org/10.1177/1932296817727550.</mixed-citation><mixed-citation xml:lang="en">Jendrike N., Baumstark A., Kamecke U., Haug C., Freckmann G. ISO 15197:2013 Evaluation of a Blood Glucose Monitoring System’s Measurement Accuracy. J Diabetes Sci Technol. 2017;11(6):1275–1276. https://doi.org/10.1177/1932296817727550.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Bailey T.S., Wallace J.F., Pardo S., Warchal-Windham M.E., Harrison B., Morin R., Christiansen M. Accuracy and User Performance Evaluation of a New, Wireless-Enabled Blood Glucose Monitoring System That Links to a Smart Mobile Device. J Diabetes Sci Technol. 2017;11(4):736–743. https://doi.org/10.1177/1932296816680829.</mixed-citation><mixed-citation xml:lang="en">Bailey T.S., Wallace J.F., Pardo S., Warchal-Windham M.E., Harrison B., Morin R., Christiansen M. Accuracy and User Performance Evaluation of a New, Wireless-Enabled Blood Glucose Monitoring System That Links to a Smart Mobile Device. J Diabetes Sci Technol. 2017;11(4):736–743. https://doi.org/10.1177/1932296816680829.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
