<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2021-19-126-133</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-6541</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Заболевания периферической нервной системы</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PERIPHERAL NERVOUS SYSTEM DISEASES</subject></subj-group></article-categories><title-group><article-title>Принципы лечения пациентов с диабетической полиневропатией в условиях пандемии COVID-19</article-title><trans-title-group xml:lang="en"><trans-title>Principles of Treatment of Patients with Diabetic Polyneuropathy in the COVID-19 Pandemic</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2752-4109</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Головачева</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Golovacheva</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Головачева Вероника Александровна, к.м.н., доцент кафедры нервных болезней и нейрохирургии Института клинической медицины</p><p>119991, Россия, Москва, ул. Трубецкая, д. 8, стр. 2</p></bio><bio xml:lang="en"><p>Veronika A. Golovacheva, Cand. Sci. (Med.), Associate Professor of the Department of Nervous Diseases and Neurosurgery of the Institute of Clinical Medicine</p><p>8, Bldg. 2, Trubetskaya St., Moscow, 119991, Russia</p></bio><email xlink:type="simple">xoxo.veronicka@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2845-7323</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Головачева</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Golovacheva</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Головачева Анжелика Александровна, клинический ординатор кафедры нервных болезней и нейрохирургии Института клинической медицины</p><p>119991, Россия, Москва, ул. Трубецкая, д. 8, стр. 2</p></bio><bio xml:lang="en"><p>Angelica A. Golovacheva, Clinical Resident of the Department of Nervous Diseases and Neurosurgery of the Institute of Clinical Medicine</p><p>8, Bldg. 2, Trubetskaya St., Moscow, 119991, Russia</p></bio><email xlink:type="simple">angelika.golovacheva@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Первый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский Университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Sechenov First Moscow State Medical University (Sechenov University)</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>30</day><month>11</month><year>2021</year></pub-date><volume>0</volume><issue>19</issue><fpage>126</fpage><lpage>133</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Головачева В.А., Головачева А.А., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Головачева В.А., Головачева А.А.</copyright-holder><copyright-holder xml:lang="en">Golovacheva V.A., Golovacheva A.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/6541">https://www.med-sovet.pro/jour/article/view/6541</self-uri><abstract><p>У пациентов, заболевших COVID-19, могут развиваться различные неврологические нарушения со стороны центральной и периферической нервной системы. Известно, что сахарный диабет (СД) 1-го или 2-го типа, заболевания сердечно-сосудистой системы, ожирение, пожилой и старческий возраст, мужской пол являются факторами риска тяжелого течения и развития осложнений COVID-19. В настоящее время пандемия COVID-19 продолжается, и пациентам с перечисленными факторами риска рекомендуется соблюдать режим социального ограничения или самоизоляции. Для данной категории пациентов наиболее приемлемо амбулаторное лечение. Пациенты с СД, перенесшие COVID-19, имеют риск развития или прогрессирования диабетической полиневропатии (ДПН). Представляется актуальным разработка принципов эффективного лечения пациентов с СД и ДПН в амбулаторных условиях. Коррекция уровня гликемии, диета, нормализация веса, терапия сочетанных сердечнососудистых заболеваний, повышение физической активности, нормализация сна, поддержание нормального психологического состояния – это основные принципы лечения пациентов с СД и ДПН в условиях пандемии COVID-19. Патогенетическая терапия ДПН продолжает обсуждаться, в нашей стране широко применяются препараты витаминов группы В, альфа-липоевой кислоты. Препараты витаминов группы В могут применяться в виде таблеток или растворов для внутримышечных инъекций. Обсуждается эффективность витаминов группы В (В1, В6, В12) в лечении тяжелого течения COVID-19, предупреждения осложнений COVID-19, особенно у пациентов пожилого возраста и с СД.