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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2021-13-42-49</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-6398</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Репродуктивное здоровье и ВРТ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Reproductive health and ART</subject></subj-group></article-categories><title-group><article-title>Современные методы экстренной контрацепции: эффективность, безопасность, приемлемость</article-title><trans-title-group xml:lang="en"><trans-title>Emergency contraception methods: efficacy, safety and acceptability</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8243-5272</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Абакарова</surname><given-names>П. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Abakarova</surname><given-names>P. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Абакарова Патимат Рапиевна, к.м.н., научный сотрудник научно-поликлинического отделения</p><p>117997, Россия, Москва, ул. Академика Опарина, д. 4</p></bio><bio xml:lang="en"><p>Patimat R. Abakarova, Cand. Sci. (Med.), Research Associate of Research Polyclinic Department</p><p>4, Academician Oparin St., Moscow, 117997, Russia</p></bio><email xlink:type="simple">p_abakarova@oparina4.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3895-8225</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гусаков</surname><given-names>К. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Gusakov</surname><given-names>K. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гусаков Кирилл Ильич, к.м.н., научный сотрудник научно-поликлинического отделения</p><p>117997, Россия, Москва, ул. Академика Опарина, д. 4</p></bio><bio xml:lang="en"><p>Kirill I. Gusakov, Cand. Sci. (Med.), Research Associate of Research Polyclinic Department</p><p>4, Academician Oparin St., Moscow, 117997, Russia</p></bio><email xlink:type="simple">kigusakov@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2835-6685</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Довлетханова</surname><given-names>Э. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Dovletkhanova</surname><given-names>E. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Довлетханова Эльмира Робертовна, к.м.н., старший научный сотрудник научно-поликлинического отделения</p><p>117997, Россия, Москва, ул. Академика Опарина, д. 4</p></bio><bio xml:lang="en"><p>Elmira R. Dovletkhanova, Cand. Sci. (Med.), Senior Research Associate of Research Polyclinic Department</p><p>4, Academician Oparin St., Moscow, 117997, Russia</p></bio><email xlink:type="simple">e_dovletkhanova@oparina4.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2977-9065</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Межевитинова</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Mezhevitinova</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Межевитинова Елена Анатольевна, д.м.н., ведущий научный сотрудник научно-поликлинического отделения</p><p>117997, Россия, Москва, ул. Академика Опарина, д. 4</p></bio><bio xml:lang="en"><p>Elena A. Mezhevitinova, Dr. Sci. (Med.), Lead Research Associate of Research Polyclinic Department</p><p>4, Academician Oparin St., Moscow, 117997, Russia</p></bio><email xlink:type="simple">mejevitinova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии имени академика В.И. Кулакова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>15</day><month>10</month><year>2021</year></pub-date><volume>0</volume><issue>13</issue><fpage>42</fpage><lpage>49</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Абакарова П.Р., Гусаков К.И., Довлетханова Э.Р., Межевитинова Е.А., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Абакарова П.Р., Гусаков К.И., Довлетханова Э.Р., Межевитинова Е.А.</copyright-holder><copyright-holder xml:lang="en">Abakarova P.R., Gusakov K.I., Dovletkhanova E.R., Mezhevitinova E.