medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2014-9-90-95medsovet-638Research ArticleИнфекции в акушерстве и гинекологииInfections in obstetrics and gynecologyМикробиота влагалища при бактериальном вагинозе. Аспекты диагностики и терапииVaginal microbiota in bacterial vaginosis. Aspects of diagnosis and therapyСавичеваА. М.SavichevaA. M.noemail@neicon.ruШипицынаЕ. В.ShipitsynaE. V.noemail@neicon.ruНИИ акушерства и гинекологии им. Д.О. ОттаРоссияD. O. Ott Research Institute of Obstetrics and GynecologyRussian FederationНИИ акушерства и гинекологии им. Д.О. Отта СЗОРоссияD. O. Ott Research Institute of Obstetrics and GynecologyRussian Federation201430122014099095Copyright © Савичева А.М., Шипицына Е.В., 20142014Савичева А.М., Шипицына Е.В.Savicheva A.M., Shipitsyna E.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/638

Бактериальный вагиноз - это полимикробный клинический синдром, для которого характерно замещение физиологической лактобациллярной микрофлоры влагалища спектром других микроорганизмов, главным образом анаэробных. Многочисленные исследования показали, что ключевыми компонентами микробиоты влагалища при БВ являются Gardnerella vaginalis и Atopobium vaginae. A. vaginae - труднокультивируемые бактерии, и их ассоциация с БВ была описана относительно недавно с использованием молекулярных методов. Показано, что эти бактерии наряду с G. vaginalis вовлечены в формирование биопленок на эпителии влагалища. Для БВ характерна высокая частота рецидивирования, основными причинами которой, как полагают, являются резистентность ассоциированных с БВ бактерий к антимикробным препаратам, а также низкая восприимчивость биопленок к воздействию антибиотиков.

Bacterial vaginosis is a polymicrobial clinical syndrome characterized by the replacement of physiological Lactobacillus species with a spectrum of other microorganisms, mostly anaerobic. Numerous studies showed that key components of the vaginal microbiota in BV are Gardnerella vaginalis and Atopobium vaginae. A. vaginae are hard-to-culture bacteria whose involvement in BV has been described recently with the help of molecular methods. The article demonstrates that A. vaginae and G. vaginalis are responsible for the formation of biofilms on the vaginal epithelium. BV has a high recurrence rate, the main causes of which are presumably the resistance of BV-associated bacteria to antimicrobial agents and low susceptibility of biofilms to antibiotics.

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The authors declare that there are no conflicts of interest present.