</p></abstract><trans-abstract xml:lang="en"><p>Patients with COVID-19 may develop various neurological disorders of the central and peripheral nervous systems. It is known that diabetes mellitus (DM) type 1 or 2, cardiovascular diseases, obesity, old age and old age, male gender are risk factors for a severe course and complications of COVID-19. Currently, the COVID-19 pandemic is ongoing, and patients with the listed risk factors are recommended to follow a regime of social restriction or self-isolation. Outpatient treatment is most appropriate for this category of patients. Patients with diabetes who have undergone COVID-19 are at risk of developing or progressing diabetic polyneuropathy (DPN). It seems relevant to develop the principles of effective treatment of patients with DM and DPN in outpatient settings. Glycemic level correction, diet, weight normalization, therapy of combined cardiovascular diseases, an increase of physical activity, sleep normalization, maintenance of normal psychological state are the main principles of treatment of patients with DM and DPN in COVID-19 pandemic conditions. Pathogenetic therapy of DPN continues to be discussed, in our country the preparations of B vitamins, alpha-lipoic acid are widely used. B-group vitamin preparations can be used in the form of tablets or solutions for intramuscular injections. The effectiveness of B vitamins (B1, B6, B12) in the treatment of a severe course of COVID- 19, prevention of complications of COVID-19, especially in elderly patients and with diabetes is discussed.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>сахарный диабет</kwd><kwd>диабетическая полиневропатия</kwd><kwd>лечение</kwd><kwd>витамины группы В</kwd><kwd>тиамин</kwd><kwd>пиридоксин</kwd><kwd>цианокобаламин</kwd><kwd>COVID-19</kwd></kwd-group><kwd-group xml:lang="en"><kwd>diabetes mellitus</kwd><kwd>diabetic polyneuropathy</kwd><kwd>treatment</kwd><kwd>B vitamins</kwd><kwd>thiamine</kwd><kwd>pyridoxine</kwd><kwd>cyanocobalamin</kwd><kwd>COVID-19</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Alonso-Lana S., Marquié M., Ruiz A, Boada M. Cognitive and Neuropsychiatric Manifestations of COVID-19 and Effects on Elderly Individuals With Dementia. Front Aging Neurosci. 2020;12:588872. https://doi.org/10.3389/fnagi.2020.588872.</mixed-citation><mixed-citation xml:lang="en">Alonso-Lana S., Marquié M., Ruiz A, Boada M. Cognitive and Neuropsychiatric Manifestations of COVID-19 and Effects on Elderly Individuals With Dementia. Front Aging Neurosci. 2020;12:588872. https://doi.org/10.3389/fnagi.2020.588872.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">World Health Organization (2020). Coronavirus Disease (COVID-19) Situation Report-190. Available at: https://who.int/docs/default-source/coronaviruse/situation-reports/20200928-weekly-epi-update.pdf?sfvrsn=9e354665_6.</mixed-citation><mixed-citation xml:lang="en">World Health Organization (2020). Coronavirus Disease (COVID-19) Situation Report-190. Available at: https://who.int/docs/default-source/coronaviruse/situation-reports/20200928-weekly-epi-update.pdf?sfvrsn=9e354665_6.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Boutoleau-Bretonnière C., Pouclet-Courtemanche H., Gillet A., Bernard A., Deruet A.L., Gouraud I. et al. The Effects of Confinement on Neuropsychiatric Symptoms in Alzheimer’s Disease During the COVID-19 Crisis. J Alzheimers Dis. 2020;76(1):41–47. https://doi.org/10.3233/JAD-200604.</mixed-citation><mixed-citation xml:lang="en">Boutoleau-Bretonnière C., Pouclet-Courtemanche H., Gillet A., Bernard A., Deruet A.L., Gouraud I. et al. The Effects of Confinement on Neuropsychiatric Symptoms in Alzheimer’s Disease During the COVID-19 Crisis. J Alzheimers Dis. 2020;76(1):41–47. https://doi.org/10.3233/JAD-200604.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Wu Z., McGoogan J.M. Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. JAMA. 2020;323(13):1239–1242. https://doi.org/10.1001/jama.2020.2648.</mixed-citation><mixed-citation xml:lang="en">Wu Z., McGoogan J.M. Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. JAMA. 2020;323(13):1239–1242. https://doi.org/10.1001/jama.2020.2648.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Tsai S.T., Lu M.K., San S., Tsai C.H. The Neurologic Manifestations of Coronavirus Disease 2019 Pandemic: A Systemic Review. Front Neurol. 2020;11:498. https://doi.org/10.3389/fneur.2020.00498.</mixed-citation><mixed-citation xml:lang="en">Tsai S.T., Lu M.K., San S., Tsai C.H. The Neurologic Manifestations of Coronavirus Disease 2019 Pandemic: A Systemic Review. Front Neurol. 2020;11:498. https://doi.org/10.3389/fneur.2020.00498.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Lim S., Bae J.H., Kwon H.S., Nauck M.A. COVID-19 and diabetes mellitus: from pathophysiology to clinical management. Nat Rev Endocrinol. 2021;17(1):11–30. https://doi.org/10.1038/s41574-020-00435-4.</mixed-citation><mixed-citation xml:lang="en">Lim S., Bae J.H., Kwon H.S., Nauck M.A. COVID-19 and diabetes mellitus: from pathophysiology to clinical management. Nat Rev Endocrinol. 