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/6398">https://www.med-sovet.pro/jour/article/view/6398</self-uri><abstract><p>Предотвращение нежелательной беременности, абортов и их осложнений является одной из главных задач медицины, направленной на сохранение репродуктивного здоровья женщин. Наиболее эффективным методом предотвращения нежеланных беременностей и борьбы с абортами является корректное планирование семьи при помощи высокоэффективных методов контрацепции. В настоящее время по-прежнему наблюдается большое количество случаев нежелательной беременности, риск наступления которой не исключает ни один метод контрацепции. Каждая четвертая беременность в мире является незапланированной, более половины из них заканчиваются абортом, который может представлять угрозу жизни и здоровью женщины. В целом более 90% абортов выполняются в связи с нежелательной беременностью. Экстренная контрацепция в настоящее время продолжает занимать важное место в вопросах планирования семьи. Известно, что чем раньше были использованы методы экстренной контрацепции после незащищенного полового акта, тем выше ее эффективность. Существующее разнообразие методов и схем назначения экстренной контрацепции дает возможность индивидуального подхода к их применению. В статье представлены результаты рандомизированных клинических исследований и метаанализов, оценивающих все применяемые в настоящее время методы экстренной контрацепции с точки зрения доказательной медицины. Описаны принципы действия препаратов, их особенности, влияние на репродуктивную систему, приемлемость.</p></abstract><trans-abstract xml:lang="en"><p>Prevention of unwanted pregnancies, abortions and their complications is one of the major problems of healthcare. The most effective method of unwanted pregnancies prevention is family planning with highly effective contraceptive methods. Currently number of unwanted pregnancies cases is still numerous. Problem of unwanted pregnancy cannot be solved completely with any method of contraception. Every fourth pregnancy in the world is considered as unplanned, more than half of them end in abortion, which can pose a threat to health of the patient. Overall, more than 90% of abortions are performed due to unwanted pregnancies. Emergency contraception continues to play an important role in family planning today. It is known that the effectiveness of emergency contraception decreases with the time after unprotected sex. Today a variety of emergency contraception methods exists, which allows individual approach to specific patient. The article presents the results of randomized clinical trials and meta-analyses evaluating all currently used methods of emergency contraception from the evidence-based point of view. The article also describes drugs specifics, features, and effects on the reproductive system.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>нежелательная беременность</kwd><kwd>экстренная контрацепция</kwd><kwd>левоноргестрел</kwd><kwd>мифепристон</kwd><kwd>эффективность</kwd></kwd-group><kwd-group xml:lang="en"><kwd>unwanted pregnancy</kwd><kwd>emergency contraception</kwd><kwd>levonorgestrel</kwd><kwd>mifepristone</kwd><kwd>efficacy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Bearak J., Popinchalk A., Alkema L., Sedgh G. Global, regional, and subregional trends in unintended pregnancy and its outcomes from 1990 to 2014: estimates from a Bayesian hierarchical model. Lancet Glob Health. 2018;6(4):e380–e389. https://doi.org/10.1016/S2214-109X(18)30029-9.</mixed-citation><mixed-citation xml:lang="en">Bearak J., Popinchalk A., Alkema L., Sedgh G. Global, regional, and subregional trends in unintended pregnancy and its outcomes from 1990 to 2014: estimates from a Bayesian hierarchical model. Lancet Glob Health. 2018;6(4):e380–e389. https://doi.org/10.1016/S2214-109X(18)30029-9.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Cleland J. The complex relationship between contraception and abortion. Best Pract Res Clin Obstet Gynaecol. 