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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2014-9-110-117</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-643</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Инфекции в акушерстве и гинекологии</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Infections in obstetrics and gynecology</subject></subj-group></article-categories><title-group><article-title>Клинико-морфологические аспекты вульвовагинальной атрофии</article-title><trans-title-group xml:lang="en"><trans-title>Clinical and morphological aspects of vulvovaginal atrophy</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Аполихина</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Apolikhina</surname><given-names>I. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Горбунова</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Gorbunova</surname><given-names>E. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Научный центр акушерства, гинекологии и перинатологии им. академика В.И. Кулакова; Первый Московский государственный медицинский университет им. И.М. Сеченова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Scientific center for obstetrics, gynecology and perinatology named after V.I. Kulakov, Russia’s; the Sechenov First Moscow State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Научный центр акушерства, гинекологии и перинатологии им. академика В.И. Кулакова Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Scientific center for obstetrics, gynecology and perinatology named after V.I. Kulakov, Russia’s Ministry of Health</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>30</day><month>12</month><year>2014</year></pub-date><volume>0</volume><issue>9</issue><fpage>110</fpage><lpage>117</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Аполихина И.А., Горбунова Е.А., 2014</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="ru">Аполихина И.А., Горбунова Е.А.</copyright-holder><copyright-holder xml:lang="en">Apolikhina I.A., Gorbunova E.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/643">https://www.med-sovet.pro/jour/article/view/643</self-uri><abstract><p>Вульвовагинальная атрофия - одно из наиболее драматичных и нежелательных проявлений дефицита эстрогенов. 77% женщин считают неудобным обсуждать ее симптомы с врачом. Повышение качества диагностики этого состояния является первым шагом для своевременного назначения лечения с доказанной эффективностью и улучшения качества жизни женщины на фоне гипоэстрогении, в т. ч. в постменопаузе.</p></abstract><trans-abstract xml:lang="en"><p>Vulvovaginal atrophy is one of the most annoying and undesirable manifestations of estrogen deficiency. 77% of women feel uncomfortable to discuss the symptoms with their doctor. Improving the quality of diagnosis is the first step to ensure timely treatment of proven efficacy and better quality of life of women against a background of hypoestrogenism, including in postmenopause.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>вульвовагинальная атрофия</kwd><kwd>гипоэстроге-ния</kwd><kwd>эстрадиол</kwd><kwd>аскорбиновая кислота</kwd><kwd>гликоген</kwd><kwd>рН влагалища</kwd><kwd>индекс вагинального здоровья</kwd><kwd>индекс созревания</kwd><kwd>vulvovaginal atrophy hypestrogenism</kwd><kwd>estradiol</kwd><kwd>ascorbic acid</kwd><kwd>glycogen</kwd><kwd>vaginal pH</kwd><kwd>vaginal health index</kwd><kwd>maturation index</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Гинекология. Национальное руководство. Под ред. В.И. Кулакова, Г.М. Савельевой, И.Б. Манухина М.: ГЕОТАР-Медиа, 2009.</mixed-citation><mixed-citation xml:lang="en">Гинекология. Национальное руководство. Под ред. В.И. Кулакова, Г.М. Савельевой, И.Б. Манухина М.: ГЕОТАР-Медиа, 2009.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Jiroutek MR et al. Changes in reproductive hormones and sex hormone-binding globulin in a group of postmenopausal women measured over 10 years. Menopause, 1998, 5 (2): 90-94.</mixed-citation><mixed-citation xml:lang="en">Jiroutek MR et al. Changes in reproductive hormones and sex hormone-binding globulin in a group of postmenopausal women measured over 10 years. Menopause, 1998, 5 (2): 90-94.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Гистология, цитология и эмбриология, под ред. Ю.И. Афанасьевой, Н.А. Юриной, Е.Ф. Котовского. М.: Медицина, 2002. С. 744.</mixed-citation><mixed-citation xml:lang="en">Гистология, цитология и эмбриология, под ред. Ю.И. Афанасьевой, Н.А. Юриной, Е.Ф. Котовского. М.: Медицина, 2002. С. 744.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Арсеньева М.Г. Кольпоцитологические исследования в диагностике и терапии эндокринных гинекологических заболеваний. М.: Медицина, 1977.</mixed-citation><mixed-citation xml:lang="en">Арсеньева М.Г. Кольпоцитологические исследования в диагностике и терапии эндокринных гинекологических заболеваний. М.: Медицина, 1977.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Кондриков Н.И. Патология матки. М.: Практическая медицина, 2008.</mixed-citation><mixed-citation xml:lang="en">Кондриков Н.И. Патология матки. М.: Практическая медицина, 2008.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Nappi RE, Kokot-Kierepa M. Women's voices in the menopause: results from an international survey on vaginal atrophy. Maturitas, 2010, Nov, 67 (3): 233-8.