2021;17(1):11–30. https://doi.org/10.1038/s41574-020-00435-4.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Cariou B., Hadjadj S., Wargny M., Pichelin M., Al-Salameh A., Allix I. et al. Phenotypic characteristics and prognosis of inpatients with COVID-19 and diabetes: the CORONADO study. Diabetologia. 2020;63(8):1500–1515. https://doi.org/10.1007/s00125-020-05180-x.</mixed-citation><mixed-citation xml:lang="en">Cariou B., Hadjadj S., Wargny M., Pichelin M., Al-Salameh A., Allix I. et al. Phenotypic characteristics and prognosis of inpatients with COVID-19 and diabetes: the CORONADO study. Diabetologia. 2020;63(8):1500–1515. https://doi.org/10.1007/s00125-020-05180-x.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Pitocco D., Viti L., Santoliquido A., Tartaglione L., Di Leo M., Bianchi A. et al. Diabetic neuropathy: a risk factor for severe COVID-19? Acta Diabetol. 2021;58(5):669–670. https://doi.org/10.1007/s00592-020-01658-7.</mixed-citation><mixed-citation xml:lang="en">Pitocco D., Viti L., Santoliquido A., Tartaglione L., Di Leo M., Bianchi A. et al. Diabetic neuropathy: a risk factor for severe COVID-19? Acta Diabetol. 2021;58(5):669–670. https://doi.org/10.1007/s00592-020-01658-7.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Tesfaye S., Boulton A.J., Dyck P.J., Freeman R., Horowitz M., Kempler P. et al. Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments. Diabetes Care. 2010;33(10):2285–2293. https://doi.org/10.2337/dc10-1303.</mixed-citation><mixed-citation xml:lang="en">Tesfaye S., Boulton A.J., Dyck P.J., Freeman R., Horowitz M., Kempler P. et al. Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments. Diabetes Care. 2010;33(10):2285–2293. https://doi.org/10.2337/dc10-1303.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Odriozola A., Ortega L., Martinez L., Odriozola S., Torrens A., Corroleu D. et al. Widespread sensory neuropathy in diabetic patients hospitalized with severe COVID-19 infection. Diabetes Res Clin Pract. 2021;172:108631. https://doi.org/10.1016/j.diabres.2020.108631.</mixed-citation><mixed-citation xml:lang="en">Odriozola A., Ortega L., Martinez L., Odriozola S., Torrens A., Corroleu D. et al. Widespread sensory neuropathy in diabetic patients hospitalized with severe COVID-19 infection. Diabetes Res Clin Pract. 2021;172:108631. https://doi.org/10.1016/j.diabres.2020.108631.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Kioskli K., Scott W., Winkley K., Kylakos S., McCracken L.M. Psychosocial factors in painful diabetic neuropathy: a systematic review of treatment trials and survey studies. Pain Med. 2019;20:1756–1773. https://doi.org/10.1093/pm/pnz071.</mixed-citation><mixed-citation xml:lang="en">Kioskli K., Scott W., Winkley K., Kylakos S., McCracken L.M. Psychosocial factors in painful diabetic neuropathy: a systematic review of treatment trials and survey studies. Pain Med. 2019;20:1756–1773. https://doi.org/10.1093/pm/pnz071.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Yang H., Sloan G., Ye Y., Wang S., Duan B., Tesfaye S., Gao L. New Perspective in Diabetic Neuropathy: From the Periphery to the Brain, a Call for Early Detection, and Precision Medicine. Front Endocrinol (Lausanne). 2020;10:929. https://doi.org/10.3389/fendo.2019.00929.</mixed-citation><mixed-citation xml:lang="en">Yang H., Sloan G., Ye Y., Wang S., Duan B., Tesfaye S., Gao L. New Perspective in Diabetic Neuropathy: From the Periphery to the Brain, a Call for Early Detection, and Precision Medicine. Front Endocrinol (Lausanne). 2020;10:929. https://doi.org/10.3389/fendo.2019.00929.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Boulton A.J., Vinik A.I., Arezzo J.C., Bril V., Feldman E.L., Freeman R. et al. Diabetic neuropathies: a statement by the American Diabetes Association. Diabetes Care. 2005;28(4):956–962. https://doi.org/10.2337/diacare.28.4.956.</mixed-citation><mixed-citation xml:lang="en">Boulton A.J., Vinik A.I., Arezzo J.C., Bril V., Feldman E.L., Freeman R. et al. Diabetic neuropathies: a statement by the American Diabetes Association. Diabetes Care. 2005;28(4):956–962. https://doi.org/10.2337/diacare.28.4.956.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Callaghan B.C., Little A.A., Feldman E.L., Hughes R.A. Enhanced glucose control for preventing and treating diabetic neuropathy. Cochrane Database Syst Rev. 2012;6(6):CD007543. https://doi.org/10.1002/14651858.CD007543.pub2.</mixed-citation><mixed-citation xml:lang="en">Callaghan B.C., Little A.A., Feldman E.L., Hughes R.A. Enhanced glucose control for preventing and treating diabetic neuropathy. Cochrane Database Syst Rev. 2012;6(6):CD007543. https://doi.org/10.1002/14651858.CD007543.pub2.