2020;62:90–100. https://doi.org/10.1016/j.bpobgyn.2019.04.007.</mixed-citation><mixed-citation xml:lang="en">Cleland J. The complex relationship between contraception and abortion. Best Pract Res Clin Obstet Gynaecol. 2020;62:90–100. https://doi.org/10.1016/j.bpobgyn.2019.04.007.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Ganatra B., Gerdts C., Rossier C., Johnson B.R.Jr., Tunçalp Ö., Assifi F. et al Global, regional, and subregional classification of abortions by safety, 2010–14: estimates from a Bayesian hierarchical model. Lancet. 2017;390(10110):2372–2381. https://doi.org/10.1016/S0140-6736(17)31794-4.</mixed-citation><mixed-citation xml:lang="en">Ganatra B., Gerdts C., Rossier C., Johnson B.R.Jr., Tunçalp Ö., Assifi F. et al Global, regional, and subregional classification of abortions by safety, 2010–14: estimates from a Bayesian hierarchical model. Lancet. 2017;390(10110):2372–2381. https://doi.org/10.1016/S0140-6736(17)31794-4.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Сухих Г.Т., Серов В.Н. (ред.). Тактика врача акушера-гинеколога: практическое руководство в 2 ч. М.: ГЭОТАР-Медиа; 2020. Ч. 2. 320 с. Режим доступа: https://bookmos.ru/components/com_jshopping/files/img_products/taktika-vracha-akushera-ginekologa-prakticheskoerukovodstvo-v-2-h-chastyah-komplekt-2020-978-5-9704-5588-3.pdf.</mixed-citation><mixed-citation xml:lang="en">Sukhikh G.T., Serov V.N. (eds.). Obstetrician-gynecologist tactics: practical guidelines in 2 parts Moscow: GEOTAR-Media; 2020. Pt. 2. 320 p. (In Russ.) Available at: https://bookmos.ru/components/com_jshopping/files/img_products/taktika-vracha-akushera-ginekologa-prakticheskoe-rukovodstvov-2-h-chastyah-komplekt-2020-978-5-9704-5588-3.pdf.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Batur P., Kransdorf L.N., Casey P.M. Emergency Contraception. Mayo Clin Proc. 2016;91(6):802–807. https://doi.org/10.1016/j.mayocp.2016.02.018.</mixed-citation><mixed-citation xml:lang="en">Batur P., Kransdorf L.N., Casey P.M. Emergency Contraception. Mayo Clin Proc. 2016;91(6):802–807. https://doi.org/10.1016/j.mayocp.2016.02.018.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Trussell J., Raymond E.G., Cleland K. Emergency Contraception: A Last Chance to Prevent Unintended Pregnancy. Contemporary Readings in Law and Social Justice. 2014;6(2):7–38. Available at: https://www.researchgate.net/publication/242730608_Emergency_Contraception_A_Last_Chance_to_Prevent_Unintended_Pregnancy.</mixed-citation><mixed-citation xml:lang="en">Trussell J., Raymond E.G., Cleland K. Emergency Contraception: A Last Chance to Prevent Unintended Pregnancy. Contemporary Readings in Law and Social Justice. 2014;6(2):7–38. Available at: https://www.researchgate.net/publication/242730608_Emergency_Contraception_A_Last_Chance_to_Prevent_Unintended_Pregnancy.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Berry-Bibee E., Curtis K., Dragoman M., Gaffield M.L., Jatlaoui T., Kim C. et al. Medical eligibility criteria for contraceptive use. 5th ed. Geneva: World Health Organization; 2015. Available at: https://www.who.int/reproductivehealth/publications/family_planning/MEC-5/en.</mixed-citation><mixed-citation xml:lang="en">Berry-Bibee E., Curtis K., Dragoman M., Gaffield M.L., Jatlaoui T., Kim C. et al. Medical eligibility criteria for contraceptive use. 5th ed. Geneva: World Health Organization; 2015. Available at: https://www.who.int/reproductivehealth/publications/family_planning/MEC-5/en.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Прилепская В.Н. (ред.). Руководство по контрацепции. 4-е изд. М.: МЕДпресс-информ; 2017. 464 с.</mixed-citation><mixed-citation xml:lang="en">Prilepskaya V.N. Contraception guideleines. 4th ed. Moscow: MEDpressinform; 2017. 464 р. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Durand M., del Carmen Cravioto M., Raymond E.G., Durán-Sánchez O., De la Luz Cruz-Hinojosa M., Castell-Rodríguez A. et al. On the mechanisms of action of short-term levonorgestrel administration in emergency contraception. Contraception. 