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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2021-17-192-202</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-6501</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ДЕРМАТОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>DERMATOLOGY</subject></subj-group></article-categories><title-group><article-title>Топическая терапия дерматозов сложных локализаций у детей</article-title><trans-title-group xml:lang="en"><trans-title>Topical therapy of dermatoses in children with complex localizations</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4401-3722</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ковалева</surname><given-names>Ю. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Kovaleva</surname><given-names>J. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ковалева Юлия Сергеевна - доктор медицинских наук, заведующая кафедрой дерматовенерологии, косметологии и иммунологии.</p><p>656038, Алтайский край, Барнаул, проспект Ленина, д. 40</p></bio><bio xml:lang="en"><p>Julia S. Kovaleva, Dr. Sci. (Med.), Head of the Department of DermatovenereoLogy, CosmetoLogy and ImmunoLogy.</p><p>40, Lenin Ave., BarnauL, ALtai Region, 656038</p></bio><email xlink:type="simple">juliajsk@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0665-709X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Оробей</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Orobei</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Оробей Мария Владимировна - кандидат медицинских наук, доцент кафедры дерматовенерологии, косметологии и иммунологии.</p><p>656038, Алтайский край, Барнаул, проспект Ленина, д. 40</p></bio><bio xml:lang="en"><p>Mania V. Orobei, Cand. Sci. (Med.), Associate Professor of the Department of DermatovenereoLogy, CosmetoLogy and ImmunoLogy.</p><p>40, Lenin Ave., BarnauL, ALtai Region, 656038</p></bio><email xlink:type="simple">orobei77@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1774-0334</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зяблицкая</surname><given-names>Н. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Zyablitskaya</surname><given-names>N. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Зяблицкая Надежда Константиновна - кандидат медицинских наук, доцент кафедры дерматовенерологии, косметологии и иммунологии.</p><p>656038, Алтайский край, Барнаул, проспект Ленина, д. 40</p></bio><bio xml:lang="en"><p>Nadezhda K. Zyablitskaya, Cand. Sci. (Med.), Associate Professor of the Department of DermatovenereoLogy, CosmetoLogy and ImmunoLogy.</p><p>40, Lenin Ave., BarnauL, ALtai Region, 656038</p></bio><email xlink:type="simple">oceann7@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5170-3852</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бишевская</surname><given-names>Н. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Bishevskaya</surname><given-names>N. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бишевская Наталья Константиновна - кандидат медицинских наук, доцент кафедры пропедевтики детских болезней.</p><p>656038, Алтайский край, Барнаул, проспект Ленина, д. 40</p></bio><bio xml:lang="en"><p>Natalya K. Bishevskaya, Cand. Sci. (Med.), Associate Professor of the Department of Propaedeuticus of ChiLdren Diseases.</p><p>40, Lenin Ave., BarnauL, ALtai Region, 656038</p></bio><email xlink:type="simple">bish_natasha@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Алтайский государственный медицинский университет<country>Россия</country></aff><aff xml:lang="en">Altay State Medical University<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>31</day><month>10</month><year>2021</year></pub-date><volume>0</volume><issue>17</issue><fpage>192</fpage><lpage>202</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ковалева Ю.С., Оробей М.В., Зяблицкая Н.К., Бишевская Н.К., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Ковалева Ю.С., Оробей М.В., Зяблицкая Н.К., Бишевская Н.К.</copyright-holder><copyright-holder xml:lang="en">Kovaleva J.S., Orobei M.V., Zyablitskaya N.K., Bishevskaya N.K.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/6501">https://www.med-sovet.pro/jour/article/view/6501</self-uri><abstract><p>Кожа у детей имеет свои анатомо-физиологические особенности, эпидермис значительно тоньше, чем у взрослых, слои дермы и базальной мембраны слабо развиты и дифференцированы, повышен показатель трансэпидермальной потери воды и снижен уровень естественного увлажняющего фактора. Такое строение кожи у детей предрасполагает к нарушению ее барьерной функции, способствует возникновению заболеваний кожи и обеспечивает повышенную резорбтивную способность кожи, что требует особого внимания при назначении наружной терапии. Использование высококачественных смягчающих средств является важной частью базовой терапии хронических дерматозов, имеет свои особенности в детском возрасте, предотвращает развитие обострений и снижает потребность в противовоспалительных топических препаратах. При локализации поражений на лице, шее, гениталиях и крупных складках необходимо отдавать предпочтение топическим глюкокортикостероидам с сильным противовоспалительным действием, низкой биодоступностью, быстрым началом действия, минимальными побочными эффектами, что позволяют проводить необходимый по длительности курс местной противовоспалительной терапии у детей. Российский опыт применения 0,1%-ного метилпреднизолона ацепоната у детей различных возрастных групп при лечении аллергодерматозов, в т. ч. с локализацией на чувствительных зонах, показал хорошую эффективность, переносимость и отсутствие побочных эффектов В статье представлены собственные клинические наблюдения эффективности использования комбинированной терапии: эмолентного средства - специального крема с физиологическими липидами омега 3-6-9 и крема метилпреднизолона ацепонат (с керамидами в основе) в лечении заболеваний кожи у детей с акцентом на сложные локализации, такие как лицо, складки, область половых органов.</p></abstract><trans-abstract xml:lang="en"><p>The skin of children has its own anatomical and physiological characteristics, the epidermis is much thinner than in adults, the layers of the dermis and basement membrane are poorly developed and differentiated, the rate of transepidermal water loss is increased and the level of natural moisturizing factor (NMF) is reduced. Such a structure of the skin predisposes to a violation of its barrier function, contributes to the occurrence of skin diseases, provides an increased resorptive capacity of the skin and requires special attention when prescribing external therapy. The use of high-quality emollients is an important part of the basic treatment of chronic dermatoses and has its own characteristics in childhood. The use of emollients prevents the development of exacerbations and reduces the need for anti-inflammatory topical drugs. With the localization of the inflammatory process on the face, neck, genitals and large folds, it is necessary to give preference to short courses of topical glucocorticosteroids (THCS) with sufficient anti-inflammatory activity, rapid onset of action, minimal side effects. Given the high risk of side effects in children in these areas of the skin, strong fluorinated THCS, high-potency THCS, and the use of THCS under occlusive dressings are not recommended. The Russian experience of using 0.1% methylprednisolone aceponate in children of various age groups in the treatment of allergic dermatoses, including those with localization in sensitive areas, has shown good efficacy, tolerance and the absence of side effects. he article presents own clinical observations of the effectiveness of the use of combination therapy: an emollient agent - a special cream with physiological lipids omega 3-6-9 and cream methylprednisolone aceponate (with ceramides in the base) in the treatment of skin diseases in children with an emphasis on complex localizations, such as face, folds, genital area.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>особенности детской кожи</kwd><kwd>чувствительные зоны кожи</kwd><kwd>топические глюкокортикостероиды</kwd><kwd>эмоленты</kwd><kwd>стероидчувствительные дерматозы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>features of children’s skin</kwd><kwd>sensitive skin areas</kwd><kwd>topical glucocorticosteroids</kwd><kwd>emollients</kwd><kwd>steroid-sensitive dermatoses</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Цыбулевский А.Ю., Дубовая Т.К. 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