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Ang L., Jaiswal M., Martin C., Pop-Busui R. Glucose control and diabetic neuropathy: lessons from recent large clinical trials. Curr Diab Rep. 2014;14(9):528. https://doi.org/10.1007/s11892-014-0528-7.</mixed-citation><mixed-citation xml:lang="en">Ang L., Jaiswal M., Martin C., Pop-Busui R. Glucose control and diabetic neuropathy: lessons from recent large clinical trials. Curr Diab Rep. 2014;14(9):528. https://doi.org/10.1007/s11892-014-0528-7.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">1Cullen W., Gulati G., Kelly B.D. Mental health in the COVID-19 pandemic. QJM. 2020;113(5):311–312. https://doi.org/10.1093/qjmed/hcaa110.</mixed-citation><mixed-citation xml:lang="en">Cullen W., Gulati G., Kelly B.D. Mental health in the COVID-19 pandemic. QJM. 2020;113(5):311–312. https://doi.org/10.1093/qjmed/hcaa110.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Pérez-Cano H.J., Moreno-Murguía M.B., Morales-López O., Crow-Buchanan O., English J.A., Lozano-Alcázar J., Somilleda-Ventura S.A. Anxiety, depression, and stress in response to the coronavirus disease-19 pandemic. Cir Cir. 2020;88(5):562–568. https://doi.org/10.24875/CIRU.20000561.</mixed-citation><mixed-citation xml:lang="en">Pérez-Cano H.J., Moreno-Murguía M.B., Morales-López O., CrowBuchanan O., English J.A., Lozano-Alcázar J., Somilleda-Ventura S.A. Anxiety, depression, and stress in response to the coronavirus disease-19 pandemic. Cir Cir. 2020;88(5):562–568. https://doi.org/10.24875/CIRU.20000561.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Smarr K.L., Keefer A.L. Measures of depression and depressive symptoms: Beck Depression Inventory-II (BDI-II), Center for Epidemiologic Studies Depression Scale (CES-D), Geriatric Depression Scale (GDS), Hospital Anxiety and Depression Scale (HADS), and Patient Health Questionnaire-9 (PHQ-9). Arthritis Care Res (Hoboken). 2011;63(11 Suppl.):S454–466. https://doi.org/10.1002/acr.20556.</mixed-citation><mixed-citation xml:lang="en">Smarr K.L., Keefer A.L. Measures of depression and depressive symptoms: Beck Depression Inventory-II (BDI-II), Center for Epidemiologic Studies Depression Scale (CES-D), Geriatric Depression Scale (GDS), Hospital Anxiety and Depression Scale (HADS), and Patient Health Questionnaire-9 (PHQ-9). Arthritis Care Res (Hoboken). 2011;63(11 Suppl.):S454–466. https://doi.org/10.1002/acr.20556.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Richter P., Werner J., Heerlein A., Kraus A., Sauer H. On the validity of the Beck Depression Inventory. A review. Psychopathology. 1998;31(3):160–168. https://doi.org/10.1159/000066239.</mixed-citation><mixed-citation xml:lang="en">Richter P., Werner J., Heerlein A., Kraus A., Sauer H. On the validity of the Beck Depression Inventory. A review. Psychopathology. 1998;31(3):160–168. https://doi.org/10.1159/000066239.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Beck S.B. Еyelid conditioning as a function of cs intensity, ucs intensity, and manifest anxiety scale score. J Exp Psychol. 1963;66:429–438. https://doi.org/10.1037/h0042820.</mixed-citation><mixed-citation xml:lang="en">Beck S.B. Еyelid conditioning as a function of cs intensity, ucs intensity, and manifest anxiety scale score. J Exp Psychol. 1963;66:429–438. https://doi.org/10.1037/h0042820.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry. 1960;23(1):56–62. https://doi.org/10.1136/jnnp.23.1.56.</mixed-citation><mixed-citation xml:lang="en">Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry. 1960;23(1):56–62. https://doi.org/10.1136/jnnp.23.1.56.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Thompson E. Hamilton Rating Scale for Anxiety (HAM-A). Occup Med (Lond). 2015;65(7):601. https://doi.org/10.1093/occmed/kqv054.</mixed-citation><mixed-citation xml:lang="en">Thompson E. Hamilton Rating Scale for Anxiety (HAM-A). Occup Med (Lond). 2015;65(7):601. https://doi.org/10.1093/occmed/kqv054.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Ziegler D., Rathmann W., Dickhaus T., Meisinger C., Mielck A. Neuropathic pain in diabetes, prediabetes and normal glucose tolerance: the MONICA/KORA Augsburg Surveys S2 and S3. Pain Med. 2009;10:393–400. https://doi.org/10.1111/j.1526-4637.2008.00555.x.</mixed-citation><mixed-citation xml:lang="en">Ziegler D., Rathmann W., Dickhaus T., Meisinger C., Mielck A. Neuropathic pain in diabetes, prediabetes and normal glucose tolerance: the MONICA/</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Centre for Clinical Practice at NICE (UK). Neuropathic Pain: The Pharmacological Management of Neuropathic Pain in Adults in Non-specialist Settings. London: National Institute for Health and Care Excellence, (UK); 2013. Available at: https://pubmed.ncbi.nlm.nih.gov/25577930.