2001;64(4):227–234. https://doi.org/10.1016/s0010-7824(01)00250-5.</mixed-citation><mixed-citation xml:lang="en">Durand M., del Carmen Cravioto M., Raymond E.G., Durán-Sánchez O., De la Luz Cruz-Hinojosa M., Castell-Rodríguez A. et al. On the mechanisms of action of short-term levonorgestrel administration in emergency contraception. Contraception. 2001;64(4):227–234. https://doi.org/10.1016/s0010-7824(01)00250-5.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Hamoda H., Ashok P.W., Stalder C., Flett G.M., Kennedy E., Templeton A. A randomized trial of mifepristone (10 mg) and levonorgestrel for emergency contraception. Obstet Gynecol. 2004;104(6):1307–1313. https://doi.org/10.1097/01.aog.0000146286.60138.47.</mixed-citation><mixed-citation xml:lang="en">Hamoda H., Ashok P.W., Stalder C., Flett G.M., Kennedy E., Templeton A. A randomized trial of mifepristone (10 mg) and levonorgestrel for emergency contraception. Obstet Gynecol. 2004;104(6):1307–1313. https://doi.org/10.1097/01.aog.0000146286.60138.47.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Arowojolu A.O., Okewole I.A., Adekunle A.O. Comparative evaluation of the effectiveness and safety of two regimens of levonorgestrel for emergency contraception in Nigerians. Contraception. 2002;66(4):269–273. https://doi.org/10.1016/s0010-7824(02)00337-2.</mixed-citation><mixed-citation xml:lang="en">Arowojolu A.O., Okewole I.A., Adekunle A.O. Comparative evaluation of the effectiveness and safety of two regimens of levonorgestrel for emergency contraception in Nigerians. Contraception. 2002;66(4):269–273. https://doi.org/10.1016/s0010-7824(02)00337-2.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Прилепская В.Н., Мгерян А.Н. Экстренная гормональная контрацепция (обзор литературы). Гинекология. 2017;19(1):10–14. Режим доступа: https://cyberleninka.ru/article/n/ekstrennaya-gormonalnayakontratseptsiya-obzor-literatury.</mixed-citation><mixed-citation xml:lang="en">Prilepskaya V.N., Mgeryan A.N. Emergency hormonal contraception (literature review). Ginekologiya = Gynecology. 2017;19(1):10–14. (In Russ.) Available at: https://cyberleninka.ru/article/n/ekstrennaya-gormonalnayakontratseptsiya-obzor-literatury.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Shen J., Che Y., Showell E., Chen K., Cheng L. Interventions for emergency contraception. Cochrane Database Syst Rev. 2017;8(8):CD001324. https://doi.org/10.1002/14651858.CD001324.pub5.</mixed-citation><mixed-citation xml:lang="en">Shen J., Che Y., Showell E., Chen K., Cheng L. Interventions for emergency contraception. Cochrane Database Syst Rev. 2017;8(8):CD001324. https://doi.org/10.1002/14651858.CD001324.pub5.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">von Hertzen H., Piaggio G., Ding J., Chen J., Song S., Bártfai G. et al. Low dose mifepristone and two regimens of levonorgestrel for emergency contraception: a WHO multicentre randomised trial. Lancet. 2002;360(9348):1803–1810. https://doi.org/10.1016/S0140-6736(02)11767-3.</mixed-citation><mixed-citation xml:lang="en">von Hertzen H., Piaggio G., Ding J., Chen J., Song S., Bártfai G. et al. Low dose mifepristone and two regimens of levonorgestrel for emergency contraception: a WHO multicentre randomised trial. Lancet. 2002;360(9348):1803–1810. https://doi.org/10.1016/S0140-6736(02)11767-3.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Marions L., Hultenby K., Lindell I., Sun X., Ståbi B., Gemzell Danielsson K. Emergency contraception with mifepristone and levonorgestrel: mechanism of action. Obstet Gynecol. 2002;100(1):65–71. https://doi.org/10.1016/s0029-7844(02)02006-9.</mixed-citation><mixed-citation xml:lang="en">Marions L., Hultenby K., Lindell I., Sun X., Ståbi B., Gemzell Danielsson K. Emergency contraception with mifepristone and levonorgestrel: mechanism of action. Obstet Gynecol. 2002;100(1):65–71. https://doi.org/10.1016/s0029-7844(02)02006-9.