medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/2079-701X-2021-13-121-126medsovet-6407Research ArticleПРЕГРАВИДАРНАЯ ПОДГОТОВКА И БЕРЕМЕННОСТЬPREGRAVID PREPARATION AND PREGNANCYОсновные принципы терапии неосложненного цистита при беременностиGeneral principles of uncomplicated cystitis therapy during pregnancyhttps://orcid.org/0000-0002-5830-5099ТютюнникВ. Л.TyutyunnikV. L.

Тютюнник Виктор Леонидович, д.м.н., профессор, ведущий научный сотрудник центра научных и клинических исследований департамента организации научной деятельности

117997, Россия, Москва, ул. Академика Опарина, д. 4

Victor L. Tyutyunnik, Dr. Sci. (Med.), Professor, Leading Researcher of Research and Development Service

4, Academician Oparin St., Moscow, 117997, Russia

tioutiounnik@mail.ruhttps://orcid.org/0000-0001-5087-5946КанН. Е.KanN. E.

Кан Наталья Енкыновна, д.м.н., профессор, заместитель директора по научной работе

117997, Россия, Москва, ул. Академика Опарина, д. 4

Natalia E. Kan, Dr. Sci. (Med.), Рrofessor, Deputy Director of Science

4, Academician Oparin St., Moscow, 117997, Russia

https://orcid.org/0000-0003-4867-500XХачатрянЛ. В.KhachatryanL. V.

Хачатрян Лия Варужановна, ординатор кафедры акушерства и гинекологии №1 лечебного факультета

119048, Россия, Москва, ул. Трубецкая, д. 8, стр. 2

Lia V. Khachatryan, Сlinical Resident of Obstetrics and Gynecology Department №1

8, Bldg. 2, Trubetskaya St., Moscow, 119991, Russia

leahkhachatryan@gmail.comНациональный медицинский исследовательский центр акушерства, гинекологии и перинатологии имени академика В.И. КулаковаРоссияKulakov National Medical Research Center of Obstetrics, Gynecology and PerinatologyRussian FederationПервый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский Университет)РоссияSechenov First Moscow State Medical University (Sechenov University)Russian Federation202116102021013121126Copyright © Тютюнник В.Л., Кан Н.Е., Хачатрян Л.В., 20212021Тютюнник В.Л., Кан Н.Е., Хачатрян Л.В.Tyutyunnik V.L., Kan N.E., Khachatryan L.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/6407Введение

Введение. Инфекции мочевых путей во время беременности ассоциированы с развитием тяжелых осложнений. Своевременное начало антибактериальной терапии, в т. ч. и острого неосложненного цистита, позволяет снизить частоту неблагоприятных исходов.

Цель

Цель.Оценить эффективность применения фосфомицина трометамола в терапии острого неосложненного цистита у беременных во II и III триместре.

Материалы и методы

Материалы и методы. В исследование, согласно критериям включения и исключения, вошли 74 беременные, которые перенесли острый неосложненный цистит во II и III триместрах. Все пациентки, включенные в исследование, в качестве терапии острого неосложненного цистита получили фосфомицина трометамол 3,754 г (эквивалентно 3 г фосфомицина) однократно на ночь после мочеиспускания. Препарат был назначен 24 беременным во II и 50 – в III триместре беременности.

Результаты

Результаты. После проведения лечения фосфомицином клинические и лабораторные признаки острого цистита исчезли у всех больных. При этом регресс клинических симптомов был отмечен в течение следующих суток после терапии в 95,9% (n = 71) случаев. Повторное микробиологическое исследование средней порции мочи проводили через 7 дней после проведенной антибактериальной терапии. В 94,6% (n = 70) случаев была достигнута полная элиминация возбудителя. В 5,4% (n = 4) случаев было отмечено значительное снижение микробной колонизации (до 102 КОЕ/мл). Динамическое наблюдение в течение трех месяцев показало отсутствие рецидивов острого цистита у всех беременных, которые были включены в исследование.

Выводы

Выводы. Фосфомицин является высокоэффективным препаратом в терапии неосложненного цистита при беременности, что сопоставимо с применением других антибактериальных препаратов при лечении данной патологии.

Urinary tract infections during pregnancy are associated with severe complications. Earlier initiation of antibiotic treatment for acute uncomplicated cystitis, reduces the various complications.

Objective

Objective. To assess the effectiveness of fosfomycin in the treatment of acute uncomplicated cystitis during II and III trimester of pregnancy.

Material and methods

Material and methods. The study included 74 pregnant women who had acute uncomplicated cystitis in II or III trimesters. All patients received fosfomycin trometamol 3.754 g (equivalent to 3 g fosfomycin) as antimicrobial therapy for acute uncomplicated cystitis. The drug was prescribed to 24 pregnant women in the II, and 50 in the III trimester of pregnancy.

Results

Results. After treatment with fosfomycin signs of acute cystitis gone in all patients. At the same time, regression of clinical symptoms was noted during the next days after therapy in 95.9% (n = 71) of cases. Repeated microbiological test of the middle portion of urine was performed 7 days after the end of antibiotic therapy. In 94.6% (n = 70) cases, total elimination of the pathogen was achieved. In 5.4% (n = 4) cases, there was a significant decrease of colonization Follow-up for three months showed the absence of recurrence of acute cystitis in all pregnant women who were included in the study.

Conclusion

Conclusion. Fosfomycin is a highly effective drug in the treatment of uncomplicated cystitis during pregnancy.

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The authors declare that there are no conflicts of interest present.