</mixed-citation><mixed-citation xml:lang="en">KORA Augsburg Surveys S2 and S3. Pain Med. 2009;10:393–400. https://doi.org/10.1111/j.1526-4637.2008.00555.x.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Schifano F. Misuse and abuse of pregabalin and gabapentin: cause for concern? CNS Drugs. 2014;28:491–496. https://doi.org/10.1007/s40263-014-0164-4.</mixed-citation><mixed-citation xml:lang="en">Centre for Clinical Practice at NICE (UK). Neuropathic Pain: The Pharmacological Management of Neuropathic Pain in Adults in Non-specialist Settings. London: National Institute for Health and Care Excellence, (UK); 2013. Available at: https://pubmed.ncbi.nlm.nih.gov/25577930.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Tesfaye S., Vileikyte L., Rayman G., Sindrup S.H., Perkins B.A., Baconja M. et al. Painful diabetic peripheral neuropathy: consensus recommendations on diagnosis, assessment and management. Diabetes Metab Res Rev. 2011;27(7):629–638. https://doi.org/10.1002/dmrr.1225.</mixed-citation><mixed-citation xml:lang="en">Schifano F. Misuse and abuse of pregabalin and gabapentin: cause for concern? CNS Drugs. 2014;28:491–496. https://doi.org/10.1007/s40263-014-0164-4.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Lunn M.P., Hughes R.A., Wiffen P.J. Duloxetine for treating painful neuropathy, chronic pain or fibromyalgia. Cochrane Database Syst Rev. 2014:Cd007115. https://doi.org/10.1002/14651858.CD007115.pub3.</mixed-citation><mixed-citation xml:lang="en">Tesfaye S., Vileikyte L., Rayman G., Sindrup S.H., Perkins B.A., Baconja M. et al. Painful diabetic peripheral neuropathy: consensus recommendations on diagnosis, assessment and management. Diabetes Metab Res Rev. 2011;27(7):629–638. https://doi.org/10.1002/dmrr.1225.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Ziegler D., Nowak H., Kempler P., Vargha P., Low P.A. Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a meta-analysis. Diabet Med. 2004;21(2):114–121. https://doi.org/10.1111/j.1464-5491.2004.01109.x.</mixed-citation><mixed-citation xml:lang="en">Lunn M.P., Hughes R.A., Wiffen P.J. Duloxetine for treating painful neuropathy, chronic pain or fibromyalgia. Cochrane Database Syst Rev. 2014:Cd007115. https://doi.org/10.1002/14651858.CD007115.pub3.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Строков И.А., Фокина А.С., Строков К.И., Дроконова О.О. Современные принципы диагностики и лечения диабетической полинейропатии. Медицинский совет. 2014;(5):38–43. https://doi.org/10.21518/2079-701X-2014-5-38-43.</mixed-citation><mixed-citation xml:lang="en">Ziegler D., Nowak H., Kempler P., Vargha P., Low P.A. Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a meta-analysis. Diabet Med. 2004;21(2):114–121. https://doi.org/10.1111/j.1464-5491.2004.01109.x.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Cure E., Cumhur Cure M. Alpha-lipoic acid may protect patients with diabetes against COVID-19 infection. Med Hypotheses. 2020;143:110185. https://doi.org/10.1016/j.mehy.2020.110185.</mixed-citation><mixed-citation xml:lang="en">Strokov I.A., Fokina A.S., Strokov K.I., Drokonova О.О. Modern principles of diagnosis and treatment of diabetic polyneuropathy. Meditsinskiy sovet = Medical Council. 2014;(5):38–43. (In Russ.) https://doi.org/10.21518/2079-701X-2014-5-38-43.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Zhong M., Sun A., Xiao T., Yao G., Sang L., Zheng X. et al. A Randomized, Single-blind, Group sequential, Active-controlled Study to evaluate the clinical efficacy and safety of α-Lipoic acid for critically ill patients with coronavirus disease 2019 (COVID-19). medRxiv. 2020. https://doi.org/10.1101/2020.04.15.20066266.</mixed-citation><mixed-citation xml:lang="en">Cure E., Cumhur Cure M. Alpha-lipoic acid may protect patients with diabetes against COVID-19 infection. Med Hypotheses. 2020;143:110185. https://doi.org/10.1016/j.mehy.2020.110185.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Ziegler D., Hanefeld M., Ruhnau K.J., Meissner H.P., Lobisch M., Schütte K., Gries F.A. Treatment of symptomatic diabetic peripheral neuropathy with the anti-oxidant alpha-lipoic acid. A 3-week multicentre randomized controlled trial (ALADIN Study). Diabetologia. 1995;38(12):1425–1433. https://doi.org/10.1007/BF00400603.</mixed-citation><mixed-citation xml:lang="en">Zhong M., Sun A., Xiao T., Yao G., Sang L., Zheng X. et al. A Randomized, Single-blind, Group sequential, Active-controlled Study to evaluate the clinical efficacy and safety of α-Lipoic acid for critically ill patients with coronavirus disease 2019 (COVID-19). medRxiv. 2020. https://doi.org/10.1101/2020.04.15.20066266.