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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2021-12-347-351</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-6367</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ДЕРМАТОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>DERMATOLOGY</subject></subj-group></article-categories><title-group><article-title>Место протеогликанов в терапии алопеций разного генеза</article-title><trans-title-group xml:lang="en"><trans-title>Role of proteoglycans in the treatment of alopecia of various genesis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2027-5987</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сакания</surname><given-names>Л. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Sakaniya</surname><given-names>L. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>врач-дерматовенеролог, младший научный сотрудник,  109029, Москва, ул. Средняя Калитниковская, д. 30;</p><p>врач-дерматовенеролог, косметолог, трихолог, 127473, Москва, ул. Селезневская, д. 20</p></bio><bio xml:lang="en"><p>Dermatovenerologist, Junior Researcher, 30, Srednyaya Kalitnikovskaya St., Moscow, 109029;</p><p>Dermatovenerologist, Cosmetologist, Trichologist, 20, Seleznevskaya St., Moscow, 127473</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0522-3225</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мельниченко</surname><given-names>О. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Melnichenko</surname><given-names>O. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., врач-дерматовенеролог, </p><p>127473, Москва, ул. Селезневская, д. 20</p></bio><bio xml:lang="en"><p>Cand. Sci. (Med.), Dermatovenerologist, </p><p>20, Seleznevskaya St., Moscow, 127473</p></bio><email xlink:type="simple">dr.melnichenko@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8039-8474</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пирузян</surname><given-names>А. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Piruzyan</surname><given-names>A. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор, главный научный сотрудник, </p><p>109029, Москва, ул. Средняя Калитниковская, д. 30</p></bio><bio xml:lang="en"><p>Dr. Sci. (Med.), Professor, Leading Researcher, </p><p>30, Srednyaya Kalitnikovskaya St., Moscow, 109029</p></bio><email xlink:type="simple">pirstas2000@hotmail.com</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6583-0318</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Корсунская</surname><given-names>И. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Korsunskaya</surname><given-names>I. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор, заведующая лабораторией, </p><p>109029, Москва, ул. Средняя Калитниковская, д. 30</p></bio><bio xml:lang="en"><p>Dr. Sci. (Med.), Professor, Head of Laboratory, </p><p>30, Srednyaya Kalitnikovskaya St., Moscow, 109029</p></bio><email xlink:type="simple">marykor@bk.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Центр теоретических проблем физико-химической фармакологии РАН; &#13;
Московский научно-практический центр дерматовенерологии и косметологии</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Center for Theoretical Problems of Physicochemical Pharmacology of the Russian Academy of Sciences; Moscow Scientific and Practical Center for Dermatovenereology and Cosmetology</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Московский научно-практический центр дерматовенерологии и косметологии</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Moscow Scientific and Practical Center for Dermatovenereology and Cosmetology</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Центр теоретических проблем физико-химической фармакологии РАН</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Center for Theoretical Problems of Physical and Chemical Pharmacology of the Russian Academy of Sciences</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>19</day><month>09</month><year>2021</year></pub-date><volume>0</volume><issue>12</issue><fpage>347</fpage><lpage>351</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Сакания Л.Р., Мельниченко О.О., Пирузян А.Л., Корсунская И.М., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Сакания Л.Р., Мельниченко О.О., Пирузян А.Л., Корсунская И.М.</copyright-holder><copyright-holder xml:lang="en">Sakaniya L.R., Melnichenko O.O., Piruzyan A.L., Korsunskaya I.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/6367">https://www.med-sovet.pro/jour/article/view/6367</self-uri><abstract><p>Выпадение волос всегда остается актуальной проблемой в современном мире. Хотя данное состояние и не является жизнеугрожающим, оказывает сильное влияние на качество жизни пациентов. Многие факторы влияют на состояние волосяного покрова: возраст, семейный анамнез, курение, питание и др. Формы алопеций разнообразны, и задача специалиста – правильно определить причину нарушения цикла роста волос посредством тщательного сбора анамнеза.</p><p>В патогенезе андрогенетической алопеции основная роль отводится изменениям гормонального статуса. Для телогеновой потери волос провоцирующим фактором может послужить стресс, прием лекарственных препаратов, беременность или другое заболевание. Так, например, на данный момент значительное количество пациентов, перенесших коронавирусную инфекцию, сталкиваются с потерей волос через несколько месяцев после выздоровления.</p><p>Несмотря на разнообразие первопричин выпадения волос, принцип терапии един – элиминация триггера и подбор средств для нормализации естественного цикла роста волос. В данном ключе перспективным выглядит применение средств, содержащих протеогликаны,  – специфичные белки, участвующие в  регуляции цикла роста волос. Многочисленные исследования демонстрируют эффективность таких протеогликанов, как версикан, декорин и синдекан. Они активируют рост волос и способствуют продлению фазы анагена. Данное влияние протеогликанов дает возможность говорить об их хороших терапевтических и даже профилактических свойствах применительно к проблеме потери волос. </p></abstract><trans-abstract xml:lang="en"><p>Hair loss has always been and remains an urgent challenge in the world today. Although this condition is not life-threatening, it still has a strong impact on the patients’ quality of life. Hairlines are affected by multiple factors including age, family history, smoking, nutrition, etc. Alopecia can take many forms, and the specialist’s objective is to determine the correct cause of the disorder of hair growth cycle by taking a medical history from a patient.</p><p>The key role in the pathogenesis of androgenetic alopecia is assigned to changes in hormonal status. Telogen effluvium can be triggered by stress, medication, pregnancy, or other medical conditions. For instance, the high number of patients who have had COVID-19 are now faced with hair loss a few months after recovery.</p><p>Despite the variety of underlining causes of hair loss, the principle of therapy is the same – the elimination of the trigger and the selection of drugs to normalize the natural hair growth cycle. In this case, the use of drugs containing proteoglycans that are specific proteins involved in the regulation of the hair growth cycle looks promising. Numerous studies demonstrate the efficacy of such proteoglycans as versican, decorin, and syndecan. They activate hair growth and help prolong the anagen phase. This effect of proteoglycans affords to speak about their good therapeutic and even prophylactic properties applied to the problem of hair loss. </p></trans-abstract><kwd-group xml:lang="ru"><kwd>протеогликаны</kwd><kwd>алопеция</kwd><kwd>диффузное поредение волос</kwd><kwd>телогеновая потеря волос</kwd><kwd>профилактика</kwd></kwd-group><kwd-group xml:lang="en"><kwd>proteoglycans</kwd><kwd>alopecia</kwd><kwd>diffuse hair thinning</kwd><kwd>telogen effluvium</kwd><kwd>prevention</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Brough K.R., Torgerson R.R. Hormonal therapy in female pattern hair loss. 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