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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2021-16-204-211</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-6479</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Рациональная фармакотерапия</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Rational pharmacotherapy</subject></subj-group></article-categories><title-group><article-title>Кашель. Место фитотерапии в лечении</article-title><trans-title-group xml:lang="en"><trans-title>Cough. The place of herbal medicine in treatment</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2222-836X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лапидус</surname><given-names>Н. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Lapidus</surname><given-names>N. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лапидус Наталья Ильинична, к.м.н., доцент кафедры медико-социальнойэкспертизы, неотложной и поликлинической терапии</p><p>119991, Россия, Москва, ул. Трубецкая, д. 8</p></bio><bio xml:lang="en"><p>Natalya I. Lapidus, Cand. Sci. (Med.). Associate Professor of the Department of Medical and Social Expertise, Emergency and Polyclinic Therapy</p><p>8, Bldg. 2, Trubetskaya St., Moscow, 119991, Russia</p></bio><email xlink:type="simple">nat_lap@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Первый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский Университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Sechenov First Moscow State Medical University (Sechenov University)</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>30</day><month>10</month><year>2021</year></pub-date><volume>0</volume><issue>16</issue><fpage>204</fpage><lpage>211</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Лапидус Н.И., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Лапидус Н.И.</copyright-holder><copyright-holder xml:lang="en">Lapidus N.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/6479">https://www.med-sovet.pro/jour/article/view/6479</self-uri><abstract><p>Кашель является одним из вспомогательных механизмов для очистки дыхательных путей от слизи, инородных частиц, микроорганизмов. Физиологический кашлевой рефлекс позволяет осуществлять механизм очищения дыхательных путей при условии достаточной работы мукоцилиарного клиренса. Однако иногда кашель утрачивает свою защитную функцию, становится упорным и нарушает качество жизни пациента. В связи с этим в лечении кашля внимание уделяется как секретомоторной, так и секретолитической терапии. В числе препаратов, обладающих такими свойствами, находятся и лекарственные растения. Многочисленная группа препаратов, содержащих растительные компоненты, обладает рефлекторным действием, что позволяет наиболее эффективно справляться с кашлем на начальных этапах заболеваний, сопровождающихся респираторными симптомами. Наиболее распространены среди них и широко применяются лист подорожника, лист мать-и-мачехи, трава термопсиса, корень ипекакуаны, корень алтея, корень солодки, плод аниса, экстракт травы тимьяна (чабреца), экстракт листьев плюща. Хорошо известен препарат, действующим веществом которого является экстракт листьев плюща обыкновенного. Механизм действия плюща заключается в усилении выработки сурфактанта и увеличении количества β2-адренорецепторов на поверхности альвеолярных клеток бронхиального дерева, к которым прикрепляется действующее вещество плюща α-гедерин, оказывающее бронхоспазмолитическое и отхаркивающее действие. В многочисленных клинических исследованиях доказана высокая эффективность и безопасность препарата на основе экстракта листьев плюща обыкновенного, что позволяет рекомендовать его в качестве препарата выбора при необходимости симптоматической терапии кашля как у детей, так и взрослых при ОРВИ.</p></abstract><trans-abstract xml:lang="en"><p>Cough is one of the auxiliary mechanisms for cleaning the airways from mucus, foreign particles, microorganisms. The physiological cough reflex allows the mechanism of airway cleansing, provided that mucociliary clearance works sufficiently. However, sometimes the cough loses its protective function, becomes persistent, and impairs the quality of life of the patient. In this regard, in the treatment of cough, attention is paid to both secretomotor and secretolytic therapy. Medicinal plants are among the drugs with such properties. Numerous group of drugs containing herbal components has a reflex action, which allows coping most effectively with cough in the initial stages of diseases accompanied by respiratory symptoms. The most common among them and widely used are plantain leaf, coltsfoot leaf, thermopsis herb, ipecacuanha root, marshmallow root, licorice root, anise fruit, thyme (thyme) herb extract, ivy leaf extract. A well-known drug, the active ingredient of which is ivy leaf extract. Its mechanism of action consists in increasing the production of surfactant and increasing the number of β2-adrenoreceptors on the surface of alveolar cells of the bronchial tree, to which ivy active substance α-hederin is attached, which has a bronchospasmodic and expectorant action. Numerous clinical studies have proven a high efficacy and safety of the product based on ivy leaf extract, which allows us to recommend it as the drug of choice for symptomatic cough therapy in both children and adults during acute respiratory infections.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>кашель</kwd><kwd>отхаркивающие препараты</kwd><kwd>растительные средства</kwd><kwd>листья плюща</kwd><kwd>сапонины</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cough</kwd><kwd>expectorant drugs</kwd><kwd>herbal remedies</kwd><kwd>ivy leaves</kwd><kwd>saponins</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Синопальников А.И., Клячкина И.Л. Кашель. М.: МИА, 2013. 168 с.</mixed-citation><mixed-citation xml:lang="en">Sinopalnikov A.I., Klyachkina I.L. Cough. M.: MIA, 2013. 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