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Ziegler D., Reljanovic M., Mehnert H., Gries F.A. Alpha-lipoic acid in the treatment of diabetic polyneuropathy in Germany: current evidence from clinical trials. Exp Clin Endocrinol Diabetes. 1999;107(7):421–430. https://doi.org/10.1055/s-0029-1212132.</mixed-citation><mixed-citation xml:lang="en">Ziegler D., Hanefeld M., Ruhnau K.J., Meissner H.P., Lobisch M., Schütte K., Gries F.A. Treatment of symptomatic diabetic peripheral neuropathy with the anti-oxidant alpha-lipoic acid. A 3-week multicentre randomized controlled trial (ALADIN Study). Diabetologia. 1995;38(12):1425–1433. https://doi.org/10.1007/BF00400603.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Ametov A.S., Barinov A., Dyck P.J., Hermann R., Kozlova N., Litchy W.J. et al. The sensory symptoms of diabetic polyneuropathy are improved with alpha-lipoic acid: the SYDNEY trial. Diabetes Care. 2003;26(3):770–776. https://doi.org/10.2337/diacare.26.3.770.</mixed-citation><mixed-citation xml:lang="en">Ziegler D., Reljanovic M., Mehnert H., Gries F.A. Alpha-lipoic acid in the treatment of diabetic polyneuropathy in Germany: current evidence from clinical trials. Exp Clin Endocrinol Diabetes. 1999;107(7):421–430. https://doi.org/10.1055/s-0029-1212132.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Hammes H.P., Du X., Edelstein D., Taguchi T., Matsumura T., Ju Q. et al. Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy. Nat Med. 2003;9(3):294–299. https://doi.org/10.1038/nm834.</mixed-citation><mixed-citation xml:lang="en">Ametov A.S., Barinov A., Dyck P.J., Hermann R., Kozlova N., Litchy W.J. et al. The sensory symptoms of diabetic polyneuropathy are improved with alpha-lipoic acid: the SYDNEY trial. Diabetes Care. 2003;26(3):770–776. https://doi.org/10.2337/diacare.26.3.770.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Ang C.D., Alviar M.J., Dans A.L., Bautista-Velez G.G., Villaruz-Sulit M.V., Tan J.J. et al. Vitamin B for treating peripheral neuropathy. Cochrane Database Syst Rev. 2008;(3):CD004573. https://doi.org/10.1002/14651858.CD004573.pub3.</mixed-citation><mixed-citation xml:lang="en">Hammes H.P., Du X., Edelstein D., Taguchi T., Matsumura T., Ju Q. et al. Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy. Nat Med. 2003;9(3):294–299. https://doi.org/10.1038/nm834.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Луцкий И.С., Лютикова Л.В., Луцкий Е.И. Витамины группы В в неврологической практике. Международный неврологический журнал. 2008;(5):89–93. Режим доступа: https://www.mif-ua.com/archive/article/7441.</mixed-citation><mixed-citation xml:lang="en">Ang C.D., Alviar M.J., Dans A.L., Bautista-Velez G.G., Villaruz-Sulit M.V., Tan J.J. et al. Vitamin B for treating peripheral neuropathy. Cochrane Database Syst Rev. 2008;(3):CD004573. https://doi.org/10.1002/14651858.CD004573.pub3.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Bâ A. Metabolic and structural role of thiamine in nervous tissues. Cell Mol Neurobiol. 2008;28(7):923–931. https://doi.org/10.1007/s10571-008-9297-7.</mixed-citation><mixed-citation xml:lang="en">Luckij I.S., Lyutikova L.V., Luckij E.I. B vitamins in neurological practice. MezhdunarodnyJ nevrologicheskiJ zhurnal = International Neurological Journal. 2008;(5):89–93. (In Russ.) Available at: https://www.mif-ua.com/archive/article/7441.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Haupt E., Ledermann H., Köpcke W. Benfotiamine in the treatment of diabetic polyneuropathy a three-week randomized, controlled pilot study (BEDIP study). Int J Clin Pharmacol Ther. 2005;43(2):71–77. https://doi.org/10.5414/cpp43071.</mixed-citation><mixed-citation xml:lang="en">Bâ A. Metabolic and structural role of thiamine in nervous tissues. Cell Mol Neurobiol. 2008;28(7):923–931. https://doi.org/10.1007/s10571-008-9297-7.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Stracke H., Gaus W., Achenbach U., Federlin K., Bretzel R.G. Benfotiamine in diabetic polyneuropathy (BENDIP): results of a randomised, double blind, placebo-controlled clinical study. Exp Clin Endocrinol Diabetes. 2008;116(10):600–605. https://doi.org/10.1055/s-2008-1065351.</mixed-citation><mixed-citation xml:lang="en">Haupt E., Ledermann H., Köpcke W. Benfotiamine in the treatment of diabetic polyneuropathy a three-week randomized, controlled pilot study (BEDIP study). Int J Clin Pharmacol Ther. 2005;43(2):71–77. https://doi.org/10.5414/cpp43071.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Mooney S., Leuendorf J.E., Hendrickson C., Hellmann H. Vitamin B6: a long known compound of surprising complexity. Molecules. 2009;14(1):329–351. https://doi.org/10.3390/molecules14010329.