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Xiao B.L., Von Hertzen H., Zhao H., Piaggio G. A randomized double-blind comparison of two single doses of mifepristone for emergency contraception. Hum Reprod. 2002;17(12):3084–3089. https://doi.org/10.1093/humrep/17.12.3084.</mixed-citation><mixed-citation xml:lang="en">Xiao B.L., Von Hertzen H., Zhao H., Piaggio G. A randomized double-blind comparison of two single doses of mifepristone for emergency contraception. Hum Reprod. 2002;17(12):3084–3089. https://doi.org/10.1093/humrep/17.12.3084.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Mori D., Ogino N., Yonezawa T., Kawaminami M., Kurusu S. Anti-ovulatory effects of RU486 and trilostane involve impaired cyclooxygenase-2 expression and mitotic activity of follicular granulosa cells in rats. Prostaglandins Other Lipid Mediat. 2011;94(3–4):118–123. https://doi.org/10.1016/j.prostaglandins.2011.02.002.</mixed-citation><mixed-citation xml:lang="en">Mori D., Ogino N., Yonezawa T., Kawaminami M., Kurusu S. Anti-ovulatory effects of RU486 and trilostane involve impaired cyclooxygenase-2 expression and mitotic activity of follicular granulosa cells in rats. Prostaglandins Other Lipid Mediat. 2011;94(3–4):118–123. https://doi.org/10.1016/j.prostaglandins.2011.02.002.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Rodriguez M.I., Gülmezoglu A.M. Mifepristone for emergency contraception: Case for recommendation in practice guidelines. Contraception. 2020;102(6):383–384. https://doi.org/10.1016/j.contraception.2020.08.005.</mixed-citation><mixed-citation xml:lang="en">Rodriguez M.I., Gülmezoglu A.M. Mifepristone for emergency contraception: Case for recommendation in practice guidelines. Contraception. 2020;102(6):383–384. https://doi.org/10.1016/j.contraception.2020.08.005.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Прилепская В.Н. (ред.). Контрацепция от менархе до менопаузы. М.: МЕДпресс-информ; 2015. 352 с.</mixed-citation><mixed-citation xml:lang="en">Prilepskaya V.N. (ed.). Contraception: from menarche to menopause. Moscow: MEDpress-inform; 2015. 352 p. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Сухих Г.Т., Прилепская В.Н., Межевитинова Е.А., Назарова Н.М., Павлович С.В., Донников А.Е., Геворкян Г.А. Контрацепция у женщин репродуктивного возраста. М.: Бином; 2019.</mixed-citation><mixed-citation xml:lang="en">Sukhykh G.T., Prilepskaya V.N., Mezhevitinova E.A., Nazarova N.M., Pavlovich S.V., Donnikov A.E., Gevorkyan G.A. Contraception in women of reproductive age. Moscow: Binom; 2019. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Wilcox A.J., Weinberg C.R., Baird D.D. Timing of sexual intercourse in relation to ovulation. Effects on the probability of conception, survival of the pregnancy, and sex of the baby. N Engl J Med. 1995;333(23):1517–1521. https://doi.org/10.1056/NEJM199512073332301.</mixed-citation><mixed-citation xml:lang="en">Wilcox A.J., Weinberg C.R., Baird D.D. Timing of sexual intercourse in relation to ovulation. Effects on the probability of conception, survival of the pregnancy, and sex of the baby. N Engl J Med. 1995;333(23):1517–1521. https://doi.org/10.1056/NEJM199512073332301.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Максимов М.Л., Толстых Т.С. Экстренная контрацепция: сравнение эффективности применяемых методов. Лечебное дело. 2012;(4):58–62. Режим доступа: https://cyberleninka.ru/article/n/ekstrennayakontratseptsiya-sravnenie-effektivnosti-primenyaemyh-metodov/viewer.</mixed-citation><mixed-citation xml:lang="en">Maksimov M.L., Tolstykh T.T. Сomparison of the effectiveness of the available methods of emergency contraception. Lechebnoe delo = Medical Business. 2012;(4):58–62. (In Russ.) Available at: https://cyberleninka.ru/article/n/ekstrennaya-kontratseptsiya-sravnenie-effektivnostiprimenyaemyh-metodov/viewer.