</mixed-citation><mixed-citation xml:lang="en">Nappi RE, Kokot-Kierepa M. Women's voices in the menopause: results from an international survey on vaginal atrophy. Maturitas, 2010, Nov, 67 (3): 233-8.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Johnston SL, Farrel SA, Bouchard C et al. The detection and management of vaginal atrophy. J. Obstet. Gynaecol. Can., 2004, May, 26 (5): 503-515.</mixed-citation><mixed-citation xml:lang="en">Johnston SL, Farrel SA, Bouchard C et al. The detection and management of vaginal atrophy. J. Obstet. Gynaecol. Can., 2004, May, 26 (5): 503-515.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Caillouette JC, Sharp CF Jr, Zimmerman GJ, Roy S. Vaginal pH as a marker for bacterial pathogens and menopausal status. Am J Obstet Gynecol, 1997, 176 (6): 1270-5.</mixed-citation><mixed-citation xml:lang="en">Caillouette JC, Sharp CF Jr, Zimmerman GJ, Roy S. Vaginal pH as a marker for bacterial pathogens and menopausal status. Am J Obstet Gynecol, 1997, 176 (6): 1270-5.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Bachmann GA, Notelovitz M, Kelly SJ, et al. Long-term non-hormonal treatment of vaginal dryness. Clin Pract Sexuality, 1992, 8: 3-8.</mixed-citation><mixed-citation xml:lang="en">Bachmann GA, Notelovitz M, Kelly SJ, et al. Long-term non-hormonal treatment of vaginal dryness. Clin Pract Sexuality, 1992, 8: 3-8.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Роговская С.И. Практическая кольпоскопия. Монография. 3-е изд., испр., доп. М.: ГЭОТАР-Медиа, 2012.</mixed-citation><mixed-citation xml:lang="en">Роговская С.И. Практическая кольпоскопия. Монография. 3-е изд., испр., доп. М.: ГЭОТАР-Медиа, 2012.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Raz R. Et al. A controlled trial of intravaginal estriol in postmenopausal women with reccurent urinary tract infections. N. Engl. J. Med., 1993, 329 (11): 753-756.</mixed-citation><mixed-citation xml:lang="en">Raz R. Et al. A controlled trial of intravaginal estriol in postmenopausal women with reccurent urinary tract infections. N. Engl. J. Med., 1993, 329 (11): 753-756.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Goldstein SR, Bachmann GA, Koninckx PR, Lin VH, Portman DJ, Ylikorkala O and the Ospemifene Study Group. Ospemifene 12-month safety and efficacy in postmenopausal women with vulvar and vaginal atrophy. CLIMACTERIC, 2014, 17: 173-182.</mixed-citation><mixed-citation xml:lang="en">Goldstein SR, Bachmann GA, Koninckx PR, Lin VH, Portman DJ, Ylikorkala O and the Ospemifene Study Group. Ospemifene 12-month safety and efficacy in postmenopausal women with vulvar and vaginal atrophy. CLIMACTERIC, 2014, 17: 173-182.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Guidelines on Urological Infections. M. Grabe (chair), R. Bartoletti, T.E. Bjerklund-Johanse еt al. EAU, 2014.</mixed-citation><mixed-citation xml:lang="en">Guidelines on Urological Infections. M. Grabe (chair), R. Bartoletti, T.E. Bjerklund-Johanse еt al. EAU, 2014.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Gorodeski GI, Hopfer U, Liu CC, Margles E. Esrogen acidifies vaginal pH by up-regulation of proton secretion via apical membrane of vaginal-ectocervical epithelial cells. Endocrinology, 2005, 146: 816824.</mixed-citation><mixed-citation xml:lang="en">Gorodeski GI, Hopfer U, Liu CC, Margles E. Esrogen acidifies vaginal pH by up-regulation of proton secretion via apical membrane of vaginal-ectocervical epithelial cells. Endocrinology, 2005, 146: 816824.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Lam MH, Birch DF. Survical of Gardnerella vaginalis in human urine. Am J Clin Pathol, 1991, 95 (2): 234-9.</mixed-citation><mixed-citation xml:lang="en">Lam MH, Birch DF. Survical of Gardnerella vaginalis in human urine. Am J Clin Pathol, 1991, 95 (2): 234-9.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Tanaka Y, Naganawa M, Sakai M, Saito S. Fundamental study of a newly developed medium on detection of Lactobacillus. Rinsho Biseibutshu Jinsoki Shindan Kenkyukai Shi, 2006, 17 (1): 23-32.</mixed-citation><mixed-citation xml:lang="en">Tanaka Y, Naganawa M, Sakai M, Saito S. Fundamental study of a newly developed medium on detection of Lactobacillus. Rinsho Biseibutshu Jinsoki Shindan Kenkyukai Shi, 2006, 17 (1): 23-32.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Громова О.А., Торшин И.Ю., Гарасько Е.А. Молекулярные механизмы топического назначения витамина С в лечении бактериального вагиноза. Акушерство и гинекология, 2010, 11: 37-42.</mixed-citation><mixed-citation xml:lang="en">Громова О.А., Торшин И.Ю., Гарасько Е.А. Молекулярные механизмы топического назначения витамина С в лечении бактериального вагиноза. Акушерство и гинекология, 2010, 11: 37-42.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Ребров В.Г., Громова О.А. Витамины, макро- и микроэлементы. М.: Геотар-Медиа, 2008. С. 968.</mixed-citation><mixed-citation xml:lang="en">Ребров В.Г., Громова О.А. Витамины, макро- и микроэлементы. М.: Геотар-Медиа, 2008. С. 968.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Polatti F. Vaginal pH-lowering effect of locally applied vitamin C in subjects with hogh vaginal pH. 2006, 22 (4): 230-234.</mixed-citation><mixed-citation xml:lang="en">Polatti F. Vaginal pH-lowering effect of locally applied vitamin C in subjects with hogh vaginal pH. 2006, 22 (4): 230-234.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