</mixed-citation><mixed-citation xml:lang="en">Stracke H., Gaus W., Achenbach U., Federlin K., Bretzel R.G. Benfotiamine in diabetic polyneuropathy (BENDIP): results of a randomised, double blind, placebo-controlled clinical study. Exp Clin Endocrinol Diabetes. 2008;116(10):600–605. https://doi.org/10.1055/s-2008-1065351.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Markle H.V. Cobalamin. Crit Rev Clin Lab Sci. 1996;33(4):247–356. https://doi.org/10.3109/10408369609081009.</mixed-citation><mixed-citation xml:lang="en">Mooney S., Leuendorf J.E., Hendrickson C., Hellmann H. Vitamin B6: a long known compound of surprising complexity. Molecules. 2009;14(1):329–351. https://doi.org/10.3390/molecules14010329.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Павлов Ч.С., Дамулин И.В., Шульпекова Ю.О., Андреев Е.А. Неврологические расстройства при дефиците витамина В12. Терарапевтический архив. 2019;91(4):122–129. Режим доступа: https://cyberleninka.ru/article/n/nevrologicheskie-rasstroystva-pridefitsite-vitamina-v12.</mixed-citation><mixed-citation xml:lang="en">Markle H.V. Cobalamin. Crit Rev Clin Lab Sci. 1996;33(4):247–356. https://doi.org/10.3109/10408369609081009.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Jayabalan B., Low L.L. Vitamin B supplementation for diabetic peripheral neuropathy. Singapore Med J. 2016;57(2):55–59. https://doi.org/10.11622/smedj.2016027.</mixed-citation><mixed-citation xml:lang="en">Pavlov Ch.S., Damulin I.V., Shulpekova Yu.O., Andreyev E.A. Neurological disorders in vitamin B12 deficiency. Terapevticheskii arkhiv = Therapeutic Archive. 2019;91(4):122–129. (In Russ.) Available at: https://cyberleninka.ru/article/n/nevrologicheskie-rasstroystva-pri-defitsite-vitamina-v12.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Верткин А.Л., Городецкий В.В. В чем преимущество бенфотиаминсодержащих препаратов Мильгамма и Бенфогамма в лечении диабетической полинейропатии. Фарматека. 2006;(11):83–89. Режим доступа: https://pharmateca.ru/ru/archive/article/6589.</mixed-citation><mixed-citation xml:lang="en">Jayabalan B., Low L.L. Vitamin B supplementation for diabetic peripheral neuropathy. Singapore Med J. 2016;57(2):55–59. https://doi.org/10.11622/smedj.2016027.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Маркина О.А. Значение лекарственной формы и пути введения витаминов группы В для обеспечения эффективного лечения диабетической полиневропатии. Клиническая фармакология и терапия. 2003;(2):6–9. Режим доступа: https://medi.ru/info/11187.</mixed-citation><mixed-citation xml:lang="en">Vertkin A.L., Gorodeckij V.V. What is the advantage of benfotiaminecontaining drugs Milgamma and Benfogamma in the treatment of diabetic polyneuropathy. Farmateka. 2006;(11):83–89. (In Russ.) Available at: https://pharmateca.ru/ru/archive/article/6589.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Парфенов В.А., Головачева В.А., Фадеев В.В., Воловик А.Ю., Головачева А.А. Оптимизация ведения пациентов с диабетической полиневропатией с помощью междисциплинарного подхода. Медицинский совет. 2017;(1S):71–79. https://doi.org/10.21518/2079-701X-2017-0-71-79.</mixed-citation><mixed-citation xml:lang="en">Markina O.A. The importance of the dosage form and the route of administration of B vitamins to ensure effective treatment of diabetic polyneuropathy. Кlinicheskaya farmakologiya i terapiya = Clinical Pharmacology and Therapy. 2003;(2):6–9. (In Russ.) Available at: https://medi.ru/info/11187.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Манушарова Р.А., Черкезов Д.И. Применение Нейромультивита при диабетической периферической полинейропатии. Медицинский совет. 2011;(1-2):68–71. Режим доступа: https://cyberleninka.ru/article/n/primenenie-neyromultivita-pri-diabeticheskoy-perifericheskoypolineyropatii.</mixed-citation><mixed-citation xml:lang="en">Parfenov V.A., Golovacheva V.A., Fadeev V.V., Volovik A.Yu., Golovacheva A.A. Оptimization diabetic polyneuropathy patients management using a multidisciplinary approach. Meditsinskiy sovet = Medical Council. 2017;(1S): 71–79. (In Russ.) https://doi.org/10.21518/2079-701X-2017-0-71-79.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Токмакова А.Ю., Анциферов М.Б. Возможности использования нейромультивита в комплексной терапии полинейропатии у больных сахарным диабетом. Сахарный диабет. 2001;4(2):33–35. https://doi.org/10.14341/2072-0351-5660.</mixed-citation><mixed-citation xml:lang="en">Manusharova R.A., Cherkezov D.I. The use of Neuromultivitis in diabetic peripheral polyneuropathy. Meditsinskiy sovet = Medical Council. 2011;(1-2):68–71. (In Russ.) Available at: https://cyberleninka.ru/article/n/primenenie-neyromultivita-pri-diabeticheskoy-perifericheskoypolineyropatii.