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Piaggio G., Kapp N., von Hertzen H. Effect on pregnancy rates of the delay in the administration of levonorgestrel for emergency contraception: a combined analysis of four WHO trials. Contraception. 2011;84(1):35–39. https://doi.org/10.1016/j.contraception.2010.11.010.</mixed-citation><mixed-citation xml:lang="en">Piaggio G., Kapp N., von Hertzen H. Effect on pregnancy rates of the delay in the administration of levonorgestrel for emergency contraception: a combined analysis of four WHO trials. Contraception. 2011;84(1):35–39. https://doi.org/10.1016/j.contraception.2010.11.010.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Дикке Г.Б. Информированность об эффективности и безопасности экстренной контрацепции – резерв в профилактике нежеланной беременности. Медицинский совет. 2016;(2):92–95. https://doi.org/10.21518/2079-701X-2016-2-92-95.</mixed-citation><mixed-citation xml:lang="en">Dikke G.B. Awareness about the effectiveness and safety of emergency contraception - a reserve in the prevention of unwanted pregnancy. Meditsinskiy sovet = Medical Council. 2016;(2):92–95. (In Russ.) https://doi.org/10.21518/2079-701X-2016-2-92-95.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Adanu R., Amaral E., Cameron S. Chipato T., Chou R., Conard J. Selected practice recommendations for contraceptive use. Available at: https://www.who.int/reproductivehealth/publications/family_planning/SPR-3/en/.</mixed-citation><mixed-citation xml:lang="en">Adanu R., Amaral E., Cameron S. Chipato T., Chou R., Conard J. Selected practice recommendations for contraceptive use. Available at: https://www.who.int/reproductivehealth/publications/family_planning/SPR-3/en/.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Dada O.A., Godfrey E.M., Piaggio G., von Hertzen H. A randomized, doubleblind, noninferiority study to compare two regimens of levonorgestrel for emergency contraception in Nigeria. Contraception. 2010;82(4):373–378. https://doi.org/10.1016/j.contraception.2010.06.004.</mixed-citation><mixed-citation xml:lang="en">Dada O.A., Godfrey E.M., Piaggio G., von Hertzen H. A randomized, doubleblind, noninferiority study to compare two regimens of levonorgestrel for emergency contraception in Nigeria. Contraception. 2010;82(4):373–378. https://doi.org/10.1016/j.contraception.2010.06.004.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Trussell J., Ellertson C., Stewart F. The effectiveness of the Yuzpe regimen of emergency contraception. Fam Plann Perspect. 1996;28(2):58–64. Available at: https://pubmed.ncbi.nlm.nih.gov/8777940/.</mixed-citation><mixed-citation xml:lang="en">Trussell J., Ellertson C., Stewart F. The effectiveness of the Yuzpe regimen of emergency contraception. Fam Plann Perspect. 1996;28(2):58–64. Available at: https://pubmed.ncbi.nlm.nih.gov/8777940/.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Ellertson C., Webb A., Blanchard K., Bigrigg A., Haskell S., Shochet T., Trussell J. Modifying the Yuzpe regimen of emergency contraception: a multicenter randomized controlled trial. Obstet Gynecol. 2003;101(6):1160–1167. https://doi.org/10.1016/s0029-7844(03)00353-3.</mixed-citation><mixed-citation xml:lang="en">Ellertson C., Webb A., Blanchard K., Bigrigg A., Haskell S., Shochet T., Trussell J. Modifying the Yuzpe regimen of emergency contraception: a multicenter randomized controlled trial. Obstet Gynecol. 2003;101(6):1160–1167. https://doi.org/10.1016/s0029-7844(03)00353-3.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Randomised controlled trial of levonorgestrel versus the Yuzpe regimen of combined oral contraceptives for emergency contraception. Task Force on Postovulatory Methods of Fertility Regulation. Lancet. 1998;352(9126):428–433. Available at:https://pubmed.ncbi.nlm.nih.gov/9708750.</mixed-citation><mixed-citation xml:lang="en">Randomised controlled trial of levonorgestrel versus the Yuzpe regimen of combined oral contraceptives for emergency contraception. Task Force on Postovulatory Methods of Fertility Regulation. Lancet. 