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Al Sulaiman K., Aljuhani O., Al Dossari M., Alshahrani A., Alharbi A., Algarni R. et al. Evaluation of thiamine as adjunctive therapy in COVID-19 critically ill patients: a two-center propensity score matched study. Crit Care. 2021;25(1):223. https://doi.org/10.1186/s13054-021-03648-9.</mixed-citation><mixed-citation xml:lang="en">Tokmakova A.Yu., Antsiferov M.B. The possibilities of using neuromultivitis in the complex therapy of polyneuropathy in patients with diabetes mellitus. Sakharnyy diabet = Diabetes Mellitus. 2001;4(2):33–35. (In Russ.) https://doi.org/10.14341/2072-0351-5660.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Branco de Oliveira M.V., Irikura S., Lourenço F.H. B., Shinsato M., Irikura T.C. D. B., Irikura R.B. et al. Encephalopathy responsive to thiamine in severe COVID-19 patients. Brain Behav Immun Health. 2021;14:100252. https://doi.org/10.1016/j.bbih.2021.100252.</mixed-citation><mixed-citation xml:lang="en">Al Sulaiman K., Aljuhani O., Al Dossari M., Alshahrani A., Alharbi A., Algarni R. et al. Evaluation of thiamine as adjunctive therapy in COVID-19 critically ill patients: a two-center propensity score matched study. Crit Care. 2021;25(1):223. https://doi.org/10.1186/s13054-021-03648-9.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Shakoor H., Feehan J., Mikkelsen K., Al Dhaheri A.S., Ali H.I., Platat C. et al. Be well: A potential role for vitamin B in COVID-19. Maturitas. 2021;144:108–111. https://doi.org/10.1016/j.maturitas.2020.08.007.</mixed-citation><mixed-citation xml:lang="en">Branco de Oliveira M.V., Irikura S., Lourenço F.H. B., Shinsato M., Irikura T.C. D. B., Irikura R.B. et al. Encephalopathy responsive to thiamine in severe COVID-19 patients. Brain Behav Immun Health. 2021;14:100252. https://doi.org/10.1016/j.bbih.2021.100252.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Kumrungsee T., Zhang P., Chartkul M., Yanaka N., Kato N. Potential Role of Vitamin B6 in Ameliorating the Severity of COVID-19 and Its Complications. Front Nutr. 2020;7:562051. https://doi.org/10.3389/fnut.2020.562051.</mixed-citation><mixed-citation xml:lang="en">Shakoor H., Feehan J., Mikkelsen K., Al Dhaheri A.S., Ali H.I., Platat C. et al. Be well: A potential role for vitamin B in COVID-19. Maturitas. 2021;144:108–111. https://doi.org/10.1016/j.maturitas.2020.08.007.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Lopes M.J. S. Can vitamin B12 be an adjuvant to COVID-19 treatment? GSC Biological and Pharmaceutical Sciences. 2020;11(3):1–5. Available at: https://gsconlinepress.com/journals/gscbps/content/can-vitamin-b12-beadjuvant-covid-19-treatment.</mixed-citation><mixed-citation xml:lang="en">Kumrungsee T., Zhang P., Chartkul M., Yanaka N., Kato N. Potential Role of Vitamin B6 in Ameliorating the Severity of COVID-19 and Its Complications. Front Nutr. 2020;7:562051. https://doi.org/10.3389/fnut.2020.562051.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Менделевич Е.Г. Дефицит витаминов группы В: аспекты диагностики и терапии. РМЖ. 2016;24(7):442–444. Режим доступа: https://rmj.ru/articles/nevrologiya/Deficit_vitaminov_gruppy_V_aspekty_diagnostikii_terapii.</mixed-citation><mixed-citation xml:lang="en">Lopes M.J. S. Can vitamin B12 be an adjuvant to COVID-19 treatment? GSC Biological and Pharmaceutical Sciences. 2020;11(3):1–5. Available at: https://gsconlinepress.com/journals/gscbps/content/can-vitamin-b12-beadjuvant-covid-19-treatment.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Бирюкова Е.В., Ганненкова Е.С., Соловьева И.В. Диабетическая полинейропатия: чего мы достигли в понимании проблемы? РМЖ. 2020;28(1):14–19. Режим доступа: https://rmj.ru/articles/endokrinologiya/Diabeticheskaya_polineyropatiya_chego_my_dostigli_v_ponimanii_problemy</mixed-citation><mixed-citation xml:lang="en">Mendelevich E.G. Vitamin B deficiency: aspects of diagnosis and therapy. RMJ. 2016;24(7):442–444. (In Russ.) Available at: https://rmj.ru/articles/nevrologiya/Deficit_vitaminov_gruppy_V_aspekty_diagnostikii_terapii.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Biryukova E.V., Gannenkova E.S., Soloveva I.V. Diabetic polyneuropathy: what have we achieved in understanding the problem? RMJ. 2020;28(1):14–19. (In Russ.) Available at: https://rmj.ru/articles/endokrinologiya/Diabeticheskaya_polineyropatiya_chego_my_dostigli_v_ponimanii_problemy</mixed-citation><mixed-citation xml:lang="en">Biryukova E.V., Gannenkova E.S., Soloveva I.V. Diabetic polyneuropathy: what have we achieved in understanding the problem? RMJ. 2020;28(1):14–19. (In Russ.) Available at: https://rmj.ru/articles/endokrinologiya/Diabeticheskaya_polineyropatiya_chego_my_dostigli_v_ponimanii_problemy</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