1998;352(9126):428–433. Available at:https://pubmed.ncbi.nlm.nih.gov/9708750.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang L., Chen J., Wang Y., Ren F., Yu W., Cheng L. Pregnancy outcome after levonorgestrel-only emergency contraception failure: a prospective cohort study. Hum Reprod. 2009;24(7):1605–1611. https://doi.org/10.1093/humrep/dep076.</mixed-citation><mixed-citation xml:lang="en">Zhang L., Chen J., Wang Y., Ren F., Yu W., Cheng L. Pregnancy outcome after levonorgestrel-only emergency contraception failure: a prospective cohort study. Hum Reprod. 2009;24(7):1605–1611. https://doi.org/10.1093/humrep/dep076.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Levy D.P., Jager M., Kapp N., Abitbol J.L. Ulipristal acetate for emergency contraception: postmarketing experience after use by more than 1 million women. Contraception. 2014;89(5):431–433. https://doi.org/10.1016/j.contraception.2014.01.003.</mixed-citation><mixed-citation xml:lang="en">Levy D.P., Jager M., Kapp N., Abitbol J.L. Ulipristal acetate for emergency contraception: postmarketing experience after use by more than 1 million women. Contraception. 2014;89(5):431–433. https://doi.org/10.1016/j.contraception.2014.01.003.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Rarick L.D. Prescription drug products; certain combined oral contraceptives for use as postcoital emergency contraception. Federal Regist. 1997;62:8610–8612. Available at: https://www.govinfo.gov/content/pkg/FR-1997-02-25/pdf/97-4663.pdf.</mixed-citation><mixed-citation xml:lang="en">Rarick L.D. Prescription drug products; certain combined oral contraceptives for use as postcoital emergency contraception. Federal Regist. 1997;62:8610–8612. Available at: https://www.govinfo.gov/content/pkg/FR-1997-02-25/pdf/97-4663.pdf.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Trussell J., Hedley A., Raymond E. Ectopic pregnancy following use of progestin-only ECPs. J Fam Plann Reprod Health Care. 2003;29(4):249. https://doi.org/10.1783/147118903101197944.</mixed-citation><mixed-citation xml:lang="en">Trussell J., Hedley A., Raymond E. Ectopic pregnancy following use of progestin-only ECPs. J Fam Plann Reprod Health Care. 2003;29(4):249. https://doi.org/10.1783/147118903101197944.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Cleland K., Raymond E., Trussell J., Cheng L., Zhu H. Ectopic pregnancy and emergency contraceptive pills: a systematic review. Obstet Gynecol. 2010;115(6):1263–1266. https://doi.org/10.1097/AOG.0b013e3181dd22ef.</mixed-citation><mixed-citation xml:lang="en">Cleland K., Raymond E., Trussell J., Cheng L., Zhu H. Ectopic pregnancy and emergency contraceptive pills: a systematic review. Obstet Gynecol. 2010;115(6):1263–1266. https://doi.org/10.1097/AOG.0b013e3181dd22ef.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Curtis K.M., Berry-Bibee E., Folger S.G., Horton L.G., Jamieson D.J., Jatlaoui T.C. U.S. Medical Eligibility Criteria for Contraceptive Use, 2010. MMWR Recomm Rep. 2010;59(RR-4):1–86. Available at: https://pubmed.ncbi.nlm.nih.gov/20559203/.</mixed-citation><mixed-citation xml:lang="en">Curtis K.M., Berry-Bibee E., Folger S.G., Horton L.G., Jamieson D.J., Jatlaoui T.C. U.S. Medical Eligibility Criteria for Contraceptive Use, 2010. MMWR Recomm Rep. 2010;59(RR-4):1–86. Available at: https://pubmed.ncbi.nlm.nih.gov/20559203/.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Прилепская В.Н., Абакарова П.Р., Бебнева Т.Н. Пятилетний опыт работы Центра по экстренной контрацепции. Гинекология. 2004;6(6):313–315. Режим доступа: https://elibrary.ru/item.asp?id=21106245.</mixed-citation><mixed-citation xml:lang="en">Prilepskaya V.N., Abakarova P.R., Bebneva T.N. Five-year experience in emergency contraception of National Center. Ginekologiya = Gynecology. 2004;6(6):313–315. (In Russ.) Available at: https://elibrary.ru/item.asp?id=21106245.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
